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ONTOLOGY REPORT - ANNOTATIONS


Term:S-adenosyl-L-methionine
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Accession:CHEBI:15414 term browser browse the term
Definition:A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.
Synonyms:exact_synonym: [(3S)-3-amino-3-carboxypropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium
 related_synonym: (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt;   Acylcarnitine;   AdoMet;   Formula=C15H23N6O5S;   InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1;   InChIKey=MEFKEPWMEQBLKI-AIRLBKTGSA-O;   S-(5'-deoxyadenosin-5'-yl)-L-methionine;   S-Adenosylmethionine;   SAM;   SAMe;   SMILES=C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12;   [1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
 alt_id: CHEBI:10786;   CHEBI:10833;   CHEBI:12742;   CHEBI:12757;   CHEBI:12760;   CHEBI:22036;   CHEBI:45607;   CHEBI:527887;   CHEBI:8946
 xref: Beilstein:3576439 "Beilstein";   CAS:29908-03-0 "ChemIDplus";   CAS:29908-03-0 "KEGG COMPOUND";   COMe:MOL000172;   DrugBank:DB00118;   HMDB:HMDB0001185;   KEGG:C00019;   KNApSAcK:C00007347
 xref_mesh: MESH:D012436
 xref: MetaCyc:S-ADENOSYLMETHIONINE;   PMID:11017945 "Europe PMC";   PMID:17439666 "Europe PMC";   Reaxys:3919754 "Reaxys";   Wikipedia:S-Adenosyl_methionine
 cyclic_relationship: is_conjugate_acid_of CHEBI:67040;   is_tautomer_of CHEBI:59789


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S-adenosyl-L-methionine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgre4 adhesion G protein-coupled receptor E4 JBrowse link 9 8,056,034 8,200,262 RGD:6480464
G Adgre5 adhesion G protein-coupled receptor E5 JBrowse link 19 24,854,981 24,875,712 RGD:6480464
G Afp alpha-fetoprotein JBrowse link 14 19,141,755 19,159,919 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Alad aminolevulinate dehydratase JBrowse link 5 78,368,867 78,379,206 RGD:6480464
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G As3mt arsenite methyltransferase JBrowse link 1 266,482,787 266,514,570 RGD:6480464
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:6480464
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:6480464
G Bhmt2 betaine-homocysteine S-methyltransferase 2 JBrowse link 2 23,272,320 23,289,266 RGD:6480464
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col1a2 collagen type I alpha 2 chain JBrowse link 4 31,534,225 31,569,152 RGD:6480464
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Ddc dopa decarboxylase JBrowse link 14 91,905,919 91,996,816 RGD:6480464
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:6480464
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Fcgr1a Fc fragment of IgG receptor Ia JBrowse link 2 198,430,536 198,439,453 RGD:6480464
G Fgf19 fibroblast growth factor 19 JBrowse link 1 218,058,405 218,061,693 RGD:6480464
G Fgl2 fibrinogen-like 2 JBrowse link 4 10,323,598 10,329,241 RGD:6480464
G Gbp2 guanylate binding protein 2 JBrowse link 2 248,276,795 248,293,784 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Greb1 growth regulating estrogen receptor binding 1 JBrowse link 6 41,932,941 42,002,770 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Gss glutathione synthetase JBrowse link 3 151,076,254 151,106,557 RGD:6480464
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:6480464
G Hbb hemoglobin subunit beta JBrowse link 1 168,971,269 168,972,680 RGD:6480464
G Hdac9 histone deacetylase 9 JBrowse link 6 53,487,367 54,358,694 RGD:6480464
G Hmbs hydroxymethylbilane synthase JBrowse link 8 48,667,278 48,674,673 RGD:6480464
G Ifi44l interferon-induced protein 44-like JBrowse link 2 256,948,722 256,979,573 RGD:6480464
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:6480464
G Il36g interleukin 36, gamma JBrowse link 3 1,285,658 1,291,836 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Klf6 Kruppel-like factor 6 JBrowse link 17 67,887,939 67,945,052 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G LOC103694381 lymphotoxin-beta JBrowse link 20 4,861,343 4,863,513 RGD:6480464
G Maf MAF bZIP transcription factor JBrowse link 19 48,179,826 48,200,995 RGD:6480464
G Mafg MAF bZIP transcription factor G JBrowse link 10 109,802,877 109,811,476 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mat1a methionine adenosyltransferase 1A JBrowse link 16 18,690,649 18,709,135 RGD:6480464
G Mat2a methionine adenosyltransferase 2A JBrowse link 4 100,297,478 100,303,047 RGD:6480464
G Mbd2 methyl-CpG binding domain protein 2 JBrowse link 18 65,814,026 65,885,115 RGD:6480464
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 6 99,282,850 99,350,367 RGD:6480464
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 17 66,210,444 66,295,014 RGD:6480464
G Ndrg1 N-myc downstream regulated 1 JBrowse link 7 107,734,326 107,775,701 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Pde4b phosphodiesterase 4B JBrowse link 5 121,759,236 122,136,814 RGD:6480464
G Pemt phosphatidylethanolamine N-methyltransferase JBrowse link 10 46,339,821 46,404,640 RGD:6480464
G Pfn2 profilin 2 JBrowse link 2 147,953,858 147,959,692 RGD:6480464
G Psmb8 proteasome 20S subunit beta 8 JBrowse link 20 3,990,809 3,993,772 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Rnasel ribonuclease L JBrowse link 13 71,188,712 71,202,636 RGD:6480464
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:6480464
G Slc19a1 solute carrier family 19 member 1 JBrowse link 20 12,334,675 12,354,517 RGD:6480464
G Smyd2 SET and MYND domain containing 2 JBrowse link 13 108,642,156 108,686,293 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Sp1 Sp1 transcription factor JBrowse link 7 144,014,173 144,044,635 RGD:6480464
G Tf transferrin JBrowse link 8 111,694,570 111,721,275 RGD:6480464
G Tff1 trefoil factor 1 JBrowse link 20 9,892,124 9,895,984 RGD:6480464
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tpmt thiopurine S-methyltransferase JBrowse link 17 18,029,090 18,047,716 RGD:6480464
G Ubd ubiquitin D JBrowse link 20 1,876,175 1,878,126 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        biochemical role 19125
          cofactor 15844
            S-adenosyl-L-methionine 79
              (R)-S-adenosyl-L-methionine 0
              (S)-S-adenosyl-L-methionine 0
              S-adenosyl-S-carboxymethyl-L-homocysteine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      p-block molecular entity 19531
                        chalcogen molecular entity 19217
                          sulfur molecular entity 15974
                            sulfonium compound 80
                              S-adenosyl-L-methionine 79
                                (R)-S-adenosyl-L-methionine 0
                                (S)-S-adenosyl-L-methionine 0
                                S-adenosyl-S-carboxymethyl-L-homocysteine 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.