DHRS4 (dehydrogenase/reductase 4) - Rat Genome Database

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Gene: DHRS4 (dehydrogenase/reductase 4) Canis lupus familiaris
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Symbol: DHRS4
Name: dehydrogenase/reductase 4
RGD ID: 12169889
Description: ENCODES a protein that exhibits 3-keto sterol reductase activity (ortholog); alcohol dehydrogenase [NAD(P)+] activity (ortholog); carbonyl reductase (NADPH) activity (ortholog); INVOLVED IN alcohol metabolic process (ortholog); cellular ketone metabolic process (ortholog); positive regulation of reactive oxygen species metabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN nucleus (ortholog); peroxisomal membrane (ortholog); peroxisome (ortholog); INTERACTS WITH 16-Ketoestrone; 3-oxo-5beta-cholanic acid; 9,10-phenanthroquinone
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dehydrogenase/reductase (SDR family) member 4; dehydrogenase/reductase SDR family member 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,046,532 - 4,058,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,046,544 - 4,084,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,968,424 - 3,980,384 (+)NCBI
ROS_Cfam_1.084,157,197 - 4,169,172 (+)NCBI
UMICH_Zoey_3.183,847,979 - 3,859,935 (+)NCBI
UNSW_CanFamBas_1.083,909,733 - 3,921,692 (+)NCBI
UU_Cfam_GSD_1.084,171,825 - 4,183,775 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:3511844   PMID:23036705  


Genomics

Comparative Map Data
DHRS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,046,532 - 4,058,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,046,544 - 4,084,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,968,424 - 3,980,384 (+)NCBI
ROS_Cfam_1.084,157,197 - 4,169,172 (+)NCBI
UMICH_Zoey_3.183,847,979 - 3,859,935 (+)NCBI
UNSW_CanFamBas_1.083,909,733 - 3,921,692 (+)NCBI
UU_Cfam_GSD_1.084,171,825 - 4,183,775 (+)NCBI
DHRS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1423,953,734 - 23,969,279 (+)EnsemblGRCh38hg38GRCh38
GRCh381423,953,735 - 23,969,279 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371424,422,979 - 24,438,488 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,492,805 - 23,508,328 (+)NCBINCBI36hg18NCBI36
Build 341423,492,804 - 23,508,326NCBI
Celera144,285,601 - 4,303,126 (+)NCBI
Cytogenetic Map14q11.2NCBI
HuRef144,539,991 - 4,555,519 (+)NCBIHuRef
CHM1_11424,421,602 - 24,437,128 (+)NCBICHM1_1
Dhrs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,715,880 - 55,727,797 (+)NCBIGRCm39mm39
GRCm39 Ensembl1455,716,215 - 55,727,797 (+)Ensembl
GRCm381455,478,741 - 55,490,340 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,478,758 - 55,490,340 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,097,595 - 56,109,177 (+)NCBIGRCm37mm9NCBIm37
MGSCv361454,432,868 - 54,444,411 (+)NCBImm8
Celera1453,283,670 - 53,295,252 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Dhrs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21528,966,544 - 28,978,135 (+)NCBI
Rnor_6.0 Ensembl1534,155,504 - 34,167,072 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01534,155,043 - 34,167,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01538,045,908 - 38,057,499 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,609,570 - 33,621,142 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11533,625,453 - 33,636,460 (+)NCBI
Celera1528,542,580 - 28,554,149 (+)NCBICelera
Cytogenetic Map15p13NCBI
LOC100974941
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11422,831,557 - 22,953,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,831,756 - 22,846,695 (+)Ensemblpanpan1.1panPan2
DHRS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,242,121 - 75,255,600 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,242,121 - 75,255,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,512,359 - 80,525,829 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHRS4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12924,170,090 - 24,185,509 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low 4 4
Below cutoff 3 4 12 6 3 6 6 1 2 5 6 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018549   ⟹   ENSCAFP00000017182
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,046,544 - 4,058,496 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000018751   ⟹   ENSCAFP00000017373
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,078,179 - 4,084,710 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000062870   ⟹   ENSCAFP00000058290
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,078,496 - 4,084,744 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077604   ⟹   ENSCAFP00000062226
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,046,544 - 4,058,496 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087328   ⟹   ENSCAFP00000046118
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,046,544 - 4,058,496 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092318   ⟹   ENSCAFP00000059200
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,078,179 - 4,084,710 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000093080   ⟹   ENSCAFP00000057213
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,078,179 - 4,084,744 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000093369   ⟹   ENSCAFP00000058295
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,046,544 - 4,081,770 (+)Ensembl
RefSeq Acc Id: NM_001048234   ⟹   NP_001041699
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,046,544 - 4,058,498 (+)NCBI
Dog10K_Boxer_Tasha83,968,424 - 3,980,384 (+)NCBI
ROS_Cfam_1.084,157,213 - 4,169,172 (+)NCBI
UMICH_Zoey_3.183,847,979 - 3,859,935 (+)NCBI
UNSW_CanFamBas_1.083,909,733 - 3,921,692 (+)NCBI
UU_Cfam_GSD_1.084,171,825 - 4,183,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005623197   ⟹   XP_005623254
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,046,532 - 4,058,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038672878   ⟹   XP_038528806
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,157,197 - 4,169,172 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001041699 (Get FASTA)   NCBI Sequence Viewer  
  XP_038528806 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAF32569 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005623254   ⟸   XM_005623197
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001041699   ⟸   NM_001048234
- UniProtKB: F1PCI3 (UniProtKB/TrEMBL),   Q0E9S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000017373   ⟸   ENSCAFT00000018751
RefSeq Acc Id: ENSCAFP00000017182   ⟸   ENSCAFT00000018549
RefSeq Acc Id: ENSCAFP00000062226   ⟸   ENSCAFT00000077604
RefSeq Acc Id: ENSCAFP00000046118   ⟸   ENSCAFT00000087328
RefSeq Acc Id: ENSCAFP00000058295   ⟸   ENSCAFT00000093369
RefSeq Acc Id: ENSCAFP00000057213   ⟸   ENSCAFT00000093080
RefSeq Acc Id: ENSCAFP00000058290   ⟸   ENSCAFT00000062870
RefSeq Acc Id: ENSCAFP00000059200   ⟸   ENSCAFT00000092318
RefSeq Acc Id: XP_038528806   ⟸   XM_038672878
- Peptide Label: isoform X1
Protein Domains
C2

Promoters
RGD ID:13684143
Promoter ID:EPDNEW_C2213
Type:initiation region
Name:DHRS4_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,046,602 - 4,046,662EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011767 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000017182 UniProtKB/TrEMBL
  ENSCAFP00000046118 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000057213 UniProtKB/TrEMBL
  ENSCAFP00000058290 UniProtKB/TrEMBL
  ENSCAFP00000058295 UniProtKB/TrEMBL
  ENSCAFP00000059200 UniProtKB/TrEMBL
  ENSCAFP00000062226 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018549 UniProtKB/TrEMBL
  ENSCAFT00000062870 UniProtKB/TrEMBL
  ENSCAFT00000077604 UniProtKB/TrEMBL
  ENSCAFT00000087328 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000092318 UniProtKB/TrEMBL
  ENSCAFT00000093080 UniProtKB/TrEMBL
  ENSCAFT00000093369 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2B_Copine UniProtKB/TrEMBL
  Copine UniProtKB/TrEMBL
  DHRS4-like UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/TrEMBL
  SDR_fam UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:480254 UniProtKB/TrEMBL
NCBI Gene DHRS4 ENTREZGENE
PANTHER PTHR43943:SF8 UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
  Copine UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART SM00239 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
UniProt A0A5F4BW56_CANLF UniProtKB/TrEMBL
  A0A5F4CVD2_CANLF UniProtKB/TrEMBL
  A0A5F4CVD7_CANLF UniProtKB/TrEMBL
  A0A5F4CWS1_CANLF UniProtKB/TrEMBL
  A0A5F4D0E4_CANLF UniProtKB/TrEMBL
  A0A5F4D636_CANLF UniProtKB/TrEMBL
  F1PCI3 ENTREZGENE, UniProtKB/TrEMBL
  Q0E9S7 ENTREZGENE, UniProtKB/TrEMBL