CPNE6 (copine 6) - Rat Genome Database

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Gene: CPNE6 (copine 6) Canis lupus familiaris
Analyze
Symbol: CPNE6
Name: copine 6
RGD ID: 12169889
Description: ENCODES a protein that exhibits 3-keto sterol reductase activity (ortholog); alcohol dehydrogenase [NAD(P)+] activity (ortholog); identical protein binding (ortholog); INVOLVED IN alcohol metabolic process (ortholog); cellular ketone metabolic process (ortholog); positive regulation of reactive oxygen species metabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); COVID-19 (ortholog); FOUND IN nucleus (ortholog); peroxisomal membrane (ortholog); peroxisome (ortholog); INTERACTS WITH 16-Ketoestrone; 3-oxo-5beta-cholanic acid; 9,10-phenanthroquinone
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dehydrogenase/reductase (SDR family) member 4; dehydrogenase/reductase 4; dehydrogenase/reductase SDR family member 4; DHRS4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,046,532 - 4,058,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,046,544 - 4,084,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,968,424 - 3,980,384 (+)NCBI
ROS_Cfam_1.084,157,197 - 4,169,172 (+)NCBI
ROS_Cfam_1.0 Ensembl84,157,179 - 4,169,172 (+)Ensembl
UMICH_Zoey_3.183,847,979 - 3,859,935 (+)NCBI
UNSW_CanFamBas_1.083,909,733 - 3,921,692 (+)NCBI
UU_Cfam_GSD_1.084,171,825 - 4,183,775 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:3511844   PMID:23036705  


Genomics

Comparative Map Data
CPNE6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,046,532 - 4,058,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,046,544 - 4,084,744 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,968,424 - 3,980,384 (+)NCBI
ROS_Cfam_1.084,157,197 - 4,169,172 (+)NCBI
ROS_Cfam_1.0 Ensembl84,157,179 - 4,169,172 (+)Ensembl
UMICH_Zoey_3.183,847,979 - 3,859,935 (+)NCBI
UNSW_CanFamBas_1.083,909,733 - 3,921,692 (+)NCBI
UU_Cfam_GSD_1.084,171,825 - 4,183,775 (+)NCBI
DHRS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,953,770 - 23,969,279 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1423,953,734 - 23,969,279 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,422,979 - 24,438,488 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,492,805 - 23,508,328 (+)NCBINCBI36hg18NCBI36
Build 341423,492,804 - 23,508,326NCBI
Celera144,285,601 - 4,303,126 (+)NCBI
Cytogenetic Map14q11.2NCBI
HuRef144,539,991 - 4,555,519 (+)NCBIHuRef
CHM1_11424,421,623 - 24,437,128 (+)NCBICHM1_1
T2T-CHM13v2.01418,154,121 - 18,169,610 (+)NCBI
Dhrs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,715,880 - 55,727,797 (+)NCBIGRCm39mm39
GRCm39 Ensembl1455,716,215 - 55,727,797 (+)Ensembl
GRCm381455,478,741 - 55,490,340 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,478,758 - 55,490,340 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,097,595 - 56,109,177 (+)NCBIGRCm37mm9NCBIm37
MGSCv361454,432,868 - 54,444,411 (+)NCBImm8
Celera1453,283,670 - 53,295,252 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Dhrs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21528,966,544 - 28,978,135 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1528,966,553 - 28,978,127 (+)Ensembl
Rnor_6.01534,155,043 - 34,167,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,155,504 - 34,167,072 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,045,908 - 38,057,499 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,609,570 - 33,621,142 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11533,625,453 - 33,636,460 (+)NCBI
Celera1528,542,580 - 28,554,149 (+)NCBICelera
Cytogenetic Map15p13NCBI
LOC100974941
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11422,831,557 - 22,953,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1422,831,756 - 22,846,695 (+)Ensemblpanpan1.1panPan2
DHRS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl775,242,124 - 75,255,598 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1775,242,121 - 75,255,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,512,359 - 80,525,829 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHRS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12924,170,090 - 24,185,509 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2924,169,818 - 24,185,634 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605922,224,518 - 22,239,925 (-)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low 4 4
Below cutoff 3 4 12 6 3 6 6 1 2 5 6 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000018549   ⟹   ENSCAFP00000017182
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,046,544 - 4,058,496 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000018751   ⟹   ENSCAFP00000017373
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,078,179 - 4,084,710 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000062870   ⟹   ENSCAFP00000058290
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,078,496 - 4,084,744 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077604   ⟹   ENSCAFP00000062226
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,046,544 - 4,058,496 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087328   ⟹   ENSCAFP00000046118
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,046,544 - 4,058,496 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092318   ⟹   ENSCAFP00000059200
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,078,179 - 4,084,710 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000093080   ⟹   ENSCAFP00000057213
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,078,179 - 4,084,744 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000093369   ⟹   ENSCAFP00000058295
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,046,544 - 4,081,770 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845007667   ⟹   ENSCAFP00845006065
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,157,179 - 4,169,172 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845007671   ⟹   ENSCAFP00845006067
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,157,179 - 4,169,172 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845007674   ⟹   ENSCAFP00845006069
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,157,179 - 4,169,172 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845007679   ⟹   ENSCAFP00845006072
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,157,179 - 4,169,168 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845007681   ⟹   ENSCAFP00845006073
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,157,179 - 4,169,168 (+)Ensembl
RefSeq Acc Id: NM_001048234   ⟹   NP_001041699
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,046,544 - 4,058,498 (+)NCBI
Dog10K_Boxer_Tasha83,968,424 - 3,980,384 (+)NCBI
ROS_Cfam_1.084,157,213 - 4,169,172 (+)NCBI
UMICH_Zoey_3.183,847,979 - 3,859,935 (+)NCBI
UNSW_CanFamBas_1.083,909,733 - 3,921,692 (+)NCBI
UU_Cfam_GSD_1.084,171,825 - 4,183,775 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038672878   ⟹   XP_038528806
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,157,197 - 4,169,172 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001041699 (Get FASTA)   NCBI Sequence Viewer  
  XP_038528806 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAF32569 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001041699   ⟸   NM_001048234
- UniProtKB: F1PCI3 (UniProtKB/TrEMBL),   Q0E9S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000017373   ⟸   ENSCAFT00000018751
RefSeq Acc Id: ENSCAFP00000017182   ⟸   ENSCAFT00000018549
RefSeq Acc Id: ENSCAFP00000062226   ⟸   ENSCAFT00000077604
RefSeq Acc Id: ENSCAFP00000046118   ⟸   ENSCAFT00000087328
RefSeq Acc Id: ENSCAFP00000058295   ⟸   ENSCAFT00000093369
RefSeq Acc Id: ENSCAFP00000057213   ⟸   ENSCAFT00000093080
RefSeq Acc Id: ENSCAFP00000058290   ⟸   ENSCAFT00000062870
RefSeq Acc Id: ENSCAFP00000059200   ⟸   ENSCAFT00000092318
RefSeq Acc Id: XP_038528806   ⟸   XM_038672878
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845006072   ⟸   ENSCAFT00845007679
RefSeq Acc Id: ENSCAFP00845006069   ⟸   ENSCAFT00845007674
RefSeq Acc Id: ENSCAFP00845006065   ⟸   ENSCAFT00845007667
RefSeq Acc Id: ENSCAFP00845006067   ⟸   ENSCAFT00845007671
RefSeq Acc Id: ENSCAFP00845006073   ⟸   ENSCAFT00845007681
Protein Domains
C2

Promoters
RGD ID:13684143
Promoter ID:EPDNEW_C2213
Type:initiation region
Name:DHRS4_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,046,602 - 4,046,662EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 4053545 4053546 A G snv Doberman Pinscher (DO159)
8 4053559 4053560 A C snv Doberman Pinscher (DO159)
8 4058061 4058062 C G snv Doberman Pinscher (DO159), Doberman Pinscher (DO263)
8 4058064 4058065 C T snv Doberman Pinscher (DO263), Doberman Pinscher (DO159)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011767 Ensembl
  ENSCAFG00030013117 UniProtKB/TrEMBL
  ENSCAFG00040003224 UniProtKB/TrEMBL
  ENSCAFG00845004249 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030021402.1 UniProtKB/TrEMBL
  ENSCAFP00040005324 UniProtKB/TrEMBL
  ENSCAFP00845006065 ENTREZGENE
  ENSCAFP00845006065.1 UniProtKB/TrEMBL
  ENSCAFP00845006067.1 UniProtKB/TrEMBL
  ENSCAFP00845006069.1 UniProtKB/TrEMBL
  ENSCAFP00845006072 ENTREZGENE
  ENSCAFP00845006072.1 UniProtKB/TrEMBL
  ENSCAFP00845006073.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030024516.1 UniProtKB/TrEMBL
  ENSCAFT00040006162 UniProtKB/TrEMBL
  ENSCAFT00845007667 ENTREZGENE
  ENSCAFT00845007667.1 UniProtKB/TrEMBL
  ENSCAFT00845007671.1 UniProtKB/TrEMBL
  ENSCAFT00845007674.1 UniProtKB/TrEMBL
  ENSCAFT00845007679 ENTREZGENE
  ENSCAFT00845007679.1 UniProtKB/TrEMBL
  ENSCAFT00845007681.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2B_Copine UniProtKB/TrEMBL
  Copine UniProtKB/TrEMBL
  Copine_C UniProtKB/TrEMBL
  DHRS4-like UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/TrEMBL
  SDR_fam UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:480254 UniProtKB/TrEMBL
NCBI Gene DHRS4 ENTREZGENE
PANTHER PTHR10857 UniProtKB/TrEMBL
  PTHR43943:SF8 UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
  Copine UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
PRINTS GDHRDH UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART SM00239 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
UniProt A0A8C0QCT9_CANLF UniProtKB/TrEMBL
  A0A8I3MKH3_CANLF UniProtKB/TrEMBL
  A0A8I3MPN6_CANLF UniProtKB/TrEMBL
  A0A8I3MUA2_CANLF UniProtKB/TrEMBL
  A0A8I3MW01_CANLF UniProtKB/TrEMBL
  A0A8I3N882_CANLF UniProtKB/TrEMBL
  F1PCI3 ENTREZGENE
  Q0E9S7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-26 CPNE6  copine 6  DHRS4  dehydrogenase/reductase 4  Symbol and/or name change 19259463 PROVISIONAL