CPNE6 (copine 6) - Rat Genome Database

Name: CPNE6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: CPNE6 (copine 6) Canis lupus familiaris

Analyze

Symbol:

CPNE6 (Ensembl: DHRS4)

Name:

copine 6 (Ensembl:dehydrogenase/reductase 4)

RGD ID:

12169889

Description:

ENCODES a protein that exhibits 3-keto sterol reductase activity (ortholog); alcohol dehydrogenase [NAD(P)+] activity (ortholog); all-trans-retinol dehydrogenase (NADP+) activity (ortholog); INVOLVED IN alcohol metabolic process (ortholog); cellular ketone metabolic process (ortholog); positive regulation of reactive oxygen species metabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); COVID-19 (ortholog); lysinuric protein intolerance (ortholog); FOUND IN nucleus (ortholog); peroxisomal membrane (ortholog); peroxisome (ortholog); INTERACTS WITH 16-Ketoestrone; 3-oxo-5beta-cholanic acid; 9,10-phenanthroquinone

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

dehydrogenase/reductase (SDR family) member 4; dehydrogenase/reductase 4; dehydrogenase/reductase SDR family member 4; DHRS4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,046,532 - 4,058,498 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,046,544 - 4,084,744 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	3,968,424 - 3,980,384 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,157,197 - 4,169,172 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,157,179 - 4,169,172 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	3,847,979 - 3,859,935 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	3,909,733 - 3,921,692 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,171,825 - 4,183,775 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain-Lung-Thyroid Syndrome (ISO)

COVID-19 (ISO)

lysinuric protein intolerance (ISO)

Specific Granule Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

16-Ketoestrone (EXP)

3-oxo-5beta-cholanic acid (EXP)

9,10-phenanthroquinone (EXP)

9-cis-retinal (EXP)

acenaphthoquinone (EXP)

bromosulfophthalein (EXP)

cholanic acid (EXP)

flufenamic acid (EXP)

genistein (EXP)

hexane-2,3-dione (EXP)

isatin (EXP)

kaempferol (EXP)

lithocholic acid (EXP)

masitinib (EXP)

menadione (EXP)

pentane-2,3-dione (EXP)

phenylglyoxylic acid (EXP)

quercetin (EXP)

tetradecanoic acid (EXP)

valerophenone (EXP)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

alcohol metabolic process (ISO)

cellular ketone metabolic process (ISO)

cellular response to calcium ion (IEA)

positive regulation of reactive oxygen species metabolic process (ISO)

retinal metabolic process (IEA,ISO)

retinoid metabolic process (ISO)

steroid metabolic process (ISO)

Cellular Component

mitochondrion (IEA)

nucleus (ISO)

peroxisomal membrane (ISO)

peroxisome (IEA,ISO)

plasma membrane (IEA)

Molecular Function

3-keto sterol reductase activity (ISO)

alcohol dehydrogenase [NAD(P)+] activity (ISO)

all-trans-retinol dehydrogenase (NADP+) activity (ISO)

calcium-dependent phospholipid binding (IEA)

carbonyl reductase (NADPH) activity (ISO)

identical protein binding (ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on CH-OH group of donors (IEA)

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (ISO)

retinal dehydrogenase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

retinol metabolic pathway (ISO)

vitamin A deficiency pathway (ISO)

References

Additional References at PubMed

PMID:3511844	PMID:23036705	PMID:30032202

Genomics

Comparative Map Data

CPNE6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,046,532 - 4,058,498 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,046,544 - 4,084,744 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	3,968,424 - 3,980,384 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,157,197 - 4,169,172 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,157,179 - 4,169,172 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	3,847,979 - 3,859,935 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	3,909,733 - 3,921,692 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,171,825 - 4,183,775 (+)	NCBI		UU_Cfam_GSD_1.0

DHRS4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	23,953,770 - 23,969,279 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	23,953,734 - 23,969,279 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	24,422,979 - 24,438,488 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	23,492,805 - 23,508,328 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	23,492,804 - 23,508,326	NCBI
Celera	14	4,285,601 - 4,303,126 (+)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	4,539,991 - 4,555,519 (+)	NCBI		HuRef
CHM1_1	14	24,421,623 - 24,437,128 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,154,102 - 18,169,615 (+)	NCBI		T2T-CHM13v2.0

Dhrs4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	55,715,880 - 55,727,797 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	55,716,215 - 55,727,797 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	55,478,741 - 55,490,340 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	55,478,758 - 55,490,340 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	56,097,595 - 56,109,177 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	54,432,868 - 54,444,411 (+)	NCBI		MGSCv36	mm8
Celera	14	53,283,670 - 53,295,252 (+)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Dhrs4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	32,924,482 - 32,948,103 (+)	NCBI		GRCr8
mRatBN7.2	15	28,966,544 - 28,978,135 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	28,966,553 - 28,978,127 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	30,812,271 - 30,823,840 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	31,959,479 - 31,971,048 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,201,827 - 30,213,396 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,155,043 - 34,167,073 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,155,504 - 34,167,072 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	38,045,908 - 38,057,499 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	33,609,570 - 33,621,142 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	33,625,453 - 33,636,460 (+)	NCBI
Celera	15	28,542,580 - 28,554,149 (+)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

DHRS4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,352,031 - 25,367,508 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,568,524 - 24,584,000 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	14	22,831,557 - 22,953,699 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	22,831,756 - 22,846,695 (+)	Ensembl	panpan1.1		panPan2

DHRS4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	75,242,124 - 75,255,598 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	75,242,121 - 75,255,594 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,512,359 - 80,525,829 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DHRS4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	24,170,090 - 24,185,509 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	24,169,818 - 24,185,634 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	22,224,518 - 22,239,925 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in CPNE6
98 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium									6
Low			4						4
Below cutoff	3	4	12	6	3	6	6	1	2	5	6	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001048234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005623197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038672878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB274721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BU749845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN413590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000086	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000018549 ⟹ ENSCAFP00000017182

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,046,544 - 4,058,496 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000018751 ⟹ ENSCAFP00000017373

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,078,179 - 4,084,710 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000062870 ⟹ ENSCAFP00000058290

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,078,496 - 4,084,744 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000077604 ⟹ ENSCAFP00000062226

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,046,544 - 4,058,496 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000087328 ⟹ ENSCAFP00000046118

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,046,544 - 4,058,496 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000092318 ⟹ ENSCAFP00000059200

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,078,179 - 4,084,710 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000093080 ⟹ ENSCAFP00000057213

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,078,179 - 4,084,744 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00000093369 ⟹ ENSCAFP00000058295

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	8	4,046,544 - 4,081,770 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845007667 ⟹ ENSCAFP00845006065

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	8	4,157,179 - 4,169,172 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845007671 ⟹ ENSCAFP00845006067

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	8	4,157,179 - 4,169,172 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845007674 ⟹ ENSCAFP00845006069

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	8	4,157,179 - 4,169,172 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845007679 ⟹ ENSCAFP00845006072

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	8	4,157,179 - 4,169,168 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845007681 ⟹ ENSCAFP00845006073

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	8	4,157,179 - 4,169,168 (+)	Ensembl

RefSeq Acc Id:

NM_001048234 ⟹ NP_001041699

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	8	4,046,544 - 4,058,498 (+)	NCBI
Dog10K_Boxer_Tasha	8	3,968,424 - 3,980,384 (+)	NCBI
ROS_Cfam_1.0	8	4,157,213 - 4,169,172 (+)	NCBI
UMICH_Zoey_3.1	8	3,847,979 - 3,859,935 (+)	NCBI
UNSW_CanFamBas_1.0	8	3,909,733 - 3,921,692 (+)	NCBI
UU_Cfam_GSD_1.0	8	4,171,825 - 4,183,775 (+)	NCBI

Sequence:

show sequence

GCTCGGCCAGGTCCCGGTTCCTCTTCCTCACTGCGGTCGTCCCGCCCGGGTGTCCCGCATTCCT
GCACCGCCAGGCGGTGCCATGCAGAAGGCCGGGCTGTCGCTGGCCTGCGGCGCCCGGGCGTGGA
GGTCTGTGCGGAAGGCCAGCTCCGGGATGGCGCGCCAGGACCCGCTCGCCAATAAGGTGGCTCT
AGTAACGGCCTCCACCGACGGGATCGGCTTCGCTATCGCCCGGCGCCTGGCCCGGGACGGGGCG
CACGTGGTGGTCAGCAGCCGGAAGCAGCACAACGTGGACCGGGCGGTGGCAGCGCTGCAGGGCG
AGGGGCTGAGCGTGACCGGCACCGTGTGCCACGTGGGGAAGGCCGAGGACCGGGAGCGGCTGGT
GGCCACGGCTGTGAACCTTCATGGGGGCATTGACATCCTGATCTCCAATGCTGCAGTCAACCCT
TTCTTTGGAAACCTAATGGATGTCACTGAGGAGGTGTGGGACAAGATCCTGGACATTAACGTGA
AGGCCACAGCCCTCATGACCAAGGCAGTGGTGCCAGAGATGGAGAAACGAGGAGGTGGCTCAGT
GGTGATTGTGGCCTCCATAGGAGCCTACCTCCCGTTTCCTGGCCTGGGCCCCTACAATGTTAGT
AAAACAGCATTGCTGGGCCTCACCAAGAACCTGGCCAGAGAGCTCGACCAAAGGAACATTAGAG
TGAACTGCCTGGCACCAGGACTCATTAAGACTAGCTTCAGCAAAGTGCTTTGGATGGACAAGGC
AAGGGAGGAGAGCATTAAAAAAGTCATGCAGATAAGAAGGATGGGCAAGCCAGATGACTGTGCA
GGCATCGTGTCATTCCTGTGCTCTGAAGATGCCAGCTACATCACTGGGGAGACAGTGGTAGTGG
GTGGAGGGACACCATCCCACCTCTGAGGACCTGGAGAGACCTCACCAGGGCAGAGATTGGGCTC
CACACCTGAGTTCTCTTCTAGTATTCATTGACTTTCCTTTCCCACCTCTGCCTAATATATTGCT
CACCTTACACCCCGCCCCACCCCCCAAATCAGTTCTGCTCTGTGAAAAGATCCAGCCTTCCCTG
TGGTCAAAGTATCCTCTTGTGAGGATTCCCTCTGTTGCTGTACCCTTGGATACAAACTTCCCCT
GAGAGTGTAGGGCAGGCCTGCTGAGAAAGCTATGTCTACCTTGGCAAAAACCAACCAGTATCTT
TTTCCCTTGCATGGGGGAACTTGAGGGAGATGGGACTGAAGGAACCCAGGTGGGAAGAGCAGGG
TGGAAAATCAACAACCTGCAAAGGGAGATGCAAATAAAATGCGGATGATTGTGTTGCTTTGAAA
AAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_038672878 ⟹ XP_038528806

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	8	4,157,197 - 4,169,172 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001041699	(Get FASTA)	NCBI Sequence Viewer
	XP_038528806	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAF32569	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000057213.2
	ENSCAFP00000059200.1
	ENSCAFP00030021402.1
	ENSCAFP00030022360.1
	ENSCAFP00040005059.1
	ENSCAFP00040005324.1
	ENSCAFP00845006065
	ENSCAFP00845006065.1
	ENSCAFP00845006067.1
	ENSCAFP00845006069.1
	ENSCAFP00845006072
	ENSCAFP00845006072.1
	ENSCAFP00845006073.1

RefSeq Acc Id:

NP_001041699 ⟸ NM_001048234

- UniProtKB:

Q0E9S7 (UniProtKB/TrEMBL), A0A8C0QC71 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQKAGLSLACGARAWRSVRKASSGMARQDPLANKVALVTASTDGIGFAIARRLARDGAHVVVSS
RKQHNVDRAVAALQGEGLSVTGTVCHVGKAEDRERLVATAVNLHGGIDILISNAAVNPFFGNLM
DVTEEVWDKILDINVKATALMTKAVVPEMEKRGGGSVVIVASIGAYLPFPGLGPYNVSKTALLG
LTKNLARELDQRNIRVNCLAPGLIKTSFSKVLWMDKAREESIKKVMQIRRMGKPDDCAGIVSFL
CSEDASYITGETVVVGGGTPSHL

hide sequence

Ensembl Acc Id:

ENSCAFP00000017373 ⟸ ENSCAFT00000018751

Ensembl Acc Id:

ENSCAFP00000017182 ⟸ ENSCAFT00000018549

Ensembl Acc Id:

ENSCAFP00000062226 ⟸ ENSCAFT00000077604

Ensembl Acc Id:

ENSCAFP00000046118 ⟸ ENSCAFT00000087328

Ensembl Acc Id:

ENSCAFP00000058295 ⟸ ENSCAFT00000093369

Ensembl Acc Id:

ENSCAFP00000057213 ⟸ ENSCAFT00000093080

Ensembl Acc Id:

ENSCAFP00000058290 ⟸ ENSCAFT00000062870

Ensembl Acc Id:

ENSCAFP00000059200 ⟸ ENSCAFT00000092318

RefSeq Acc Id:	XP_038528806 ⟸ XM_038672878
- Peptide Label:	isoform X1
- UniProtKB:	Q0E9S7 (UniProtKB/TrEMBL), A0A8I3MKH3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845006072 ⟸ ENSCAFT00845007679

Ensembl Acc Id:

ENSCAFP00845006069 ⟸ ENSCAFT00845007674

Ensembl Acc Id:

ENSCAFP00845006065 ⟸ ENSCAFT00845007667

Ensembl Acc Id:

ENSCAFP00845006067 ⟸ ENSCAFT00845007671

Ensembl Acc Id:

ENSCAFP00845006073 ⟸ ENSCAFT00845007681

Protein Domains

Promoters

RGD ID:

13684143

Promoter ID:

EPDNEW_C2213

Type:

initiation region

Name:

DHRS4_1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	8	4,046,602 - 4,046,662	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000011767	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030013117	UniProtKB/TrEMBL
	ENSCAFG00030013654	UniProtKB/TrEMBL
	ENSCAFG00040003025	UniProtKB/TrEMBL
	ENSCAFG00040003224	UniProtKB/TrEMBL
	ENSCAFG00845004249	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000092318.2	UniProtKB/TrEMBL
	ENSCAFT00000093080.2	UniProtKB/TrEMBL
	ENSCAFT00030024516.1	UniProtKB/TrEMBL
	ENSCAFT00030025608.1	UniProtKB/TrEMBL
	ENSCAFT00040005865.1	UniProtKB/TrEMBL
	ENSCAFT00040006162.1	UniProtKB/TrEMBL
	ENSCAFT00845007667	ENTREZGENE
	ENSCAFT00845007667.1	UniProtKB/TrEMBL
	ENSCAFT00845007671.1	UniProtKB/TrEMBL
	ENSCAFT00845007674.1	UniProtKB/TrEMBL
	ENSCAFT00845007679	ENTREZGENE
	ENSCAFT00845007679.1	UniProtKB/TrEMBL
	ENSCAFT00845007681.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.150	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	C2_dom	UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/TrEMBL
	C2B_Copine	UniProtKB/TrEMBL
	Copine	UniProtKB/TrEMBL
	Copine_C	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
	VWF_A	UniProtKB/TrEMBL
	vWFA_dom_sf	UniProtKB/TrEMBL
KEGG Report	cfa:480254	UniProtKB/TrEMBL
NCBI Gene	DHRS4	ENTREZGENE
PANTHER	COPINE-6	UniProtKB/TrEMBL
	DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4	UniProtKB/TrEMBL
	PTHR10857	UniProtKB/TrEMBL
	PTHR43943:SF8	UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/TrEMBL
	adh_short_C2	UniProtKB/TrEMBL
	Copine	UniProtKB/TrEMBL
	PF00168	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/TrEMBL
	PS50004	UniProtKB/TrEMBL
SMART	SM00239	UniProtKB/TrEMBL
	VWA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49562	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
	SSF53300	UniProtKB/TrEMBL
UniProt	A0A8C0QC71	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0QCT9_CANLF	UniProtKB/TrEMBL
	A0A8I3MKH3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3MPN6_CANLF	UniProtKB/TrEMBL
	A0A8I3MUA2_CANLF	UniProtKB/TrEMBL
	A0A8I3MW01_CANLF	UniProtKB/TrEMBL
	A0A8I3N882_CANLF	UniProtKB/TrEMBL
	A0A8P0P6H8_CANLF	UniProtKB/TrEMBL
	A0A8P0TB39_CANLF	UniProtKB/TrEMBL
	Q0E9S7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-07-26	CPNE6	copine 6	DHRS4	dehydrogenase/reductase 4	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB