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Accession:CHEBI:45409 term browser browse the term
Definition:An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.
Synonyms:exact_synonym: N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
 related_synonym: Formula=C37H48N6O5S2;   InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1;   InChIKey=NCDNCNXCDXHOMX-XGKFQTDJSA-N;   SMILES=CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1
 alt_id: CHEBI:8873
 xref: CAS:155213-67-5 "ChemIDplus";   CAS:155213-67-5 "KEGG COMPOUND";   Drug_Central:2391 "DrugCentral";   HMDB:HMDB0014646;   KEGG:C07240;   KEGG:D00427;   LINCS:LSM-5623
 xref_mesh: MESH:D019438
 xref: PDBeChem:RIT;   PMID:11363086 "Europe PMC";   PMID:11363184 "Europe PMC";   PMID:11363300 "Europe PMC";   PMID:11363329 "Europe PMC";   PMID:11363397 "Europe PMC";   PMID:11363517 "Europe PMC";   PMID:11996889 "Europe PMC";   PMID:24202050 "Europe PMC";   PMID:8568292 "Europe PMC";   PMID:9140265 "Europe PMC";   PMID:9278209 "Europe PMC";   PMID:9585800 "Europe PMC";   Reaxys:768009 "Reaxys";   Wikipedia:Ritonavir

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ritonavir term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 14 13,644,891 13,852,829 RGD:6480464
G NR1I2 nuclear receptor subfamily 1 group I member 2 JBrowse link 33 23,444,367 23,456,405 RGD:6480464

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  CHEBI ontology 225
    role 225
      biological role 225
        xenobiotic 35
          ritonavir 2
            Kaletra 0
            Technivie 0
            Viekira Pak 0
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  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    p-block element atom 218
                      carbon group element atom 207
                        carbon atom 206
                          organic molecular entity 206
                            organic group 154
                              organic divalent group 153
                                organodiyl group 153
                                  carbonyl group 153
                                    carbonyl compound 153
                                      carboxylic acid 113
                                        carboacyl group 47
                                          univalent carboacyl group 47
                                            carbamoyl group 44
                                              carboxamide 44
                                                monocarboxylic acid amide 19
                                                  urea 9
                                                    ureas 7
                                                      ritonavir 2
                                                        Kaletra 0
                                                        Technivie 0
                                                        Viekira Pak 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.