PTGS1 (prostaglandin-endoperoxide synthase 1)

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Gene: PTGS1 (prostaglandin-endoperoxide synthase 1) Canis lupus familiaris

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Symbol:

PTGS1

Name:

prostaglandin-endoperoxide synthase 1

RGD ID:

12328669

Description:

ENCODES a protein that exhibits dioxygenase activity (inferred); heme binding (inferred); metal ion binding (inferred); INVOLVED IN learning (ortholog); maintenance of blood-brain barrier (ortholog); memory (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anaphylaxis (ortholog); autism spectrum disorder (ortholog); FOUND IN nuclear envelope (ortholog); nucleus (ortholog); INTERACTS WITH acetylsalicylic acid; antipyrine; diclofenac

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

COX-1; COX-3; COX1; cyclooxygenase; Cyclooxygenase-1; PGH synthase 1; PGHS-1; PHS 1; prostaglandin G/H synthase 1; Prostaglandin H2 synthase 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	60,195,118 - 60,216,847 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	60,195,124 - 60,216,819 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	59,390,579 - 59,412,227 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	61,110,468 - 61,132,351 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	61,110,470 - 61,132,343 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	59,884,516 - 59,906,289 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	60,200,281 - 60,222,098 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	60,289,919 - 60,311,671 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Anaphylaxis (ISO)

autism spectrum disorder (ISO)

bipolar disorder (ISO)

Brain Injuries (ISO)

brain ischemia (ISO)

breast cancer (ISO)

Breast Neoplasms (ISO)

Bronchial Hyperreactivity (ISO)

carcinoma (ISO)

cervix carcinoma (ISO)

congestive heart failure (ISO)

Creutzfeldt-Jakob disease (ISO)

drug allergy (ISO)

end stage renal disease (ISO)

endometrial carcinoma (ISO)

Esophageal Neoplasms (ISO)

esophagus adenocarcinoma (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Autoimmune Neuritis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

Experimental Radiation Injuries (ISO)

Flushing (ISO)

gastric ulcer (ISO)

glaucoma (ISO)

glioblastoma (ISO)

gliosarcoma (ISO)

Hemorrhage (ISO)

hepatic encephalopathy (ISO)

Hyperalgesia (ISO)

Intestinal Polyps (ISO)

Nasal Polyps (ISO)

occupational asthma (ISO)

ovarian cancer (ISO)

ovarian cyst (ISO)

Ovarian Neoplasms (ISO)

Pain (ISO)

Perennial Allergic Rhinitis (ISO)

Peripheral Nerve Injuries (ISO)

polycystic kidney disease (ISO)

pre-eclampsia (ISO)

renal cell carcinoma (ISO)

renovascular hypertension (ISO)

Reperfusion Injury (ISO)

rheumatoid arthritis (ISO)

salivary gland carcinoma (ISO)

Seasonal Allergic Rhinitis (ISO)

Sleep Deprivation (ISO)

Spinal Cord Injuries (ISO)

ulcerative colitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

acetylsalicylic acid (EXP)

antipyrine (EXP)

diclofenac (EXP)

ibuprofen (EXP)

indometacin (EXP)

metamizole sodium (EXP)

paracetamol (EXP)

phenacetin (EXP)

Sulpyrine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular oxidant detoxification (IEA)

cyclooxygenase pathway (IBA,IEA)

fatty acid metabolic process (IEA)

learning (ISO)

maintenance of blood-brain barrier (ISO)

memory (ISO)

negative regulation of epinephrine secretion (ISO)

negative regulation of norepinephrine secretion (ISO)

positive regulation of smooth muscle contraction (ISO)

positive regulation of vasoconstriction (ISO)

prostaglandin biosynthetic process (IEA,ISO)

prostaglandin metabolic process (IEA,ISO)

regulation of blood pressure (IEA,ISO)

regulation of cell population proliferation (IEA,ISO)

response to corticosterone (ISO)

response to fatty acid (ISO)

response to oxidative stress (IEA)

Cellular Component

cytoplasm (IBA,IEA)

endomembrane system (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

Golgi apparatus (IEA)

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

neuron projection (IBA)

nuclear envelope (ISO)

nucleus (ISO)

photoreceptor outer segment (IEA)

Molecular Function

dioxygenase activity (IEA)

heme binding (IEA)

metal ion binding (IEA)

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (IBA)

peroxidase activity (IEA)

prostaglandin-endoperoxide synthase activity (IBA,IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

celecoxib pharmacokinetics pathway (ISO)

cyclooxygenase mediated pathway of arachidonic acid metabolism (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

etoposide pharmacodynamics pathway (ISO)

etoposide pharmacokinetics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacokinetics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

prostanoid biosynthetic pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:12242329	PMID:16341006	PMID:17921331	PMID:19274754	PMID:20207364	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PTGS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	60,195,118 - 60,216,847 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	60,195,124 - 60,216,819 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	59,390,579 - 59,412,227 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	61,110,468 - 61,132,351 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	61,110,470 - 61,132,343 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	59,884,516 - 59,906,289 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	60,200,281 - 60,222,098 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	60,289,919 - 60,311,671 (-)	NCBI		UU_Cfam_GSD_1.0

PTGS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	122,370,533 - 122,395,703 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	122,370,530 - 122,395,703 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	125,132,812 - 125,157,982 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	124,173,050 - 124,197,802 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	122,212,782 - 122,237,535	NCBI
Celera	9	95,781,549 - 95,806,298 (+)	NCBI		Celera
Cytogenetic Map	9	q33.2	NCBI
HuRef	9	94,747,532 - 94,772,698 (+)	NCBI		HuRef
CHM1_1	9	125,280,871 - 125,306,038 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	134,568,002 - 134,593,163 (+)	NCBI		T2T-CHM13v2.0

Ptgs1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	36,106,758 - 36,142,287 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	36,120,438 - 36,142,284 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	36,216,742 - 36,258,593 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	36,230,426 - 36,252,272 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	36,085,946 - 36,107,789 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	36,052,536 - 36,074,271 (+)	NCBI		MGSCv36	mm8
Celera	2	35,934,252 - 35,956,092 (+)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	24.19	NCBI

Ptgs1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	39,981,419 - 40,002,993 (+)	NCBI		GRCr8
mRatBN7.2	3	19,584,015 - 19,605,589 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	19,584,015 - 19,605,586 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	22,661,928 - 22,683,470 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	31,246,853 - 31,268,395 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	29,494,672 - 29,516,226 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	15,560,685 - 15,582,339 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	15,560,712 - 15,582,344 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	20,869,915 - 20,891,512 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	15,343,832 - 15,365,412 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	15,240,203 - 15,261,784 (+)	NCBI
Celera	3	14,295,836 - 14,317,392 (+)	NCBI		Celera
Cytogenetic Map	3	p11	NCBI

Ptgs1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	5,678,694 - 5,699,305 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	5,678,750 - 5,699,305 (-)	NCBI	ChiLan1.0	ChiLan1.0

PTGS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	16,953,759 - 16,975,988 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	16,953,703 - 16,978,307 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	93,495,365 - 93,517,557 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	121,837,095 - 121,859,283 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	121,837,095 - 121,859,283 (+)	Ensembl	panpan1.1		panPan2

Ptgs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	190,976,385 - 190,990,294 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	10,745,327 - 10,758,823 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	10,745,465 - 10,758,812 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTGS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	262,456,155 - 262,483,035 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	262,456,106 - 262,482,159 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	294,753,789 - 294,779,835 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PTGS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	17,195,403 - 17,218,450 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	17,192,628 - 17,218,315 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666035	25,831,631 - 25,856,861 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptgs1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	12,915,206 - 12,937,824 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	12,917,244 - 12,937,858 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PTGS1
345 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001003023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005625008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005625009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005625010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005625011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005625012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005625014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022422518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038674926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038674927	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038674928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038674929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038674930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF535138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF535139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000032279 ⟹ ENSCAFP00000030061

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	60,195,300 - 60,216,819 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000032287 ⟹ ENSCAFP00000030067

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	60,195,124 - 60,216,763 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000062600 ⟹ ENSCAFP00000054704

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	60,195,124 - 60,216,763 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000062685 ⟹ ENSCAFP00000052626

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	60,195,124 - 60,216,774 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000070785 ⟹ ENSCAFP00000062890

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	60,195,124 - 60,212,575 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000075296 ⟹ ENSCAFP00000044164

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	60,195,124 - 60,212,575 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000080930 ⟹ ENSCAFP00000044458

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	60,195,124 - 60,212,575 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000085706 ⟹ ENSCAFP00000058379

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	9	60,195,124 - 60,216,750 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845024089 ⟹ ENSCAFP00845018920

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	61,110,470 - 61,132,343 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845024265 ⟹ ENSCAFP00845019067

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	61,110,470 - 61,132,343 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845024287 ⟹ ENSCAFP00845019079

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	61,110,470 - 61,132,343 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845024316 ⟹ ENSCAFP00845019104

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	61,110,470 - 61,132,343 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845024344 ⟹ ENSCAFP00845019128

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	61,110,470 - 61,132,306 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845024350 ⟹ ENSCAFP00845019132

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	61,110,470 - 61,128,067 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845024385 ⟹ ENSCAFP00845019167

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	61,110,470 - 61,125,664 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845024410 ⟹ ENSCAFP00845019189

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	9	61,110,474 - 61,132,277 (-)	Ensembl

RefSeq Acc Id:

NM_001003023 ⟹ NP_001003023

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	60,195,120 - 60,216,774 (-)	NCBI
Dog10K_Boxer_Tasha	9	59,390,579 - 59,412,227 (-)	NCBI
ROS_Cfam_1.0	9	61,110,470 - 61,132,277 (-)	NCBI
UMICH_Zoey_3.1	9	59,884,516 - 59,906,289 (-)	NCBI
UNSW_CanFamBas_1.0	9	60,200,281 - 60,222,098 (-)	NCBI
UU_Cfam_GSD_1.0	9	60,289,919 - 60,311,671 (-)	NCBI

Sequence:

show sequence

CGAGCGCAGCAGCCGCCCAGAGCTATGAGCCGTGAGTTCGACCCTGAGGCCCCCAGGAACCCTC
TTCGCCTCCCGGGGGAGCCTCGAATGCCAGGCCCAGCCCTCACCTCTCGCTCCGCAGGGGGGAG
TCGCCTGCACCGGTGGCCGCTGCTCCTGCTGCTGCTGCTGCTGCTCCCGCCGCCCCCGGTCCTG
CCCGCGGAAGCCCGGACCCCGGCGCCTGTGAACCCGTGTTGTTACTACCCATGTCAGCACCAAG
GGATCTGTGTCCGCTTCGGCCTTGACCGCTACCAGTGTGACTGCACCCGCACGGGCTATTCTGG
CCCCAACTGCACCATCCCCGAGCTGTGGACCTGGCTCCGGAATTCACTGCGCCCCAGTCCCTCT
TTCCTCCACTTCCTGCTGACGCATGGGCGCTGGTTTTGGGAATTCATCAATGCCACCTTCATCC
GTGACATGCTCATGCGTCTGGTACTCACAGCGCGTTCCAACCTTATCCCCAGTCCTCCCACCTA
CAACATAGCGCATGACTACATCAGCTGGGAGTCCTTCTCCAATGTGAGCTATTACACTCGTGTT
CTGCCCTCTGTGCCCCAAGATTGCCCCACGCCCATGGGGACCAAAGGGAAGAAGCAGTTGCCAG
ACGCCCAACTCCTGGGCCGTCGCTTCCTGCTCAGGAGGAAGTTCATACCTGACCCCCAAGGCAC
CAACCTCATGTTCGCCTTCTTTGCACAACACTTCACCCATCAGTTCTTCAAAACTTCTGGCAAG
ATGGGTCCTGGCTTCACCAAGGCCTTGGGCCATGGGGTAGATCTTGGCCACATTTATGGGGACA
ATCTGGACCGTCAGTATCAGCTGCGGCTCTTTAAGGATGGGAAACTCAAGTATCAGGTTCTGGA
TGGAGAGATGTACCCGCCATCTGTGGAGGAGGCGCCTGTGTTGATGCACTACCCACGGGGCATT
CTGCCCCAGAGTCAGATGGCCGTGGGCCAGGAGGTGTTTGGGCTGCTTCCTGGGCTCATGCTCT
ATGCCACGCTCTGGCTGCGTGAGCACAATCGTGTGTGTGACCTGCTGAAGGCTGAGCACCCCAC
TTGGGGTGATGAGCAACTCTTCCAGACGGCCCGACTCATCCTCATTGGGGAGACCATCAAGATT
GTGATTGAGGAGTATGTGCAGCAGCTGAGTGGCTACTTCTTGCAGCTGAAGTTCGACCCGGAGC
TGCTGTTTAGCGCCCAGTTCCAGTACCGCAACCGCATCGCCATGGAGTTCAACCAGCTGTACCA
CTGGCACCCGCTCATGCCAGACTCCTTCTGGGTGGGTTCCCAGGAGTACAGCTATGAGCAGTTC
CTGTTCAACACCTCCATGCTGACGCACTACGGGATCGAGGCCCTGGTGGATGCCTTCTCTCGCC
AGAGCGCCGGCCGGATTGGTGGAGGTAGAAACATAGACCACCATGTCCTGCACGTGGCTGTGGA
AACCATCAAGGAATCCCGCGAGTTGCGGCTGCAGCCCTTCAATGAGTACCGCAAGAGGTTTGGC
ATGAGGCCCTACATGTCCTTCCAGGAACTCACAGGGGAGAAGGAGATGGCAGCCGAGTTGGAGG
AGCTGTATGGAGACATTGATGCCTTGGAATTCTACCCGGGGCTTCTTCTGGAGAAGTGCCATCC
AAACTCCATCTTTGGAGAGAGTATGATAGAAATTGGGGCTCCCTTCTCCCTTAAGGGCCTCCTA
GGGAATCCCATCTGTTCTCCAGAGTACTGGAAGCCAAGCACATTCGGTGGTGAGATGGGCTTCA
ATATGGTCAAGACAGCCACACTGAAGAAGCTGGTCTGCCTTAACACCAAGACTTGTCCCTATGT
TTCCTTCCGTGTGCCTGACCCCCACCAGGATGGCGGGCCTGGTGTGCAGCGGCCGTCCACAGAG
CTCTGAGGGGGCAGAGCAGCAGCATTCTGGAGGGTGGACTTGTCATCCCAGAATGCTGAGGCTG
GGGTTAATAATCCCAAATGTTGGGTCTTTGGTTTGCCTCAAGAATATCAAGGTCAACATTTAGA
ACTTTGTGTCTCTCACCCATTATCTGGAATATCATGGTCTTGTTTGTTATTCTAGAATGCTGAA
TTCCTGGTTGACCATCTAGAATGGATGGAGTGATGCTTCTTTGGCAAGCCAGAACACTGGTTCC
TGGCCGACAACCTAGAATGTCAGACTTCTGGTTGACTTAAGACGTAGGCATTCTCTAATGTGAA
GCTCCTGACAGAATCATCTAGAAAGATAGGGGATTCTTATTTTGCATTCTAGAATTCTGGGCAG
CCCTCCAGCATGTTGATTTTTTTCACTGGCAGTTCAGAATGTTGTGCTCTTGATTGCTGATCCA
AAATAGTGGCTGGTATGCCAGATCAGTCTTGCTCTGAATGCCTAGAATGGTAATTTGATTCATT
TTCCTGTTCAGTGAGATACCCCCAAAGCAGGAGAATCTACAGCCTAACCAGAGTGCATTGCCTG
CCTCTGTGCCTGCCCCGAGGACTTAGGGGGCAGAGTGTTCTTCCTGGGACGCTGACTCAGACCC
TGGTCCAAGGAGCTAGAACAGGTGGGCTTTTTCCAGGTCATTGGTTGGAGGCCACCAGAGCTCT
GTTGCCATCTTTGTCTTGACTCATGACAGCTGTTTCTCATGAAACTAATAAAATTCTTTTTCCA
AAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_038674926 ⟹ XP_038530854

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	61,110,468 - 61,127,621 (-)	NCBI

RefSeq Acc Id:

XM_038674927 ⟹ XP_038530855

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	61,110,857 - 61,127,620 (-)	NCBI

RefSeq Acc Id:

XM_038674928 ⟹ XP_038530856

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	61,110,857 - 61,132,318 (-)	NCBI

RefSeq Acc Id:

XM_038674929 ⟹ XP_038530857

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	61,110,857 - 61,132,351 (-)	NCBI

RefSeq Acc Id:

XM_038674930 ⟹ XP_038530858

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	9	61,110,857 - 61,132,265 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001003023	(Get FASTA)	NCBI Sequence Viewer
	XP_038530854	(Get FASTA)	NCBI Sequence Viewer
	XP_038530855	(Get FASTA)	NCBI Sequence Viewer
	XP_038530856	(Get FASTA)	NCBI Sequence Viewer
	XP_038530857	(Get FASTA)	NCBI Sequence Viewer
	XP_038530858	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAN33049	(Get FASTA)	NCBI Sequence Viewer
	AAN38739	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000030061.2
	ENSCAFP00000030067.3
	ENSCAFP00000044458.1
	ENSCAFP00000052626.1
	ENSCAFP00000054704.2
	ENSCAFP00000058379.2
	ENSCAFP00030004745.1
	ENSCAFP00030004763.1
	ENSCAFP00030004778.1
	ENSCAFP00030004808.1
	ENSCAFP00030004840.1
	ENSCAFP00030004864.1
	ENSCAFP00030004888.1
	ENSCAFP00030004911.1
	ENSCAFP00040003864.1
	ENSCAFP00040003882.1
	ENSCAFP00040003894.1
	ENSCAFP00040003912.1
	ENSCAFP00040003928.1
	ENSCAFP00040003944.1
	ENSCAFP00040003972.1
	ENSCAFP00845018920
	ENSCAFP00845018920.1
	ENSCAFP00845019067.1
	ENSCAFP00845019079.1
	ENSCAFP00845019104.1
	ENSCAFP00845019128.1
	ENSCAFP00845019132.1
	ENSCAFP00845019167.1
	ENSCAFP00845019189
	ENSCAFP00845019189.1
GenBank Protein	Q8HZR1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001003023 ⟸ NM_001003023
- Peptide Label:	precursor
- UniProtKB:	A0A8C0M635 (UniProtKB/TrEMBL), A0A8I3NTG8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSREFDPEAPRNPLRLPGEPRMPGPALTSRSAGGSRLHRWPLLLLLLLLLPPPPVLPAEARTPA PVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPELWTWLRNSLRPSPSFLHFLLTH GRWFWEFINATFIRDMLMRLVLTARSNLIPSPPTYNIAHDYISWESFSNVSYYTRVLPSVPQDC PTPMGTKGKKQLPDAQLLGRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKA LGHGVDLGHIYGDNLDRQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGILPQSQMAV GQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQ LSGYFLQLKFDPELLFSAQFQYRNRIAMEFNQLYHWHPLMPDSFWVGSQEYSYEQFLFNTSMLT HYGIEALVDAFSRQSAGRIGGGRNIDHHVLHVAVETIKESRELRLQPFNEYRKRFGMRPYMSFQ ELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPE YWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFRVPDPHQDGGPGVQRPSTEL hide sequence

Ensembl Acc Id:

ENSCAFP00000062890 ⟸ ENSCAFT00000070785

Ensembl Acc Id:

ENSCAFP00000054704 ⟸ ENSCAFT00000062600

Ensembl Acc Id:

ENSCAFP00000052626 ⟸ ENSCAFT00000062685

Ensembl Acc Id:

ENSCAFP00000044458 ⟸ ENSCAFT00000080930

Ensembl Acc Id:

ENSCAFP00000044164 ⟸ ENSCAFT00000075296

Ensembl Acc Id:

ENSCAFP00000058379 ⟸ ENSCAFT00000085706

Ensembl Acc Id:

ENSCAFP00000030067 ⟸ ENSCAFT00000032287

Ensembl Acc Id:

ENSCAFP00000030061 ⟸ ENSCAFT00000032279

RefSeq Acc Id:	XP_038530854 ⟸ XM_038674926
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0KR96 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038530857 ⟸ XM_038674929
- Peptide Label:	isoform X4
- UniProtKB:	Q8HZR1 (UniProtKB/Swiss-Prot), Q8HZR0 (UniProtKB/Swiss-Prot), F1PBX3 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038530856 ⟸ XM_038674928
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I3NTG8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038530858 ⟸ XM_038674930
- Peptide Label:	isoform X5
- UniProtKB:	A0A8C0Q9L9 (UniProtKB/TrEMBL), A0A8P0TAE2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038530855 ⟸ XM_038674927
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C0KR96 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845019128 ⟸ ENSCAFT00845024344

Ensembl Acc Id:

ENSCAFP00845018920 ⟸ ENSCAFT00845024089

Ensembl Acc Id:

ENSCAFP00845019079 ⟸ ENSCAFT00845024287

Ensembl Acc Id:

ENSCAFP00845019067 ⟸ ENSCAFT00845024265

Ensembl Acc Id:

ENSCAFP00845019132 ⟸ ENSCAFT00845024350

Ensembl Acc Id:

ENSCAFP00845019189 ⟸ ENSCAFT00845024410

Ensembl Acc Id:

ENSCAFP00845019104 ⟸ ENSCAFT00845024316

Ensembl Acc Id:

ENSCAFP00845019167 ⟸ ENSCAFT00845024385

Protein Domains

EGF-like

Promoters

RGD ID:

13684849

Promoter ID:

EPDNEW_C2917

Type:

initiation region

Name:

PTGS1_1

Description:

prostaglandin-endoperoxide synthase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_C2918

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	60,216,675 - 60,216,735	EPDNEW

RGD ID:

13684852

Promoter ID:

EPDNEW_C2918

Type:

single initiation site

Name:

PTGS1_2

Description:

prostaglandin-endoperoxide synthase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_C2917

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	9	60,216,785 - 60,216,845	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000020263	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSCAFG00030002781	UniProtKB/TrEMBL
	ENSCAFG00040002347	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSCAFG00845013501	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000032279.4	UniProtKB/Swiss-Prot
	ENSCAFT00000032287.6	UniProtKB/Swiss-Prot
	ENSCAFT00000062600.2	UniProtKB/TrEMBL
	ENSCAFT00000062685.2	UniProtKB/Swiss-Prot
	ENSCAFT00000080930.2	UniProtKB/TrEMBL
	ENSCAFT00000085706.2	UniProtKB/TrEMBL
	ENSCAFT00030005335.1	UniProtKB/TrEMBL
	ENSCAFT00030005354.1	UniProtKB/TrEMBL
	ENSCAFT00030005371.1	UniProtKB/TrEMBL
	ENSCAFT00030005409.1	UniProtKB/TrEMBL
	ENSCAFT00030005442.1	UniProtKB/TrEMBL
	ENSCAFT00030005467.1	UniProtKB/TrEMBL
	ENSCAFT00030005491.1	UniProtKB/TrEMBL
	ENSCAFT00030005516.1	UniProtKB/TrEMBL
	ENSCAFT00040004500.1	UniProtKB/Swiss-Prot
	ENSCAFT00040004521.1	UniProtKB/Swiss-Prot
	ENSCAFT00040004534.1	UniProtKB/TrEMBL
	ENSCAFT00040004552.1	UniProtKB/TrEMBL
	ENSCAFT00040004573.1	UniProtKB/TrEMBL
	ENSCAFT00040004593.1	UniProtKB/TrEMBL
	ENSCAFT00040004622.1	UniProtKB/Swiss-Prot
	ENSCAFT00845024089	ENTREZGENE
	ENSCAFT00845024089.1	UniProtKB/Swiss-Prot
	ENSCAFT00845024265.1	UniProtKB/TrEMBL
	ENSCAFT00845024287.1	UniProtKB/TrEMBL
	ENSCAFT00845024316.1	UniProtKB/TrEMBL
	ENSCAFT00845024344.1	UniProtKB/TrEMBL
	ENSCAFT00845024350.1	UniProtKB/TrEMBL
	ENSCAFT00845024385.1	UniProtKB/TrEMBL
	ENSCAFT00845024410	ENTREZGENE
	ENSCAFT00845024410.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.640.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	EGF-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Haem_peroxidase_animal	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Haem_peroxidase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Haem_peroxidase_sf_animal	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Oxylipin_biosynth_metab	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	cfa:403544	UniProtKB/Swiss-Prot
NCBI Gene	PTGS1	ENTREZGENE
PANTHER	PROSTAGLANDIN G/H SYNTHASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11903:SF6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	An_peroxidase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EGF	UniProtKB/TrEMBL
PRINTS	ANPEROXIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	EGF_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PEROXIDASE_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48113	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8C0KR96	ENTREZGENE
	A0A8C0M1C0_CANLF	UniProtKB/TrEMBL
	A0A8C0M1D8_CANLF	UniProtKB/TrEMBL
	A0A8C0M1F9_CANLF	UniProtKB/TrEMBL
	A0A8C0M4M8_CANLF	UniProtKB/TrEMBL
	A0A8C0M502_CANLF	UniProtKB/TrEMBL
	A0A8C0M5A6_CANLF	UniProtKB/TrEMBL
	A0A8C0M635	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0PTJ6_CANLF	UniProtKB/TrEMBL
	A0A8C0PXV0_CANLF	UniProtKB/TrEMBL
	A0A8C0Q062_CANLF	UniProtKB/TrEMBL
	A0A8C0Q9L9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0RBE9_CANLF	UniProtKB/TrEMBL
	A0A8I3NGM1_CANLF	UniProtKB/TrEMBL
	A0A8I3NGN0_CANLF	UniProtKB/TrEMBL
	A0A8I3NTA0_CANLF	UniProtKB/TrEMBL
	A0A8I3NTB9_CANLF	UniProtKB/TrEMBL
	A0A8I3NTG8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3RXN2_CANLF	UniProtKB/TrEMBL
	A0A8I3S0A3_CANLF	UniProtKB/TrEMBL
	A0A8P0P453_CANLF	UniProtKB/TrEMBL
	A0A8P0TAE2	ENTREZGENE
	F1PBX3	ENTREZGENE
	PGH1_CANLF	UniProtKB/Swiss-Prot
	Q8HZR0	ENTREZGENE
	Q8HZR1	ENTREZGENE
UniProt Secondary	A0A8P0SXU1	UniProtKB/TrEMBL
	A0A8P0TAE2	UniProtKB/TrEMBL
	F1PBX3	UniProtKB/Swiss-Prot
	Q8HZR0	UniProtKB/Swiss-Prot
VGNC ID	VGNC:45151	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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