JUN (Jun proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: JUN (Jun proto-oncogene, AP-1 transcription factor subunit) Canis lupus familiaris
Analyze
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
RGD ID: 12374086
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic process (ortholog); axon regeneration (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH Alcohol-Related Disorders (ortholog); angiosarcoma (ortholog); Asphyxia (ortholog); FOUND IN chromatin (ortholog); protein-containing complex (ortholog); RNA polymerase II transcription regulator complex (ortholog); INTERACTS WITH anthra[1,9-cd]pyrazol-6(2H)-one; masitinib; sodium chloride
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AP-1; c-jun; jun oncogene; transcription factor AP-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl551,148,001 - 51,149,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (ISO)
axon regeneration  (ISO)
cell population proliferation  (ISO)
cellular response to anisomycin  (ISO)
cellular response to cadmium ion  (IEA)
cellular response to calcium ion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to potassium ion starvation  (ISO)
cellular response to prolactin  (ISO)
cellular response to reactive oxygen species  (IEA)
cellular response to zinc ion starvation  (ISO)
circadian rhythm  (ISO)
DNA-templated transcription  (ISO)
eyelid development in camera-type eye  (ISO)
immune response  (ISO)
leading edge cell differentiation  (ISO)
learning  (ISO)
liver development  (ISO)
membrane depolarization  (ISO)
microglial cell activation  (ISO)
monocyte differentiation  (ISO)
negative regulation by host of viral transcription  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
outflow tract morphogenesis  (ISO)
positive regulation by host of viral transcription  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of DNA-templated transcription initiation  (IEA)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of monocyte differentiation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA)
regulation of cell cycle  (IEA,ISO)
regulation of cell population proliferation  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
release from viral latency  (IEA)
release of cytochrome c from mitochondria  (ISO)
response to cAMP  (ISO)
response to cytokine  (ISO)
response to endoplasmic reticulum stress  (IEA)
response to ethanol  (ISO)
response to hydrogen peroxide  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to muscle stretch  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
SMAD protein signal transduction  (IEA)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:16380175   PMID:23816505   PMID:28472120   PMID:30032202  


Genomics

Comparative Map Data
JUN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl551,148,001 - 51,149,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBIUU_Cfam_GSD_1.0
JUN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl158,776,845 - 58,784,048 (-)EnsemblGRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBICelera
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
T2T-CHM13v2.0158,659,236 - 58,662,492 (-)NCBIT2T-CHM13v2.0
Jun
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,937,273 - 94,940,459 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl494,937,271 - 94,940,459 (-)EnsemblGRCm39 Ensembl
GRCm38495,049,036 - 95,052,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl495,049,034 - 95,052,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37494,715,727 - 94,718,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36494,541,073 - 94,544,205 (-)NCBIMGSCv36mm8
Celera493,436,543 - 93,439,728 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Jun
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85115,009,900 - 115,012,993 (-)NCBIGRCr8
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,464,752 - 112,467,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05114,190,270 - 114,193,359 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05114,252,804 - 114,255,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
Jun
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554641,107,598 - 1,110,326 (+)NCBIChiLan1.0ChiLan1.0
JUN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,063,962 - 168,067,574 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,218,036 - 167,219,853 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0158,042,794 - 58,045,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1159,747,129 - 59,750,446 (-)NCBIpanpan1.1PanPan1.1panPan2
Jun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505872,379,192 - 72,381,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365223,035,346 - 3,036,350 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365223,034,364 - 3,037,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6153,685,682 - 153,687,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12074,204,481 - 74,207,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603343,155,224 - 43,158,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jun
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248621,538,455 - 1,539,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248621,537,886 - 1,540,633 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in JUN
21 total Variants

Expression


Sequence


RefSeq Acc Id: ENSCAFT00845011604   ⟹   ENSCAFP00845009067
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl551,148,001 - 51,149,014 (+)Ensembl
RefSeq Acc Id: XM_005620245   ⟹   XP_005620302
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1550,966,698 - 50,968,939 (+)NCBI
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038476209   ⟹   XP_038332137
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBI
RefSeq Acc Id: XM_038537394   ⟹   XP_038393322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBI
RefSeq Acc Id: XM_038601523   ⟹   XP_038457451
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBI
RefSeq Acc Id: XM_038666089   ⟹   XP_038522017
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBI
RefSeq Acc Id: XP_005620302   ⟸   XM_005620245
- UniProtKB: A0A8I3RTD9 (UniProtKB/TrEMBL),   A0A8P0TN96 (UniProtKB/TrEMBL),   A0A8C0R052 (UniProtKB/TrEMBL),   A0A8C0Z0Z1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038332137   ⟸   XM_038476209
RefSeq Acc Id: XP_038457451   ⟸   XM_038601523
RefSeq Acc Id: XP_038522017   ⟸   XM_038666089
- UniProtKB: A0A8I3RTD9 (UniProtKB/TrEMBL),   A0A8P0TN96 (UniProtKB/TrEMBL),   A0A8C0R052 (UniProtKB/TrEMBL),   A0A8C0Z0Z1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038393322   ⟸   XM_038537394
- UniProtKB: A0A8I3RTD9 (UniProtKB/TrEMBL),   A0A8P0TN96 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845009067   ⟸   ENSCAFT00845011604
Protein Domains
bZIP

Promoters
RGD ID:13683306
Promoter ID:EPDNEW_C1374
Type:multiple initiation site
Name:JUN_1
Description:Jun proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1550,967,874 - 50,967,934EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018897 UniProtKB/TrEMBL
  ENSCAFG00030001843 UniProtKB/TrEMBL
  ENSCAFG00040017781 UniProtKB/TrEMBL
  ENSCAFG00845006541 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029996.6 UniProtKB/TrEMBL
  ENSCAFT00030003343.1 UniProtKB/TrEMBL
  ENSCAFT00040032826.1 UniProtKB/TrEMBL
  ENSCAFT00845011604 ENTREZGENE
  ENSCAFT00845011604.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
  JNK UniProtKB/TrEMBL
  Leuzip_Jun UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report cfa:609429 UniProtKB/TrEMBL
NCBI Gene JUN ENTREZGENE
PANTHER JUN TRANSCRIPTION FACTOR-RELATED UniProtKB/TrEMBL
  PTHR11462:SF8 UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/TrEMBL
  Jun UniProtKB/TrEMBL
PRINTS LEUZIPPRJUN UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF47454 UniProtKB/TrEMBL
  SSF57959 UniProtKB/TrEMBL
UniProt A0A8C0R052 ENTREZGENE
  A0A8C0Z0Z1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RTD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TN96 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42197 ENTREZGENE