JUN (Jun proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: JUN (Jun proto-oncogene, AP-1 transcription factor subunit) Canis lupus familiaris
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Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
RGD ID: 12374086
Description: ENCODES a protein that exhibits cAMP response element binding (ortholog); chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN aging (ortholog); angiogenesis (ortholog); axon regeneration (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH angiosarcoma (ortholog); Asphyxia (ortholog); Brain Injuries (ortholog); FOUND IN chromatin (ortholog); cytosol (ortholog); euchromatin (ortholog); INTERACTS WITH anthra[1,9-cd]pyrazol-6(2H)-one; masitinib; sodium chloride
Type: protein-coding
RefSeq Status: MODEL
Also known as: AP-1; c-jun; jun oncogene; transcription factor AP-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBI
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBI
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBI
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBI
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis  (ISO)
axon regeneration  (ISO)
cellular response to anisomycin  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to calcium ion  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to potassium ion starvation  (ISO)
cellular response to reactive oxygen species  (ISO)
circadian rhythm  (ISO)
eyelid development in camera-type eye  (ISO)
immune response  (ISO)
leading edge cell differentiation  (ISO)
learning  (ISO)
liver development  (ISO)
membrane depolarization  (ISO)
microglial cell activation  (ISO)
monocyte differentiation  (ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation by host of viral transcription  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription, initiation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of monocyte differentiation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
Ras protein signal transduction  (ISO)
regulation of cell cycle  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to cAMP  (ISO)
response to cytokine  (ISO)
response to hydrogen peroxide  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to muscle stretch  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to radiation  (ISO)
response to xenobiotic stimulus  (ISO)
SMAD protein signal transduction  (ISO)
transcription by RNA polymerase II  (ISO)
transcription, DNA-templated  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

References
Additional References at PubMed
PMID:16380175   PMID:23816505   PMID:28472120  


Genomics

Comparative Map Data
JUN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBI
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBI
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBI
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBI
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBI
JUN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl158,776,845 - 58,784,048 (-)EnsemblGRCh38hg38GRCh38
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBI
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
Jun
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,937,273 - 94,940,459 (-)NCBIGRCm39mm39
GRCm39 Ensembl494,937,271 - 94,940,459 (-)Ensembl
GRCm38495,049,036 - 95,052,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl495,049,034 - 95,052,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37494,715,727 - 94,718,913 (-)NCBIGRCm37mm9NCBIm37
MGSCv36494,541,073 - 94,544,205 (-)NCBImm8
Celera493,436,543 - 93,439,728 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Jun
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)Ensembl
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
Jun
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554641,107,598 - 1,110,326 (+)NCBIChiLan1.0ChiLan1.0
JUN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1159,747,129 - 59,750,446 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0158,042,794 - 58,045,536 (-)NCBIMhudiblu_PPA_v0panPan3
Jun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505872,379,192 - 72,381,903 (-)NCBI
SpeTri2.0NW_0049365223,034,364 - 3,037,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12074,204,481 - 74,207,835 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603343,155,224 - 43,158,790 (-)NCBIVero_WHO_p1.0
Jun
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248621,537,886 - 1,540,633 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005620245   ⟹   XP_005620302
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1550,966,698 - 50,968,939 (+)NCBI
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038476209   ⟹   XP_038332137
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBI
RefSeq Acc Id: XM_038537394   ⟹   XP_038393322
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBI
RefSeq Acc Id: XM_038601523   ⟹   XP_038457451
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBI
RefSeq Acc Id: XM_038666089   ⟹   XP_038522017
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005620302   ⟸   XM_005620245
- UniProtKB: E2R6T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038332137   ⟸   XM_038476209
RefSeq Acc Id: XP_038457451   ⟸   XM_038601523
RefSeq Acc Id: XP_038522017   ⟸   XM_038666089
RefSeq Acc Id: XP_038393322   ⟸   XM_038537394

Promoters
RGD ID:13683306
Promoter ID:EPDNEW_C1374
Type:multiple initiation site
Name:JUN_1
Description:Jun proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1550,967,874 - 50,967,934EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 50967974 50967975 C T snv Beagle (BE020)


Additional Information

Database Acc Id Source(s)
NCBI Gene JUN ENTREZGENE
UniProt E2R6T4 ENTREZGENE
VGNC ID VGNC:42197 ENTREZGENE