RGD Reference Report - c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer. - Rat Genome Database

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c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer.

Authors: Cai, C  Hsieh, CL  Shemshedini, L 
Citation: Cai C, etal., Mol Cancer Res. 2007 Jul;5(7):725-35.
RGD ID: 2290478
Pubmed: PMID:17634427   (View Abstract at PubMed)
DOI: DOI:10.1158/1541-7786.MCR-06-0430   (Journal Full-text)

The multiple transcriptional roles of c-Jun are shown in a novel cross-talk between the androgen receptor (AR) and its new target gene, Ets variant gene 1 (ETV1). In this report, we show that c-Jun can mediate AR induction of ETV1 expression independent of c-Jun transactivation function. Interestingly, c-Jun can transactivate the cloned ETV1 promoter also in the absence of ligand-activated AR, suggesting two mechanisms by which c-Jun can induce ETV1 expression. In addition, both wild-type c-Jun and a transactivation-deficient mutant can enhance the transcriptional activity of ETV1, as measured by both reporter gene assay and endogenous expression of matrix metalloproteinase genes, well-known targets of Ets proteins. Overexpression of the c-Jun mutant protein also led to increased prostate cancer cell invasion. Immunoprecipitation and immunocytochemistry experiments showed copurification and colocalization of c-Jun with AR or ETV1, suggesting that c-Jun acts on AR or ETV1 via a physical association. Collectively, these results, together with a parallel overexpression of ETV1, c-Jun, and AR in prostate tumors, imply that c-Jun plays a pivotal role in the pathway that connects ligand-activated AR to elevated ETV1 expression, leading to enhanced expression of matrix metalloproteinases and prostate cancer cell invasion.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Prostatic Neoplasms disease_progressionIDA 2290478Jun interacts with androgen receptor and ETV1 to mediate invasionRGD 
Prostatic Neoplasms  IEP 2290478protein:increased expression:malignant tissuesRGD 
Prostatic Neoplasms  ISOJUN (Homo sapiens)2290478; 2290478 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Jun  (Jun proto-oncogene, AP-1 transcription factor subunit)

Genes (Mus musculus)
Jun  (jun proto-oncogene)

Genes (Homo sapiens)
JUN  (Jun proto-oncogene, AP-1 transcription factor subunit)


Additional Information