RGD Reference Report - Expression of c-jun oncogene in hyperplastic and carcinomatous human prostate. - Rat Genome Database

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Expression of c-jun oncogene in hyperplastic and carcinomatous human prostate.

Authors: Tiniakos, DG  Mitropoulos, D  Kyroudi-Voulgari, A  Soura, K  Kittas, C 
Citation: Tiniakos DG, etal., Urology. 2006 Jan;67(1):204-8.
RGD ID: 2290480
Pubmed: PMID:16413376   (View Abstract at PubMed)
DOI: DOI:10.1016/j.urology.2005.07.045   (Journal Full-text)

OBJECTIVES: To investigate c-jun oncoprotein (JUN) expression in diseases of the human prostate gland at the tissue level and to determine its relationship to clinicopathologic variables. METHODS: The expression of JUN was studied using immunohistochemistry in archival tissue from benign prostatic hyperplasia (BPH) (n = 16) and prostate adenocarcinoma (PCa) (n = 36) specimens. RESULTS: JUN-specific positive nuclear immunostaining was observed in 13 (81.25%) of 16 BPH and 31 (86.1%) of 36 PCa specimens. JUN-specific immunostaining was significantly stronger in the PCa than in the BPH tissue (P = 0.006). In the PCa tissue, no significant correlation was found between JUN immunohistochemical expression and tumor histologic grade (Gleason score) or serum prostate-specific antigen level. CONCLUSIONS: JUN expression may play a role in normal cell function of the prostatic epithelium and is expressed in most BPH and PCa samples. The finding that JUN-specific immunostaining intensity was stronger in the vast majority of PCa than in the BPH samples implies that the role of c-jun may be enhanced during malignant transformation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
JUNHumanprostate carcinoma  IEP protein:increased activation:tumor:nuclear localization in 13/16 (81.25%) of BPH and 31/36 (86.1%) of adenocarcinomas (PCa) with significantly stronger staining in PCa (P=0.006)RGD 
JunRatprostate carcinoma  ISOJUN (Homo sapiens) RGD 
JunMouseprostate carcinoma  ISOJUN (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Jun  (Jun proto-oncogene, AP-1 transcription factor subunit)

Genes (Mus musculus)
Jun  (jun proto-oncogene)

Genes (Homo sapiens)
JUN  (Jun proto-oncogene, AP-1 transcription factor subunit)


Additional Information