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Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B.

Authors: Mathas, S  Hinz, M  Anagnostopoulos, I  Krappmann, D  Lietz, A  Jundt, F  Bommert, K  Mechta-Grigoriou, F  Stein, H  Dorken, B  Scheidereit, C 
Citation: Mathas S, etal., EMBO J 2002 Aug 1;21(15):4104-13.
Pubmed: (View Article at PubMed) PMID:12145210

AP-1 family transcription factors have been implicated in the control of proliferation, apoptosis and malignant transformation. However, their role in oncogenesis is unclear and no recurrent alterations of AP-1 activities have been described in human cancers. Here, we show that constitutively activated AP-1 with robust c-Jun and JunB overexpression is found in all tumor cells of patients with classical Hodgkin's disease. A similar AP-1 activation is present in anaplastic large cell lymphoma (ALCL), but is absent in other lymphoma types. Whereas c-Jun is up-regulated by an autoregulatory process, JunB is under control of NF-kappa B. Activated AP-1 supports proliferation of Hodgkin cells, while it suppresses apoptosis of ALCL cells. Furthermore, AP-1 cooperates with NF-kappa B and stimulates expression of the cell-cycle regulator cyclin D2, proto-oncogene c-met and the lymphocyte homing receptor CCR7, which are all strongly expressed in primary HRS cells. Together, these data suggest an important role of AP-1 in lymphoma pathogenesis.

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RGD Object Information
RGD ID: 1549449
Created: 2005-08-29
Species: All species
Last Modified: 2005-08-29
Status: ACTIVE



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