JUN (Jun proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: JUN (Jun proto-oncogene, AP-1 transcription factor subunit) Sus scrofa
Analyze
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
RGD ID: 14217642
Description: ENCODES a protein that exhibits DNA binding; activating transcription factor binding (ortholog); cAMP response element binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide; immune response; positive regulation of DNA-binding transcription factor activity; PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH angiosarcoma (ortholog); Asphyxia (ortholog); Brain Injuries (ortholog); FOUND IN nucleus; chromatin (ortholog); cytosol (ortholog); INTERACTS WITH cadmium dichloride; clofibrate; mercury dichloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: activator protein 1; AP1; C-JUN; proto-oncogene c-jun; transcription factor AP-1; V-jun avian sarcoma virus 17 oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis  (ISO)
axon regeneration  (ISO)
cellular process  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to calcium ion  (ISO)
cellular response to lipopolysaccharide  (IDA)
cellular response to potassium ion starvation  (ISO)
cellular response to reactive oxygen species  (ISO)
circadian rhythm  (ISO)
eyelid development in camera-type eye  (ISO)
immune response  (IDA)
leading edge cell differentiation  (ISO)
learning  (ISO)
liver development  (ISO)
membrane depolarization  (ISO)
microglial cell activation  (ISO)
monocyte differentiation  (ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation by host of viral transcription  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-binding transcription factor activity  (IMP)
positive regulation of DNA-templated transcription, initiation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of monocyte differentiation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (IMP,ISO,ISS)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
Ras protein signal transduction  (ISS)
regulation of cell cycle  (IBA,ISO)
regulation of cell population proliferation  (IBA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to cAMP  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to hydrogen peroxide  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to muscle stretch  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to radiation  (ISO)
SMAD protein signal transduction  (ISO)
transcription by RNA polymerase II  (ISO)
transcription, DNA-templated  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:8793856   PMID:8898353   PMID:14681463   PMID:22083952   PMID:23089279   PMID:25110868   PMID:28347884   PMID:28931675  


Genomics

Comparative Map Data
JUN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl158,776,845 - 58,784,048 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl158,780,791 - 58,784,047 (-)EnsemblGRCh38hg38GRCh38
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,785 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37159,246,463 - 59,249,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBI
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
Jun
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,937,273 - 94,940,459 (-)NCBIGRCm39mm39
GRCm38495,049,036 - 95,052,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl495,049,034 - 95,052,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37494,715,727 - 94,718,913 (-)NCBIGRCm37mm9NCBIm37
MGSCv36494,541,073 - 94,544,205 (-)NCBImm8
Celera493,436,543 - 93,439,728 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Jun
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25109,894,175 - 109,897,268 (-)NCBI
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
Jun
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554641,107,598 - 1,110,326 (+)NCBIChiLan1.0ChiLan1.0
JUN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1159,747,129 - 59,750,446 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0158,042,794 - 58,045,536 (-)NCBIMhudiblu_PPA_v0panPan3
JUN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Jun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365223,034,364 - 3,037,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12074,204,481 - 74,207,835 (+)NCBI
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)Ensembl
Jun
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248621,537,886 - 1,540,633 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_213880   ⟹   NP_999045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999045 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB50808 (Get FASTA)   NCBI Sequence Viewer  
  P56432 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999045   ⟸   NM_213880
- UniProtKB: P56432 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
InterPro bZIP UniProtKB/Swiss-Prot
  C_Jun/v-Jun UniProtKB/Swiss-Prot
  JNK UniProtKB/Swiss-Prot
  Leuzip_Jun UniProtKB/Swiss-Prot
  TF_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report ssc:396913 UniProtKB/Swiss-Prot
NCBI Gene JUN ENTREZGENE
PANTHER PTHR11462:SF8 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
  Jun UniProtKB/Swiss-Prot
PRINTS LEUZIPPRJUN UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot
UniProt JUN_PIG UniProtKB/Swiss-Prot, ENTREZGENE