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G |
Abcf1 |
ATP binding cassette subfamily F member 1 |
increases expression |
ISO |
ferrous sulfate results in increased expression of ABCF1 mRNA |
CTD |
PMID:19428942 |
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NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825
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G |
Aco1 |
aconitase 1 |
multiple interactions |
ISO |
[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein] |
CTD |
PMID:16039939 |
|
NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of ACTA2 protein |
CTD |
PMID:7593635 |
|
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:17172471 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Atp2a1 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 |
multiple interactions |
EXP |
[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] |
CTD |
PMID:12870653 |
|
NCBI chr 1:197,855,912...197,875,038
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
EXP |
ferrous sulfate results in increased expression of BAX protein 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of BAX protein] |
CTD |
PMID:28583816 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
EXP |
ferrous sulfate results in decreased expression of BCL2 protein 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in decreased expression of BCL2 protein] |
CTD |
PMID:28583816 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2a1 |
BCL2-related protein A1 |
increases expression |
ISO |
ferrous sulfate results in increased expression of BCL2A1 mRNA |
CTD |
PMID:21540303 |
|
NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
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G |
Casp3 |
caspase 3 |
increases cleavage multiple interactions |
EXP ISO |
ferrous sulfate results in increased cleavage of CASP3 protein [Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA] 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased cleavage of CASP3 protein] |
CTD |
PMID:17879260 PMID:28583816 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA] |
CTD |
PMID:17879260 |
|
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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G |
Cat |
catalase |
multiple interactions |
ISO |
CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased degradation of Hyaluronic Acid]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein] |
CTD |
PMID:23692848 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Cav1 |
caveolin 1 |
affects localization |
EXP |
ferrous sulfate affects the localization of CAV1 protein |
CTD |
PMID:17172471 |
|
NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
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G |
Ccl17 |
C-C motif chemokine ligand 17 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CCL17 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
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G |
Ccl19 |
C-C motif chemokine ligand 19 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CCL19 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
increases expression |
ISO |
ferrous sulfate results in increased expression of CCL20 mRNA |
CTD |
PMID:19428942 PMID:21540303 |
|
NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
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G |
Ccl21 |
C-C motif chemokine ligand 21 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CCL21 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
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G |
Ccl24 |
C-C motif chemokine ligand 24 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CCL24 mRNA |
CTD |
PMID:19428942 |
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NCBI chr12:24,131,529...24,152,626
Ensembl chr12:24,148,567...24,152,625
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G |
Ccr6 |
C-C motif chemokine receptor 6 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CCR6 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
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G |
Ccr7 |
C-C motif chemokine receptor 7 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CCR7 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
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G |
Ccr8 |
C-C motif chemokine receptor 8 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CCR8 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456
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G |
Cd44 |
CD44 molecule (Indian blood group) |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein] |
CTD |
PMID:23692848 |
|
NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
ferrous sulfate results in increased expression of CDKN1A mRNA |
CTD |
PMID:21540303 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression |
ISO |
ferrous sulfate results in increased expression of CEBPB mRNA |
CTD |
PMID:19428942 |
|
NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions |
EXP |
deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]] |
CTD |
PMID:17172471 |
|
NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
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G |
Crp |
C-reactive protein |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CRP mRNA; ferrous sulfate results in decreased expression of CRP protein |
CTD |
PMID:17119383 PMID:19428942 |
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NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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G |
Csf2 |
colony stimulating factor 2 |
increases expression |
ISO |
ferrous sulfate results in increased expression of CSF2 mRNA |
CTD |
PMID:21540303 |
|
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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G |
Cxcl10 |
C-X-C motif chemokine ligand 10 |
increases expression |
ISO |
ferrous sulfate results in increased expression of CXCL10 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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G |
Cxcl11 |
C-X-C motif chemokine ligand 11 |
increases expression |
ISO |
ferrous sulfate results in increased expression of CXCL11 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
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G |
Cxcl13 |
C-X-C motif chemokine ligand 13 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CXCL13 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
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G |
Cxcl14 |
C-X-C motif chemokine ligand 14 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CXCL14 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
EXP |
ferrous sulfate results in increased expression of CXCL2 mRNA |
CTD |
PMID:11708899 |
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NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of CXCR2 mRNA |
CTD |
PMID:19428942 |
|
NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; ferrous sulfate inhibits the reaction [picolinic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]] |
CTD |
PMID:10799651 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
decreases response to substance |
ISO |
DNAJB1 protein results in decreased susceptibility to ferrous sulfate |
CTD |
PMID:11359866 |
|
NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
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G |
Egln1 |
egl-9 family hypoxia-inducible factor 1 |
increases activity |
ISO |
ferrous sulfate results in increased activity of EGLN1 protein |
CTD |
PMID:16649251 |
|
NCBI chr19:57,660,194...57,701,158
Ensembl chr19:57,662,278...57,699,113
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G |
Egr1 |
early growth response 1 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of EGR1 mRNA |
CTD |
PMID:21540303 |
|
NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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G |
Epas1 |
endothelial PAS domain protein 1 |
multiple interactions |
ISO |
ferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein]; ferrous sulfate inhibits the reaction [Quercetin results in increased expression of EPAS1 protein] |
CTD |
PMID:17973296 |
|
NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
multiple interactions |
ISO |
ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; ferrous sulfate inhibits the reaction [Quercetin results in decreased expression of and results in increased ubiquitination of ERBB2 protein] |
CTD |
PMID:18655187 |
|
NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
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G |
F10 |
coagulation factor X |
decreases activity |
ISO |
ferrous sulfate results in decreased activity of F10 protein |
CTD |
PMID:6421970 |
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NCBI chr16:81,803,169...81,822,476
Ensembl chr16:81,803,110...81,822,716
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G |
F2 |
coagulation factor II |
decreases activity |
ISO |
ferrous sulfate results in decreased activity of F2 protein |
CTD |
PMID:6421970 |
|
NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
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G |
Ftl1 |
ferritin light chain 1 |
multiple interactions increases expression |
ISO EXP |
[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein] ferrous sulfate results in increased expression of FTL1 protein |
CTD |
PMID:16039939 PMID:28993186 |
|
NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions decreases expression |
ISO |
ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein] ferrous sulfate results in decreased expression of GCLC protein |
CTD |
PMID:27424009 |
|
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G |
Gdnf |
glial cell derived neurotrophic factor |
decreases response to substance |
ISO |
GDNF protein results in decreased susceptibility to ferrous sulfate |
CTD |
PMID:17935603 |
|
NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression multiple interactions |
EXP |
ferrous sulfate results in increased expression of GPX1 protein 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of GPX1 protein] |
CTD |
PMID:28583816 |
|
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation |
EXP |
ferrous sulfate results in increased phosphorylation of GSK3B protein |
CTD |
PMID:19608791 |
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NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
EXP |
ferrous sulfate results in increased expression of H2AX protein 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein] |
CTD |
PMID:28583816 |
|
NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
ferrous sulfate inhibits the reaction [Chromium results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Cobalt results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [galangin results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Nickel results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Quercetin results in increased expression of HIF1A protein] |
CTD |
PMID:16386771 PMID:17973296 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [sulforaphane results in increased expression of HMOX1 mRNA]] 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of HMOX1 protein] |
CTD |
PMID:20934533 PMID:26945724 PMID:28583816 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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|
G |
Hras |
HRas proto-oncogene, GTPase |
affects localization multiple interactions |
EXP |
ferrous sulfate affects the localization of HRAS protein ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:17172471 |
|
NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
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G |
Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
multiple interactions |
ISO |
ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]] |
CTD |
PMID:18655187 |
|
NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 Ensembl chr 6:135,107,271...135,112,775
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
EXP |
deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]] |
CTD |
PMID:17172471 |
|
NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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G |
Il10rb |
interleukin 10 receptor subunit beta |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of IL10RB mRNA |
CTD |
PMID:19428942 |
|
NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO EXP |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein] 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of IL1B protein] |
CTD |
PMID:23692848 PMID:28583816 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il1rn |
interleukin 1 receptor antagonist |
increases expression |
ISO |
ferrous sulfate results in increased expression of IL1RN mRNA |
CTD |
PMID:19428942 |
|
NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
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G |
Il36rn |
interleukin 36 receptor antagonist |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of IL36RN mRNA |
CTD |
PMID:19428942 |
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NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
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G |
Il4 |
interleukin 4 |
increases expression |
ISO |
ferrous sulfate results in increased expression of IL4 protein |
CTD |
PMID:15963385 |
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NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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G |
Il6 |
interleukin 6 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of IL6 protein |
CTD |
PMID:17119383 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
ferrous sulfate results in increased expression of JUN mRNA |
CTD |
PMID:21540303 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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G |
Klk1 |
kallikrein 1 |
decreases activity |
ISO |
ferrous sulfate results in decreased activity of KLK1 protein |
CTD |
PMID:6421970 |
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NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329
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G |
Lep |
leptin |
increases expression |
ISO |
ferrous sulfate results in increased expression of LEP mRNA |
CTD |
PMID:21540303 |
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NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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G |
Lta |
lymphotoxin alpha |
increases expression decreases expression |
ISO |
ferrous sulfate results in increased expression of LTA mRNA ferrous sulfate results in decreased expression of LTA mRNA |
CTD |
PMID:19428942 PMID:21540303 |
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NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
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G |
Map2k6 |
mitogen-activated protein kinase kinase 6 |
multiple interactions increases phosphorylation |
EXP |
ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein] |
CTD |
PMID:17172471 |
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NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
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G |
Map3k14 |
mitogen-activated protein kinase kinase kinase 14 |
multiple interactions |
EXP |
MAP3K14 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein] |
CTD |
PMID:17172471 |
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NCBI chr10:91,303,428...91,353,601
Ensembl chr10:91,303,428...91,353,601
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G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
affects localization increases activity multiple interactions |
EXP |
ferrous sulfate affects the localization of MAP3K7 protein ferrous sulfate results in increased activity of MAP3K7 protein ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein] |
CTD |
PMID:17172471 |
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NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416 Ensembl chr 9:47,186,558...47,244,416
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:17172471 PMID:19608791 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:17172471 PMID:19608791 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mir146a |
microRNA 146a |
multiple interactions |
ISO |
[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA; Curcumin inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]; Resveratrol analog inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA] |
CTD |
PMID:22099153 |
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NCBI chr10:28,962,476...28,962,570
Ensembl chr10:28,962,476...28,962,570
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G |
Mmp13 |
matrix metallopeptidase 13 |
multiple interactions increases expression |
ISO EXP |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein] Diltiazem promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]; Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]; Verapamil promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein] |
CTD |
PMID:23692848 PMID:27095094 |
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NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
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G |
Mt1 |
metallothionein 1 |
increases expression multiple interactions |
EXP |
ferrous sulfate results in increased expression of MT1A mRNA [Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT1A protein; ferrous sulfate results in increased expression of and affects the localization of MT1A protein |
CTD |
PMID:17241390 PMID:19679144 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Mt2A |
metallothionein 2A |
multiple interactions |
EXP |
[Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT2A protein; ferrous sulfate results in increased expression of and affects the localization of MT2A protein |
CTD |
PMID:17241390 |
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NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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G |
Myb |
MYB proto-oncogene, transcription factor |
multiple interactions |
EXP |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MYB protein |
CTD |
PMID:7593635 |
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NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions increases expression |
ISO EXP |
ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of NFE2L2 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of and affects the localization of NFE2L2 protein]] ferrous sulfate results in increased expression of NFE2L2 mRNA 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of NFE2L2 protein]; ferrous sulfate results in increased expression of and affects the localization of NFE2L2 protein |
CTD |
PMID:26945724 PMID:28583816 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]] [Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein; [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of and results in increased activity of [RELA protein binds to NFKB1 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein] |
CTD |
PMID:17879260 PMID:22099153 PMID:23692848 |
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NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions increases phosphorylation |
EXP ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein] [Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein] |
CTD |
PMID:17172471 PMID:17879260 PMID:28583816 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein] |
CTD |
PMID:23692848 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression multiple interactions |
EXP |
ferrous sulfate results in increased expression of NQO1 protein 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NQO1 protein] |
CTD |
PMID:28583816 |
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NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
EXP |
ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein] |
CTD |
PMID:17172471 |
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NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
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G |
Pmepa1 |
prostate transmembrane protein, androgen induced 1 |
increases expression |
ISO |
ferrous sulfate results in increased expression of PMEPA1 mRNA |
CTD |
PMID:21540303 |
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NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646
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G |
Pon1 |
paraoxonase 1 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; [Ascorbic Acid co-treated with ferrous sulfate] results in decreased activity of PON1 protein |
CTD |
PMID:12871208 PMID:15375178 |
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NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression multiple interactions |
EXP |
ferrous sulfate results in increased expression of PTGS2 protein 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of PTGS2 protein] |
CTD |
PMID:28583816 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions affects localization |
ISO EXP |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]] ferrous sulfate affects the localization of RELA protein 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of RELA protein] [Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein; [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of and results in increased activity of [RELA protein binds to NFKB1 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein] |
CTD |
PMID:17879260 PMID:22099153 PMID:23692848 PMID:28583816 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Selplg |
selectin P ligand |
increases expression |
ISO |
ferrous sulfate results in increased expression of SELPLG mRNA |
CTD |
PMID:21540303 |
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NCBI chr12:48,577,905...48,579,196
Ensembl chr12:48,577,905...48,579,196
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G |
Slc11a2 |
solute carrier family 11 member 2 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of SLC11A2 mRNA |
CTD |
PMID:10966897 |
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NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
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G |
Slc40a1 |
solute carrier family 40 member 1 |
multiple interactions |
ISO |
SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased abundance of Reactive Oxygen Species]; SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased uptake of Iron] |
CTD |
PMID:19913091 |
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NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
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G |
Snca |
synuclein alpha |
multiple interactions |
ISO |
ferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; ferrous sulfate inhibits the reaction [SNCA protein results in decreased expression of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased activity of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein]; ferrous sulfate promotes the reaction [SNCA protein results in increased abundance of Reactive Oxygen Species] |
CTD |
PMID:27424009 |
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NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions decreases activity |
ISO |
ferrous sulfate inhibits the reaction [SNCA protein results in decreased expression of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased activity of SOD1 protein] ferrous sulfate results in decreased activity of SOD1 protein |
CTD |
PMID:27424009 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
increases activity decreases expression |
ISO |
ferrous sulfate results in increased activity of SOD2 protein ferrous sulfate results in decreased expression of SOD2 protein |
CTD |
PMID:27424009 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Spp1 |
secreted phosphoprotein 1 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of SPP1 mRNA |
CTD |
PMID:19428942 |
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NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
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G |
Stat1 |
signal transducer and activator of transcription 1 |
increases phosphorylation |
EXP |
ferrous sulfate results in increased phosphorylation of STAT1 protein |
CTD |
PMID:17607690 |
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NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
[ferrous sulfate co-treated with Copper Sulfate] promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein] |
CTD |
PMID:10364193 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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G |
Tas1r3 |
taste 1 receptor member 3 |
affects response to substance |
ISO |
TAS1R3 protein affects the susceptibility to ferrous sulfate |
CTD |
PMID:19244541 |
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NCBI chr 5:173,307,325...173,312,950
Ensembl chr 5:173,308,870...173,312,023
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G |
Tf |
transferrin |
multiple interactions increases expression |
ISO EXP |
ferrous sulfate promotes the reaction [TF protein results in increased uptake of Iron] ferrous sulfate results in increased expression of TF protein |
CTD |
PMID:11335103 PMID:28993186 |
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NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
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G |
Tfrc |
transferrin receptor |
decreases expression |
ISO EXP |
ferrous sulfate results in decreased expression of TFRC mRNA ferrous sulfate results in decreased expression of TFRC protein |
CTD |
PMID:10966897 PMID:16039939 PMID:28993186 |
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NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
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G |
Timp1 |
TIMP metallopeptidase inhibitor 1 |
multiple interactions increases expression |
EXP |
Diltiazem inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]; Nimodipine inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]; Verapamil inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein] |
CTD |
PMID:27095094 |
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NCBI chr X:1,364,771...1,369,451
Ensembl chr X:1,364,786...1,369,384
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein] |
CTD |
PMID:23692848 |
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NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein] |
CTD |
PMID:23692848 |
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NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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G |
Tnf |
tumor necrosis factor |
increases expression multiple interactions increases secretion |
ISO EXP |
ferrous sulfate results in increased expression of TNF mRNA; ferrous sulfate results in increased expression of TNF protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]; ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; tetramethylthiourea inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]; U 0126 inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein] [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein] ferrous sulfate inhibits the reaction [Deferoxamine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein] |
CTD |
PMID:7539275 PMID:15550384 PMID:15963385 PMID:17172471 PMID:19428942 PMID:21540303 PMID:23692848 PMID:28583816 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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G |
Trpm5 |
transient receptor potential cation channel, subfamily M, member 5 |
affects response to substance |
ISO |
TRPM5 protein affects the susceptibility to ferrous sulfate |
CTD |
PMID:19244541 |
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NCBI chr 1:216,256,653...216,281,504
Ensembl chr 1:216,257,820...216,274,930
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G |
Trpv1 |
transient receptor potential cation channel, subfamily V, member 1 |
increases activity |
ISO |
ferrous sulfate results in increased activity of TRPV1 protein |
CTD |
PMID:17567713 |
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NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
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G |
Xcr1 |
X-C motif chemokine receptor 1 |
decreases expression |
ISO |
ferrous sulfate results in decreased expression of XCR1 mRNA |
CTD |
PMID:19428942 |
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NCBI chr 8:132,911,474...132,919,110
Ensembl chr 8:132,911,486...132,919,110
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