Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glyoxylic acid
go back to main search page
Accession:CHEBI:16891 term browser browse the term
Definition:A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.
Synonyms:exact_synonym: oxoacetic acid
 related_synonym: Formula=C2H2O3;   Glyoxalate;   Glyoxalsaeure;   Glyoxylate;   Glyoxylsaeure;   InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5);   InChIKey=HHLFWLYXYJOTON-UHFFFAOYSA-N;   SMILES=[H]C(=O)C(O)=O;   alpha-ketoacetic acid;   formylformic acid;   oxalaldehydic acid;   oxoethanoic acid
 alt_id: CHEBI:24421;   CHEBI:42767;   CHEBI:5509
 xref: Beilstein:741891;   CAS:298-12-4;   DrugBank:DB04343;   Gmelin:25752;   HMDB:HMDB0000119;   KEGG:C00048;   KNApSAcK:C00001186
 xref_mesh: MESH:C031150
 xref: MetaCyc:GLYOX;   PDBeChem:GLV;   PMID:11479160;   PMID:16396466;   PMID:22580421;   PMID:23790896;   Reaxys:741891;   Wikipedia:Glyoxylic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:36655


show annotations for term's descendants           Sort by:
 
glyoxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO glyoxylic acid results in increased expression of BAX protein
Resveratrol inhibits the reaction [glyoxylic acid results in increased expression of BAX protein]		 CTD PMID:34333021 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO glyoxylic acid results in decreased expression of BCL2 protein
Resveratrol inhibits the reaction [glyoxylic acid results in decreased expression of BCL2 protein]		 CTD PMID:34333021 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO Resveratrol inhibits the reaction [glyoxylic acid results in increased cleavage of CASP3 protein] CTD PMID:34333021 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP glyoxylic acid results in decreased activity of G6PD protein CTD PMID:15144222 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO glyoxylic acid results in increased expression of HMOX1 protein CTD PMID:34333021 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in decreased abundance of glyoxylic acid analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Sirt1 sirtuin 1 decreases expression ISO glyoxylic acid results in decreased expression of SIRT1 protein CTD PMID:34333021 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression		 EXP [glyoxylic acid co-treated with Calcitriol] results in increased expression of SPP1 mRNA
glyoxylic acid results in increased expression of SPP1 protein		 CTD PMID:7571189 PMID:8325891 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
phenylglyoxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid] CTD PMID:25562543 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        solvent 16685
          formic acid 8833
            formyl group 8806
              aldehyde 8806
                aldehydic acid 15
                  glyoxylic acid 10
                    2-aminophenylglyoxylic acid 0
                    3,5-dihydroxyphenylglyoxylic acid 0
                    4-hydroxyphenylglyoxylic acid 0
                    glyoxylate ester + 0
                    phenylglyoxylic acid + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            formyl group 8806
                                              aldehyde 8806
                                                aldehydic acid 15
                                                  glyoxylic acid 10
                                                    2-aminophenylglyoxylic acid 0
                                                    3,5-dihydroxyphenylglyoxylic acid 0
                                                    4-hydroxyphenylglyoxylic acid 0
                                                    glyoxylate ester + 0
                                                    phenylglyoxylic acid + 2
paths to the root