CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: glyoxylic acid
Accession: CHEBI:16891
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Definition: A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.
Synonyms: exact_synonym: oxoacetic acid
related_synonym: Formula=C2H2O3; Glyoxalate; Glyoxalsaeure; Glyoxylate; Glyoxylsaeure; InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5); InChIKey=HHLFWLYXYJOTON-UHFFFAOYSA-N; SMILES=[H]C(=O)C(O)=O; alpha-ketoacetic acid; formylformic acid; oxalaldehydic acid; oxoethanoic acid
alt_id: CHEBI:24421; CHEBI:42767; CHEBI:5509
xref: Beilstein:741891; CAS:298-12-4; DrugBank:DB04343; Gmelin:25752; HMDB:HMDB0000119; KEGG:C00048; KNApSAcK:C00001186
xref_mesh: MESH:C031150
xref: MetaCyc:GLYOX; PDBeChem:GLV; PMID:11479160; PMID:16396466; PMID:22580421; PMID:23790896; Reaxys:741891; Wikipedia:Glyoxylic_acid
cyclic_relationship: is_conjugate_acid_of CHEBI:36655
G
Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
glyoxylic acid results in increased expression of BAX protein Resveratrol inhibits the reaction [glyoxylic acid results in increased expression of BAX protein]
CTD
PMID:34333021
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO
glyoxylic acid results in decreased expression of BCL2 protein Resveratrol inhibits the reaction [glyoxylic acid results in decreased expression of BCL2 protein]
CTD
PMID:34333021
NCBI chr13:22,689,783...22,853,920
G
Casp3
caspase 3
multiple interactions increases cleavage
ISO
Resveratrol inhibits the reaction [glyoxylic acid results in increased cleavage of CASP3 protein]
CTD
PMID:34333021
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
G6pd
glucose-6-phosphate dehydrogenase
decreases activity
EXP
glyoxylic acid results in decreased activity of G6PD protein
CTD
PMID:15144222
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Hmox1
heme oxygenase 1
increases expression
ISO
glyoxylic acid results in increased expression of HMOX1 protein
CTD
PMID:34333021
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Ins2
insulin 2
multiple interactions
ISO
[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in decreased abundance of glyoxylic acid analog
CTD
PMID:26820058
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
G
Sirt1
sirtuin 1
decreases expression
ISO
glyoxylic acid results in decreased expression of SIRT1 protein
CTD
PMID:34333021
NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
G
Spp1
secreted phosphoprotein 1
multiple interactions increases expression
EXP
[glyoxylic acid co-treated with Calcitriol] results in increased expression of SPP1 mRNA glyoxylic acid results in increased expression of SPP1 protein
CTD
PMID:7571189 PMID:8325891
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
CYP2E1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]
CTD
PMID:25562543
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Ephx1
epoxide hydrolase 1
multiple interactions
ISO
EPHX1 polymorphism affects the metabolism of [mandelic acid co-treated with phenylglyoxylic acid]
CTD
PMID:25562543
NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
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