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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:CDP-choline
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Accession:CHEBI:16436 term browser browse the term
Definition:A member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes.
Synonyms:exact_synonym: 5'-O-[hydroxy({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphoryl]cytidine
 related_synonym: CDP-colina;   Citicoline;   Cytidindiphosphocholin;   Cytidine 5'-diphosphocholine;   Formula=C14H26N4O11P2;   InChI=1S/C14H26N4O11P2/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25)/t9-,11-,12-,13-/m1/s1;   InChIKey=RZZPDXZPRHQOCG-OJAKKHQRSA-N;   SMILES=C[N+](C)(C)CCOP([O-])(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(N)nc1=O;   [2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM;   citicolina;   citicolinum;   citidin difosfato de colina;   cyticholine;   cytidine 5'-(choline diphosphate);   cytidine 5'-(cholinyl pyrophosphate);   cytidine 5'-diphosphoric choline
 alt_id: CHEBI:13268;   CHEBI:20867;   CHEBI:3268;   CHEBI:41440
 xref: Beilstein:4170138;   CAS:987-78-0;   DrugBank:DB04290;   Drug_Central:664;   HMDB:HMDB0001413;   KEGG:C00307;   KEGG:D00057;   KNApSAcK:C00007231
 xref_mesh: MESH:D003566
 xref: PDBeChem:CDC;   PMID:10701532;   PMID:10796523;   PMID:8709678;   Reaxys:4170138;   Wikipedia:Citicoline
 cyclic_relationship: is_conjugate_base_of CHEBI:49086



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CDP-choline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 decreases expression ISO Cytidine Diphosphate Choline results in decreased expression of CASP3 protein CTD PMID:12443983 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression EXP Cytidine Diphosphate Choline results in decreased expression of ICAM1 mRNA CTD PMID:16193989 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 multiple interactions ISO NCEH1 protein inhibits the reaction [[Chlorpyrifos metabolite co-treated with Cytidine Diphosphate Choline] results in increased abundance of Platelet Activating Factor] CTD PMID:18164358 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases expression ISO Cytidine Diphosphate Choline results in decreased expression of PARP1 protein modified form CTD PMID:12443983 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions
EXP Cytidine Diphosphate Choline results in increased expression of SIRT1 protein
Cytidine Diphosphate Choline results in increased expression of and results in increased activity of SIRT1 protein
CTD PMID:23600725 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link

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  CHEBI ontology 20056
    role 20008
      application 19745
        pharmaceutical 19618
          drug 19618
            central nervous system drug 16569
              psychotropic drug 15253
                CDP-choline 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      chalcogen 19693
                        oxygen atom 19666
                          oxygen molecular entity 19666
                            hydroxides 19412
                              oxoacid 18715
                                pnictogen oxoacid 11007
                                  phosphorus oxoacid 9812
                                    phosphoric acids 8640
                                      phosphoric acid 8640
                                        phosphoric acid derivative 8344
                                          phosphate 8344
                                            organic phosphate 8343
                                              carbohydrate phosphate 1831
                                                phospho sugar 1679
                                                  aldose phosphate 1677
                                                    aldopentose phosphate 1669
                                                      ribose phosphate 1664
                                                        ribonucleotide 1623
                                                          ribonucleoside 5'-phosphate 625
                                                            ribonucleoside 5'-diphosphate 111
                                                              pyrimidine ribonucleoside 5'-diphosphate 21
                                                                CDP 5
                                                                  CDP-choline 5
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