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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-cystathionine
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Accession:CHEBI:17482 term browser browse the term
Definition:A modified amino acid generated by enzymic means from L-homocysteine and L-serine.
Synonyms:exact_synonym: (2S)-2-amino-4-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanoic acid
 related_synonym: (R)-S-(2-amino-2-carboxyethyl)-L-Homocysteine;   Formula=C7H14N2O4S;   InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1;   InChIKey=ILRYLPWNYFXEMH-WHFBIAKZSA-N;   S-(beta-amino-beta-carboxyethyl)homocysteine;   SMILES=N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
 alt_id: CHEBI:13093;   CHEBI:21259;   CHEBI:6205
 xref: CAS:56-88-2;   HMDB:HMDB0000099;   KEGG:C02291;   KNApSAcK:C00007498
 xref_mesh: MESH:D003540
 xref: MetaCyc:CYSTATHIONINE;   PMID:1025897;   Reaxys:2331423;   Wikipedia:Cystathionine
 cyclic_relationship: is_tautomer_of CHEBI:58161



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L-cystathionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]]; Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]; Cystathionine inhibits the reaction [Homocysteine results in increased expression of and affects the localization of BAX protein] CTD PMID:31885769 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Casp3 caspase 3 multiple interactions ISO BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased cleavage of CASP3 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:31885769 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp9 caspase 9 multiple interactions ISO BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein] CTD PMID:31885769
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Cystathionine analog CTD PMID:26820058 NCBI chr 1:207,272,738...207,421,998 JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases amination ISO KYAT1 protein results in increased amination of Cystathionine CTD PMID:22093698 NCBI chr 3:33,857,407...33,891,153 JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Cystathionine inhibits the reaction [Formaldehyde results in increased expression of MMP1 protein] CTD PMID:27664576 NCBI chr 8:12,943,453...12,963,966 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        biochemical role 19577
          metabolite 19563
            cystathionine 6
              L-cystathionine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19652
                          hydrides 19164
                            inorganic hydride 18180
                              pnictogen hydride 18170
                                nitrogen hydride 18083
                                  azane 17892
                                    ammonia 17891
                                      organic amino compound 17891
                                        amino acid 16077
                                          non-proteinogenic amino acid 4019
                                            non-proteinogenic alpha-amino acid 3813
                                              homocysteines 424
                                                cystathionines 6
                                                  cystathionine 6
                                                    L-cystathionine 6
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