ACHE (acetylcholinesterase) - Rat Genome Database

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Gene: ACHE (acetylcholinesterase) Canis lupus familiaris
Analyze
Symbol: ACHE
Name: acetylcholinesterase
RGD ID: 12185421
Description: ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholinesterase activity (ortholog); choline binding (ortholog); INVOLVED IN acetylcholine catabolic process (ortholog); acetylcholine metabolic process (ortholog); acetylcholine receptor signaling pathway (ortholog); PARTICIPATES IN acetylcholine metabolic pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptor; acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH acute stress disorder (ortholog); Alzheimer's disease (ortholog); amphetamine abuse (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); basement membrane (ortholog); INTERACTS WITH atropine; dichlorvos; sarin
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acetylcholinesterase (Cartwright blood group)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,874,747 - 8,879,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,873,584 - 8,879,702 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,580,127 - 10,585,994 (+)NCBI
ROS_Cfam_1.068,809,869 - 8,815,742 (+)NCBI
ROS_Cfam_1.0 Ensembl68,809,457 - 8,816,935 (+)Ensembl
UMICH_Zoey_3.168,661,436 - 8,668,230 (+)NCBI
UNSW_CanFamBas_1.068,640,504 - 8,646,368 (+)NCBI
UU_Cfam_GSD_1.068,822,240 - 8,828,117 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

References

Genomics

Comparative Map Data
ACHE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,874,747 - 8,879,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,873,584 - 8,879,702 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,580,127 - 10,585,994 (+)NCBI
ROS_Cfam_1.068,809,869 - 8,815,742 (+)NCBI
ROS_Cfam_1.0 Ensembl68,809,457 - 8,816,935 (+)Ensembl
UMICH_Zoey_3.168,661,436 - 8,668,230 (+)NCBI
UNSW_CanFamBas_1.068,640,504 - 8,646,368 (+)NCBI
UU_Cfam_GSD_1.068,822,240 - 8,828,117 (+)NCBI
ACHE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,889,994 - 100,896,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7100,889,994 - 100,896,974 (-)EnsemblGRCh38hg38GRCh38
GRCh377100,487,615 - 100,494,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,325,551 - 100,331,477 (-)NCBINCBI36hg18NCBI36
Build 347100,132,268 - 100,138,147NCBI
Celera795,218,191 - 95,224,120 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,117,968 - 95,123,900 (-)NCBIHuRef
CHM1_17100,418,205 - 100,424,133 (-)NCBICHM1_1
T2T-CHM13v2.07102,130,076 - 102,137,081 (-)NCBI
CRA_TCAGchr7v2799,847,220 - 99,853,146 (-)NCBI
Ache
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,286,516 - 137,292,728 (+)NCBIGRCm39mm39
GRCm39 Ensembl5137,285,781 - 137,292,728 (+)Ensembl
GRCm385137,288,247 - 137,294,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,287,519 - 137,294,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv375137,729,505 - 137,735,691 (+)NCBIGRCm37mm9NCBIm37
MGSCv365137,518,065 - 137,524,251 (+)NCBImm8
Celera5134,271,243 - 134,277,456 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.32NCBI
Ache
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21219,407,359 - 19,413,713 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1219,407,360 - 19,413,651 (-)Ensembl
Rnor_6.01222,472,358 - 22,477,052 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,472,358 - 22,478,753 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,487,632 - 24,491,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1221,207,976 - 21,212,604 (-)NCBICelera
Cytogenetic Map12q12NCBI
Ache
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495557380,298 - 85,799 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495557379,606 - 85,799 (+)NCBIChiLan1.0ChiLan1.0
ACHE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17106,311,944 - 106,318,190 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,311,944 - 106,318,184 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0792,915,065 - 92,922,079 (-)NCBIMhudiblu_PPA_v0panPan3
Ache
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,174,520 - 133,179,854 (+)NCBI
SpeTri2.0NW_004936543856,678 - 862,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACHE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,732,441 - 8,738,605 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,732,451 - 8,738,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.238,159,377 - 8,165,197 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACHE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,328,304 - 12,335,302 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,331,039 - 12,335,076 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660703,993,802 - 4,000,839 (-)NCBIVero_WHO_p1.0
Ache
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,275,117 - 16,281,793 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474016,275,108 - 16,280,639 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 7 1
Low 5 4 14 6 6 6 5 8 9 6
Below cutoff 1 6 6 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005621023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014114202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038477972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038538181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038538183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038538191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038538201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_546946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000022306   ⟹   ENSCAFP00000020717
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl68,874,655 - 8,879,702 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000064180   ⟹   ENSCAFP00000044986
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl68,873,584 - 8,878,948 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077980   ⟹   ENSCAFP00000056870
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl68,874,655 - 8,878,948 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000080058   ⟹   ENSCAFP00000057744
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl68,874,655 - 8,878,948 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845001162   ⟹   ENSCAFP00845000883
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl68,809,457 - 8,816,935 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845001183   ⟹   ENSCAFP00845000904
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl68,809,902 - 8,814,764 (+)Ensembl
RefSeq Acc Id: XM_038477972   ⟹   XP_038333900
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.168,661,436 - 8,668,230 (+)NCBI
RefSeq Acc Id: XM_038538181   ⟹   XP_038394109
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha610,580,127 - 10,585,994 (+)NCBI
RefSeq Acc Id: XM_038538183   ⟹   XP_038394111
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha610,580,130 - 10,585,994 (+)NCBI
RefSeq Acc Id: XM_038538191   ⟹   XP_038394119
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha610,580,140 - 10,585,994 (+)NCBI
RefSeq Acc Id: XM_038538201   ⟹   XP_038394129
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha610,580,140 - 10,585,994 (+)NCBI
RefSeq Acc Id: XM_038539229   ⟹   XP_038395157
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.068,822,240 - 8,828,117 (+)NCBI
RefSeq Acc Id: XM_038539230   ⟹   XP_038395158
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.068,822,243 - 8,828,117 (+)NCBI
RefSeq Acc Id: XM_038539231   ⟹   XP_038395159
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.068,822,253 - 8,828,117 (+)NCBI
RefSeq Acc Id: XM_038539232   ⟹   XP_038395160
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.068,822,253 - 8,828,117 (+)NCBI
RefSeq Acc Id: XM_038603309   ⟹   XP_038459237
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.068,640,504 - 8,646,368 (+)NCBI
RefSeq Acc Id: XM_038603310   ⟹   XP_038459238
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.068,640,507 - 8,646,368 (+)NCBI
RefSeq Acc Id: XM_038603311   ⟹   XP_038459239
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.068,640,519 - 8,646,368 (+)NCBI
RefSeq Acc Id: XM_038603312   ⟹   XP_038459240
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.068,640,519 - 8,646,368 (+)NCBI
RefSeq Acc Id: XM_038668014   ⟹   XP_038523942
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.068,809,869 - 8,815,742 (+)NCBI
RefSeq Acc Id: XM_038668015   ⟹   XP_038523943
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.068,809,872 - 8,815,742 (+)NCBI
RefSeq Acc Id: XM_038668016   ⟹   XP_038523944
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.068,809,882 - 8,815,742 (+)NCBI
RefSeq Acc Id: XM_038668017   ⟹   XP_038523945
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.068,809,882 - 8,815,742 (+)NCBI
Reference Sequences
RefSeq Acc Id: ENSCAFP00000044986   ⟸   ENSCAFT00000064180
RefSeq Acc Id: ENSCAFP00000057744   ⟸   ENSCAFT00000080058
RefSeq Acc Id: ENSCAFP00000056870   ⟸   ENSCAFT00000077980
RefSeq Acc Id: ENSCAFP00000020717   ⟸   ENSCAFT00000022306
RefSeq Acc Id: XP_038333900   ⟸   XM_038477972
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038459237   ⟸   XM_038603309
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459238   ⟸   XM_038603310
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459239   ⟸   XM_038603311
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459240   ⟸   XM_038603312
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038523942   ⟸   XM_038668014
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038523943   ⟸   XM_038668015
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038523944   ⟸   XM_038668016
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038523945   ⟸   XM_038668017
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038394109   ⟸   XM_038538181
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038394111   ⟸   XM_038538183
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038394119   ⟸   XM_038538191
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038394129   ⟸   XM_038538201
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038395157   ⟸   XM_038539229
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038395158   ⟸   XM_038539230
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038395159   ⟸   XM_038539231
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038395160   ⟸   XM_038539232
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845000883   ⟸   ENSCAFT00845001162
RefSeq Acc Id: ENSCAFP00845000904   ⟸   ENSCAFT00845001183
Protein Domains
AChE_tetra   COesterase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014054 Ensembl
  ENSCAFG00030023030 UniProtKB/TrEMBL
  ENSCAFG00845000697 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030036932.1 UniProtKB/TrEMBL
  ENSCAFP00030036958.1 UniProtKB/TrEMBL
  ENSCAFP00030036975.1 UniProtKB/TrEMBL
  ENSCAFP00845000883.1 UniProtKB/TrEMBL
  ENSCAFP00845000904 ENTREZGENE
  ENSCAFP00845000904.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030042328.1 UniProtKB/TrEMBL
  ENSCAFT00030042358.1 UniProtKB/TrEMBL
  ENSCAFT00030042375.1 UniProtKB/TrEMBL
  ENSCAFT00845001162.1 UniProtKB/TrEMBL
  ENSCAFT00845001183 ENTREZGENE
  ENSCAFT00845001183.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AChE_tetra UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/TrEMBL
  Cholinesterase UniProtKB/TrEMBL
NCBI Gene ACHE ENTREZGENE
Pfam AChE_tetra UniProtKB/TrEMBL
  COesterase UniProtKB/TrEMBL
PRINTS CHOLNESTRASE UniProtKB/TrEMBL
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A8C0P7V1_CANLF UniProtKB/TrEMBL
  A0A8C0PE37_CANLF UniProtKB/TrEMBL
  A0A8C0RRJ6_CANLF UniProtKB/TrEMBL
  A0A8I3MGA9_CANLF UniProtKB/TrEMBL
  A0A8I3MIG7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:49076 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-12 ACHE  acetylcholinesterase    acetylcholinesterase (Cartwright blood group)  Symbol and/or name change 5135510 APPROVED