CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: allantoin
Accession: CHEBI:15676
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Definition: An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.
Synonyms: exact_synonym: N-(2,5-dioxoimidazolidin-4-yl)urea
related_synonym: 2,5-Dioxo-4-imidazolidinyl-urea; 4-ureido-2,5-imidazolidinedione; 5-Ureido-2,4-imidazolidindione; 5-ureidohydantoin; Formula=C4H6N4O3; Glyoxyldiureide; InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11); InChIKey=POJWUDADGALRAB-UHFFFAOYSA-N; N-(2,5-Dioxo-4-imidazolidinyl)urea; SMILES=NC(=O)NC1NC(=O)NC1=O
alt_id: CHEBI:13761; CHEBI:22354; CHEBI:2594
xref: CAS:97-59-6; Drug_Central:4268; HMDB:HMDB0000462; KEGG:C01551; KEGG:D00121; KNApSAcK:C00007468; LINCS:LSM-5190
xref_mesh: MESH:D000481
xref: MetaCyc:ALLANTOIN; PMID:11157020; PMID:14619112; PMID:17190852; Patent:US2158098; Reaxys:83514; Wikipedia:Allantoin
cyclic_relationship: is_tautomer_of CHEBI:74345
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Col2a1
collagen type II alpha 1 chain
multiple interactions
EXP
[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]
CTD
PMID:24709313
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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Il1b
interleukin 1 beta
increases secretion decreases secretion
ISO EXP
Allantoin results in increased secretion of IL1B protein Allantoin results in decreased secretion of IL1B protein
CTD
PMID:30654793 PMID:32382552
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
increases secretion decreases secretion
ISO EXP
Allantoin results in increased secretion of IL6 protein Allantoin results in decreased secretion of IL6 protein
CTD
PMID:30654793 PMID:32382552
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Lepr
leptin receptor
affects abundance
ISO
LEPR affects the abundance of Allantoin
CTD
PMID:20567778
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Nos2
nitric oxide synthase 2
decreases expression increases expression
EXP ISO
Allantoin results in decreased expression of NOS2 protein Allantoin results in increased expression of NOS2 protein
CTD
PMID:30654793 PMID:32382552
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
EXP
Allantoin results in decreased expression of PTGS2 protein
CTD
PMID:30654793
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Tgfb1
transforming growth factor, beta 1
increases expression
ISO
Allantoin results in increased expression of TGFB1 protein
CTD
PMID:32382552
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
decreases secretion increases secretion
EXP ISO
Allantoin results in decreased secretion of TNF protein Allantoin results in increased secretion of TNF protein
CTD
PMID:30654793 PMID:32382552
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Vegfa
vascular endothelial growth factor A
increases expression affects secretion
ISO EXP
Allantoin results in increased expression of VEGFA protein Allantoin affects the secretion of VEGFA protein
CTD
PMID:30654793 PMID:32382552
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Xdh
xanthine dehydrogenase
multiple interactions
EXP
[2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Allantoin
CTD
PMID:21920950
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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