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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:allantoin
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Accession:CHEBI:15676 term browser browse the term
Definition:An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.
Synonyms:exact_synonym: N-(2,5-dioxoimidazolidin-4-yl)urea
 related_synonym: 2,5-Dioxo-4-imidazolidinyl-urea;   4-ureido-2,5-imidazolidinedione;   5-Ureido-2,4-imidazolidindione;   5-ureidohydantoin;   Formula=C4H6N4O3;   Glyoxyldiureide;   InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11);   InChIKey=POJWUDADGALRAB-UHFFFAOYSA-N;   N-(2,5-Dioxo-4-imidazolidinyl)urea;   SMILES=NC(=O)NC1NC(=O)NC1=O
 alt_id: CHEBI:13761;   CHEBI:22354;   CHEBI:2594
 xref: CAS:97-59-6;   Drug_Central:4268;   HMDB:HMDB0000462;   KEGG:C01551;   KEGG:D00121;   KNApSAcK:C00007468;   LINCS:LSM-5190
 xref_mesh: MESH:D000481
 xref: MetaCyc:ALLANTOIN;   PMID:11157020;   PMID:14619112;   PMID:17190852;   Patent:US2158098;   Reaxys:83514;   Wikipedia:Allantoin
 cyclic_relationship: is_tautomer_of CHEBI:74345



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allantoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Il1b interleukin 1 beta increases secretion
decreases secretion
ISO
EXP
Allantoin results in increased secretion of IL1B protein
Allantoin results in decreased secretion of IL1B protein
CTD PMID:30654793 PMID:32382552 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases secretion
decreases secretion
ISO
EXP
Allantoin results in increased secretion of IL6 protein
Allantoin results in decreased secretion of IL6 protein
CTD PMID:30654793 PMID:32382552 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Allantoin CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
increases expression
EXP
ISO
Allantoin results in decreased expression of NOS2 protein
Allantoin results in increased expression of NOS2 protein
CTD PMID:30654793 PMID:32382552 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Allantoin results in decreased expression of PTGS2 protein CTD PMID:30654793 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Allantoin results in increased expression of TGFB1 protein CTD PMID:32382552 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor decreases secretion
increases secretion
EXP
ISO
Allantoin results in decreased secretion of TNF protein
Allantoin results in increased secretion of TNF protein
CTD PMID:30654793 PMID:32382552 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
affects secretion
ISO
EXP
Allantoin results in increased expression of VEGFA protein
Allantoin affects the secretion of VEGFA protein
CTD PMID:30654793 PMID:32382552 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Allantoin CTD PMID:21920950 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      application 19653
        pharmaceutical 19492
          drug 19492
            vulnerary 1005
              allantoin 10
                (R)-(-)-allantoin 0
                (S)-(+)-allantoin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19730
                        carbon atom 19727
                          organic molecular entity 19727
                            organic group 18947
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18879
                                    carbonyl compound 18879
                                      carboxylic acid 18605
                                        carboacyl group 17694
                                          univalent carboacyl group 17694
                                            carbamoyl group 17544
                                              carboxamide 17544
                                                monocarboxylic acid amide 15679
                                                  urea 5574
                                                    ureas 5572
                                                      allantoin 10
                                                        (R)-(-)-allantoin 0
                                                        (S)-(+)-allantoin + 0
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