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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:allantoin
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Accession:CHEBI:15676 term browser browse the term
Definition:An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.
Synonyms:exact_synonym: N-(2,5-dioxoimidazolidin-4-yl)urea
 related_synonym: 2,5-Dioxo-4-imidazolidinyl-urea;   4-ureido-2,5-imidazolidinedione;   5-Ureido-2,4-imidazolidindione;   5-ureidohydantoin;   Formula=C4H6N4O3;   Glyoxyldiureide;   InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11);   InChIKey=POJWUDADGALRAB-UHFFFAOYSA-N;   N-(2,5-Dioxo-4-imidazolidinyl)urea;   SMILES=NC(=O)NC1NC(=O)NC1=O
 alt_id: CHEBI:13761;   CHEBI:22354;   CHEBI:2594
 xref: CAS:97-59-6;   Drug_Central:4268;   HMDB:HMDB0000462;   KEGG:C01551;   KEGG:D00121;   KNApSAcK:C00007468;   LINCS:LSM-5190
 xref_mesh: MESH:D000481
 xref: MetaCyc:ALLANTOIN;   PMID:11157020;   PMID:14619112;   PMID:17190852;   Patent:US2158098;   Reaxys:83514;   Wikipedia:Allantoin
 cyclic_relationship: is_tautomer_of CHEBI:74345



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allantoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Il1b interleukin 1 beta increases secretion
decreases secretion
ISO
EXP
Allantoin results in increased secretion of IL1B protein
Allantoin results in decreased secretion of IL1B protein
CTD PMID:30654793 PMID:32382552 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases secretion
decreases secretion
ISO
EXP
Allantoin results in increased secretion of IL6 protein
Allantoin results in decreased secretion of IL6 protein
CTD PMID:30654793 PMID:32382552 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Allantoin CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
increases expression
EXP
ISO
Allantoin results in decreased expression of NOS2 protein
Allantoin results in increased expression of NOS2 protein
CTD PMID:30654793 PMID:32382552 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Allantoin results in decreased expression of PTGS2 protein CTD PMID:30654793 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Allantoin results in increased expression of TGFB1 protein CTD PMID:32382552 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor decreases secretion
increases secretion
EXP
ISO
Allantoin results in decreased secretion of TNF protein
Allantoin results in increased secretion of TNF protein
CTD PMID:30654793 PMID:32382552 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
affects secretion
ISO
EXP
Allantoin results in increased expression of VEGFA protein
Allantoin affects the secretion of VEGFA protein
CTD PMID:30654793 PMID:32382552 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Allantoin CTD PMID:21920950 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        pharmaceutical 19351
          drug 19351
            vulnerary 942
              allantoin 10
                (R)-(-)-allantoin 0
                (S)-(+)-allantoin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        carboacyl group 17466
                                          univalent carboacyl group 17466
                                            carbamoyl group 17282
                                              carboxamide 17282
                                                monocarboxylic acid amide 15009
                                                  urea 5115
                                                    ureas 5112
                                                      allantoin 10
                                                        (R)-(-)-allantoin 0
                                                        (S)-(+)-allantoin + 0
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