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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-methioninate
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Accession:CHEBI:32631 term browser browse the term
Definition:The L-enantiomer of methioninate.
Synonyms:related_synonym: (2S)-2-amino-4-(methylsulfanyl)butanoate;   Formula=C5H10NO2S;   InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/p-1/t4-/m0/s1;   InChIKey=FFEARJCKVFRZRR-BYPYZUCNSA-M;   L-methionine anion;   SMILES=CSCC[C@H](N)C([O-])=O
 xref: Beilstein:4740675;   Gmelin:326566;   Reaxys:4740675
 cyclic_relationship: is_conjugate_base_of CHEBI:16643;   is_enantiomer_of CHEBI:32637


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S-adenosyl-L-methioninate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgre4 adhesion G protein-coupled receptor E4 decreases expression ISO S-Adenosylmethionine results in decreased expression of ADGRE4 mRNA CTD PMID:18098314 NCBI chr 9:9,758,106...9,901,908
Ensembl chr 9:9,760,355...9,900,760 		JBrowse link
G Adgre5 adhesion G protein-coupled receptor E5 decreases expression ISO S-Adenosylmethionine results in decreased expression of ADGRE5 mRNA CTD PMID:18098314 NCBI chr19:24,397,972...24,418,648
Ensembl chr19:24,398,689...24,418,638 		JBrowse link
G Afp alpha-fetoprotein multiple interactions
decreases expression		 ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]
S-Adenosylmethionine results in decreased expression of AFP mRNA		 CTD PMID:18098314 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ahr aryl hydrocarbon receptor decreases abundance
multiple interactions		 ISO AHR protein results in decreased abundance of S-Adenosylmethionine
PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine]		 CTD PMID:29416063 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Alad aminolevulinate dehydratase increases activity ISO S-Adenosylmethionine results in increased activity of ALAD protein CTD PMID:9559101 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G App amyloid beta precursor protein increases secretion ISO S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G As3mt arsenite methyltransferase multiple interactions
affects binding		 ISO Cysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine] CTD PMID:22955273 PMID:24124590 PMID:25349987 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO S-Adenosylmethionine results in increased expression of ATF3 mRNA CTD PMID:18098314 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B protein mutant form promotes the reaction [Betaine results in increased abundance of S-Adenosylmethionine] CTD PMID:22945834 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] CTD PMID:18230605 NCBI chr 2:24,895,525...24,912,475
Ensembl chr 2:24,895,533...24,912,475 		JBrowse link
G Casp12 caspase 12 decreases expression ISO S-Adenosylmethionine results in decreased expression of CASP12 mRNA CTD PMID:18098314 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity		 ISO
EXP		 S-Adenosylmethionine inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
S-Adenosylmethionine results in decreased activity of CASP3 protein		 CTD PMID:17869084 PMID:18571630 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein] CTD PMID:22683606 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions		 ISO S-Adenosylmethionine results in decreased expression of COL1A1 mRNA
S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]		 CTD PMID:15983038 PMID:16996477 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions
decreases expression		 ISO
EXP		 S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]; S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]
S-Adenosylmethionine results in decreased expression of COL1A2 mRNA		 CTD PMID:8878782 PMID:15983038 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine] CTD PMID:16758261 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen affects the localization of CYCS protein] CTD PMID:22683606 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions		 ISO
EXP		 S-Adenosylmethionine results in decreased activity of CYP2E1 protein
S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]
S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]		 CTD PMID:15763544 PMID:15983038 PMID:22683606 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO [Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine CTD PMID:11445284 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] CTD PMID:27624276 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein] CTD PMID:22558281 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein]
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]		 CTD PMID:18098314 PMID:22558281 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [S-Adenosylmethionine co-treated with Arsenic] affects the expression of EGR1 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter]] which results in decreased expression of EGR1 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of EGR1 promoter] CTD PMID:35490796 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased methylation of ESR1 promoter]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of ESR1 protein] CTD PMID:22558281 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fcgr1a Fc gamma receptor 1A decreases expression ISO S-Adenosylmethionine results in decreased expression of FCGR1 mRNA CTD PMID:18098314 NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases abundance ISO FGF19 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Fgl2 fibrinogen-like 2 decreases expression ISO S-Adenosylmethionine results in decreased expression of FGL2 mRNA CTD PMID:18098314 NCBI chr 4:13,710,566...13,716,207
Ensembl chr 4:13,710,575...13,716,207 		JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression ISO S-Adenosylmethionine results in decreased expression of GBP2 mRNA CTD PMID:18098314 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]] CTD PMID:20146260 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of GREB1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of GREB1 mRNA] CTD PMID:22558281 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of GSR protein] CTD PMID:22683606 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gss glutathione synthetase multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]] CTD PMID:20146260 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA] CTD PMID:18098314 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 multiple interactions ISO [Progesterone co-treated with S-Adenosylmethionine] results in increased methylation of HAND2 promoter; S-Adenosylmethionine inhibits the reaction [Progesterone results in increased expression of HAND2 mRNA] CTD PMID:30892605 NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
G Hbb hemoglobin subunit beta multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hdac9 histone deacetylase 9 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA] CTD PMID:18098314 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylmethionine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO S-Adenosylmethionine results in decreased expression of IFI44L mRNA CTD PMID:18098314 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359 		JBrowse link
G Ifng interferon gamma multiple interactions ISO S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IFNG mRNA] CTD PMID:17080400 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL1B protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]		 CTD PMID:17080400 PMID:19822164 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL2 mRNA] CTD PMID:17080400 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma decreases expression ISO S-Adenosylmethionine results in decreased expression of IL2RG mRNA CTD PMID:18098314 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il36g interleukin 36, gamma decreases expression ISO S-Adenosylmethionine results in decreased expression of IL36G mRNA CTD PMID:18098314 NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]		 CTD PMID:17080400 PMID:19822164 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Klf6 KLF transcription factor 6 decreases expression
multiple interactions		 ISO S-Adenosylmethionine results in decreased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]		 CTD PMID:18098314 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Lep leptin multiple interactions ISO S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA]; S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Ltb lymphotoxin beta multiple interactions ISO S-Adenosylmethionine inhibits the reaction [fumonisin B1 results in increased expression of LTB mRNA] CTD PMID:17080400 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Maf MAF bZIP transcription factor multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]] CTD PMID:20146260 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365 		JBrowse link
G Mafg MAF bZIP transcription factor G multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]] CTD PMID:20146260 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]		 CTD PMID:15983038 PMID:16996477 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]
[1,2-linoleoylphosphatidylcholine co-treated with S-Adenosylmethionine] inhibits the reaction [Vitamin K 3 results in increased phosphorylation of MAPK3 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]		 CTD PMID:15983038 PMID:16996477 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mat1a methionine adenosyltransferase 1A affects abundance
increases chemical synthesis		 ISO MAT1A affects the abundance of S-Adenosylmethionine
MAT1A protein results in increased chemical synthesis of S-Adenosylmethionine		 CTD PMID:8373829 PMID:12060674 NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274 		JBrowse link
G Mat2a methionine adenosyltransferase 2A increases chemical synthesis ISO MAT2A protein results in increased chemical synthesis of S-Adenosylmethionine CTD PMID:8373829 NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of MBD2 protein] CTD PMID:22558281 NCBI chr18:64,174,002...64,240,795
Ensembl chr18:64,174,002...64,240,794 		JBrowse link
G Meg3 maternally expressed 3 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Arsenicals results in increased expression of MEG3 mRNA] CTD PMID:33033900 NCBI chr 6:128,491,808...128,524,010 JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 increases abundance ISO MTHFD1 protein results in increased abundance of S-Adenosylmethionine CTD PMID:19033438 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects binding
multiple interactions		 ISO S-Adenosylmethionine binds to MTR protein
[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; [Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]		 CTD PMID:17477549 PMID:26989453 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 decreases expression ISO S-Adenosylmethionine results in decreased expression of NDRG1 mRNA CTD PMID:18098314 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [S-Adenosylmethionine co-treated with Arsenic] results in increased expression of NFE2L2 mRNA; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]] CTD PMID:20146260 PMID:35490796 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP S-Adenosylmethionine inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased phosphorylation of NFKBIA protein] CTD PMID:18404532 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlgn3 neuroligin 3 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] CTD PMID:27624276 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases abundance ISO NR0B2 protein results in increased abundance of S-Adenosylmethionine CTD PMID:29416063 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nrxn1 neurexin 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; S-Adenosylmethionine inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] CTD PMID:27624276 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of PARP1 mRNA] CTD PMID:35490796 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions ISO [[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP; S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA] CTD PMID:21266552 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in decreased abundance of S-Adenosylmethionine] CTD PMID:29416063 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013 		JBrowse link
G Pfn2 profilin 2 decreases expression ISO S-Adenosylmethionine results in decreased expression of PFN2 mRNA CTD PMID:18098314 NCBI chr 2:142,067,102...142,072,938
Ensembl chr 2:142,067,104...142,072,938 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 increases expression ISO S-Adenosylmethionine results in increased expression of PSMB8 mRNA CTD PMID:18098314 NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO S-Adenosylmethionine results in decreased expression of PTGS1 mRNA CTD PMID:18098314 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [S-Adenosylmethionine co-treated with Arsenic] affects the expression of PTGS2 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter]] which results in decreased expression of PTGS2 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter] CTD PMID:35490796 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] CTD PMID:21266552 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rnasel ribonuclease L decreases expression ISO S-Adenosylmethionine results in decreased expression of RNASEL mRNA CTD PMID:18098314 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 decreases expression ISO S-Adenosylmethionine results in decreased expression of H2-EB1 mRNA CTD PMID:18098314 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 affects abundance ISO SLC19A1 protein affects the abundance of S-Adenosylmethionine CTD PMID:15705887 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Smyd2 SET and MYND domain containing 2 affects binding ISO S-Adenosylmethionine binds to SMYD2 protein CTD PMID:21782458 NCBI chr13:101,425,270...101,466,576
Ensembl chr13:101,425,273...101,466,576 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO [S-Adenosylmethionine co-treated with Arsenic] affects the expression of SOCS3 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter]] which results in decreased expression of SOCS3 mRNA; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of SOCS3 promoter] CTD PMID:35490796 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD1 protein] CTD PMID:22683606 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased activity of SOD2 protein] CTD PMID:22683606 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter]		 CTD PMID:15983038 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Syn1 synapsin I multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] CTD PMID:27624276 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Tf transferrin multiple interactions
increases expression		 EXP [S-Adenosylmethionine results in increased expression of TF protein] which affects the abundance of Iron CTD PMID:18571630 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [[arsenic trioxide results in increased expression of ESR1 protein] which results in increased expression of TFF1 mRNA]; S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in increased expression of TFF1 mRNA] CTD PMID:22558281 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tfrc transferrin receptor decreases expression EXP S-Adenosylmethionine results in decreased expression of TFRC mRNA CTD PMID:18571630 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]]
S-Adenosylmethionine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein binds to COL1A2 promoter]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; S-Adenosylmethionine inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:15983038 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
S-Adenosylmethionine inhibits the reaction [Thioacetamide results in increased expression of TNF protein]		 CTD PMID:19822164 PMID:21266552 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpmt thiopurine S-methyltransferase multiple interactions ISO [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-methylbenzenethiol; [S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol; S-Adenosylmethionine analog inhibits the reaction [[S-Adenosylmethionine co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol]; S-Adenosylmethionine inhibits the reaction [[S-Adenosylmethionine analog co-treated with TPMT protein] results in increased methylation of 4-nitrobenzenthiol] CTD PMID:20196537 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709 		JBrowse link
G Ubd ubiquitin D multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA] CTD PMID:18098314 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639 		JBrowse link
G Vim vimentin multiple interactions ISO S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM mRNA]; S-Adenosylmethionine inhibits the reaction [monobutyl phthalate results in increased expression of VIM protein] CTD PMID:26745512 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased expression of XRCC1 mRNA] CTD PMID:35490796 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19896
      biological role 19894
        biochemical role 19584
          metabolite 19568
            eukaryotic metabolite 19378
              plant metabolite 17924
                L-methioninate 90
                  S-adenosyl-L-methioninate 90
                  S-methyl-L-methioninate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    p-block element atom 19867
                      p-block molecular entity 19867
                        chalcogen molecular entity 19616
                          oxygen molecular entity 19589
                            oxide 12759
                              oxoanion 10303
                                carboxylic acid anion 2468
                                  amino-acid anion 831
                                    alpha-amino-acid anion 823
                                      methioninate 90
                                        L-methioninate 90
                                          S-adenosyl-L-methioninate 90
                                          S-methyl-L-methioninate 0
paths to the root