CYP2B6 (cytochrome P450 2B11) - Rat Genome Database

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Gene: CYP2B6 (cytochrome P450 2B11) Canis lupus familiaris
Analyze
Symbol: CYP2B6
Name: cytochrome P450 2B11
RGD ID: 12239792
Description: ENCODES a protein that exhibits anandamide 11,12 epoxidase activity (ortholog); anandamide 14,15 epoxidase activity (ortholog); anandamide 8,9 epoxidase activity (ortholog); INVOLVED IN cellular ketone metabolic process (ortholog); response to bacterium (ortholog); response to organic cyclic compound (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); acute myeloid leukemia (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); INTERACTS WITH clofibrate; cyclophosphamide; dextromethorphan
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYP2B11; CYPIIB11; cytochrome P450 PBD-2; cytochrome P450, family 2, subfamily B, polypeptide 11; Cytochrome-P450-2B11
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,817,561 - 112,833,294 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,816,502 - 112,833,293 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,220,751 - 112,236,323 (+)NCBI
ROS_Cfam_1.01113,415,892 - 113,431,675 (+)NCBI
ROS_Cfam_1.0 Ensembl1113,415,766 - 113,431,674 (+)Ensembl
UMICH_Zoey_3.11112,976,144 - 112,991,691 (+)NCBI
UNSW_CanFamBas_1.01112,607,509 - 112,623,091 (+)NCBI
UU_Cfam_GSD_1.01113,602,017 - 113,617,585 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (ISO)
carbamazepine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
clopidogrel pharmacodynamics pathway  (ISO)
clopidogrel pharmacokinetics pathway  (ISO)
cyclophosphamide pharmacodynamics pathway  (ISO)
cyclophosphamide pharmacokinetics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ifosfamide pharmacodynamics pathway  (ISO)
ifosfamide pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway  (ISO)
neviparine pharmacokinetics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nicotine pharmacokinetics pathway  (ISO)
organophosphate response pathway  (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
retinol metabolic pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sorafenib pharmacokinetics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tamoxifen pharmacodynamics pathway  (ISO)
tamoxifen pharmacokinetics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
tramadol pharmacokinetics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)
valproic acid pharmacokinetics pathway  (ISO)
vitamin A deficiency pathway  (ISO)

References
Additional References at PubMed
PMID:2116765   PMID:19944064   PMID:27015760  


Genomics

Comparative Map Data
CYP2B6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,817,561 - 112,833,294 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,816,502 - 112,833,293 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,220,751 - 112,236,323 (+)NCBI
ROS_Cfam_1.01113,415,892 - 113,431,675 (+)NCBI
ROS_Cfam_1.0 Ensembl1113,415,766 - 113,431,674 (+)Ensembl
UMICH_Zoey_3.11112,976,144 - 112,991,691 (+)NCBI
UNSW_CanFamBas_1.01112,607,509 - 112,623,091 (+)NCBI
UU_Cfam_GSD_1.01113,602,017 - 113,617,585 (+)NCBI
CYP2B6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,991,282 - 41,018,398 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1940,991,282 - 41,018,398 (+)EnsemblGRCh38hg38GRCh38
GRCh371941,497,187 - 41,524,303 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,189,044 - 46,216,141 (+)NCBINCBI36hg18NCBI36
Build 341946,189,043 - 46,216,141NCBI
Celera1938,297,361 - 38,324,463 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1937,929,211 - 37,956,335 (+)NCBIHuRef
CHM1_11941,496,934 - 41,524,020 (+)NCBICHM1_1
T2T-CHM13v2.01943,812,191 - 43,839,297 (+)NCBI
Cyp2b10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39725,597,083 - 25,626,049 (+)NCBIGRCm39mm39
GRCm39 Ensembl725,597,045 - 25,626,049 (+)Ensembl
GRCm38725,897,658 - 25,926,624 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl725,897,620 - 25,926,624 (+)EnsemblGRCm38mm10GRCm38
MGSCv37726,682,683 - 26,711,643 (+)NCBIGRCm37mm9NCBIm37
MGSCv36725,606,424 - 25,635,384 (+)NCBImm8
Celera720,506,748 - 20,536,205 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map714.11NCBI
Cyp2b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2181,652,762 - 81,732,153 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl181,652,787 - 81,732,143 (+)Ensembl
Rnor_6.0183,163,103 - 83,236,615 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,163,079 - 83,236,615 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,445,481 - 84,491,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,084,984 - 81,185,251 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1181,486,546 - 81,659,871 (+)NCBI
Celera176,082,604 - 76,158,885 (+)NCBICelera
Cytogenetic Map1q21NCBI
CYP2B6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11946,509,370 - 46,534,672 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,509,370 - 46,534,672 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01938,003,083 - 38,028,980 (+)NCBIMhudiblu_PPA_v0panPan3
CYP2B6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,110,812 - 49,178,334 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1649,158,175 - 49,173,872 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,968,257 - 44,978,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2B6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,392,699 - 35,418,171 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl635,393,342 - 35,418,106 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607313,588,241 - 13,611,993 (+)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 1
Medium 6 6 6 4 2
Low 1 5 3 4 4
Below cutoff 4 5 11 6 6 3 9 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000036927   ⟹   ENSCAFP00000032358
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1112,816,502 - 112,833,293 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000075730   ⟹   ENSCAFP00000059074
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1112,817,561 - 112,833,293 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004869   ⟹   ENSCAFP00845003894
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1113,415,766 - 113,431,674 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004887   ⟹   ENSCAFP00845003905
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1113,415,892 - 113,431,674 (+)Ensembl
RefSeq Acc Id: NM_001006652   ⟹   NP_001006653
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11112,817,561 - 112,833,294 (+)NCBI
Dog10K_Boxer_Tasha1112,220,751 - 112,236,323 (+)NCBI
ROS_Cfam_1.01113,415,892 - 113,431,675 (+)NCBI
UMICH_Zoey_3.11112,976,144 - 112,991,691 (+)NCBI
UNSW_CanFamBas_1.01112,607,509 - 112,623,091 (+)NCBI
UU_Cfam_GSD_1.01113,602,017 - 113,617,585 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001006653 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA30881 (Get FASTA)   NCBI Sequence Viewer  
  CDO19451 (Get FASTA)   NCBI Sequence Viewer  
  CDO19452 (Get FASTA)   NCBI Sequence Viewer  
  CDO96708 (Get FASTA)   NCBI Sequence Viewer  
  P24460 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001006653   ⟸   NM_001006652
- Peptide Label: precursor
- UniProtKB: P24460 (UniProtKB/Swiss-Prot),   X5L555 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000059074   ⟸   ENSCAFT00000075730
RefSeq Acc Id: ENSCAFP00000032358   ⟸   ENSCAFT00000036927
RefSeq Acc Id: ENSCAFP00845003905   ⟸   ENSCAFT00845004887
RefSeq Acc Id: ENSCAFP00845003894   ⟸   ENSCAFT00845004869

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 112821687 112821688 C T snv Golden Retriever (GR0859), Golden Retriever (GR0892), Golden Retriever (GR1078), Labrador Retriever (LA2382), Labrador Retriever (LA882), Labrador Retriever (LA900)
1 112822066 112822067 G C snv Chinese indigenous dogs (YJ4), Tibetan Mastiff (TM4)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005052 Ensembl
  ENSCAFG00030002229 UniProtKB/TrEMBL
  ENSCAFG00040009392 UniProtKB/TrEMBL
  ENSCAFG00845002728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030003636.1 UniProtKB/TrEMBL
  ENSCAFP00030003667.1 UniProtKB/TrEMBL
  ENSCAFP00040015172 UniProtKB/TrEMBL
  ENSCAFP00040015257 UniProtKB/TrEMBL
  ENSCAFP00845003894 ENTREZGENE
  ENSCAFP00845003894.1 UniProtKB/TrEMBL
  ENSCAFP00845003905.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030004101.1 UniProtKB/TrEMBL
  ENSCAFT00030004135.1 UniProtKB/TrEMBL
  ENSCAFT00040017490 UniProtKB/TrEMBL
  ENSCAFT00040017584 UniProtKB/TrEMBL
  ENSCAFT00845004869 ENTREZGENE
  ENSCAFT00845004869.1 UniProtKB/TrEMBL
  ENSCAFT00845004887.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2B-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:474177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene CYP2B6 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0M3L7_CANLF UniProtKB/TrEMBL
  A0A8C0S366_CANLF UniProtKB/TrEMBL
  A0A8I3MQJ9_CANLF UniProtKB/TrEMBL
  A0A8I3N358_CANLF UniProtKB/TrEMBL
  CP2BB_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
  X5L555 ENTREZGENE, UniProtKB/TrEMBL