AHCY (adenosylhomocysteinase) - Rat Genome Database

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Gene: AHCY (adenosylhomocysteinase) Canis lupus familiaris
Analyze
Symbol: AHCY
Name: adenosylhomocysteinase
RGD ID: 12053380
Description: ENCODES a protein that exhibits adenosylhomocysteinase activity (ortholog); adenyl nucleotide binding (ortholog); copper ion binding (ortholog); INVOLVED IN chronic inflammatory response to antigenic stimulus (ortholog); circadian sleep/wake cycle (ortholog); response to hypoxia (ortholog); PARTICIPATES IN choline metabolic pathway; glycine N-methyltransferase deficiency pathway; homocysteine metabolic pathway; ASSOCIATED WITH amino acid metabolic disorder (ortholog); Animal Disease Models (ortholog); Experimental Arthritis (ortholog); FOUND IN cytosol (ortholog); neuron projection (ortholog); nucleus (ortholog); INTERACTS WITH clofibrate; phenobarbital
Type: protein-coding
RefSeq Status: MODEL
Also known as: S-adenosylhomocysteine hydrolase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,410,553 - 23,423,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,411,140 - 23,419,767 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,058,324 - 23,071,803 (-)NCBI
ROS_Cfam_1.02424,101,284 - 24,114,771 (-)NCBI
UMICH_Zoey_3.12423,389,987 - 23,403,460 (-)NCBI
UNSW_CanFamBas_1.02423,484,066 - 23,497,508 (-)NCBI
UU_Cfam_GSD_1.02423,923,430 - 23,937,131 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)
neuron projection  (ISO)
nucleus  (ISO)

Molecular Function

References

Genomics

Comparative Map Data
AHCY
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,410,553 - 23,423,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,411,140 - 23,419,767 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,058,324 - 23,071,803 (-)NCBI
ROS_Cfam_1.02424,101,284 - 24,114,771 (-)NCBI
UMICH_Zoey_3.12423,389,987 - 23,403,460 (-)NCBI
UNSW_CanFamBas_1.02423,484,066 - 23,497,508 (-)NCBI
UU_Cfam_GSD_1.02423,923,430 - 23,937,131 (-)NCBI
AHCY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2034,280,268 - 34,311,802 (-)EnsemblGRCh38hg38GRCh38
GRCh382034,235,012 - 34,311,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372032,868,074 - 32,899,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,331,737 - 32,354,784 (-)NCBINCBI36hg18NCBI36
Build 342032,331,736 - 32,354,784NCBI
Celera2029,617,551 - 29,649,079 (-)NCBI
Cytogenetic Map20q11.22ENTREZGENE
HuRef2029,649,874 - 29,681,357 (-)NCBIHuRef
CHM1_12032,769,165 - 32,800,706 (-)NCBICHM1_1
Ahcy
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,901,230 - 154,916,417 (-)NCBIGRCm39mm39
GRCm39 Ensembl2154,901,230 - 154,916,417 (-)Ensembl
GRCm382155,059,310 - 155,074,497 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,059,310 - 155,074,497 (-)EnsemblGRCm38mm10GRCm38
MGSCv372154,885,046 - 154,900,233 (-)NCBIGRCm37mm9NCBIm37
MGSCv362154,750,751 - 154,765,867 (-)NCBImm8
Celera2160,986,232 - 161,001,420 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.94NCBI
Ahcy
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23143,569,134 - 143,584,359 (-)NCBI
Rnor_6.0 Ensembl3150,587,833 - 150,603,082 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03150,587,833 - 150,603,057 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03156,957,240 - 156,972,464 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,544,834 - 145,560,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13145,450,455 - 145,465,680 (-)NCBI
Celera3142,299,485 - 142,314,709 (-)NCBICelera
Cytogenetic Map3q41NCBI
Ahcy
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,992,295 - 27,013,100 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,992,295 - 27,013,100 (+)NCBIChiLan1.0ChiLan1.0
AHCY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12031,738,007 - 31,760,803 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,738,007 - 31,760,803 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02030,603,701 - 30,626,835 (-)NCBIMhudiblu_PPA_v0panPan3
Ahcy
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,415,357 - 172,434,758 (-)NCBI
SpeTri2.0NW_0049365616,314,797 - 6,333,961 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHCY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,726,077 - 37,744,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11737,726,084 - 37,744,378 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,693,955 - 42,706,644 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap17q21NCBI
AHCY
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1238,579,254 - 38,601,218 (-)NCBI
ChlSab1.1 Ensembl238,579,024 - 38,601,208 (-)Ensembl
Vero_WHO_p1.0NW_02366605088,256,407 - 88,278,319 (+)NCBI
Ahcy
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248425,053,336 - 5,071,902 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038433551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038433552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038433553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038433554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038457980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038508737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038572043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038572044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038572045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038572046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038636299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_534388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000012019   ⟹   ENSCAFP00000011145
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2423,411,140 - 23,419,767 (-)Ensembl
RefSeq Acc Id: XM_038433551   ⟹   XP_038289479
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02424,101,284 - 24,114,771 (-)NCBI
RefSeq Acc Id: XM_038433552   ⟹   XP_038289480
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02424,101,284 - 24,114,286 (-)NCBI
RefSeq Acc Id: XM_038433553   ⟹   XP_038289481
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02424,101,284 - 24,114,436 (-)NCBI
RefSeq Acc Id: XM_038433554   ⟹   XP_038289482
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02424,101,284 - 24,114,314 (-)NCBI
RefSeq Acc Id: XM_038457977   ⟹   XP_038313905
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2423,058,324 - 23,071,803 (-)NCBI
RefSeq Acc Id: XM_038457978   ⟹   XP_038313906
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2423,058,324 - 23,071,318 (-)NCBI
RefSeq Acc Id: XM_038457979   ⟹   XP_038313907
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2423,058,324 - 23,071,468 (-)NCBI
RefSeq Acc Id: XM_038457980   ⟹   XP_038313908
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2423,058,324 - 23,071,346 (-)NCBI
RefSeq Acc Id: XM_038508733   ⟹   XP_038364661
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12423,389,987 - 23,403,460 (-)NCBI
RefSeq Acc Id: XM_038508735   ⟹   XP_038364663
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12423,389,987 - 23,402,975 (-)NCBI
RefSeq Acc Id: XM_038508736   ⟹   XP_038364664
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12423,389,987 - 23,403,125 (-)NCBI
RefSeq Acc Id: XM_038508737   ⟹   XP_038364665
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12423,389,987 - 23,403,003 (-)NCBI
RefSeq Acc Id: XM_038572043   ⟹   XP_038427971
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02423,923,430 - 23,937,131 (-)NCBI
RefSeq Acc Id: XM_038572044   ⟹   XP_038427972
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02423,923,430 - 23,936,646 (-)NCBI
RefSeq Acc Id: XM_038572045   ⟹   XP_038427973
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02423,923,430 - 23,936,796 (-)NCBI
RefSeq Acc Id: XM_038572046   ⟹   XP_038427974
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02423,923,430 - 23,936,674 (-)NCBI
RefSeq Acc Id: XM_038636295   ⟹   XP_038492223
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02423,484,066 - 23,497,508 (-)NCBI
RefSeq Acc Id: XM_038636297   ⟹   XP_038492225
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02423,484,066 - 23,497,023 (-)NCBI
RefSeq Acc Id: XM_038636298   ⟹   XP_038492226
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02423,484,066 - 23,497,173 (-)NCBI
RefSeq Acc Id: XM_038636299   ⟹   XP_038492227
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02423,484,066 - 23,497,051 (-)NCBI
RefSeq Acc Id: XM_534388   ⟹   XP_534388
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12423,410,553 - 23,423,494 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_534388   ⟸   XM_534388
- Sequence:
RefSeq Acc Id: ENSCAFP00000011145   ⟸   ENSCAFT00000012019
RefSeq Acc Id: XP_038364661   ⟸   XM_038508733
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038364664   ⟸   XM_038508736
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038364665   ⟸   XM_038508737
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038364663   ⟸   XM_038508735
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038492223   ⟸   XM_038636295
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038492226   ⟸   XM_038636298
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038492227   ⟸   XM_038636299
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038492225   ⟸   XM_038636297
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038289479   ⟸   XM_038433551
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038289481   ⟸   XM_038433553
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038289482   ⟸   XM_038433554
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038289480   ⟸   XM_038433552
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038313905   ⟸   XM_038457977
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038313907   ⟸   XM_038457979
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038313908   ⟸   XM_038457980
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038313906   ⟸   XM_038457978
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038427971   ⟸   XM_038572043
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038427973   ⟸   XM_038572045
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038427974   ⟸   XM_038572046
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038427972   ⟸   XM_038572044
- Peptide Label: isoform X2
Protein Domains
AdoHcyase_NAD

Promoters
RGD ID:13687578
Promoter ID:EPDNEW_C5646
Type:single initiation site
Name:AHCY_1
Description:adenosylhomocysteinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12423,423,458 - 23,423,518EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007504 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000011145 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012019 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1480 UniProtKB/TrEMBL
InterPro Adenosylhomocyst_ase-like_sf UniProtKB/TrEMBL
  Adenosylhomocysteinase-like UniProtKB/TrEMBL
  Ado_hCys_hydrolase_NAD-bd UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  S-Ado-L-homoCys_hydrolase_CS UniProtKB/TrEMBL
NCBI Gene AHCY ENTREZGENE
PANTHER PTHR23420 UniProtKB/TrEMBL
Pfam AdoHcyase UniProtKB/TrEMBL
  AdoHcyase_NAD UniProtKB/TrEMBL
PIRSF Ad_hcy_hydrolase UniProtKB/TrEMBL
PROSITE ADOHCYASE_2 UniProtKB/TrEMBL
SMART AdoHcyase UniProtKB/TrEMBL
  AdoHcyase_NAD UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
TIGRFAMs ahcY UniProtKB/TrEMBL
UniProt E2QXS7_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37724 ENTREZGENE