ACTA2 (actin alpha 2, smooth muscle) - Rat Genome Database

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Gene: ACTA2 (actin alpha 2, smooth muscle) Canis lupus familiaris
Analyze
Symbol: ACTA2
Name: actin alpha 2, smooth muscle
RGD ID: 12268039
Description: ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN mesenchyme migration (ortholog); muscle contraction (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH aortic disease (ortholog); arterial tortuosity syndrome (ortholog); autoimmune lymphoproliferative syndrome (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); cytoskeleton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: actin, alpha 2, smooth muscle, aorta; actin, aortic smooth muscle; smooth muscle aortic actin alpha 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,700,434 - 38,714,915 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,700,480 - 38,711,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,451,228 - 38,465,187 (-)NCBI
ROS_Cfam_1.02640,285,064 - 40,299,518 (-)NCBI
UMICH_Zoey_3.12638,154,857 - 38,169,070 (-)NCBI
UNSW_CanFamBas_1.02637,720,236 - 37,734,291 (-)NCBI
UU_Cfam_GSD_1.02638,990,553 - 39,005,038 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17206491  


Genomics

Comparative Map Data
ACTA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,700,434 - 38,714,915 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,700,480 - 38,711,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,451,228 - 38,465,187 (-)NCBI
ROS_Cfam_1.02640,285,064 - 40,299,518 (-)NCBI
UMICH_Zoey_3.12638,154,857 - 38,169,070 (-)NCBI
UNSW_CanFamBas_1.02637,720,236 - 37,734,291 (-)NCBI
UU_Cfam_GSD_1.02638,990,553 - 39,005,038 (-)NCBI
ACTA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1088,935,074 - 88,991,339 (-)EnsemblGRCh38hg38GRCh38
GRCh381088,935,074 - 88,991,397 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371090,694,831 - 90,751,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,684,811 - 90,702,491 (-)NCBINCBI36hg18NCBI36
Build 341090,684,810 - 90,702,491NCBI
Celera1084,441,676 - 84,497,934 (-)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1084,329,337 - 84,385,614 (-)NCBIHuRef
CHM1_11090,976,918 - 91,033,214 (-)NCBICHM1_1
Acta2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,217,736 - 34,232,985 (-)NCBIGRCm39mm39
GRCm39 Ensembl1934,218,490 - 34,232,990 (-)Ensembl
GRCm381934,240,336 - 34,255,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,241,090 - 34,255,590 (-)EnsemblGRCm38mm10GRCm38
MGSCv371934,315,581 - 34,329,826 (-)NCBIGRCm37mm9NCBIm37
MGSCv361934,307,088 - 34,321,333 (-)NCBImm8
Celera1935,018,279 - 35,032,476 (-)NCBICelera
Cytogenetic Map19C1NCBI
Acta2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21231,746,527 - 231,759,307 (-)NCBI
Rnor_6.0 Ensembl1252,537,615 - 252,550,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01252,537,614 - 252,550,394 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01259,760,521 - 259,773,301 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1228,860,239 - 228,873,019 (-)NCBICelera
Cytogenetic Map1q52NCBI
Acta2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554254,026,430 - 4,040,747 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554254,023,001 - 4,039,980 (+)NCBIChiLan1.0ChiLan1.0
ACTA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11089,164,344 - 89,182,131 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,164,344 - 89,182,080 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01085,660,983 - 85,678,729 (-)NCBIMhudiblu_PPA_v0panPan3
Acta2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721378,509,060 - 78,526,056 (-)NCBI
SpeTri2.0NW_004936735266,918 - 283,858 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14100,867,733 - 100,886,713 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114100,868,145 - 100,886,732 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214109,852,854 - 109,871,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,358,937 - 82,376,289 (-)NCBI
ChlSab1.1 Ensembl982,359,086 - 82,372,446 (-)Ensembl
Acta2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479115,243,074 - 15,259,362 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 16 6 6 6 6 3 10 6
Low 6 3 12 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038437709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038437710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038459155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038512585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038576075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038576076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038640289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_534781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN968927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000024881   ⟹   ENSCAFP00000023085
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2638,700,480 - 38,711,486 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000066436   ⟹   ENSCAFP00000064897
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2638,700,480 - 38,711,753 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090130   ⟹   ENSCAFP00000061973
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2638,700,542 - 38,711,486 (-)Ensembl
RefSeq Acc Id: XM_038437709   ⟹   XP_038293637
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02640,286,040 - 40,299,518 (-)NCBI
RefSeq Acc Id: XM_038437710   ⟹   XP_038293638
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02640,285,064 - 40,299,518 (-)NCBI
RefSeq Acc Id: XM_038459155   ⟹   XP_038315083
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2638,452,203 - 38,465,187 (-)NCBI
RefSeq Acc Id: XM_038512584   ⟹   XP_038368512
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12638,155,825 - 38,169,070 (-)NCBI
RefSeq Acc Id: XM_038512585   ⟹   XP_038368513
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12638,154,857 - 38,169,070 (-)NCBI
RefSeq Acc Id: XM_038576075   ⟹   XP_038432003
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02638,991,529 - 39,005,038 (-)NCBI
RefSeq Acc Id: XM_038576076   ⟹   XP_038432004
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02638,990,553 - 39,005,038 (-)NCBI
RefSeq Acc Id: XM_038640288   ⟹   XP_038496216
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02637,721,211 - 37,734,291 (-)NCBI
RefSeq Acc Id: XM_038640289   ⟹   XP_038496217
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02637,720,236 - 37,734,291 (-)NCBI
RefSeq Acc Id: XM_534781   ⟹   XP_534781
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12638,700,434 - 38,714,915 (-)NCBI
Dog10K_Boxer_Tasha2638,451,228 - 38,465,187 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_534781   ⟸   XM_534781
- Peptide Label: isoform X2
- UniProtKB: F2Z4N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023085   ⟸   ENSCAFT00000024881
RefSeq Acc Id: ENSCAFP00000064897   ⟸   ENSCAFT00000066436
RefSeq Acc Id: ENSCAFP00000061973   ⟸   ENSCAFT00000090130
RefSeq Acc Id: XP_038368513   ⟸   XM_038512585
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038368512   ⟸   XM_038512584
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038496217   ⟸   XM_038640289
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038496216   ⟸   XM_038640288
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038293638   ⟸   XM_038437710
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038293637   ⟸   XM_038437709
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038315083   ⟸   XM_038459155
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038432004   ⟸   XM_038576076
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038432003   ⟸   XM_038576075
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015708 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000023085 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000061973 UniProtKB/TrEMBL
  ENSCAFP00000064897 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024881 UniProtKB/TrEMBL
  ENSCAFT00000066436 UniProtKB/TrEMBL
  ENSCAFT00000090130 UniProtKB/TrEMBL
InterPro Actin UniProtKB/TrEMBL
  Actin/actin-like_CS UniProtKB/TrEMBL
  Actin_CS UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
KEGG Report cfa:477587 UniProtKB/TrEMBL
NCBI Gene ACTA2 ENTREZGENE
PANTHER PTHR11937 UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PRINTS ACTIN UniProtKB/TrEMBL
PROSITE ACTINS_1 UniProtKB/TrEMBL
  ACTINS_2 UniProtKB/TrEMBL
  ACTINS_ACT_LIKE UniProtKB/TrEMBL
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A5F4D695_CANLF UniProtKB/TrEMBL
  A0A5F4DDV9_CANLF UniProtKB/TrEMBL
  F2Z4N0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:37539 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-22 ACTA2  actin alpha 2, smooth muscle    actin, alpha 2, smooth muscle, aorta  Symbol and/or name change 5135510 APPROVED