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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-threonine
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Accession:CHEBI:16857 term browser browse the term
Definition:An optically active form of threonine having L-configuration.
Synonyms:related_synonym: (2S)-threonine;   (2S,3R)-(-)-Threonine;   (2S,3R)-2-amino-3-hydroxybutanoic acid;   2-Amino-3-hydroxybutyric acid;   Formula=C4H9NO3;   InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1;   InChIKey=AYFVYJQAPQTCCC-GBXIJSLDSA-N;   L-2-Amino-3-hydroxybutyric acid;   L-Threonin;   L-alpha-amino-beta-hydroxybutyric acid;   SMILES=C[C@@H](O)[C@H](N)C(O)=O;   T;   THREONINE;   Thr
 alt_id: CHEBI:13175;   CHEBI:21403;   CHEBI:42083;   CHEBI:45843;   CHEBI:45983;   CHEBI:6308
 xref: Beilstein:1721646;   CAS:72-19-5;   DrugBank:DB00156;   Drug_Central:4254;   ECMDB:ECMDB00167;   Gmelin:82510;   HMDB:HMDB0000167;   KEGG:C00188;   KEGG:D00041;   KNApSAcK:C00001394
 xref_mesh: MESH:D013912
 xref: PDBeChem:THR;   PMID:11964235;   PMID:12523390;   PMID:16659349;   PMID:17379183;   PMID:22289691;   PMID:22342587;   PMID:22513921;   PMID:22770225;   PMID:24671569;   Reaxys:1721646;   UM-BBD_compID:c0413;   Wikipedia:Threonine;   YMDB:YMDB00214
 cyclic_relationship: is_conjugate_acid_of CHEBI:32820;   is_conjugate_base_of CHEBI:32822;   is_enantiomer_of CHEBI:16398;   is_tautomer_of CHEBI:57926


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L-threonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein; resorcinol inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein] CTD PMID:26262998 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein; [MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein; resorcinol inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein] CTD PMID:26262998 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      application 19557
        pharmaceutical 19440
          drug 19440
            nutraceutical 12896
              L-threonine 2
                Ala-Leu-Leu-Thr 0
                Ala-Leu-Thr-Gln 0
                Ala-Leu-Thr-Pro 0
                Ala-Phe-Thr-Ser 0
                Ala-Thr-Ala-Pro 0
                Arg-Thr-Cys-Cys 0
                Arg-Thr-Thr-Asp 0
                Asn-Met-Thr-Thr 0
                Asp-Leu-Thr-Asp 0
                Asp-Leu-Thr-Ser 0
                Asp-Met-Thr-Pro 0
                Asp-Thr 0
                Cys-Met-Thr-Tyr 0
                Glu-Arg-Gly-Met-Thr 0
                Glu-Thr 0
                Glu-Thr-Thr-Tyr 0
                Glu-Val-Thr-Leu-Tyr peptide residue 0
                Ile-Thr 0
                L-threonin-O(3)-yl group 0
                L-threonine derivative + 0
                L-threonine residue + 0
                L-threonino group 0
                L-threonyl group 0
                Leu-Thr 0
                Leu-Thr-Ala 0
                Leu-Thr-Asp 0
                Leu-Thr-Gln 0
                Leu-Thr-Ser 0
                Lys-Glu-Thr 0
                Lys-Thr 0
                Lys-Thr-Pro-Pro 0
                Lys-Thr-Trp-Tyr 0
                Met-Thr 0
                Phe-Arg-Thr 0
                Phe-Pro-Thr 0
                Phe-Thr 0
                Pro-Thr 0
                Ser-Thr 0
                Thr-Ala-Ala 0
                Thr-Ala-Asp 0
                Thr-Ala-His 0
                Thr-Ala-Ser 0
                Thr-Asn 0
                Thr-Asp-Gly 0
                Thr-His 0
                Thr-Ile 0
                Thr-Lys 0
                Thr-Pro 0
                Thr-Pro-Pro 0
                Thr-Pro-Tyr 0
                Thr-Ser 0
                Thr-Thr 0
                Thr-Thr-Asp 0
                Thr-Thr-Thr 0
                Thr-Trp 0
                Thr-Trp-Asp 0
                Thr-Tyr 0
                Trp-Thr 0
                Tyr-Thr 0
                delanzomib 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18799
                                    carbonyl compound 18799
                                      carboxylic acid 18515
                                        amino acid 15511
                                          alpha-amino acid 13640
                                            L-alpha-amino acid 12573
                                              aspartate family amino acid 3666
                                                L-threonine 2
                                                  Ala-Leu-Leu-Thr 0
                                                  Ala-Leu-Thr-Gln 0
                                                  Ala-Leu-Thr-Pro 0
                                                  Ala-Phe-Thr-Ser 0
                                                  Ala-Thr-Ala-Pro 0
                                                  Arg-Thr-Cys-Cys 0
                                                  Arg-Thr-Thr-Asp 0
                                                  Asn-Met-Thr-Thr 0
                                                  Asp-Leu-Thr-Asp 0
                                                  Asp-Leu-Thr-Ser 0
                                                  Asp-Met-Thr-Pro 0
                                                  Asp-Thr 0
                                                  Cys-Met-Thr-Tyr 0
                                                  Glu-Arg-Gly-Met-Thr 0
                                                  Glu-Thr 0
                                                  Glu-Thr-Thr-Tyr 0
                                                  Glu-Val-Thr-Leu-Tyr peptide residue 0
                                                  Ile-Thr 0
                                                  L-threonin-O(3)-yl group 0
                                                  L-threonine derivative + 0
                                                  L-threonine residue + 0
                                                  L-threonino group 0
                                                  L-threonyl group 0
                                                  Leu-Thr 0
                                                  Leu-Thr-Ala 0
                                                  Leu-Thr-Asp 0
                                                  Leu-Thr-Gln 0
                                                  Leu-Thr-Ser 0
                                                  Lys-Glu-Thr 0
                                                  Lys-Thr 0
                                                  Lys-Thr-Pro-Pro 0
                                                  Lys-Thr-Trp-Tyr 0
                                                  Met-Thr 0
                                                  Phe-Arg-Thr 0
                                                  Phe-Pro-Thr 0
                                                  Phe-Thr 0
                                                  Pro-Thr 0
                                                  Ser-Thr 0
                                                  Thr-Ala-Ala 0
                                                  Thr-Ala-Asp 0
                                                  Thr-Ala-His 0
                                                  Thr-Ala-Ser 0
                                                  Thr-Asn 0
                                                  Thr-Asp-Gly 0
                                                  Thr-His 0
                                                  Thr-Ile 0
                                                  Thr-Lys 0
                                                  Thr-Pro 0
                                                  Thr-Pro-Pro 0
                                                  Thr-Pro-Tyr 0
                                                  Thr-Ser 0
                                                  Thr-Thr 0
                                                  Thr-Thr-Asp 0
                                                  Thr-Thr-Thr 0
                                                  Thr-Trp 0
                                                  Thr-Trp-Asp 0
                                                  Thr-Tyr 0
                                                  Trp-Thr 0
                                                  Tyr-Thr 0
                                                  delanzomib 0
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