Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha,alpha-trehalose
go back to main search page
Accession:CHEBI:16551 term browser browse the term
Definition:A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.
Synonyms:related_synonym: (Glc)2;   D-(+)-trehalose;   Formula=C12H22O11;   InChI=1S/C12H22O11/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-/m1/s1;   InChIKey=HDTRYLNUVZCQOY-LIZSDCNHSA-N;   SMILES=OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O;   Trehalose;   alpha-D-Glcp-(1<->1)-alpha-D-Glcp;   alpha-D-Trehalose;   alpha-D-glucopyranosyl-alpha-D-glucopyranoside;   alpha-trehalose;   ergot sugar;   mycose
 alt_id: CHEBI:10202;   CHEBI:12281;   CHEBI:12284;   CHEBI:12287;   CHEBI:15251;   CHEBI:22365;   CHEBI:46211
 xref: Beilstein:1292766;   CAS:99-20-7;   Gmelin:2145829;   HMDB:HMDB0000975;   KEGG:C01083;   KEGG:G00293;   KNApSAcK:C00001152;   LINCS:LSM-37121
 xref_mesh: MESH:D014199
 xref: MetaCyc:TREHALOSE;   PDBeChem:TRE;   PMID:17439666;   Reaxys:1292766;   Wikipedia:Trehalose


show annotations for term's descendants           Sort by:
 
alpha,alpha-trehalose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in increased expression of CAT protein] CTD PMID:29140578 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in increased expression of GCLC protein] CTD PMID:29140578 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in increased expression of GCLM protein] CTD PMID:29140578 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GFAP protein] CTD PMID:25064079 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in increased expression of GPX1 protein] CTD PMID:29140578 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in increased expression of GSR protein] CTD PMID:29140578 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in increased expression of HMOX1 protein] CTD PMID:29140578 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma multiple interactions ISO Trehalose inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in decreased expression of KEAP1 protein] CTD PMID:29140578 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases cleavage ISO Trehalose results in increased cleavage of MAP1LC3B protein CTD PMID:29486218 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in increased expression of NQO1 protein] CTD PMID:29140578 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Ocln occludin multiple interactions ISO Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of OCLN protein] CTD PMID:25064079 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Trehalose inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
ISO Trehalose inhibits the reaction [Cholesterol inhibits the reaction [Cadmium Chloride results in increased cleavage of RPS6KB1 protein]]; Trehalose inhibits the reaction [Cholesterol results in increased phosphorylation of RPS6KB1 protein]
Trehalose results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:29486218 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC2A1 protein] CTD PMID:25064079 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein] CTD PMID:25064079 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in increased expression of SOD1 protein] CTD PMID:29140578 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Trehalose inhibits the reaction [cadmium acetate results in increased expression of SOD2 protein] CTD PMID:29140578 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO Trehalose results in decreased expression of SQSTM1 protein CTD PMID:29486218 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein] CTD PMID:25064079 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
sulfolipid I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nod2 nucleotide-binding oligomerization domain containing 2 affects binding
multiple interactions
ISO NOD2 protein binds to sulfolipid I
sulfolipid I inhibits the reaction [NOD2 protein binds to Sulfoglycosphingolipids]
CTD PMID:23880069 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            prokaryotic metabolite 18402
              bacterial metabolite 18402
                Escherichia coli metabolite 18283
                  alpha,alpha-trehalose 21
                    2'-O-sulfo-2-O-tetracosanoyl-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose 0
                    2,3-dipalmitoyl-2'-sulfo-alpha,alpha-trehalose 0
                    2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose 0
                    2-O-[(2E,4S)-2,4-dimethyldocos-2-enoyl]-3-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                    2-O-octanoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose 0
                    2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose 0
                    2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltriacont-2-enoyl]-alpha,alpha-trehalose 0
                    2-O-palmitoyl-2'-O-sulfo-3-O-[(2S,4S,6S)-2,4,6-trimethyltetracosanoyl]-alpha,alpha-trehalose 0
                    2-O-palmitoyl-2'-O-sulfo-3-O-[(2S,4S,6S,8S)-2,4,6,8-tetramethyltetracosanoyl]-alpha,alpha-trehalose 0
                    2-O-palmitoyl-2'-O-sulfo-3-O-triacontanoyl-alpha,alpha-trehalose 0
                    2-O-palmitoyl-3-O-[(2E,4S,6S)-2,4,6-trimethyltetracos-2-enoyl]-2'-O-sulfo-alpha,alpha-trehalose 0
                    2-O-palmitoyl-3-O-[(2E,4S,6S,8S,10S)-2,4,6,8,10-pentamethylhexacos-2-enoyl]-2'-O-sulfo-alpha,alpha-trehalose 0
                    2-O-sulfo-2'-O-stearoyl-alpha,alpha-trehalose(1-) 0
                    3-O-(16-hydroxyhexadecanoyl)-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                    3-O-(2-methyloctadecanoyl)-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                    3-O-[(2E)-2-methylicos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                    3-O-[(2E,4R)-2,4-dimethyldocos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                    3-O-[(2E,4S)-2,4-dimethyldocos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                    3-O-[(2S,4S)-2,4-dimethyldocosanoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                    3-O-hydroxyphthioceranoyl-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                    3-O-hydroxyphthioceranoyl-2-O-stearoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                    SL1278 0
                    SL659 0
                    acyl alpha,alpha-trehalose + 1
                    alpha,alpha-trehalose 6-phosphate 0
                    alpha,alpha-trehalose 6-phosphate(2-) 0
                    alpha,alpha-trehalose-2-sulfate 0
                    alpha,alpha-trehalose-2-sulfate(1-) 0
                    beta-D-Galp-(1->6)-alpha-D-Glcp-(1->1)-alpha-D-Glcp 0
                    brartemicin 0
                    monoacyl alpha,alpha-trehalose + 0
                    polyacyl alpha,alpha-trehalose + 1
                    sulfolipid I 1
                    sulfolipid-1(1-) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            heteroorganic entity 19184
                              organochalcogen compound 18894
                                organooxygen compound 18816
                                  carbohydrates and carbohydrate derivatives 12191
                                    carbohydrate 12191
                                      oligosaccharide 516
                                        disaccharide 425
                                          glycosyl glycoside 100
                                            hexopyranosyl hexopyranoside 29
                                              trehalose 29
                                                alpha,alpha-trehalose 21
                                                  2'-O-sulfo-2-O-tetracosanoyl-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose 0
                                                  2,3-dipalmitoyl-2'-sulfo-alpha,alpha-trehalose 0
                                                  2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose 0
                                                  2-O-[(2E,4S)-2,4-dimethyldocos-2-enoyl]-3-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  2-O-octanoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose 0
                                                  2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose 0
                                                  2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltriacont-2-enoyl]-alpha,alpha-trehalose 0
                                                  2-O-palmitoyl-2'-O-sulfo-3-O-[(2S,4S,6S)-2,4,6-trimethyltetracosanoyl]-alpha,alpha-trehalose 0
                                                  2-O-palmitoyl-2'-O-sulfo-3-O-[(2S,4S,6S,8S)-2,4,6,8-tetramethyltetracosanoyl]-alpha,alpha-trehalose 0
                                                  2-O-palmitoyl-2'-O-sulfo-3-O-triacontanoyl-alpha,alpha-trehalose 0
                                                  2-O-palmitoyl-3-O-[(2E,4S,6S)-2,4,6-trimethyltetracos-2-enoyl]-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  2-O-palmitoyl-3-O-[(2E,4S,6S,8S,10S)-2,4,6,8,10-pentamethylhexacos-2-enoyl]-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  2-O-sulfo-2'-O-stearoyl-alpha,alpha-trehalose(1-) 0
                                                  3-O-(16-hydroxyhexadecanoyl)-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  3-O-(2-methyloctadecanoyl)-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  3-O-[(2E)-2-methylicos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  3-O-[(2E,4R)-2,4-dimethyldocos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  3-O-[(2E,4S)-2,4-dimethyldocos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  3-O-[(2S,4S)-2,4-dimethyldocosanoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  3-O-hydroxyphthioceranoyl-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  3-O-hydroxyphthioceranoyl-2-O-stearoyl-2'-O-sulfo-alpha,alpha-trehalose 0
                                                  SL1278 0
                                                  SL659 0
                                                  acyl alpha,alpha-trehalose + 1
                                                  alpha,alpha-trehalose 6-phosphate 0
                                                  alpha,alpha-trehalose 6-phosphate(2-) 0
                                                  alpha,alpha-trehalose-2-sulfate 0
                                                  alpha,alpha-trehalose-2-sulfate(1-) 0
                                                  beta-D-Galp-(1->6)-alpha-D-Glcp-(1->1)-alpha-D-Glcp 0
                                                  brartemicin 0
                                                  monoacyl alpha,alpha-trehalose + 0
                                                  polyacyl alpha,alpha-trehalose + 1
                                                  sulfolipid I 1
                                                  sulfolipid-1(1-) 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.