alpha,alpha-trehalose - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	alpha,alpha-trehalose	go back to main search page
Accession:	CHEBI:16551	browse the term
Definition:	A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.
Synonyms:	related_synonym:	(Glc)2; D-(+)-trehalose; Formula=C12H22O11; InChI=1S/C12H22O11/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-/m1/s1; InChIKey=HDTRYLNUVZCQOY-LIZSDCNHSA-N; SMILES=OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O; Trehalose; alpha-D-Glcp-(1<->1)-alpha-D-Glcp; alpha-D-Trehalose; alpha-D-glucopyranosyl-alpha-D-glucopyranoside; alpha-trehalose; ergot sugar; mycose
	alt_id:	CHEBI:10202; CHEBI:12281; CHEBI:12284; CHEBI:12287; CHEBI:15251; CHEBI:22365; CHEBI:46211
	xref:	CAS:99-20-7; Gmelin:2145829; HMDB:HMDB0000975; KEGG:C01083; KEGG:G00293; KNApSAcK:C00001152; LINCS:LSM-37121
	xref_mesh:	MESH:D014199
	xref:	MetaCyc:TREHALOSE; PDBeChem:TRE; PMID:17439666; PMID:20477758; Reaxys:1292766; Wikipedia:Trehalose

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Genes (40)

alpha,alpha-trehalose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

autophagy related 10

increases expression

Trehalose results in increased expression of ATG10 mRNA

NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233

G

autophagy related 12

increases expression

Trehalose results in increased expression of ATG12 mRNA

NCBI chr18:41,638,841...41,649,311
Ensembl chr18:39,452,191...39,462,418

G

autophagy related 5

increases expression

Trehalose results in increased expression of ATG5 mRNA

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209

G

ATPase H+ transporting V1 subunit A

multiple interactions

Trehalose inhibits the reaction [Swainsonine results in decreased expression of ATP6V1A protein]

NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694

G

BAG cochaperone 3

increases expression

Trehalose results in increased expression of BAG3 mRNA

NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:183,102,871...183,126,858

G

beclin 1

increases expression

Trehalose results in increased expression of BECN1 mRNA

PMID:23851366 PMID:30335591

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

catalase

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in increased expression of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

cathepsin B

multiple interactions
increases expression

TFEB affects the reaction [Trehalose results in increased expression of CTSB mRNA]
Trehalose inhibits the reaction [Swainsonine results in decreased expression of CTSB protein]

PMID:30335591 PMID:38579922

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

multiple interactions

Trehalose inhibits the reaction [Swainsonine results in decreased expression of CTSD protein]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488

G

forkhead box O1

affects localization

Trehalose affects the localization of FOXO1 protein

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in increased expression of GCLC protein]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in increased expression of GCLM protein]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535

G

glial fibrillary acidic protein

multiple interactions

Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GFAP protein]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589

G

glutathione peroxidase 1

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in increased expression of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in increased expression of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661

G

heme oxygenase 1

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in increased expression of HMOX1 protein]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family B (small) member 8

increases expression

Trehalose results in increased expression of HSPB8 mRNA

NCBI chr12:45,835,899...45,866,449
Ensembl chr12:40,176,532...40,191,185

G

interferon gamma

multiple interactions

Trehalose inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

Kelch-like ECH-associated protein 1

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in decreased expression of KEAP1 protein]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862

G

lysosomal-associated membrane protein 2

multiple interactions
increases expression

TFEB affects the reaction [Trehalose results in increased expression of LAMP2 mRNA]
Trehalose inhibits the reaction [Swainsonine results in decreased expression of LAMP2 protein]

PMID:30335591 PMID:38579922

NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522

G

microtubule-associated protein 1 light chain 3 alpha

increases expression

Trehalose results in increased expression of MAP1LC3A mRNA

NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

increases cleavage
increases expression
multiple interactions

Trehalose results in increased cleavage of MAP1LC3B protein
Trehalose results in increased expression of MAP1LC3B protein
Trehalose results in increased expression of MAP1LC3B mRNA
TFEB affects the reaction [Trehalose results in increased expression of MAP1LC3B mRNA]

PMID:29486218 PMID:30335591 PMID:38579922

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mucolipin TRP cation channel 1

increases expression
multiple interactions

Trehalose results in increased expression of MCOLN1 mRNA
TFEB affects the reaction [Trehalose results in increased expression of MCOLN1 mRNA]

NCBI chr12:6,357,851...6,372,151
Ensembl chr12:1,560,359...1,574,252

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in increased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

occludin

multiple interactions

Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150

G

poly (ADP-ribose) polymerase 1

multiple interactions

Trehalose inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein]; Trehalose promotes the reaction [ovatodiolide results in increased cleavage of PARP1 protein]

PMID:23011206 PMID:38000454

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

PPARG coactivator 1 alpha

increases expression
multiple interactions

Trehalose results in increased expression of PPARGC1A mRNA
TFEB affects the reaction [Trehalose results in increased expression of PPARGC1A mRNA]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656

G

protein phosphatase 3 catalytic subunit beta

multiple interactions

PPP3CB affects the reaction [Trehalose affects the localization of TFEB protein]

NCBI chr15:3,809,182...3,854,204
Ensembl chr15:3,760,030...3,804,981

G

ribosomal protein S6 kinase B1

multiple interactions
decreases phosphorylation

Trehalose inhibits the reaction [Cholesterol inhibits the reaction [Cadmium Chloride results in increased cleavage of RPS6KB1 protein]]; Trehalose inhibits the reaction [Cholesterol results in increased phosphorylation of RPS6KB1 protein]; Trehalose inhibits the reaction [Dronabinol results in increased phosphorylation of RPS6KB1 protein]
Trehalose results in decreased phosphorylation of RPS6KB1 protein

PMID:29486218 PMID:32773031

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

solute carrier family 2 member 1

multiple interactions

Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC2A1 protein]

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 6 member 3

multiple interactions

Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413

G

superoxide dismutase 1

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in increased expression of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

Trehalose inhibits the reaction [cadmium acetate results in increased expression of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

sequestosome 1

decreases expression
multiple interactions
increases expression

Trehalose results in decreased expression of SQSTM1 protein
Trehalose inhibits the reaction [Swainsonine results in increased expression of SQSTM1 protein]
Trehalose inhibits the reaction [ovatodiolide results in increased expression of SQSTM1 protein]
Trehalose results in increased expression of SQSTM1 mRNA
TFEB affects the reaction [Trehalose results in increased expression of SQSTM1 mRNA]; Trehalose inhibits the reaction [Dronabinol results in increased expression of SQSTM1 protein]

PMID:23851366 PMID:29486218 PMID:30335591 PMID:32773031 PMID:38000454 More...

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

transcription factor EB

multiple interactions
affects localization

Cyclosporine inhibits the reaction [Trehalose affects the localization of TFEB protein]; PPP3CB affects the reaction [Trehalose affects the localization of TFEB protein]; TFEB affects the reaction [Trehalose results in increased expression of CTSB mRNA]; TFEB affects the reaction [Trehalose results in increased expression of LAMP2 mRNA]; TFEB affects the reaction [Trehalose results in increased expression of MAP1LC3B mRNA]; TFEB affects the reaction [Trehalose results in increased expression of MCOLN1 mRNA]; TFEB affects the reaction [Trehalose results in increased expression of PPARGC1A mRNA]; TFEB affects the reaction [Trehalose results in increased expression of SQSTM1 mRNA]; TFEB affects the reaction [Trehalose results in increased expression of TPP1 mRNA]
Trehalose inhibits the reaction [Swainsonine results in decreased expression of TFEB protein]

PMID:30335591 PMID:38579922

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:13,198,891...13,254,714

G

tight junction protein 1

multiple interactions

Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432

G

tripeptidyl peptidase 1

increases expression
multiple interactions

Trehalose results in increased expression of TPP1 mRNA
TFEB affects the reaction [Trehalose results in increased expression of TPP1 mRNA]

NCBI chr 1:160,097,984...160,104,108
Ensembl chr 1:160,096,833...160,104,129

G

unc-51 like autophagy activating kinase 1

multiple interactions

Trehalose inhibits the reaction [Dronabinol results in increased phosphorylation of ULK1 protein]

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966

G

zinc finger with KRAB and SCAN domains 3

increases expression

Trehalose results in increased expression of ZKSCAN3 mRNA

NCBI chr17:43,217,168...43,232,828
Ensembl chr17:43,217,222...43,232,827

sulfolipid I

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nucleotide-binding oligomerization domain containing 2

affects binding
multiple interactions

NOD2 protein binds to sulfolipid I
sulfolipid I inhibits the reaction [NOD2 protein binds to Sulfoglycosphingolipids]

NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19909
role	19880
application	19720
pharmaceutical	19558
drug	19558
protective agent	18281
geroprotector	17450
alpha,alpha-trehalose	40
2'-O-sulfo-2-O-tetracosanoyl-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose	0
2,3-dipalmitoyl-2'-sulfo-alpha,alpha-trehalose	0
2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose	0
2-O-[(2E,4S)-2,4-dimethyldocos-2-enoyl]-3-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
2-O-octanoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethylhexadec-2-enoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltriacont-2-enoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2S,4S,6S)-2,4,6-trimethyltetracosanoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2S,4S,6S,8S)-2,4,6,8-tetramethyltetracosanoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-triacontanoyl-alpha,alpha-trehalose	0
2-O-palmitoyl-3-O-[(2E,4S,6S)-2,4,6-trimethyltetracos-2-enoyl]-2'-O-sulfo-alpha,alpha-trehalose	0
2-O-palmitoyl-3-O-[(2E,4S,6S,8S,10S)-2,4,6,8,10-pentamethylhexacos-2-enoyl]-2'-O-sulfo-alpha,alpha-trehalose	0
2-O-sulfo-2'-O-stearoyl-alpha,alpha-trehalose(1-)	0
3-O-(16-hydroxyhexadecanoyl)-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-(2-methyloctadecanoyl)-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-[(2E)-2-methylicos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-[(2E,4R)-2,4-dimethyldocos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-[(2E,4S)-2,4-dimethyldocos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-[(2S,4S)-2,4-dimethyldocosanoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-hydroxyphthioceranoyl-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-hydroxyphthioceranoyl-2-O-stearoyl-2'-O-sulfo-alpha,alpha-trehalose	0
SL1278	0
SL659	0
acyl alpha,alpha-trehalose +	1
alpha,alpha-trehalose 6-phosphate	0
alpha,alpha-trehalose 6-phosphate(2-)	0
alpha,alpha-trehalose-2-sulfate	0
alpha,alpha-trehalose-2-sulfate(1-) +	0
beta-D-Galp-(1->6)-alpha-D-Glcp-(1->1)-alpha-D-Glcp	0
brartemicin	0
monoacyl alpha,alpha-trehalose +	0
polyacyl alpha,alpha-trehalose +	1
sulfolipid I	1
sulfolipid-1(1-)	0
Path 2
Term	Annotations
CHEBI ontology	19909
subatomic particle	19907
composite particle	19907
hadron	19907
baryon	19907
nucleon	19907
atomic nucleus	19907
atom	19907
main group element atom	19846
p-block element atom	19846
carbon group element atom	19784
carbon atom	19781
organic molecular entity	19781
heteroorganic entity	19540
organochalcogen compound	19301
organooxygen compound	19216
carbohydrates and carbohydrate derivatives	15321
carbohydrate	15321
oligosaccharide	633
disaccharide	534
glycosyl glycoside	147
hexopyranosyl hexopyranoside	59
trehalose	59
alpha,alpha-trehalose	40
2'-O-sulfo-2-O-tetracosanoyl-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose	0
2,3-dipalmitoyl-2'-sulfo-alpha,alpha-trehalose	0
2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose	0
2-O-[(2E,4S)-2,4-dimethyldocos-2-enoyl]-3-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
2-O-octanoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethylhexadec-2-enoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltetracos-2-enoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2E,4S,6S,8S)-2,4,6,8-tetramethyltriacont-2-enoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2S,4S,6S)-2,4,6-trimethyltetracosanoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-[(2S,4S,6S,8S)-2,4,6,8-tetramethyltetracosanoyl]-alpha,alpha-trehalose	0
2-O-palmitoyl-2'-O-sulfo-3-O-triacontanoyl-alpha,alpha-trehalose	0
2-O-palmitoyl-3-O-[(2E,4S,6S)-2,4,6-trimethyltetracos-2-enoyl]-2'-O-sulfo-alpha,alpha-trehalose	0
2-O-palmitoyl-3-O-[(2E,4S,6S,8S,10S)-2,4,6,8,10-pentamethylhexacos-2-enoyl]-2'-O-sulfo-alpha,alpha-trehalose	0
2-O-sulfo-2'-O-stearoyl-alpha,alpha-trehalose(1-)	0
3-O-(16-hydroxyhexadecanoyl)-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-(2-methyloctadecanoyl)-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-[(2E)-2-methylicos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-[(2E,4R)-2,4-dimethyldocos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-[(2E,4S)-2,4-dimethyldocos-2-enoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-[(2S,4S)-2,4-dimethyldocosanoyl]-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-hydroxyphthioceranoyl-2-O-palmitoyl-2'-O-sulfo-alpha,alpha-trehalose	0
3-O-hydroxyphthioceranoyl-2-O-stearoyl-2'-O-sulfo-alpha,alpha-trehalose	0
SL1278	0
SL659	0
acyl alpha,alpha-trehalose +	1
alpha,alpha-trehalose 6-phosphate	0
alpha,alpha-trehalose 6-phosphate(2-)	0
alpha,alpha-trehalose-2-sulfate	0
alpha,alpha-trehalose-2-sulfate(1-) +	0
beta-D-Galp-(1->6)-alpha-D-Glcp-(1->1)-alpha-D-Glcp	0
brartemicin	0
monoacyl alpha,alpha-trehalose +	0
polyacyl alpha,alpha-trehalose +	1
sulfolipid I	1
sulfolipid-1(1-)	0

paths to the root