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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Tanshinone I
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Accession:CHEBI:149906 term browser browse the term
Synonyms:related_synonym: Formula=C18H12O3;   InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3;   InChIKey=AIGAZQPHXLWMOJ-UHFFFAOYSA-N;   SMILES=C=1C=C2C(=C3C(C(C4=C(C31)OC=C4C)=O)=O)C=CC=C2C;   Tanshinone
 xref: CAS:568-73-0
 xref_mesh: MESH:C021751


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Tanshinone I term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP
ISO		 tanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 mRNA]; tanshinone inhibits the reaction [Rifampin results in decreased expression of ABCB11 protein]
tanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]		 CTD PMID:35101544 PMID:35544702 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein] CTD PMID:35243748 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein
[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein]		 CTD PMID:35243748 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain increases expression ISO tanshinone results in increased expression of ACADVL mRNA CTD PMID:15849732 NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO tanshinone results in increased expression of ACSL1 mRNA CTD PMID:15849732 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP
ISO		 tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:32097614 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tanshinone binds to and results in increased activity of AHR protein; tanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] CTD PMID:21262253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]
tanshinone results in increased phosphorylation of AKT1 protein		 CTD PMID:34655285 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO tanshinone results in decreased expression of ALDH1A3 mRNA CTD PMID:15849732 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression ISO tanshinone results in decreased expression of ALDH3A2 mRNA CTD PMID:15849732 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281 		JBrowse link
G Apoc1 apolipoprotein C1 increases expression ISO tanshinone results in increased expression of APOC1 mRNA CTD PMID:15849732 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375 		JBrowse link
G Apom apolipoprotein M increases expression ISO tanshinone results in increased expression of APOM mRNA CTD PMID:15849732 NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550 		JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO [[tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [[tetraarsenic tetrasulfide co-treated with tanshinone] results in increased expression of AQP9 protein] which results in increased uptake of tetraarsenic tetrasulfide; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone co-treated with indirubin] results in increased expression of AQP9 protein; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 mRNA]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of AQP9 protein] CTD PMID:18344322 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO tanshinone results in decreased expression of ASNS mRNA CTD PMID:15849732 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression ISO tanshinone results in decreased expression of ASS1 mRNA CTD PMID:15849732 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atp6v0b ATPase H+ transporting V0 subunit B increases expression ISO tanshinone results in increased expression of ATP6V0B mRNA CTD PMID:15849732 NCBI chr 5:131,423,384...131,424,900
Ensembl chr 5:131,423,387...131,426,401 		JBrowse link
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 increases expression ISO tanshinone results in increased expression of ATP6V1E1 mRNA CTD PMID:15849732 NCBI chr 4:154,022,358...154,044,486
Ensembl chr 4:154,022,358...154,044,584 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of BAD protein] CTD PMID:34655285 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tanshinone results in increased expression of BAX protein CTD PMID:21699893 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta decreases expression ISO tanshinone results in decreased expression of BCKDHB mRNA CTD PMID:15849732 NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tanshinone results in decreased expression of BCL2 protein CTD PMID:16009009 PMID:19885617 PMID:20369472 PMID:21699893 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO tanshinone results in decreased expression of BIRC3 mRNA CTD PMID:15849732 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions		 ISO tanshinone results in decreased expression of BIRC5 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of BIRC5 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of BIRC5 mRNA]		 CTD PMID:21165580 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 increases expression ISO tanshinone results in increased expression of CALCOCO2 mRNA CTD PMID:15849732 NCBI chr10:81,055,467...81,069,298 JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions		 ISO
EXP		 tanshinone results in increased expression of CASP3 protein
tanshinone results in increased activity of CASP3 protein
Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]		 CTD PMID:15849732 PMID:21699893 PMID:34655285 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein] CTD PMID:26203587 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO tanshinone inhibits the reaction [Particulate Matter results in increased expression of CCND1 protein] CTD PMID:35304817 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd33 CD33 molecule decreases expression ISO tanshinone results in decreased expression of CD33 protein CTD PMID:16009009 NCBI chr 1:93,935,418...93,940,452
Ensembl chr 1:93,930,971...93,950,149 		JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression		 ISO 15-deoxyprostaglandin J2 inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]; tanshinone inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; tanshinone inhibits the reaction [Troglitazone results in increased expression of CD36 mRNA]; Troglitazone inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]
tanshinone results in decreased expression of CD36 mRNA; tanshinone results in decreased expression of CD36 protein		 CTD PMID:20854809 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd68 Cd68 molecule decreases expression ISO tanshinone results in decreased expression of CD68 protein CTD PMID:20854809 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Doxorubicin co-treated with tanshinone] affects the expression of CDH1 protein; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of CDH1 protein] CTD PMID:32097614 PMID:32886829 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [tanshinone co-treated with indirubin] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of CDK2 protein]; [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased expression of CDK2 protein] CTD PMID:18344322 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO tanshinone results in increased expression of CDKN1A mRNA CTD PMID:15849732 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions
increases expression		 ISO indirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]; tanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]; tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]; tetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]] CTD PMID:18344322 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Ceacam6 CEA cell adhesion molecule 6 decreases expression ISO tanshinone results in decreased expression of CEACAM6 mRNA CTD PMID:15849732 NCBI chr 1:80,416,531...80,434,668
Ensembl chr 1:80,416,531...80,434,668 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression		 ISO [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPA protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPA protein] CTD PMID:18344322 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression
multiple interactions		 ISO tanshinone results in increased expression of CEBPB protein
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPB protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPB protein]		 CTD PMID:18344322 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions
increases expression		 ISO [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CEBPE protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of CEBPE protein] CTD PMID:18344322 NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO tanshinone results in increased expression of CFLAR protein CTD PMID:26203587 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Clu clusterin increases expression ISO tanshinone results in increased expression of CLU mRNA CTD PMID:15849732 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO tanshinone results in decreased expression of COL6A1 mRNA CTD PMID:15849732 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597 		JBrowse link
G Cst6 cystatin E/M increases expression ISO tanshinone results in increased expression of CST6 mRNA CTD PMID:15849732 NCBI chr 1:202,655,322...202,657,030
Ensembl chr 1:202,655,322...202,657,030 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions		 ISO tanshinone results in increased expression of CTNNB1 mRNA
[Doxorubicin co-treated with tanshinone] affects the expression of CTNNB1 protein; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of CTNNB1 protein]		 CTD PMID:25186638 PMID:32886829 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of CYCS protein] CTD PMID:34655285 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO tanshinone results in increased expression of CYP1A1 mRNA; tanshinone results in increased expression of CYP1A1 protein
Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]		 CTD PMID:15849732 PMID:16955220 PMID:21262253 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO tanshinone results in increased expression of CYP1A2 mRNA; tanshinone results in increased expression of CYP1A2 protein
Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; Resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein]		 CTD PMID:21262253 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO tanshinone results in decreased activity of CYP2C19 protein CTD PMID:25686904 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO tanshinone results in decreased activity of CYP2C8 protein CTD PMID:29689254
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression		 ISO NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein]; NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein]; NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dck deoxycytidine kinase increases expression ISO tanshinone results in increased expression of DCK mRNA CTD PMID:15849732 NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO [TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; Acetylcysteine inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; pyrazolanthrone inhibits the reaction [tanshinone results in increased expression of DDIT3 protein]
tanshinone results in increased expression of DDIT3 mRNA; tanshinone results in increased expression of DDIT3 protein		 CTD PMID:26203587 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in decreased expression of DUSP1 protein] CTD PMID:29906494 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp11 dual specificity phosphatase 11 increases expression ISO tanshinone results in increased expression of DUSP11 mRNA CTD PMID:15849732 NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181 		JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO tanshinone results in increased expression of DUSP5 mRNA CTD PMID:15849732 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Dyrk4 dual specificity tyrosine phosphorylation regulated kinase 4 decreases expression ISO tanshinone results in decreased expression of DYRK4 mRNA CTD PMID:15849732 NCBI chr 4:159,715,658...159,757,660
Ensembl chr 4:159,715,417...159,757,627 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] CTD PMID:28985491 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein] CTD PMID:28985491 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of EDNRB protein] CTD PMID:28985491 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Elk1 ETS transcription factor ELK1 decreases response to substance
decreases expression		 ISO ELK1 mRNA results in decreased susceptibility to tanshinone
tanshinone results in decreased expression of ELK1 mRNA		 CTD PMID:30506648 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression ISO tanshinone results in increased expression of ENC1 mRNA CTD PMID:15849732 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression
multiple interactions		 ISO tanshinone results in decreased expression of ERCC1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of ERCC1 mRNA]		 CTD PMID:21165580 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor decreases expression ISO tanshinone results in decreased expression of ETS2 mRNA CTD PMID:15849732 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 increases expression ISO tanshinone results in increased expression of F2RL1 mRNA CTD PMID:15849732 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Flad1 flavin adenine dinucleotide synthetase 1 increases expression ISO tanshinone results in increased expression of FLAD1 mRNA CTD PMID:15849732 NCBI chr 2:174,819,451...174,828,921
Ensembl chr 2:174,819,453...174,828,977 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP		 NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein] CTD PMID:32097614 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO tanshinone results in increased expression of FOS protein CTD PMID:16009009 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gba1 glucosylceramidase beta 1 increases expression ISO tanshinone results in increased expression of GBA1 mRNA CTD PMID:15849732 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression ISO tanshinone results in increased expression of GFAP mRNA; tanshinone results in increased expression of GFAP protein CTD PMID:16955220 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gnaq G protein subunit alpha q multiple interactions EXP [tanshinone co-treated with Fulvestrant] inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein] CTD PMID:34655285 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO tanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] CTD PMID:36804361 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Grb7 growth factor receptor bound protein 7 increases expression ISO tanshinone results in increased expression of GRB7 mRNA CTD PMID:15849732 NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO tanshinone results in decreased expression of GSK3B mRNA CTD PMID:25186638 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO tanshinone results in decreased expression of GSTP1 mRNA CTD PMID:21165580 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H1f2 H1.2 linker histone, cluster member multiple interactions ISO [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein]; tanshinone promotes the reaction [indirubin results in decreased phosphorylation of H1F2 protein] CTD PMID:18344322 NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635 		JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]] CTD PMID:18344322 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac3 histone deacetylase 3 increases expression ISO tanshinone results in increased expression of HDAC3 mRNA CTD PMID:15849732 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 tanshinone results in increased expression of HMOX1 protein
tanshinone promotes the reaction [Silicon Dioxide results in increased expression of HMOX1 protein]		 CTD PMID:19356721 PMID:32097614 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO tanshinone results in increased expression of ID2 mRNA CTD PMID:15849732 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions EXP [Fulvestrant co-treated with tanshinone] promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein]; [IGF2 protein mutant form co-treated with tanshinone] results in decreased expression of IGF2R protein; [tanshinone co-treated with Fulvestrant] inhibits the reaction [IGF2 protein mutant form results in increased expression of GNAQ protein]; Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein]]; Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]]; Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased phosphorylation of AKT1 protein]; tanshinone inhibits the reaction [IGF2 protein mutant form results in increased cleavage of CASP3 protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of BAD protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of CYCS protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein] CTD PMID:34655285 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions
decreases expression		 EXP [IGF2 protein mutant form co-treated with tanshinone] results in decreased expression of IGF2R protein
tanshinone results in decreased expression of IGF2R protein		 CTD PMID:34655285 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tanshinone inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] CTD PMID:30098273 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; tanshinone inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:29906494 PMID:35304817 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases activity ISO tanshinone results in decreased activity of IMPDH2 protein CTD PMID:37871880 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 increases expression ISO tanshinone results in increased expression of INPPL1 mRNA CTD PMID:15849732 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO tanshinone results in increased expression of ISG20 mRNA CTD PMID:15849732 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027 		JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO tanshinone results in decreased expression of ITGA6 mRNA CTD PMID:15849732 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itgam integrin subunit alpha M increases expression ISO tanshinone results in increased expression of ITGAM protein CTD PMID:16009009 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO tanshinone promotes the reaction [Silicon Dioxide results in decreased expression of KEAP1 protein] CTD PMID:32097614 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Kras KRAS proto-oncogene, GTPase decreases response to substance
decreases expression		 ISO KRAS mRNA results in decreased susceptibility to tanshinone
tanshinone results in decreased expression of KRAS mRNA; tanshinone results in decreased expression of KRAS protein		 CTD PMID:30506648 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression
multiple interactions		 ISO tanshinone results in decreased expression of LRP1 mRNA
SB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA]; tanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA]		 CTD PMID:21165580 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Lrp5 LDL receptor related protein 5 decreases expression ISO tanshinone results in decreased expression of LRP5 mRNA CTD PMID:15849732 NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581 		JBrowse link
G Lrp8 LDL receptor related protein 8 decreases expression ISO tanshinone results in decreased expression of LRP8 mRNA CTD PMID:15849732 NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352 		JBrowse link
G Maob monoamine oxidase B increases expression ISO tanshinone results in increased expression of MAOB mRNA CTD PMID:15849732 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO tanshinone results in decreased expression of MAP3K1 mRNA CTD PMID:15849732 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein] CTD PMID:29906494 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:29906494 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mipep mitochondrial intermediate peptidase decreases expression ISO tanshinone results in decreased expression of MIPEP mRNA CTD PMID:15849732 NCBI chr15:34,926,198...35,051,722
Ensembl chr15:34,926,207...35,051,727 		JBrowse link
G Mir21 microRNA 21 multiple interactions ISO tanshinone inhibits the reaction [Particulate Matter results in increased expression of MIR21 protein] CTD PMID:35304817 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO tanshinone inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA] CTD PMID:30098273 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Doxorubicin co-treated with tanshinone] affects the expression of MMP2 protein; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of MMP2 protein] CTD PMID:32886829 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO tanshinone results in decreased expression of MMP7 mRNA CTD PMID:15849732 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [Doxorubicin co-treated with tanshinone] affects the expression of MMP9 protein; tanshinone inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of MMP9 protein] CTD PMID:24929186 PMID:32886829 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Msr1 macrophage scavenger receptor 1 decreases expression ISO tanshinone results in decreased expression of MSR1 mRNA CTD PMID:20854809 NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676 		JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression ISO tanshinone results in increased expression of MYBL2 mRNA CTD PMID:15849732 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions		 ISO tanshinone results in decreased expression of MYC protein
tanshinone results in decreased expression of MYC mRNA; tanshinone results in decreased expression of MYC protein
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC mRNA]; [indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in decreased expression of MYC protein]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in decreased expression of MYC protein]
[Doxorubicin co-treated with tanshinone] affects the expression of MYC protein; WAY-262611 affects the reaction [[Doxorubicin co-treated with tanshinone] affects the expression of MYC protein]		 CTD PMID:16009009 PMID:18344322 PMID:21699893 PMID:32886829 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myl1 myosin, light chain 1 increases expression ISO tanshinone results in increased expression of MYL1 mRNA CTD PMID:15849732 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261 		JBrowse link
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit increases expression ISO tanshinone results in increased expression of NAA10 mRNA CTD PMID:15849732 NCBI chr  X:151,656,056...151,661,304
Ensembl chr  X:151,656,056...151,661,252 		JBrowse link
G Nanog Nanog homeobox multiple interactions
increases expression		 EXP
ISO		 tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of NANOG protein]
tanshinone results in increased expression of NANOG mRNA		 CTD PMID:25186638 PMID:31108107 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 increases expression ISO tanshinone results in increased expression of NDUFB2 mRNA CTD PMID:15849732 NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
Ensembl chr 4:46,536,062...46,536,851 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 increases expression ISO tanshinone results in increased expression of NDUFV1 mRNA CTD PMID:15849732 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466 		JBrowse link
G Nes nestin decreases expression ISO tanshinone results in decreased expression of NES mRNA; tanshinone results in decreased expression of NES protein CTD PMID:16955220 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NFE2L2 protein]
[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA; [tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 protein; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC2 protein]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of ABCC4 protein]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[tanshinone co-treated with Acetaminophen] results in increased expression of NFE2L2 protein]; tanshinone promotes the reaction [Acetaminophen results in increased expression of NFE2L2 mRNA]		 CTD PMID:32097614 PMID:35243748 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein]
tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]		 CTD PMID:29906494 PMID:30268796 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] CTD PMID:23500011 PMID:24239652 PMID:29906494 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions		 ISO
EXP		 tanshinone results in increased expression of NOS3 mRNA
tanshinone inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein]		 CTD PMID:15849732 PMID:28985491 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nppb natriuretic peptide B decreases expression ISO tanshinone results in decreased expression of NPPB protein CTD PMID:37643320 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO tanshinone promotes the reaction [Silicon Dioxide results in increased expression of NQO1 protein] CTD PMID:32097614 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO tanshinone results in increased activity of NR1I2 protein
NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein]		 CTD PMID:18805405 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] CTD PMID:18805405 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 decreases expression ISO tanshinone results in decreased expression of OLR1 mRNA; tanshinone results in decreased expression of OLR1 protein CTD PMID:22677363 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO [TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein] CTD PMID:26203587 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 increases expression ISO tanshinone results in increased expression of PARP4 mRNA CTD PMID:15849732 PMID:16955220 NCBI chr15:30,690,503...30,792,868
Ensembl chr15:30,686,613...30,828,810 		JBrowse link
G Pcsk7 proprotein convertase subtilisin/kexin type 7 increases expression ISO tanshinone results in increased expression of PCSK7 mRNA CTD PMID:15849732 NCBI chr 8:46,202,079...46,224,699
Ensembl chr 8:46,202,131...46,224,705 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression
multiple interactions		 EXP tanshinone results in increased expression of PHGDH mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in increased methylation of PHGDH promoter]		 CTD PMID:31108107 NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Fulvestrant inhibits the reaction [tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein]]; tanshinone inhibits the reaction [IGF2 protein mutant form results in decreased expression of PIK3R1 protein] CTD PMID:34655285 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 decreases expression ISO tanshinone results in decreased expression of PLOD2 mRNA CTD PMID:15849732 NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression
multiple interactions		 ISO
EXP		 tanshinone results in increased expression of POU5F1 mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of POU5F1 protein]		 CTD PMID:25186638 PMID:31108107 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO tanshinone results in decreased expression of PPARG mRNA CTD PMID:20854809 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions EXP [Fulvestrant co-treated with tanshinone] promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein]; tanshinone promotes the reaction [IGF2 protein mutant form results in increased expression of PPP3CA protein] CTD PMID:34655285 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 multiple interactions ISO [tetraarsenic tetrasulfide co-treated with indirubin co-treated with tanshinone] results in increased ubiquitination of and results in increased degradation of PRAM1 protein CTD PMID:18344322 NCBI chr 7:14,428,548...14,438,081
Ensembl chr 7:14,420,165...14,438,166 		JBrowse link
G Prpf6 pre-mRNA processing factor 6 decreases expression ISO tanshinone results in decreased expression of PRPF6 mRNA CTD PMID:15849732 NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression ISO tanshinone results in increased expression of PSMB5 mRNA CTD PMID:15849732 NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440 		JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 increases expression ISO tanshinone results in increased expression of PSMD2 mRNA CTD PMID:15849732 NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tanshinone inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]
tanshinone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]		 CTD PMID:22288910 PMID:23500011 PMID:24239652 PMID:24967690 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptprk protein tyrosine phosphatase, receptor type, K decreases expression ISO tanshinone results in decreased expression of PTPRK mRNA CTD PMID:15849732 NCBI chr 1:16,738,896...17,236,687
Ensembl chr 1:16,850,576...17,103,605 		JBrowse link
G Ptx3 pentraxin 3 decreases secretion
multiple interactions
decreases expression		 ISO tanshinone results in decreased secretion of PTX3 protein
tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein]
tanshinone results in decreased expression of PTX3 mRNA		 CTD PMID:30268796 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression
multiple interactions		 ISO tanshinone results in increased expression of RARB mRNA
[indirubin co-treated with tanshinone] promotes the reaction [tetraarsenic tetrasulfide results in increased expression of RARB mRNA]; [indirubin co-treated with tetraarsenic tetrasulfide] promotes the reaction [tanshinone results in increased expression of RARB mRNA]; [tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]; [tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]; indirubin promotes the reaction [[tetraarsenic tetrasulfide co-treated with tanshinone] inhibits the reaction [RARB protein binds to HDAC1 protein]]; tetraarsenic tetrasulfide promotes the reaction [[tanshinone co-treated with indirubin] inhibits the reaction [RARB protein binds to HDAC1 protein]]		 CTD PMID:18344322 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
increases expression		 ISO [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein; [indirubin co-treated with tanshinone co-treated with tetraarsenic tetrasulfide] results in increased phosphorylation of RB1 protein; [tanshinone co-treated with indirubin] results in increased expression of RB1 protein; [tanshinone co-treated with tetraarsenic tetrasulfide] results in increased expression of RB1 protein
tanshinone results in increased expression of RB1 protein		 CTD PMID:18344322 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein] CTD PMID:30268796 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoc ras homolog family member C increases expression ISO tanshinone results in increased expression of RHOC mRNA CTD PMID:15849732 NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306 		JBrowse link
G Sephs2 selenophosphate synthetase 2 increases expression ISO tanshinone results in increased expression of SEPHS2 mRNA CTD PMID:15849732 NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:181,892,599...181,895,497 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad7 SMAD family member 7 multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in decreased expression of SMAD7 protein] CTD PMID:32097614 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression
multiple interactions		 ISO
EXP		 tanshinone results in increased expression of SOX2 mRNA
tanshinone inhibits the reaction [Estrogens deficiency results in decreased expression of SOX2 protein]		 CTD PMID:25186638 PMID:31108107 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Sp2 Sp2 transcription factor decreases expression ISO tanshinone results in decreased expression of SP2 mRNA CTD PMID:15849732 NCBI chr10:81,940,580...81,970,040
Ensembl chr10:81,940,587...81,970,548 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP tanshinone inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein] CTD PMID:19356721 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO tanshinone inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein] CTD PMID:35304817 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tesk1 testis associated actin remodelling kinase 1 increases expression ISO tanshinone results in increased expression of TESK1 mRNA CTD PMID:15849732 NCBI chr 5:57,691,922...57,697,698
Ensembl chr 5:57,691,969...57,697,698 		JBrowse link
G Tfap4 transcription factor AP-4 decreases expression ISO tanshinone results in decreased expression of TFAP4 mRNA CTD PMID:15849732 NCBI chr10:11,001,338...11,019,386
Ensembl chr10:11,002,911...11,019,386 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]
tanshinone results in increased expression of TGFB1 protein		 CTD PMID:32097614 PMID:37643320 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO tanshinone results in increased expression of TK1 mRNA CTD PMID:15849732 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tanshinone inhibits the reaction [TNF protein results in decreased expression of NFKBIA protein]; tanshinone inhibits the reaction [TNF protein results in increased expression of PTX3 mRNA]; tanshinone inhibits the reaction [TNF protein results in increased expression of RELA protein]; tanshinone inhibits the reaction [TNF protein results in increased secretion of PTX3 protein] CTD PMID:29906494 PMID:30268796 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance		 ISO [TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of DDIT3 protein; [TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; DDIT3 mutant form inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased expression of TNFRSF10B protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of CASP8 protein]; tanshinone promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [tanshinone results in increased cleavage of PARP1 protein]
tanshinone results in increased susceptibility to TNFSF10 protein		 CTD PMID:26203587 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression		 ISO tanshinone results in increased expression of TP53 protein
tanshinone results in decreased expression of TP53 protein		 CTD PMID:16009009 PMID:19885617 PMID:20369472 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO tanshinone results in increased expression of VEGFA mRNA; tanshinone results in increased expression of VEGFA protein CTD PMID:25186638 PMID:37643320 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions ISO NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]]; tanshinone inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:32097614 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wfdc2 WAP four-disulfide core domain 2 increases expression ISO tanshinone results in increased expression of WFDC2 mRNA CTD PMID:15849732 NCBI chr 3:153,286,946...153,314,832
Ensembl chr 3:153,286,131...153,292,807 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          antiviral agent 11069
            anticoronaviral agent 9658
              Tanshinone I 158
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            organic hydride 18669
                              organic fundamental parent 18669
                                hydrocarbon 18415
                                  terpene 14057
                                    terpenoid 13755
                                      diterpenoid 13024
                                        abietane diterpenoid 407
                                          Tanshinone I 158
paths to the root