Symbol:
Tfap4
Name:
transcription factor AP-4
RGD ID:
1308357
Description:
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human TFAP4 (transcription factor AP-4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
LOC360482; Tcfap4; transcription factor AP-4 (activating enhancer binding protein 4); transcription factor AP4
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 10 11,507,242 - 11,525,794 (+) NCBI GRCr8 mRatBN7.2 10 11,001,338 - 11,019,386 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 10 11,002,911 - 11,019,386 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 10 15,711,539 - 15,727,556 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 10 15,200,351 - 15,216,367 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 10 10,869,709 - 10,885,786 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 10 11,204,616 - 11,222,975 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 10 11,206,226 - 11,223,370 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 10 9,968,255 - 9,986,048 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 11,144,057 - 11,159,763 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 10 11,144,056 - 11,159,763 (+) NCBI Celera 10 9,964,931 - 9,979,711 (+) NCBI Celera Cytogenetic Map 10 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Molecular Function
DNA binding (IEA,ISO) DNA-binding transcription activator activity, RNA polymerase II-specific (IEA,ISO) DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA,ISO) E-box binding (IEA,ISO) histone deacetylase binding (IEA,ISO) protein binding (ISO) protein dimerization activity (IEA) protein homodimerization activity (IEA,ISO) RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA,ISO) sequence-specific DNA binding (IEA,ISO) sequence-specific double-stranded DNA binding (IEA,ISO) transcription cis-regulatory region binding (IEA,ISO)
Tfap4 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 10 11,507,242 - 11,525,794 (+) NCBI GRCr8 mRatBN7.2 10 11,001,338 - 11,019,386 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 10 11,002,911 - 11,019,386 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 10 15,711,539 - 15,727,556 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 10 15,200,351 - 15,216,367 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 10 10,869,709 - 10,885,786 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 10 11,204,616 - 11,222,975 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 10 11,206,226 - 11,223,370 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 10 9,968,255 - 9,986,048 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 11,144,057 - 11,159,763 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 10 11,144,056 - 11,159,763 (+) NCBI Celera 10 9,964,931 - 9,979,711 (+) NCBI Celera Cytogenetic Map 10 q12 NCBI
TFAP4 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 16 4,257,186 - 4,273,023 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 16 4,257,186 - 4,273,075 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 16 4,307,187 - 4,323,024 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 16 4,247,188 - 4,263,002 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 16 4,247,188 - 4,262,999 NCBI Celera 16 4,514,186 - 4,529,994 (-) NCBI Celera Cytogenetic Map 16 p13.3 NCBI HuRef 16 4,274,201 - 4,289,950 (-) NCBI HuRef CHM1_1 16 4,306,776 - 4,322,587 (-) NCBI CHM1_1 T2T-CHM13v2.0 16 4,284,515 - 4,300,348 (-) NCBI T2T-CHM13v2.0
Tfap4 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 16 4,362,525 - 4,378,625 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 16 4,362,525 - 4,377,718 (-) Ensembl GRCm39 Ensembl GRCm38 16 4,544,661 - 4,560,762 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 16 4,544,661 - 4,559,854 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 16 4,544,661 - 4,559,720 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 16 4,459,889 - 4,474,948 (-) NCBI MGSCv36 mm8 Celera 16 5,172,967 - 5,188,068 (-) NCBI Celera Cytogenetic Map 16 A1 NCBI cM Map 16 2.45 NCBI
Tfap4 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955442 13,160,450 - 13,175,057 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955442 13,160,467 - 13,174,288 (+) NCBI ChiLan1.0 ChiLan1.0
TFAP4 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 18 4,780,566 - 4,830,819 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 16 8,564,889 - 8,615,240 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 16 3,176,129 - 3,226,404 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 16 4,348,066 - 4,394,809 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 16 4,348,929 - 4,368,525 (-) Ensembl panpan1.1 panPan2
TFAP4 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 6 37,075,462 - 37,111,039 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 6 37,097,786 - 37,111,072 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 6 38,403,673 - 38,439,255 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 6 37,279,975 - 37,315,672 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 6 37,302,967 - 37,315,669 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 6 37,073,932 - 37,109,475 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 6 36,967,095 - 37,002,646 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 6 37,368,408 - 37,404,234 (+) NCBI UU_Cfam_GSD_1.0
Tfap4
TFAP4
TFAP4 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 5 3,931,288 - 3,960,039 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 5 3,932,149 - 3,954,486 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666068 26,695,606 - 26,761,798 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Tfap4
.
Predicted Target Of
Count of predictions: 158 Count of miRNA genes: 99 Interacting mature miRNAs: 119 Transcripts: ENSRNOT00000006979 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
2313095 Bss62 Bone structure and strength QTL 62 1.5 0.0001 tibia size trait (VT:0100001) tibia midshaft cross-sectional area (CMO:0001717) 10 5387014 50387014 Rat 631660 Hcar1 Hepatocarcinoma resistance QTL 1 3.4 0.0001 liver integrity trait (VT:0010547) volume of individual liver tumorous lesion (CMO:0001078) 10 6154182 15990232 Rat 1576304 Schws7 Schwannoma susceptibility QTL 7 0.0115 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 10 4765527 19816042 Rat 8662860 Vetf10 Vascular elastic tissue fragility QTL 10 artery integrity trait (VT:0010639) number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562) 10 6154182 73453136 Rat 2313066 Bss63 Bone structure and strength QTL 63 1.4 0.0001 tibia strength trait (VT:1000284) bone polar moment of inertia (CMO:0001558) 10 5387014 50387014 Rat 7411611 Foco17 Food consumption QTL 17 18.7 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 10 1 42315980 Rat 631554 Bp133 Blood pressure QTL 133 0.005 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 743364 63851208 Rat 2313064 Bmd71 Bone mineral density QTL 71 0.9 0.0001 tibia mineral mass (VT:1000283) compact volumetric bone mineral density (CMO:0001730) 10 5387014 50387014 Rat 2303118 Mamtr7 Mammary tumor resistance QTL 7 0.003 mammary gland integrity trait (VT:0010552) mammary tumor growth rate (CMO:0000344) 10 9658275 104670812 Rat 70223 Bp57 Blood pressure QTL 57 5 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 10 1 80676123 Rat 634329 Pia15 Pristane induced arthritis QTL 15 3.1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 1 24158324 Rat 1578761 Stresp21 Stress response QTL 21 3.3 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 10 6375746 51375746 Rat 2293680 Bss40 Bone structure and strength QTL 40 5.66 0.0001 femur strength trait (VT:0010010) femur total energy absorbed before break (CMO:0001677) 10 1 35225947 Rat 7387235 Uae41 Urinary albumin excretion QTL 41 5.26 0.1874 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 10 1 29497586 Rat 2313104 Bss61 Bone structure and strength QTL 61 0.9 0.0001 tibia area (VT:1000281) tibia midshaft cross-sectional area (CMO:0001717) 10 5387014 50387014 Rat 2298544 Neuinf9 Neuroinflammation QTL 9 4.6 nervous system integrity trait (VT:0010566) spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126) 10 5801990 62146030 Rat 61427 Cia16 Collagen induced arthritis QTL 16 3.2 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 10 6357896 96121100 Rat 10401803 Kidm50 Kidney mass QTL 50 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 10 418344 45418344 Rat 737820 Alc9 Alcohol consumption QTL 9 2.2 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) 10 5144027 19233348 Rat 2313081 Bss64 Bone structure and strength QTL 64 1.3 0.0001 tibia strength trait (VT:1000284) tibia total energy absorbed before break (CMO:0001736) 10 5387014 50387014 Rat 631828 Alc5 Alcohol consumption QTL 5 2.4 consumption behavior trait (VT:0002069) ethanol drink intake rate (CMO:0001407) 10 5144027 17245662 Rat 634327 Hc4 Hypercalciuria QTL 4 2.4 urine calcium amount (VT:0002985) urine calcium excretion rate (CMO:0000763) 10 1 38328221 Rat
AI101186
Rat Assembly Chr Position (strand) Source JBrowse GRCr8 10 11,525,533 - 11,525,767 (+) Marker Load Pipeline mRatBN7.2 10 11,019,125 - 11,019,359 (+) MAPPER mRatBN7.2 Rnor_6.0 10 11,222,715 - 11,222,948 NCBI Rnor6.0 Rnor_5.0 10 9,985,788 - 9,986,021 UniSTS Rnor5.0 RGSC_v3.4 10 11,159,503 - 11,159,736 UniSTS RGSC3.4 Celera 10 9,979,450 - 9,979,684 UniSTS RH 3.4 Map 9 675.6 UniSTS Cytogenetic Map 10 q12 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000006979 ⟹ ENSRNOP00000006979
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 10 11,002,911 - 11,019,386 (+) Ensembl Rnor_6.0 Ensembl 10 11,206,226 - 11,223,370 (+) Ensembl
RefSeq Acc Id:
NM_001108267 ⟹ NP_001101737
RefSeq Status:
PROVISIONAL
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 11,509,321 - 11,525,794 (+) NCBI mRatBN7.2 10 11,002,911 - 11,019,386 (+) NCBI Rnor_6.0 10 11,206,104 - 11,222,975 (+) NCBI Rnor_5.0 10 9,968,255 - 9,986,048 (+) NCBI RGSC_v3.4 10 11,144,057 - 11,159,763 (+) RGD Celera 10 9,964,931 - 9,979,711 (+) RGD
Sequence:
GCCCGGGGAGGCAGGCTGGAGAGACCTCCCTCCCGCCCCTCCCGCCCGCCTCCCTCCCCTCGCCGCTGCTGCTGCCGCCAGCATCTGGGACCGGCCGATTCTGCACCTCCGTCCGGCGCTGCCCTTTG
hide sequence
RefSeq Acc Id:
XM_006245819 ⟹ XP_006245881
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 11,507,242 - 11,525,793 (+) NCBI mRatBN7.2 10 11,001,338 - 11,019,385 (+) NCBI Rnor_6.0 10 11,204,616 - 11,222,974 (+) NCBI Rnor_5.0 10 9,968,255 - 9,986,048 (+) NCBI
Sequence:
CTAGGAAGTGCTGCTTTTCAAGTCTCCCTGAGAATTAGGTGCTAACTGATCTGGGATCTAAGATTAGAGAAATTGCTTATCAGGTTGATCTGAAGATTGACCAATATGAGCGCAAAACTAACTAGCCA
hide sequence
RefSeq Acc Id:
XM_006245822 ⟹ XP_006245884
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 11,510,384 - 11,525,793 (+) NCBI mRatBN7.2 10 11,003,972 - 11,019,385 (+) NCBI Rnor_6.0 10 11,207,157 - 11,222,974 (+) NCBI Rnor_5.0 10 9,968,255 - 9,986,048 (+) NCBI
Sequence:
GCTGCATTGTGGGACTTGTAGGCGCTTCGGGGCCACGCTTTACTTGCACAAAGCTTGGTCGTAG
hide sequence
RefSeq Acc Id:
XM_006245823 ⟹ XP_006245885
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 11,515,230 - 11,525,793 (+) NCBI mRatBN7.2 10 11,009,542 - 11,019,385 (+) NCBI Rnor_6.0 10 11,213,107 - 11,222,974 (+) NCBI Rnor_5.0 10 9,968,255 - 9,986,048 (+) NCBI
Sequence:
CCAGGGCCTTGCGCTTCCTAAGCAATCGCTCTACCATTGAGCTAAATCCCCAACCCCTAGGGTAGCTCTTGAAGTAGCCTAAGGGTGGTTACAAGGCTTTCTCTTGAGACCCAGTCTTCGGTCAGTTT
hide sequence
RefSeq Acc Id:
XM_017597365 ⟹ XP_017452854
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 11,510,084 - 11,525,793 (+) NCBI mRatBN7.2 10 11,003,239 - 11,019,385 (+) NCBI Rnor_6.0 10 11,206,448 - 11,222,974 (+) NCBI
Sequence:
GCCCGGGCGGGTGCGCGTGTGCGCACGCATGGCTCGCGCCTCCGACCTCGCTCGCCTTTCTTAG
hide sequence
RefSeq Acc Id:
XM_039086267 ⟹ XP_038942195
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 11,507,242 - 11,525,793 (+) NCBI mRatBN7.2 10 11,001,979 - 11,019,385 (+) NCBI
RefSeq Acc Id:
XM_039086268 ⟹ XP_038942196
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 10 11,515,230 - 11,525,793 (+) NCBI mRatBN7.2 10 11,009,543 - 11,019,385 (+) NCBI
RefSeq Acc Id:
NP_001101737 ⟸ NM_001108267
- UniProtKB:
D3ZJT6 (UniProtKB/TrEMBL), A6K4S7 (UniProtKB/TrEMBL)
- Sequence:
MEYFMVPTQKVPSLQHFRKTEKEVIGGLCSLANIPLTPETQRDQERRIRREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRR
hide sequence
RefSeq Acc Id:
XP_006245881 ⟸ XM_006245819
- Peptide Label:
isoform X2
- Sequence:
MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDLRREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKL
hide sequence
RefSeq Acc Id:
XP_006245884 ⟸ XM_006245822
- Peptide Label:
isoform X2
- Sequence:
MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSS
hide sequence
RefSeq Acc Id:
XP_006245885 ⟸ XM_006245823
- Peptide Label:
isoform X2
- Sequence:
MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSSPKRRRAEDKDEGIGSPDIWEDEKAEDLRREMIELRQQLDKERSVRMMLEEQVRSLEAHMYPEKL
hide sequence
RefSeq Acc Id:
XP_017452854 ⟸ XM_017597365
- Peptide Label:
isoform X2
- Sequence:
MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLEQEKTRLLQQNTQLKRFIQELSGSS
hide sequence
Ensembl Acc Id:
ENSRNOP00000006979 ⟸ ENSRNOT00000006979
RefSeq Acc Id:
XP_038942195 ⟸ XM_039086267
- Peptide Label:
isoform X1
RefSeq Acc Id:
XP_038942196 ⟸ XM_039086268
- Peptide Label:
isoform X2
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2011-06-09
Tfap4
transcription factor AP-4
Tcfap4
transcription factor AP4
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-04-30
Tcfap4
transcription factor AP4
Tcfap4_predicted
transcription factor AP4 (predicted)
'predicted' is removed
2292626 APPROVED
2006-03-30
Tcfap4_predicted
transcription factor AP4 (predicted)
Tfap4_predicted
transcription factor AP-4 (activating enhancer binding protein 4) (predicted)
Symbol and Name updated
1299863 APPROVED
2005-01-12
Tfap4_predicted
transcription factor AP-4 (activating enhancer binding protein 4) (predicted)
Symbol and Name status set to approved
70820 APPROVED
