Tfap4 (transcription factor AP-4) - Rat Genome Database

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Gene: Tfap4 (transcription factor AP-4) Rattus norvegicus
Analyze
Symbol: Tfap4
Name: transcription factor AP-4
RGD ID: 1308357
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of macromolecule metabolic process; and regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human TFAP4 (transcription factor AP-4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC360482; Tcfap4; transcription factor AP-4 (activating enhancer binding protein 4); transcription factor AP4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,507,242 - 11,525,794 (+)NCBIGRCr8
mRatBN7.21011,001,338 - 11,019,386 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,002,911 - 11,019,386 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,711,539 - 15,727,556 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,200,351 - 15,216,367 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,869,709 - 10,885,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,204,616 - 11,222,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,206,226 - 11,223,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,968,255 - 9,986,048 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,144,057 - 11,159,763 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11011,144,056 - 11,159,763 (+)NCBI
Celera109,964,931 - 9,979,711 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2123466   PMID:2833704   PMID:7933101   PMID:9931457   PMID:11171123   PMID:12663744   PMID:14645924   PMID:15944155   PMID:16540471   PMID:16924111   PMID:18818310   PMID:19505873  


Genomics

Comparative Map Data
Tfap4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,507,242 - 11,525,794 (+)NCBIGRCr8
mRatBN7.21011,001,338 - 11,019,386 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,002,911 - 11,019,386 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,711,539 - 15,727,556 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,200,351 - 15,216,367 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,869,709 - 10,885,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,204,616 - 11,222,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,206,226 - 11,223,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,968,255 - 9,986,048 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,144,057 - 11,159,763 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11011,144,056 - 11,159,763 (+)NCBI
Celera109,964,931 - 9,979,711 (+)NCBICelera
Cytogenetic Map10q12NCBI
TFAP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38164,257,186 - 4,273,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl164,257,186 - 4,273,075 (-)EnsemblGRCh38hg38GRCh38
GRCh37164,307,187 - 4,323,024 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,247,188 - 4,263,002 (-)NCBINCBI36Build 36hg18NCBI36
Build 34164,247,188 - 4,262,999NCBI
Celera164,514,186 - 4,529,994 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef164,274,201 - 4,289,950 (-)NCBIHuRef
CHM1_1164,306,776 - 4,322,587 (-)NCBICHM1_1
T2T-CHM13v2.0164,284,515 - 4,300,348 (-)NCBIT2T-CHM13v2.0
Tfap4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,362,525 - 4,378,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,362,525 - 4,377,718 (-)EnsemblGRCm39 Ensembl
GRCm38164,544,661 - 4,560,762 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,544,661 - 4,559,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv37164,544,661 - 4,559,720 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,459,889 - 4,474,948 (-)NCBIMGSCv36mm8
Celera165,172,967 - 5,188,068 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.45NCBI
Tfap4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544213,160,450 - 13,175,057 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544213,160,467 - 13,174,288 (+)NCBIChiLan1.0ChiLan1.0
TFAP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2184,780,566 - 4,830,819 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1168,564,889 - 8,615,240 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0163,176,129 - 3,226,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1164,348,066 - 4,394,809 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl164,348,929 - 4,368,525 (-)Ensemblpanpan1.1panPan2
TFAP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1637,075,462 - 37,111,039 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl637,097,786 - 37,111,072 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha638,403,673 - 38,439,255 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0637,279,975 - 37,315,672 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl637,302,967 - 37,315,669 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1637,073,932 - 37,109,475 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0636,967,095 - 37,002,646 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0637,368,408 - 37,404,234 (+)NCBIUU_Cfam_GSD_1.0
Tfap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344106,486,934 - 106,527,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936694210,672 - 222,619 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936694210,863 - 222,531 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFAP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl338,050,308 - 38,060,817 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1338,043,735 - 38,060,820 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TFAP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.153,931,288 - 3,960,039 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl53,932,149 - 3,954,486 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606826,695,606 - 26,761,798 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfap4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248242,044,235 - 2,058,662 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248242,044,322 - 2,105,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tfap4
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:99
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000006979
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat

Markers in Region
AI101186  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21011,019,125 - 11,019,359 (+)MAPPERmRatBN7.2
Rnor_6.01011,222,715 - 11,222,948NCBIRnor6.0
Rnor_5.0109,985,788 - 9,986,021UniSTSRnor5.0
RGSC_v3.41011,159,503 - 11,159,736UniSTSRGSC3.4
Celera109,979,450 - 9,979,684UniSTS
RH 3.4 Map9675.6UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006979   ⟹   ENSRNOP00000006979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1011,002,911 - 11,019,386 (+)Ensembl
Rnor_6.0 Ensembl1011,206,226 - 11,223,370 (+)Ensembl
RefSeq Acc Id: NM_001108267   ⟹   NP_001101737
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,509,321 - 11,525,794 (+)NCBI
mRatBN7.21011,002,911 - 11,019,386 (+)NCBI
Rnor_6.01011,206,104 - 11,222,975 (+)NCBI
Rnor_5.0109,968,255 - 9,986,048 (+)NCBI
RGSC_v3.41011,144,057 - 11,159,763 (+)RGD
Celera109,964,931 - 9,979,711 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245819   ⟹   XP_006245881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,507,242 - 11,525,793 (+)NCBI
mRatBN7.21011,001,338 - 11,019,385 (+)NCBI
Rnor_6.01011,204,616 - 11,222,974 (+)NCBI
Rnor_5.0109,968,255 - 9,986,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245822   ⟹   XP_006245884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,510,384 - 11,525,793 (+)NCBI
mRatBN7.21011,003,972 - 11,019,385 (+)NCBI
Rnor_6.01011,207,157 - 11,222,974 (+)NCBI
Rnor_5.0109,968,255 - 9,986,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245823   ⟹   XP_006245885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,515,230 - 11,525,793 (+)NCBI
mRatBN7.21011,009,542 - 11,019,385 (+)NCBI
Rnor_6.01011,213,107 - 11,222,974 (+)NCBI
Rnor_5.0109,968,255 - 9,986,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597365   ⟹   XP_017452854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,510,084 - 11,525,793 (+)NCBI
mRatBN7.21011,003,239 - 11,019,385 (+)NCBI
Rnor_6.01011,206,448 - 11,222,974 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086267   ⟹   XP_038942195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,507,242 - 11,525,793 (+)NCBI
mRatBN7.21011,001,979 - 11,019,385 (+)NCBI
RefSeq Acc Id: XM_039086268   ⟹   XP_038942196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81011,515,230 - 11,525,793 (+)NCBI
mRatBN7.21011,009,543 - 11,019,385 (+)NCBI
RefSeq Acc Id: NP_001101737   ⟸   NM_001108267
- UniProtKB: D3ZJT6 (UniProtKB/TrEMBL),   A6K4S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245881   ⟸   XM_006245819
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006245884   ⟸   XM_006245822
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006245885   ⟸   XM_006245823
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452854   ⟸   XM_017597365
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000006979   ⟸   ENSRNOT00000006979
RefSeq Acc Id: XP_038942195   ⟸   XM_039086267
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038942196   ⟸   XM_039086268
- Peptide Label: isoform X2
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJT6-F1-model_v2 AlphaFold D3ZJT6 1-338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308357 AgrOrtholog
BioCyc Gene G2FUF-26028 BioCyc
Ensembl Genes ENSRNOG00000005227 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006979.8 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro HLH_DNA-bd UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Max-like/E-box_TFs UniProtKB/TrEMBL
KEGG Report rno:360482 UniProtKB/TrEMBL
NCBI Gene 360482 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR AP-4 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PhenoGen Tfap4 PhenoGen
PROSITE HLH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005227 RatGTEx
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
UniProt A6K4S7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJT6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-09 Tfap4  transcription factor AP-4  Tcfap4  transcription factor AP4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tcfap4  transcription factor AP4   Tcfap4_predicted  transcription factor AP4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tcfap4_predicted  transcription factor AP4 (predicted)  Tfap4_predicted  transcription factor AP-4 (activating enhancer binding protein 4) (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Tfap4_predicted  transcription factor AP-4 (activating enhancer binding protein 4) (predicted)      Symbol and Name status set to approved 70820 APPROVED