Tfap4 (transcription factor AP-4) - Rat Genome Database

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Gene: Tfap4 (transcription factor AP-4) Heterocephalus glaber
Analyze
Symbol: Tfap4
Name: transcription factor AP-4
RGD ID: 18917944
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); E-box binding (ortholog); histone deacetylase binding (ortholog); INVOLVED IN DNA damage response, signal transduction by p53 class mediator (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of cyclin-dependent protein serine/threonine kinase activity (ortholog); ASSOCIATED WITH epilepsy (ortholog); Idiopathic Generalized Epilepsy (ortholog); intellectual disability (ortholog); FOUND IN mitochondrion (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248242,044,235 - 2,058,662 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248242,044,322 - 2,105,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tfap4Naked Mole-Ratepilepsy  ISOTFAP4 (Homo sapiens)8554872ClinVar Annotator: match by term: EpilepsyClinVarPMID:28492532
Tfap4Naked Mole-RatIdiopathic Generalized Epilepsy  ISOTFAP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Idiopathic generalized epilepsyClinVarPMID:28492532
Tfap4Naked Mole-Ratintellectual disability  ISOTFAP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and mildClinVar 
Tfap4Naked Mole-RatKohlschutter-Tonz syndrome  ISOTFAP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Amelocerebrohypohidrotic syndromeClinVarPMID:28492532
Tfap4Naked Mole-RatRubinstein-Taybi syndrome  ISOTFAP4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12114483 more ...
Tfap4Naked Mole-Ratshort-rib thoracic dysplasia 9 with or without polydactyly  ISOTFAP4 (Homo sapiens)8554872ClinVar Annotator: match by term: Saldino-Mainzer syndromeClinVarPMID:28492532


Biological Process
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tfap4Naked Mole-RatDNA damage response, signal transduction by p53 class mediator involved_inISOTFAP4 (Homo sapiens)9068941 PMID:18818310UniProtPMID:18818310
Tfap4Naked Mole-Ratnegative regulation of cell population proliferation involved_inISOTFAP4 (Homo sapiens)9068941 PMID:18818310UniProtPMID:18818310
Tfap4Naked Mole-Ratnegative regulation of cyclin-dependent protein serine/threonine kinase activity involved_inISOTFAP4 (Homo sapiens)9068941 PMID:18818310UniProtPMID:18818310
Tfap4Naked Mole-Ratnegative regulation of DNA-templated transcription involved_inISOTFAP4 (Homo sapiens)9068941 PMID:18818310UniProtPMID:18818310
Tfap4Naked Mole-Ratnegative regulation of DNA-templated transcription involved_inISOTFAP4 (Homo sapiens)9068941 PMID:16924111 more ...UniProtPMID:16924111 more ...
Tfap4Naked Mole-Ratpositive regulation of apoptotic process involved_inISOTFAP4 (Homo sapiens)9068941 PMID:18818310UniProtPMID:18818310
Tfap4Naked Mole-Ratpositive regulation of DNA-templated transcription involved_inISOTFAP4 (Homo sapiens)9068941 PMID:12663744UniProtPMID:12663744
Tfap4Naked Mole-Ratpositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOTfap4 (Mus musculus)9068941 PMID:15944155MGIPMID:15944155
Tfap4Naked Mole-Ratprotein-containing complex assembly involved_inISOTFAP4 (Homo sapiens)9068941 PMID:19505873UniProtPMID:19505873
Tfap4Naked Mole-Ratregulation of mitotic cell cycle phase transition involved_inISOTFAP4 (Homo sapiens)9068941 PMID:18818310UniProtPMID:18818310
Tfap4Naked Mole-Ratregulation of transcription by RNA polymerase II involved_inIEAPANTHER:PTN001438555150520179 TreeGrafterGO_REF:0000118
1 to 11 of 11 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tfap4Naked Mole-Ratmitochondrion located_inISOTFAP4 (Homo sapiens)9068941 HPAGO_REF:0000052
Tfap4Naked Mole-Ratnucleoplasm located_inISOTFAP4 (Homo sapiens)9068941 HPAGO_REF:0000052
Tfap4Naked Mole-Ratnucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
Tfap4Naked Mole-Ratnucleus located_inIEAPANTHER:PTN001438555150520179 TreeGrafterGO_REF:0000118
Tfap4Naked Mole-Ratnucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043

Molecular Function
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tfap4Naked Mole-RatDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
Tfap4Naked Mole-RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOTFAP4 (Homo sapiens)9068941 PMID:2833704ARUK-UCLPMID:2833704
Tfap4Naked Mole-RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOTfap4 (Mus musculus)9068941 PMID:15944155MGIPMID:15944155
Tfap4Naked Mole-RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAPANTHER:PTN001438555150520179 TreeGrafterGO_REF:0000118
Tfap4Naked Mole-RatE-box binding enablesISOTFAP4 (Homo sapiens)9068941 PMID:11171123 more ...UniProtPMID:11171123 more ...
Tfap4Naked Mole-Rathistone deacetylase binding enablesISOUniProtKB:O153799068941 PMID:16924111UniProtPMID:16924111
Tfap4Naked Mole-Rathistone deacetylase binding enablesISOUniProtKB:Q135479068941 PMID:16540471UniProtPMID:16540471
Tfap4Naked Mole-Ratprotein binding enablesISOUniProtKB:Q928769068941 PMID:32814053IntActPMID:32814053
Tfap4Naked Mole-Ratprotein binding enablesISOUniProtKB:P17568 more ...9068941 PMID:32296183IntActPMID:32296183
Tfap4Naked Mole-Ratprotein binding enablesISOUniProtKB:P04637 more ...9068941 PMID:19505873UniProtPMID:19505873
Tfap4Naked Mole-Ratprotein binding enablesISOUniProtKB:Q08379 more ...9068941 PMID:25416956IntActPMID:25416956
Tfap4Naked Mole-Ratprotein binding enablesISOUniProtKB:P550409068941 PMID:16924111IntActPMID:16924111
Tfap4Naked Mole-Ratprotein dimerization activity enablesIEAInterPro:IPR011598 and InterPro:IPR036638150520179 InterProGO_REF:0000002
Tfap4Naked Mole-Ratprotein homodimerization activity enablesISOUniProtKB:Q016649068941 PMID:2123466UniProtPMID:2123466
Tfap4Naked Mole-RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAPANTHER:PTN001438555150520179 TreeGrafterGO_REF:0000118
Tfap4Naked Mole-Ratsequence-specific DNA binding enablesISOTFAP4 (Homo sapiens)9068941 PMID:2123466UniProtPMID:2123466
Tfap4Naked Mole-Ratsequence-specific double-stranded DNA binding enablesISOTFAP4 (Homo sapiens)9068941 PMID:28473536ARUK-UCLPMID:28473536
Tfap4Naked Mole-Rattranscription cis-regulatory region binding enablesISOTFAP4 (Homo sapiens)9068941 PMID:14645924 more ...ARUK-UCLPMID:14645924 more ...
1 to 18 of 18 rows

PMID:21993625   PMID:22301074   PMID:30032202  



Tfap4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248242,044,235 - 2,058,662 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248242,044,322 - 2,105,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TFAP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38164,257,186 - 4,273,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl164,257,186 - 4,273,075 (-)EnsemblGRCh38hg38GRCh38
GRCh37164,307,187 - 4,323,024 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36164,247,188 - 4,263,002 (-)NCBINCBI36Build 36hg18NCBI36
Build 34164,247,188 - 4,262,999NCBI
Celera164,514,186 - 4,529,994 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef164,274,201 - 4,289,950 (-)NCBIHuRef
CHM1_1164,306,776 - 4,322,587 (-)NCBICHM1_1
T2T-CHM13v2.0164,284,515 - 4,300,348 (-)NCBIT2T-CHM13v2.0
Tfap4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,362,525 - 4,378,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,362,525 - 4,377,718 (-)EnsemblGRCm39 Ensembl
GRCm38164,544,661 - 4,560,762 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,544,661 - 4,559,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv37164,544,661 - 4,559,720 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,459,889 - 4,474,948 (-)NCBIMGSCv36mm8
Celera165,172,967 - 5,188,068 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.45NCBI
Tfap4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81011,507,242 - 11,525,794 (+)NCBIGRCr8
mRatBN7.21011,001,338 - 11,019,386 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1011,002,911 - 11,019,386 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,711,539 - 15,727,556 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01015,200,351 - 15,216,367 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,869,709 - 10,885,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01011,204,616 - 11,222,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1011,206,226 - 11,223,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,968,255 - 9,986,048 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41011,144,057 - 11,159,763 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11011,144,056 - 11,159,763 (+)NCBI
Celera109,964,931 - 9,979,711 (+)NCBICelera
Cytogenetic Map10q12NCBI
Tfap4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544213,160,450 - 13,175,057 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544213,160,467 - 13,174,288 (+)NCBIChiLan1.0ChiLan1.0
TFAP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2184,780,566 - 4,830,819 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1168,564,889 - 8,615,240 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0163,176,129 - 3,226,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1164,348,066 - 4,394,809 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl164,348,929 - 4,368,525 (-)Ensemblpanpan1.1panPan2
TFAP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1637,075,462 - 37,111,039 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl637,097,786 - 37,111,072 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha638,403,673 - 38,439,255 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0637,279,975 - 37,315,672 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl637,302,967 - 37,315,669 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1637,073,932 - 37,109,475 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0636,967,095 - 37,002,646 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0637,368,408 - 37,404,234 (+)NCBIUU_Cfam_GSD_1.0
Tfap4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344106,486,934 - 106,527,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936694210,672 - 222,619 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936694210,863 - 222,531 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFAP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl338,050,308 - 38,060,817 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1338,043,735 - 38,060,820 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TFAP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.153,931,288 - 3,960,039 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl53,932,149 - 3,954,486 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606826,695,606 - 26,761,798 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000019236   ⟹   ENSHGLP00000019046
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248242,044,235 - 2,058,662 (-)Ensembl
RefSeq Acc Id: XM_004864772   ⟹   XP_004864829
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248242,044,322 - 2,058,540 (-)NCBI
RefSeq Acc Id: XM_004864773   ⟹   XP_004864830
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248242,044,322 - 2,105,571 (-)NCBI
RefSeq Acc Id: XM_004864774   ⟹   XP_004864831
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248242,044,322 - 2,075,230 (-)NCBI
RefSeq Acc Id: XM_021244366   ⟹   XP_021100025
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248242,044,322 - 2,057,373 (-)NCBI
RefSeq Acc Id: XM_021244367   ⟹   XP_021100026
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248242,044,322 - 2,057,072 (-)NCBI
Protein RefSeqs XP_004864829 (Get FASTA)   NCBI Sequence Viewer  
  XP_004864830 (Get FASTA)   NCBI Sequence Viewer  
  XP_004864831 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100025 (Get FASTA)   NCBI Sequence Viewer  
  XP_021100026 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB15051 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019046
GenBank Protein JAO03283 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004864830   ⟸   XM_004864773
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RU36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004864831   ⟸   XM_004864774
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RU36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004864829   ⟸   XM_004864772
- Peptide Label: isoform X1
- UniProtKB: G5C0J0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100025   ⟸   XM_021244366
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RU36 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100026   ⟸   XM_021244367
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RU36 (UniProtKB/TrEMBL)



1 to 16 of 16 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000013646 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000019236 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Max-like/E-box_TFs UniProtKB/TrEMBL
KEGG Report hgl:101715683 UniProtKB/TrEMBL
NCBI Gene Tfap4 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR AP-4 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt A0AAX6RU36 ENTREZGENE, UniProtKB/TrEMBL
  G5C0J0 ENTREZGENE, UniProtKB/TrEMBL
1 to 16 of 16 rows