Gene: Gba (glucosylceramidase beta) Rattus norvegicus
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Symbol: Gba
Name: glucosylceramidase beta
Description: ENCODES a protein that exhibits glucosylceramidase activity; glucosyltransferase activity (ortholog); hydrolase activity (ortholog); INVOLVED IN beta-glucoside catabolic process; regulation of water loss via skin; response to dexamethasone; PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; ASSOCIATED WITH ARC syndrome (ortholog); cerebrotendinous xanthomatosis (ortholog); dementia (ortholog); FOUND IN lysosome; endoplasmic reticulum (ortholog); extracellular space (ortholog); INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 3,3',5-triiodo-L-thyronine; acrylamide
AGR Description: Exhibits glucosylceramidase activity; involved in several processes, including beta-glucoside catabolic process, regulation of water loss via skin, and response to dexamethasone; localizes to the lysosome; orthologous to human GBA (glucosylceramidase beta).
Merged Description: Exhibits glucosylceramidase activity; involved in several processes, including beta-glucoside catabolic process, regulation of water loss via skin, and response to dexamethasone; localizes to the lysosome; orthologous to human GBA (glucosylceramidase beta); PARTICIPATES IN Fabry disease pathway; Gaucher's disease pathway; Krabbe disease pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 3,3',5-triiodo-L-thyronine; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: glucocerebrosidase; glucosidase, beta, acid; glucosylceramidase; LOC684536; MGC188451; similar to Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase)
Orthologs:
Homo sapiens (human) : GBA (glucosylceramidase beta)  HGNC  Alliance
Mus musculus (house mouse) : Gba (glucosidase, beta, acid)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gba (glucosylceramidase beta)
Canis lupus familiaris (dog) : GBA (glucosylceramidase beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gba (glucosylceramidase beta)
Sus scrofa (pig) : GBA (glucosylceramidase beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02188,511,781 - 188,522,602 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02207,931,042 - 207,937,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2168,551,737 - 168,557,757 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Gba
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1589149
Created: 2006-11-19
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.