epoxy steroid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	epoxy steroid	go back to main search page
Accession:	CHEBI:145217	browse the term
Definition:	Any steroid whose structure includes an epoxy group.
Synonyms:	related_synonym:	epoxy-steroids

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Rat (143) Mouse (143) Human (143) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (143)

24(S),25-epoxycholesterol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1, group H, member 3

increases expression

24(S),25-epoxycholesterol increases expression of NR1H3 mRNA in macrophages

RGD

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

5,6alpha-epoxy-5alpha-cholestan-3beta-ol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

epidermal growth factor receptor

increases phosphorylation

cholesterol alpha-oxide results in increased phosphorylation of EGFR protein

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

epoxide hydrolase 1

increases metabolic processing
multiple interactions

EPHX1 protein results in increased metabolism of cholesterol alpha-oxide
disparlure promotes the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]; Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

epoxide hydrolase 2

multiple interactions

cholesterol alpha-oxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog]

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 2

increases expression

cholesterol alpha-oxide results in increased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

increases expression

cholesterol alpha-oxide results in increased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mechanistic target of rapamycin kinase

increases phosphorylation
multiple interactions

cholesterol alpha-oxide results in increased phosphorylation of MTOR protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

bufogenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression
multiple interactions
increases metabolic processing
increases activity

bufogenin results in increased expression of CYP3A4 mRNA
bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin]
bufogenin results in increased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

eplerenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

angiotensinogen

multiple interactions

eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

catalase

increases expression

eplerenone results in increased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cd80 molecule

multiple interactions

Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA]

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

cadherin 1

multiple interactions

eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

collagen type I alpha 1 chain

multiple interactions

Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

multiple interactions

Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA]

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

multiple interactions
decreases expression

[eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]
eplerenone results in decreased expression of COL4A1 mRNA; eplerenone results in decreased expression of COL4A1 protein

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

cytochrome b-245 alpha chain

decreases expression
multiple interactions

eplerenone results in decreased expression of CYBA mRNA
[trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases abundance
increases metabolic processing

CYP3A4 protein results in increased abundance of Eplerenone metabolite
CYP3A4 protein results in increased metabolism of Eplerenone

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases abundance
increases metabolic processing

CYP3A5 protein results in increased abundance of Eplerenone metabolite
CYP3A5 protein results in increased metabolism of Eplerenone

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

fibronectin 1

multiple interactions

[trandolapril co-treated with eplerenone] results in decreased expression of FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

interleukin 18

multiple interactions

eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

decreases expression

eplerenone decreases expression of protein in hippocampus of post-surgical rats

RGD

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

decreases expression

eplerenone decreases expression of protein in hippocampus of post-surgical rats

RGD

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

multiple interactions

eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

neutrophil cytosolic factor 1

decreases expression
multiple interactions

eplerenone results in decreased expression of NCF1 mRNA; eplerenone results in decreased expression of NCF1 protein
[trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

nitric oxide synthase 3

multiple interactions
increases activity
increases expression
decreases expression

[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA
eplerenone results in increased activity of NOS3 protein
eplerenone results in increased expression of NOS3 mRNA
Eplerenone results in decreased expression of NOS3 mRNA; Eplerenone results in decreased expression of NOS3 protein

PMID:15974890 PMID:20571278

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions
decreases expression

eplerenone binds to and results in decreased activity of NR3C2 protein
eplerenone decreases expression of protein in hippocampus of post-surgical rats

CTD
RGD

PMID:15974890 PMID:33390808

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

odd-skipped related transcription factor 1

multiple interactions

eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]

NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817

G

oxidative stress responsive kinase 1

multiple interactions

[eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of OXSR1 protein

NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027

G

serpin family E member 1

multiple interactions
decreases expression

[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
eplerenone results in decreased expression of SERPINE1 mRNA; eplerenone results in decreased expression of SERPINE1 protein

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 12 member 3

multiple interactions

[eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of SLC12A3 protein; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]

PMID:20175999 PMID:22949526

NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091

G

solute carrier family 9 member A1

multiple interactions

eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA]

NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624

G

snail family transcriptional repressor 1

multiple interactions

eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

superoxide dismutase 1

increases expression

eplerenone results in increased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression

eplerenone results in increased expression of SOD2 protein

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

serine threonine kinase 39

multiple interactions

[eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of STK39 protein

NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060

G

T-box transcription factor 1

decreases expression

Eplerenone decreases expression of Tbx1 mRNA and protein in infarcted heart

RGD

NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380

G

transforming growth factor, beta 1

multiple interactions
decreases expression

[Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]
eplerenone results in decreased expression of TGFB1 mRNA; eplerenone results in decreased expression of TGFB1 protein

PMID:18682491 PMID:27773435

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta induced

decreases secretion
multiple interactions

eplerenone results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

tumor necrosis factor

multiple interactions
decreases expression

Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA]
eplerenone decreases expression of protein in hippocampus of post-surgical rats

CTD
RGD

PMID:27773435 PMID:33390808

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

marinobufagenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

collagen type I alpha 1 chain

increases expression

marinobufagenin results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

microRNA 101a

decreases expression

marinobufagenin results in decreased expression of MIR101A mRNA

NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410

G

microRNA 106b

decreases expression

marinobufagenin results in decreased expression of MIR106B mRNA

NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425

G

microRNA 122

increases expression

marinobufagenin results in increased expression of MIR122 mRNA

NCBI chr18:58,758,703...58,758,787

G

microRNA 130a

decreases expression

marinobufagenin results in decreased expression of MIR130A mRNA

NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629

G

microRNA 140

decreases expression

marinobufagenin results in decreased expression of MIR140 mRNA

NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675

G

microRNA 141

decreases expression

marinobufagenin results in decreased expression of MIR141 mRNA

NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332

G

microRNA 142

decreases expression

marinobufagenin results in decreased expression of MIR142 mRNA

NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967

G

microRNA 144

decreases expression

marinobufagenin results in decreased expression of MIR144 mRNA

NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430

G

microRNA 185

decreases expression

marinobufagenin results in decreased expression of MIR185 mRNA

NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795

G

microRNA 18a

decreases expression

marinobufagenin results in decreased expression of MIR18A mRNA

NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860

G

microRNA 196a

decreases expression

marinobufagenin results in decreased expression of MIR196A mRNA

NCBI chr 7:134,110,400...134,110,509
Ensembl chr 7:134,110,400...134,110,509

G

microRNA 196b

decreases expression

marinobufagenin results in decreased expression of MIR196B mRNA

NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571

G

microRNA 210

decreases expression

marinobufagenin results in decreased expression of MIR210 mRNA

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

G

microRNA 222

decreases expression

marinobufagenin results in decreased expression of MIR222 mRNA

NCBI chr X:3,428,904...3,429,006
Ensembl chr X:3,428,904...3,429,006

G

microRNA 23a

increases expression

marinobufagenin results in increased expression of MIR23A mRNA

NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071

G

microRNA 29b-1

decreases expression

marinobufagenin results in decreased expression of MIR29B1 mRNA

NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067

G

microRNA 32

decreases expression

marinobufagenin results in decreased expression of MIR32 mRNA

NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152

G

microRNA 320a

decreases expression

marinobufagenin results in decreased expression of MIR320A mRNA

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

G

microRNA 322

increases expression

marinobufagenin results in increased expression of MIR322 mRNA

NCBI chr X:132,806,594...132,806,688
Ensembl chr X:132,806,594...132,806,688

G

microRNA 324

decreases expression

marinobufagenin results in decreased expression of MIR324 mRNA

NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766

G

microRNA 375

decreases expression

marinobufagenin results in decreased expression of MIR375 mRNA

NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985

G

microRNA 423

decreases expression

marinobufagenin results in decreased expression of MIR423 mRNA

NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226

G

microRNA 93

decreases expression

marinobufagenin results in decreased expression of MIR93 mRNA

NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221

G

microRNA 96

decreases expression

marinobufagenin results in decreased expression of MIR96 mRNA

NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516

trilostane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

multiple interactions

trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

caspase 3

multiple interactions

trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

estrogen receptor 2

increases expression

trilostane results in increased expression of ESR2 mRNA

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

fibroblast growth factor 9

multiple interactions

FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone]

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

follicle stimulating hormone subunit beta

multiple interactions

[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases activity

trilostane results in decreased activity of HSD3B2 protein

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3

increases expression

trilostane results in increased expression of HSD3B3 mRNA

NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033

G

insulin-like growth factor 1

multiple interactions

[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

proopiomelanocortin

decreases expression

trilostane results in decreased expression of POMC protein

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

presenilin 1

multiple interactions

trilostane inhibits the reaction [Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]]

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

withaferin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetyl-CoA carboxylase alpha

multiple interactions

withaferin A promotes the reaction [Ethanol results in decreased expression of ACACA mRNA]

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

ADAM metallopeptidase domain 17

multiple interactions

withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]

NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639

G

AKT serine/threonine kinase 1

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

arachidonate 15-lipoxygenase

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased activity of ALOX15 protein]

NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874

G

activating transcription factor 4

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

BCL2-associated agonist of cell death

multiple interactions

withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

withaferin A results in decreased expression of BCL2 protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of BCL2 protein]

PMID:20438634 PMID:21256832 PMID:21964475 PMID:35734936

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA]

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 11

decreases expression
multiple interactions

withaferin A results in decreased expression of BCL2L11 protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BCL2L11 protein]

PMID:20438634 PMID:35734936

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

caspase 3

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 protein]
withaferin A inhibits the reaction [Elements, Radioactive results in increased activity of CASP3 protein]

PMID:35734936 PMID:36716864

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
increases expression

withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased activity of CAT protein]
withaferin A results in increased expression of CAT protein

PMID:35734936 PMID:36716864

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

affects binding
increases expression
multiple interactions

withaferin A binds to CDKN1A protein
withaferin A results in increased expression of CDKN1A mRNA
withaferin A results in increased expression of and affects the localization of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CDKN2A interacting protein

decreases expression

withaferin A results in decreased expression of CDKN2AIP protein

NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033

G

claudin 1

decreases response to substance
decreases expression

CLDN1 protein results in decreased susceptibility to withaferin A
withaferin A results in decreased expression of CLDN1 mRNA; withaferin A results in decreased expression of CLDN1 protein

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

ceruloplasmin

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CP protein]

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carnitine palmitoyltransferase 1c

multiple interactions

withaferin A inhibits the reaction [Ethanol results in decreased expression of CPT1C mRNA]

NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342

G

C-reactive protein

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CRP protein]

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

DNA-damage inducible transcript 3

affects response to substance
increases expression
multiple interactions

DDIT3 mRNA affects the susceptibility to withaferin A
withaferin A results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein]

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DNA methyltransferase 1

decreases expression

withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

decreases expression

withaferin A results in decreased expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

decreases expression

withaferin A results in decreased expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

EGF like repeats and discoidin domains 3

decreases expression

withaferin A results in decreased expression of EDIL3 mRNA

NCBI chr 2:19,890,396...20,405,028
Ensembl chr 2:19,890,373...20,405,008

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

multiple interactions

withaferin A promotes the reaction [Ethanol results in decreased expression of EHHADH mRNA]

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

eukaryotic translation initiation factor 2A

increases phosphorylation

withaferin A results in increased phosphorylation of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

ezrin

multiple interactions

[withanone co-treated with withaferin A] results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

Fas cell surface death receptor

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of FAS protein]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of FASN mRNA]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

FOS like 1, AP-1 transcription factor subunit

increases expression

withaferin A results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

withaferin A results in decreased expression of G6PC1 protein

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamic--pyruvic transaminase

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

multiple interactions

withaferin A binds to and affects the localization of GSR protein

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

histone deacetylase 1

decreases expression

withaferin A results in decreased expression of HDAC1 protein

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

heme oxygenase 1

increases expression

withaferin A results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein K

multiple interactions

[withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

G

heat shock transcription factor 1

increases activity

withaferin A results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family A (Hsp70) member 9

affects binding
multiple interactions

withaferin A binds to HSPA9 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]

PMID:22973447 PMID:25236891

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

interleukin 1 beta

multiple interactions

withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:24632454 PMID:37467946

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein]
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 protein]

PMID:20438634 PMID:35734936

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

keratin 13

decreases expression

withaferin A results in decreased expression of KRT13 mRNA

NCBI chr10:85,051,887...85,056,099
Ensembl chr10:85,051,889...85,056,084

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]

PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]

PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation

withaferin A results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
increases expression

MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
withaferin A results in increased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

methyl CpG binding protein 2

decreases expression

withaferin A results in decreased expression of MECP2 protein

NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689

G

matrix metallopeptidase 2

multiple interactions

[withanone co-treated with withaferin A] results in decreased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

myeloperoxidase

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

affects binding
increases phosphorylation

withaferin A binds to NFE2L2 protein
withaferin A results in increased phosphorylation of NFE2L2 protein

PMID:22973447 PMID:36716864

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of NQO1 mRNA]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

5' nucleotidase, ecto

increases expression

withaferin A results in increased expression of NT5E mRNA

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]

PMID:20438634 PMID:24019090

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

peroxiredoxin 2

increases expression

withaferin A results in increased expression of PRDX2 protein

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein C receptor

multiple interactions

withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]

NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903

G

prostaglandin-endoperoxide synthase 2

multiple interactions

withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

serpin family A member 6

decreases expression

withaferin A results in decreased expression of SERPINA6 protein

NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349

G

solute carrier organic anion transporter family, member 4a1

increases expression

withaferin A results in increased expression of SLCO4A1 mRNA

NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305

G

superoxide dismutase 2

multiple interactions
increases expression

SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]
withaferin A results in increased expression of SOD2 protein

PMID:24019090 PMID:36716864

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sterol regulatory element binding transcription factor 1

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

multiple interactions

withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF2 mRNA]

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

signal transducer and activator of transcription 1

multiple interactions

withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions

withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

tyrosine aminotransferase

decreases expression

withaferin A results in decreased expression of TAT protein

NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031

G

thiol methyltransferase 1A

decreases expression

withaferin A results in decreased expression of TMT1A mRNA

NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154

G

tumor necrosis factor

multiple interactions
decreases activity

withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
withaferin A results in decreased activity of TNF protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of TNF protein]

PMID:20438634 PMID:24632454 PMID:35734936 PMID:37467946

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

multiple interactions

withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

tumor protein p53

increases expression
multiple interactions
affects binding

withaferin A results in increased expression of TP53 mRNA
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
withaferin A binds to TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tubulin, alpha 1A

decreases expression

withaferin A results in decreased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, beta 5 class I

decreases expression

withaferin A results in decreased expression of TUBB mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

vascular endothelial growth factor A

multiple interactions
decreases expression

[withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
withaferin A results in decreased expression of VEGFA protein

PMID:20438634 PMID:25236891

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

X-box binding protein 1

increases expression
increases splicing

withaferin A results in increased expression of XBP1 protein
withaferin A results in increased splicing of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19808
chemical entity	19806
molecular entity	19806
main group molecular entity	19756
gas molecular entity	18421
oxirane	11263
epoxide	11262
epoxy steroid	143
(22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol	0
(24S,25)-epoxy-7alpha-hydroxycholesterol	0
(3beta,24R,24'R)-fucosterol epoxide	0
17alpha-hydroxywithaferin A	0
17alpha-hydroxywithanolide D	0
17alpha-sitoindoside IX	0
2,3-dihydro-3beta-O-sulfate withaferin A	0
2,3-dihydro-3beta-methoxy withaferin A	0
2,3-dihydrowithaferin A	0
20-hydroxytubocapsanolide A	0
23-hydroxytubocapsanolide A	0
24(S),25-epoxycholesterol	1
27-hydroxywithanone	0
3beta-hydroxy-16alpha,17alpha-epoxypregnenolone +	0
3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside	0
5,6alpha-epoxy-5alpha-cholestan-3beta-ol	8
5,6alpha-epoxy-5alpha-cholestane	0
5,6beta-epoxy-5alpha-cholestan-3beta-ol	0
7-deacetyl-7-benzoylepoxyazadiradione	0
9,11alpha-epoxypregn-4-ene-3,20-dione	0
astropectenol C	0
bufogenin	1
cholestanol 7alpha,8alpha-epoxide	0
cholesterol beta-epoxide	0
deacetyltanghinin	0
eplerenone	33
marinobufagenin	25
physalin F	0
resibufagenin	0
sitoindoside IX	0
tanghinigenin +	0
trilostane	9
tubocapsanolide A +	0
tubocapsanolide F	0
viscosalactone B	0
withaferin A +	79
withalongolide A	0
withalongolide B	0
withalongolide C	0
withalongolide D	0
withalongolide E	0
withalongolide G	0
withalongolide H	0
withanolide D +	0
withanone 27-O-beta-D-glucoside	0
Path 2
Term	Annotations
CHEBI ontology	19808
subatomic particle	19806
composite particle	19806
hadron	19806
baryon	19806
nucleon	19806
atomic nucleus	19806
atom	19806
main group element atom	19756
p-block element atom	19756
carbon group element atom	19705
carbon atom	19702
organic molecular entity	19702
organic molecule	19655
organic cyclic compound	19468
organic heterocyclic compound	18848
organic heteromonocyclic compound	17773
saturated organic heteromonocyclic parent	11283
oxirane	11263
epoxide	11262
epoxy steroid	143
(22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol	0
(24S,25)-epoxy-7alpha-hydroxycholesterol	0
(3beta,24R,24'R)-fucosterol epoxide	0
17alpha-hydroxywithaferin A	0
17alpha-hydroxywithanolide D	0
17alpha-sitoindoside IX	0
2,3-dihydro-3beta-O-sulfate withaferin A	0
2,3-dihydro-3beta-methoxy withaferin A	0
2,3-dihydrowithaferin A	0
20-hydroxytubocapsanolide A	0
23-hydroxytubocapsanolide A	0
24(S),25-epoxycholesterol	1
27-hydroxywithanone	0
3beta-hydroxy-16alpha,17alpha-epoxypregnenolone +	0
3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside	0
5,6alpha-epoxy-5alpha-cholestan-3beta-ol	8
5,6alpha-epoxy-5alpha-cholestane	0
5,6beta-epoxy-5alpha-cholestan-3beta-ol	0
7-deacetyl-7-benzoylepoxyazadiradione	0
9,11alpha-epoxypregn-4-ene-3,20-dione	0
astropectenol C	0
bufogenin	1
cholestanol 7alpha,8alpha-epoxide	0
cholesterol beta-epoxide	0
deacetyltanghinin	0
eplerenone	33
marinobufagenin	25
physalin F	0
resibufagenin	0
sitoindoside IX	0
tanghinigenin +	0
trilostane	9
tubocapsanolide A +	0
tubocapsanolide F	0
viscosalactone B	0
withaferin A +	79
withalongolide A	0
withalongolide B	0
withalongolide C	0
withalongolide D	0
withalongolide E	0
withalongolide G	0
withalongolide H	0
withanolide D +	0
withanone 27-O-beta-D-glucoside	0

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