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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trilostane
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Accession:CHEBI:32260 term browser browse the term
Definition:An epoxy steroid that is 3,17beta-dihydroxy-5alpha-androst-2-ene-2-carbonitrile in which the oxygen of the epoxy group is joined to the 4alpha and 5 alpha positions.
Synonyms:exact_synonym: 3,17beta-dihydroxy-4alpha,5-epoxy-5alpha-androst-2-ene-2-carbonitrile
 related_synonym: Formula=C20H27NO3;   InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1;   InChIKey=KVJXBPDAXMEYOA-CXANFOAXSA-N;   SMILES=[H][C@@]12CC[C@@]34O[C@@H]3C(O)=C(C[C@]4(C)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H])C#N;   trilostano;   trilostanum
 xref: CAS:13647-35-3;   DrugBank:DB01108;   Drug_Central:2746;   KEGG:D01180
 xref_mesh: MESH:C009954
 xref: Patent:US3296255;   VSDB:1891;   Wikipedia:Trilostane


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trilostane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]] CTD PMID:25461682 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Casp3 caspase 3 multiple interactions EXP trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]] CTD PMID:25461682 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO trilostane results in increased expression of ESR2 mRNA CTD PMID:20981412 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions ISO FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr15:38,341,657...38,386,945
Ensembl chr15:38,341,089...38,387,316
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO trilostane results in decreased activity of HSD3B2 protein CTD PMID:21558439 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 increases expression ISO trilostane results in increased expression of HSD3B3 mRNA CTD PMID:19117688 NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO trilostane results in decreased expression of POMC protein CTD PMID:19117688 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Psen1 presenilin 1 multiple interactions EXP trilostane inhibits the reaction [Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]] CTD PMID:25461682 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        pseudohalo group 2881
          cyano group 2881
            nitrile 2881
              trilostane 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteromonocyclic compound 16444
                                    saturated organic heteromonocyclic parent 5779
                                      oxirane 5746
                                        epoxide 5744
                                          epoxy steroid 108
                                            trilostane 9
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