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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:marinobufagenin
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Accession:CHEBI:146151 term browser browse the term
Definition:A cardiotonic steroid secreted by the toad Bufo rubescens and other related species such as Bufo marinus. An endogenous Na/K-ATPase inhibitor, it is a vasoconstrictor with effects similar to digitalis.
Synonyms:exact_synonym: 3beta,5-dihydroxy-5beta,15beta-14,15-epoxybufa-20,22-dienolide
 related_synonym: (3beta,5beta,14alpha,15beta)-3,5-dihydroxy-14,15-epoxybufa-20,22-dienolide;   Formula=C24H32O5;   InChI=1S/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1;   InChIKey=JMNQTHQLNRILMH-OBBGIPBRSA-N;   MBG;   Marinobufagin;   SMILES=[C@]12(CC[C@@H](C[C@]2(CC[C@]3([C@]45[C@](CC[C@]13[H])([C@H](C[C@H]4O5)C6=COC(C=C6)=O)C)[H])O)O)C
 xref: CAS:470-42-8
 xref_mesh: MESH:C093896
 xref: PDBeChem:P4S;   PMID:11877366;   PMID:15804527;   PMID:29853035;   PMID:29993282;   PMID:30382957;   PMID:30817774;   PMID:31236418;   PMID:31879340;   Wikipedia:Marinobufagenin



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marinobufagenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain increases expression EXP marinobufagenin results in increased expression of COL1A1 mRNA CTD PMID:26702050 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Mir101a microRNA 101a decreases expression EXP marinobufagenin results in decreased expression of MIR101A mRNA CTD PMID:26702050 NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410
JBrowse link
G Mir106b microRNA 106b decreases expression EXP marinobufagenin results in decreased expression of MIR106B mRNA CTD PMID:26702050 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425
JBrowse link
G Mir122 microRNA 122 increases expression EXP marinobufagenin results in increased expression of MIR122 mRNA CTD PMID:26702050 NCBI chr18:58,758,703...58,758,787 JBrowse link
G Mir130a microRNA 130a decreases expression EXP marinobufagenin results in decreased expression of MIR130A mRNA CTD PMID:26702050 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629
JBrowse link
G Mir140 microRNA 140 decreases expression EXP marinobufagenin results in decreased expression of MIR140 mRNA CTD PMID:26702050 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
JBrowse link
G Mir141 microRNA 141 decreases expression EXP marinobufagenin results in decreased expression of MIR141 mRNA CTD PMID:26702050 NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
JBrowse link
G Mir142 microRNA 142 decreases expression EXP marinobufagenin results in decreased expression of MIR142 mRNA CTD PMID:26702050 NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967
JBrowse link
G Mir144 microRNA 144 decreases expression EXP marinobufagenin results in decreased expression of MIR144 mRNA CTD PMID:26702050 NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430
JBrowse link
G Mir185 microRNA 185 decreases expression EXP marinobufagenin results in decreased expression of MIR185 mRNA CTD PMID:26702050 NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
JBrowse link
G Mir18a microRNA 18a decreases expression EXP marinobufagenin results in decreased expression of MIR18A mRNA CTD PMID:26702050 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
JBrowse link
G Mir196a microRNA 196a decreases expression EXP marinobufagenin results in decreased expression of MIR196A mRNA CTD PMID:26702050 NCBI chr 7:134,110,400...134,110,509
Ensembl chr 7:134,110,400...134,110,509
JBrowse link
G Mir196b microRNA 196b decreases expression EXP marinobufagenin results in decreased expression of MIR196B mRNA CTD PMID:26702050 NCBI chr 4:81,330,487...81,330,571
Ensembl chr 4:81,330,487...81,330,571
JBrowse link
G Mir210 microRNA 210 decreases expression EXP marinobufagenin results in decreased expression of MIR210 mRNA CTD PMID:26702050 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
JBrowse link
G Mir222 microRNA 222 decreases expression EXP marinobufagenin results in decreased expression of MIR222 mRNA CTD PMID:26702050 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006
JBrowse link
G Mir23a microRNA 23a increases expression EXP marinobufagenin results in increased expression of MIR23A mRNA CTD PMID:26702050 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071
JBrowse link
G Mir29b1 microRNA 29b-1 decreases expression EXP marinobufagenin results in decreased expression of MIR29B1 mRNA CTD PMID:26702050 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
JBrowse link
G Mir32 microRNA 32 decreases expression EXP marinobufagenin results in decreased expression of MIR32 mRNA CTD PMID:26702050 NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152
JBrowse link
G Mir320a microRNA 320a decreases expression EXP marinobufagenin results in decreased expression of MIR320A mRNA CTD PMID:26702050 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
JBrowse link
G Mir322 microRNA 322 increases expression EXP marinobufagenin results in increased expression of MIR322 mRNA CTD PMID:26702050 NCBI chr  X:132,806,594...132,806,688
Ensembl chr  X:132,806,594...132,806,688
JBrowse link
G Mir324 microRNA 324 decreases expression EXP marinobufagenin results in decreased expression of MIR324 mRNA CTD PMID:26702050 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766
JBrowse link
G Mir375 microRNA 375 decreases expression EXP marinobufagenin results in decreased expression of MIR375 mRNA CTD PMID:26702050 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985
JBrowse link
G Mir423 microRNA 423 decreases expression EXP marinobufagenin results in decreased expression of MIR423 mRNA CTD PMID:26702050 NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226
JBrowse link
G Mir93 microRNA 93 decreases expression EXP marinobufagenin results in decreased expression of MIR93 mRNA CTD PMID:26702050 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
JBrowse link
G Mir96 microRNA 96 decreases expression EXP marinobufagenin results in decreased expression of MIR96 mRNA CTD PMID:26702050 NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        epitope 7010
          marinobufagenin 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18798
                                    carbonyl compound 18798
                                      carboxylic ester 15962
                                        lactone 11411
                                          delta-lactone 3897
                                            bufadienolides 25
                                              bufadienolide 25
                                                (5beta)-bufadienolide 25
                                                  marinobufagenin 25
paths to the root