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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:marinobufagenin
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Accession:CHEBI:146151 term browser browse the term
Definition:A cardiotonic steroid secreted by the toad Bufo rubescens and other related species such as Bufo marinus. An endogenous Na/K-ATPase inhibitor, it is a vasoconstrictor with effects similar to digitalis.
Synonyms:exact_synonym: 3beta,5-dihydroxy-5beta,15beta-14,15-epoxybufa-20,22-dienolide
 related_synonym: (3beta,5beta,14alpha,15beta)-3,5-dihydroxy-14,15-epoxybufa-20,22-dienolide;   Formula=C24H32O5;   InChI=1S/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1;   InChIKey=JMNQTHQLNRILMH-OBBGIPBRSA-N;   MBG;   Marinobufagin;   SMILES=[C@]12(CC[C@@H](C[C@]2(CC[C@]3([C@]45[C@](CC[C@]13[H])([C@H](C[C@H]4O5)C6=COC(C=C6)=O)C)[H])O)O)C
 xref: CAS:470-42-8
 xref_mesh: MESH:C093896
 xref: PDBeChem:P4S;   PMID:11877366;   PMID:15804527;   PMID:29853035;   PMID:29993282;   PMID:30382957;   PMID:30817774;   PMID:31236418;   PMID:31879340;   Wikipedia:Marinobufagenin

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marinobufagenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain increases expression EXP marinobufagenin results in increased expression of COL1A1 mRNA CTD PMID:26702050 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Mir101a microRNA 101a decreases expression EXP marinobufagenin results in decreased expression of MIR101A mRNA CTD PMID:26702050 NCBI chr 5:120,168,437...120,168,511
Ensembl chr 5:120,168,433...120,168,515 		JBrowse link
G Mir106b microRNA 106b decreases expression EXP marinobufagenin results in decreased expression of MIR106B mRNA CTD PMID:26702050 NCBI chr12:19,307,752...19,307,833
Ensembl chr12:19,307,752...19,307,833 		JBrowse link
G Mir122 microRNA 122 increases expression EXP marinobufagenin results in increased expression of MIR122 mRNA CTD PMID:26702050 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir130a microRNA 130a decreases expression EXP marinobufagenin results in decreased expression of MIR130A mRNA CTD PMID:26702050 NCBI chr 3:72,141,037...72,141,124
Ensembl chr 3:72,141,037...72,141,124 		JBrowse link
G Mir140 microRNA 140 decreases expression EXP marinobufagenin results in decreased expression of MIR140 mRNA CTD PMID:26702050 NCBI chr19:39,608,951...39,609,049
Ensembl chr19:39,608,951...39,609,049 		JBrowse link
G Mir141 microRNA 141 decreases expression EXP marinobufagenin results in decreased expression of MIR141 mRNA CTD PMID:26702050 NCBI chr 4:157,236,346...157,236,439
Ensembl chr 4:157,236,346...157,236,439 		JBrowse link
G Mir142 microRNA 142 decreases expression EXP marinobufagenin results in decreased expression of MIR142 mRNA CTD PMID:26702050 NCBI chr10:75,050,839...75,050,925
Ensembl chr10:75,050,832...75,050,942 		JBrowse link
G Mir144 microRNA 144 decreases expression EXP marinobufagenin results in decreased expression of MIR144 mRNA CTD PMID:26702050 NCBI chr10:65,291,365...65,291,447
Ensembl chr10:65,291,365...65,291,447 		JBrowse link
G Mir185 microRNA 185 decreases expression EXP marinobufagenin results in decreased expression of MIR185 mRNA CTD PMID:26702050 NCBI chr11:86,812,702...86,812,781
Ensembl chr11:86,812,702...86,812,781 		JBrowse link
G Mir18a microRNA 18a decreases expression EXP marinobufagenin results in decreased expression of MIR18A mRNA CTD PMID:26702050 NCBI chr15:100,180,015...100,180,110
Ensembl chr15:100,180,015...100,180,110 		JBrowse link
G Mir196a microRNA 196a decreases expression EXP marinobufagenin results in decreased expression of MIR196A mRNA CTD PMID:26702050 NCBI chr 7:144,584,235...144,584,344
Ensembl chr 7:144,584,235...144,584,344 		JBrowse link
G Mir196b microRNA 196b decreases expression EXP marinobufagenin results in decreased expression of MIR196B mRNA CTD PMID:26702050 NCBI chr 4:82,199,056...82,199,140
Ensembl chr 4:82,199,056...82,199,140 		JBrowse link
G Mir210 microRNA 210 decreases expression EXP marinobufagenin results in decreased expression of MIR210 mRNA CTD PMID:26702050 NCBI chr 1:214,208,355...214,208,464 JBrowse link
G Mir222 microRNA 222 decreases expression EXP marinobufagenin results in decreased expression of MIR222 mRNA CTD PMID:26702050 NCBI chr  X:3,683,919...3,684,021
Ensembl chr  X:3,683,919...3,684,021 		JBrowse link
G Mir23a microRNA 23a increases expression EXP marinobufagenin results in increased expression of MIR23A mRNA CTD PMID:26702050 NCBI chr19:25,318,582...25,318,656
Ensembl chr19:25,318,582...25,318,656 		JBrowse link
G Mir29b1 microRNA 29b-1 decreases expression EXP marinobufagenin results in decreased expression of MIR29B1 mRNA CTD PMID:26702050 NCBI chr 4:58,344,310...58,344,390
Ensembl chr 4:58,344,310...58,344,390 		JBrowse link
G Mir32 microRNA 32 decreases expression EXP marinobufagenin results in decreased expression of MIR32 mRNA CTD PMID:26702050 NCBI chr 5:73,934,255...73,934,324
Ensembl chr 5:73,934,255...73,934,324 		JBrowse link
G Mir320a microRNA 320a decreases expression EXP marinobufagenin results in decreased expression of MIR320A mRNA CTD PMID:26702050 NCBI chr15:52,134,276...52,134,357
Ensembl chr15:52,134,276...52,134,357 		JBrowse link
G Mir322 microRNA 322 increases expression EXP marinobufagenin results in increased expression of MIR322 mRNA CTD PMID:26702050 NCBI chr  X:158,148,161...158,148,255
Ensembl chr  X:158,148,161...158,148,255 		JBrowse link
G Mir324 microRNA 324 decreases expression EXP marinobufagenin results in decreased expression of MIR324 mRNA CTD PMID:26702050 NCBI chr10:56,621,126...56,621,208
Ensembl chr10:56,621,124...56,621,212 		JBrowse link
G Mir375 microRNA 375 decreases expression EXP marinobufagenin results in decreased expression of MIR375 mRNA CTD PMID:26702050 NCBI chr 9:82,161,716...82,161,790
Ensembl chr 9:82,161,716...82,161,790 		JBrowse link
G Mir423 microRNA 423 decreases expression EXP marinobufagenin results in decreased expression of MIR423 mRNA CTD PMID:26702050 NCBI chr10:63,098,366...63,098,444
Ensembl chr10:63,098,360...63,098,453 		JBrowse link
G Mir93 microRNA 93 decreases expression EXP marinobufagenin results in decreased expression of MIR93 mRNA CTD PMID:26702050 NCBI chr12:19,307,543...19,307,629
Ensembl chr12:19,307,543...19,307,629 		JBrowse link
G Mir96 microRNA 96 decreases expression EXP marinobufagenin results in decreased expression of MIR96 mRNA CTD PMID:26702050 NCBI chr 4:57,463,366...57,463,471
Ensembl chr 4:57,463,366...57,463,471 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        epitope 6982
          marinobufagenin 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic ester 15500
                                        lactone 9716
                                          delta-lactone 3829
                                            bufadienolides 25
                                              bufadienolide 25
                                                (5beta)-bufadienolide 25
                                                  marinobufagenin 25
paths to the root