Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:withaferin A
go back to main search page
Accession:CHEBI:69120 term browser browse the term
Definition:A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity.
Synonyms:exact_synonym: (4beta,5beta,6beta,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione
 related_synonym: 4beta,27-dihydroxy-1-oxo-5beta,6beta-epoxywitha-2,24-dienolide;   Formula=C28H38O6;   InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1;   InChIKey=DBRXOUCRJQVYJQ-CKNDUULBSA-N;   SMILES=C[C@@H]([C@H]1CC[C@H]2[C@@H]3C[C@H]4O[C@]44[C@@H](O)C=CC(=O)[C@]4(C)[C@H]3CC[C@]12C)[C@H]1CC(C)=C(CO)C(=O)O1
 alt_id: CHEBI:10040
 xref: CAS:5119-48-2;   KEGG:C08841;   KNApSAcK:C00003676
 xref_mesh: MESH:C009684
 xref: PMID:22098611;   PMID:22935676;   PMID:22989414;   PMID:23107437;   PMID:23129310;   PMID:23318585;   PMID:23821767;   Patent:WO2010030395;   Patent:WO2010053655;   Reaxys:6284722;   Wikipedia:Withaferin_A



show annotations for term's descendants           Sort by:
withaferin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] CTD PMID:20438634 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO withaferin A promotes the reaction [Ethanol results in decreased expression of ACACA mRNA] CTD PMID:34995708 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of AKT1 protein] CTD PMID:35734936 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions EXP withaferin A inhibits the reaction [Cholesterol, Dietary results in increased activity of ALOX15 protein] CTD PMID:35734936 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein] CTD PMID:21266191 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein CTD PMID:20438634 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BAX protein] CTD PMID:35734936 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
withaferin A results in decreased expression of BCL2 protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of BCL2 protein]
CTD PMID:20438634 PMID:21256832 PMID:21964475 PMID:35734936 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890
JBrowse link
G Bcl2l11 Bcl2-like 11 decreases expression
multiple interactions
ISO
EXP
withaferin A results in decreased expression of BCL2L11 protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of BCL2L11 protein]
CTD PMID:20438634 PMID:35734936 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695
JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 protein]
withaferin A inhibits the reaction [Elements, Radioactive results in increased activity of CASP3 protein]
CTD PMID:35734936 PMID:36716864 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp9 caspase 9 multiple interactions EXP withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased expression of CASP9 protein] CTD PMID:35734936 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions
increases expression
EXP
ISO
withaferin A inhibits the reaction [Cholesterol, Dietary results in decreased activity of CAT protein]
withaferin A results in increased expression of CAT protein
CTD PMID:35734936 PMID:36716864 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] CTD PMID:20438634 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO withaferin A results in increased expression of CDH1 protein
VIM protein mutant form inhibits the reaction [withaferin A results in increased expression of CDH1 protein]
CTD PMID:39613173 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565
JBrowse link
G Cdh2 cadherin 2 multiple interactions
decreases expression
ISO VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of CDH2 protein] CTD PMID:39613173 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects binding
increases expression
multiple interactions
ISO withaferin A binds to CDKN1A protein
withaferin A results in increased expression of CDKN1A mRNA
withaferin A results in increased expression of and affects the localization of CDKN1A protein
CTD PMID:22973447 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cdkn2aip CDKN2A interacting protein decreases expression ISO withaferin A results in decreased expression of CDKN2AIP protein CTD PMID:22973447 NCBI chr16:51,266,613...51,274,051
Ensembl chr16:51,268,896...51,274,049
JBrowse link
G Cldn1 claudin 1 decreases response to substance
decreases expression
ISO CLDN1 protein results in decreased susceptibility to withaferin A
withaferin A results in decreased expression of CLDN1 mRNA; withaferin A results in decreased expression of CLDN1 protein
CTD PMID:33665778 NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529
JBrowse link
G Cp ceruloplasmin multiple interactions EXP withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CP protein] CTD PMID:35734936 NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:104,368,456...104,427,087
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in decreased expression of CPT1C mRNA] CTD PMID:34995708 NCBI chr 1:104,579,297...104,593,824
Ensembl chr 1:104,579,298...104,593,763
JBrowse link
G Crp C-reactive protein multiple interactions EXP withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of CRP protein] CTD PMID:35734936 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects response to substance
increases expression
multiple interactions
ISO DDIT3 mRNA affects the susceptibility to withaferin A
withaferin A results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]
CTD PMID:21266191 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein] CTD PMID:21266191 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein CTD PMID:23593078 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO withaferin A results in decreased expression of DNMT3A mRNA CTD PMID:23593078 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO withaferin A results in decreased expression of DNMT3B mRNA CTD PMID:23593078 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313
JBrowse link
G Edil3 EGF like repeats and discoidin domains 3 decreases expression ISO withaferin A results in decreased expression of EDIL3 mRNA CTD PMID:33665778 NCBI chr 2:21,625,604...22,140,380
Ensembl chr 2:21,625,596...22,140,379
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO withaferin A promotes the reaction [Ethanol results in decreased expression of EHHADH mRNA] CTD PMID:34995708 NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO withaferin A results in increased phosphorylation of EIF2A protein CTD PMID:21266191 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:144,911,153...144,945,201
JBrowse link
G Ezr ezrin multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of EZR protein CTD PMID:25236891 NCBI chr 1:49,373,033...49,416,573
Ensembl chr 1:49,373,035...49,416,573
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of FAS protein] CTD PMID:35734936 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:34995708 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO withaferin A results in increased expression of FOSL1 mRNA CTD PMID:33665778 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO withaferin A results in decreased expression of G6PC1 protein CTD PMID:37467946 NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of GCLC mRNA] CTD PMID:34995708 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of GPT protein] CTD PMID:34995708 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO withaferin A binds to and affects the localization of GSR protein CTD PMID:37467946 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO withaferin A results in decreased expression of HDAC1 protein CTD PMID:23593078 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO withaferin A results in increased expression of HMOX1 protein CTD PMID:36716864 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [withanone co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein CTD PMID:25236891 NCBI chr17:6,269,302...6,280,429
Ensembl chr17:6,268,385...6,280,565
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO withaferin A results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding
multiple interactions
ISO withaferin A binds to HSPA9 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; [withanone co-treated with withaferin A] results in decreased expression of HSPA9 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
CTD PMID:22973447 PMID:25236891 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:24632454 PMID:37467946 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein]
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 protein]
CTD PMID:20438634 PMID:35734936 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Krt13 keratin 13 decreases expression ISO withaferin A results in decreased expression of KRT13 mRNA CTD PMID:33665778 NCBI chr10:85,552,287...85,556,499
Ensembl chr10:85,552,287...85,556,499
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [withanone co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 PMID:24632454 PMID:25236891 PMID:36716864 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO withaferin A results in increased phosphorylation of MAPK8 protein CTD PMID:21964475 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression
ISO MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
withaferin A results in increased expression of MCL1 protein
CTD PMID:24019090 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
JBrowse link
G Mecp2 methyl CpG binding protein 2 decreases expression ISO withaferin A results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:156,932,481...156,995,981
Ensembl chr  X:156,941,234...156,943,560
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO [withanone co-treated with withaferin A] results in decreased expression of MMP2 protein; VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of MMP2 protein] CTD PMID:25236891 PMID:39613173 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO withaferin A results in decreased expression of MMP9 protein
VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of MMP9 protein]
CTD PMID:39613173 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of MPO protein] CTD PMID:35734936 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions
decreases expression
ISO [withaferin A results in increased phosphorylation of VIM protein] inhibits the reaction [NEDD9 protein binds to VIM protein]; withaferin A inhibits the reaction [NEDD9 protein binds to VIM protein]
withaferin A results in decreased expression of NEDD9 protein
CTD PMID:39613173 NCBI chr17:23,495,531...23,673,780
Ensembl chr17:23,495,492...23,675,668
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects binding
increases phosphorylation
ISO withaferin A binds to NFE2L2 protein
withaferin A results in increased phosphorylation of NFE2L2 protein
CTD PMID:22973447 PMID:36716864 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:20438634 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of NOS2 protein] CTD PMID:35734936 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of NQO1 mRNA] CTD PMID:34995708 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO withaferin A results in increased expression of NT5E mRNA CTD PMID:33665778 NCBI chr 8:98,150,925...98,195,646
Ensembl chr 8:98,150,900...98,195,645
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] CTD PMID:20438634 PMID:24019090 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO withaferin A results in increased expression of PRDX2 protein CTD PMID:36716864 NCBI chr19:40,085,788...40,091,083
Ensembl chr19:40,084,430...40,091,006
JBrowse link
G Procr protein C receptor multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 3:164,714,727...164,718,994
Ensembl chr 3:164,711,636...164,718,989
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21396905 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] CTD PMID:20438634 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Serpina6 serpin family A member 6 decreases expression ISO withaferin A results in decreased expression of SERPINA6 protein CTD PMID:37467946 NCBI chr 6:128,544,828...128,555,064
Ensembl chr 6:128,544,831...128,555,139
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 increases expression ISO withaferin A results in increased expression of SLCO4A1 mRNA CTD PMID:33665778 NCBI chr 3:187,936,735...187,955,873
Ensembl chr 3:187,936,820...187,955,871
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO withaferin A results in decreased expression of SNAI1 protein CTD PMID:39613173 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]
withaferin A results in increased expression of SOD2 protein
CTD PMID:24019090 PMID:36716864 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:34995708 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO withaferin A inhibits the reaction [Ethanol results in increased expression of SREBF2 mRNA] CTD PMID:34995708 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein] CTD PMID:21396905 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:21396905 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Tat tyrosine aminotransferase decreases expression ISO withaferin A results in decreased expression of TAT protein CTD PMID:37467946 NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482
JBrowse link
G Tmt1a thiol methyltransferase 1A decreases expression ISO withaferin A results in decreased expression of TMT1A mRNA CTD PMID:33665778 NCBI chr 7:133,330,141...133,377,172
Ensembl chr 7:133,330,447...133,338,959
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO
EXP
withaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
withaferin A results in decreased activity of TNF protein
withaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of TNF protein]
CTD PMID:20438634 PMID:24632454 PMID:35734936 PMID:37467946 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
affects binding
ISO withaferin A results in increased expression of TP53 mRNA
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
withaferin A binds to TP53 protein
CTD PMID:22973447 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO withaferin A results in decreased expression of TUBA1A mRNA CTD PMID:24297176 NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:131,968,770...131,996,035
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO withaferin A results in decreased expression of TUBB mRNA CTD PMID:24297176 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [withanone co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
withaferin A results in decreased expression of VEGFA protein
CTD PMID:20438634 PMID:25236891 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vim vimentin multiple interactions
increases phosphorylation
ISO [withaferin A results in increased phosphorylation of VIM protein] inhibits the reaction [NEDD9 protein binds to VIM protein]; VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of CDH2 protein]; VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of MMP2 protein]; VIM protein mutant form inhibits the reaction [withaferin A results in decreased expression of MMP9 protein]; VIM protein mutant form inhibits the reaction [withaferin A results in increased expression of CDH1 protein]; withaferin A inhibits the reaction [NEDD9 protein binds to VIM protein]
[withaferin A results in increased phosphorylation of VIM protein] inhibits the reaction [NEDD9 protein binds to VIM protein]; withaferin A inhibits the reaction [NEDD9 protein binds to VIM protein]
CTD PMID:39613173 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
increases splicing
ISO withaferin A results in increased expression of XBP1 protein
withaferin A results in increased splicing of XBP1 mRNA
CTD PMID:21266191 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          apoptosis inducer 13731
            withaferin A 85
              2,3-dihydro-3beta-O-sulfate withaferin A 0
              2,3-dihydro-3beta-methoxy withaferin A 0
              2,3-dihydrowithaferin A 0
              sitoindoside IX 0
              withalongolide A 0
              withalongolide B 0
              withalongolide C 0
              withalongolide G 0
              withalongolide H 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  organic heteromonocyclic compound 18212
                                    saturated organic heteromonocyclic parent 11505
                                      oxirane 11487
                                        epoxide 11486
                                          epoxy steroid 148
                                            withaferin A 85
                                              2,3-dihydro-3beta-O-sulfate withaferin A 0
                                              2,3-dihydro-3beta-methoxy withaferin A 0
                                              2,3-dihydrowithaferin A 0
                                              sitoindoside IX 0
                                              withalongolide A 0
                                              withalongolide B 0
                                              withalongolide C 0
                                              withalongolide G 0
                                              withalongolide H 0
paths to the root