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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:69120
Term: withaferin A
Definition: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity.
Chemical ID: MESH:C009684
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationISORGD:6195706480464CTDwithaferin A results in increased phosphorylation of MAPK3 protein

PMID:24019090
Mapk3multiple interactionsISORGD:6195706480464CTD2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] [6 7-epoxy-5 17-dihydroxy-1-oxowitha-2 24-dienolide co-treated with withaferin A] results in decreased expression of MAPK3 protein Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]

PMID:24019090 PMID:24632454 PMID:25236891
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