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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5,6alpha-epoxy-5alpha-cholestan-3beta-ol
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Accession:CHEBI:49305 term browser browse the term
Definition:An oxysterol that has formula C27H46O2.
Synonyms:related_synonym: 5,6alpha epoxy-cholesterol;   5-alpha,6-alpha-Epoxycholestanol;   Cholesterol alpha-oxide;   Cholesterol-5alpha,6alpha-epoxide;   Cholesterol-alpha-epoxide;   Formula=C27H46O2;   InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24-27(29-24)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,24+,25-,26-,27+/m1/s1;   InChIKey=PRYIJAGAEJZDBO-ZEQHCUNVSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])C[C@@H]4O[C@@]44C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
 xref: Beilstein:89511;   CAS:1250-95-9;   KEGG:C15992;   LIPID_MAPS_instance:LMST01010011
 xref_mesh: MESH:C002415



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5,6alpha-epoxy-5alpha-cholestan-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor increases phosphorylation EXP cholesterol alpha-oxide results in increased phosphorylation of EGFR protein CTD PMID:20466046 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Ephx1 epoxide hydrolase 1 increases metabolic processing
multiple interactions
ISO EPHX1 protein results in increased metabolism of cholesterol alpha-oxide
disparlure promotes the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]; Lanosterol analog inhibits the reaction [EPHX1 protein results in increased metabolism of cholesterol alpha-oxide]
CTD PMID:2043152 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO cholesterol alpha-oxide inhibits the reaction [EPHX2 protein results in increased metabolism of stilbene oxide analog] CTD PMID:2043152 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK1 protein] CTD PMID:20466046 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MAPK3 protein]
CTD PMID:20466046 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP cholesterol alpha-oxide results in increased expression of MMP2 mRNA CTD PMID:20466046 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression EXP cholesterol alpha-oxide results in increased expression of MMP9 mRNA CTD PMID:20466046 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation
multiple interactions
EXP cholesterol alpha-oxide results in increased phosphorylation of MTOR protein
RTKI cpd inhibits the reaction [cholesterol alpha-oxide results in increased phosphorylation of MTOR protein]
CTD PMID:20466046 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      molecular entity 20058
        main group molecular entity 19960
          gas molecular entity 18240
            oxirane 9785
              epoxide 9784
                epoxy steroid 118
                  5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic polycyclic compound 17201
                                  steroid 14380
                                    hydroxy steroid 14111
                                      3-hydroxy steroid 12157
                                        3beta-hydroxy steroid 2027
                                          3beta-hydroxy-Delta(5)-steroid 1848
                                            cholesterol 336
                                              oxysterol 106
                                                5,6alpha-epoxy-5alpha-cholestan-3beta-ol 8
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