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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetracyclic antidepressant
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Accession:CHEBI:50940 term browser browse the term
Definition:An antidepressant whose molecular structure consists of four ring-like structures in a T-shape.
Synonyms:related_synonym: antidepresivo tetraciclico;   antidepresivos tetraciclicos;   piperazinoazepine antidepressant;   tetracyclic antidepressants


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dizocilpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 affects binding EXP Dizocilpine binds to Drd2 protein RGD PMID:15852061 RGD:1581406 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Dizocilpine inhibits the reaction [Cocaine increases expression of Gria1 protein in the nucleus accumbens] RGD PMID:11801363 RGD:405650201 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Sirt1 sirtuin 1 increases expression EXP dizocilpine cotreated with cocaine increases expression of Sirt1 protein in nucleus accumbens RGD PMID:27664298 RGD:401900166 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
dizocilpine maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora3 adenosine A3 receptor multiple interactions ISO [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine binds to and results in increased activity of ADORA3 protein] which results in decreased susceptibility to Dizocilpine Maleate CTD PMID:12672554 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357 		JBrowse link
G Ahcyl2 adenosylhomocysteinase-like 2 increases expression EXP Dizocilpine Maleate results in increased expression of AHCYL2 protein CTD PMID:21297352 NCBI chr 4:58,381,290...58,531,061
Ensembl chr 4:58,381,218...58,531,060 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] CTD PMID:17973980 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of AIFM1 protein] CTD PMID:19201465 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C increases expression EXP Dizocilpine Maleate results in increased expression of ALDOC protein CTD PMID:21297352 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA] CTD PMID:9720974 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein multiple interactions ISO Dizocilpine Maleate inhibits the reaction [phosphinothricin results in increased expression of ARC mRNA] CTD PMID:30557575 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO
EXP		 Dizocilpine Maleate results in increased expression of BAX protein
Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of BAX protein]; Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein]		 CTD PMID:19201465 PMID:19759125 PMID:25937004 PMID:28916251 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 EXP
ISO		 Dizocilpine Maleate results in decreased expression of BCL2 protein
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]
Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in decreased expression of BCL2 protein]		 CTD PMID:10859492 PMID:19879923 PMID:29151189 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in decreased expression of BCL2L1 protein] CTD PMID:28916251 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
affects expression
multiple interactions		 EXP Dizocilpine Maleate results in decreased expression of BDNF mRNA
Dizocilpine Maleate affects the expression of BDNF mRNA
Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of and results in increased localization of BDNF mRNA]; Pentobarbital inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]; Scopolamine inhibits the reaction [Dizocilpine Maleate affects the expression of BDNF mRNA]		 CTD PMID:8247360 PMID:8405262 PMID:15282290 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CAMK4 protein] CTD PMID:17973980 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 EXP
ISO		 Dizocilpine Maleate inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased cleavage of CASP3 protein]
Dizocilpine Maleate results in increased expression of CASP3 protein modified form
Dizocilpine Maleate results in increased activity of CASP3 protein		 CTD PMID:19759125 PMID:21873648 PMID:22824136 PMID:25937004 PMID:28916251 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO Dizocilpine Maleate results in increased activity of CASP9 protein CTD PMID:19759125 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP [bastadin 12 co-treated with Ryanodine co-treated with Dizocilpine Maleate] inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]; Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of CAT protein] CTD PMID:12885441 PMID:27718046 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cck cholecystokinin multiple interactions
decreases expression		 EXP Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CCK protein]
Dizocilpine Maleate results in decreased expression of CCK mRNA; Dizocilpine Maleate results in decreased expression of CCK protein		 CTD PMID:16567023 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Quinolinic Acid results in decreased activity of CHAT protein] CTD PMID:2976130 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 protein affects the susceptibility to Dizocilpine Maleate CTD PMID:17442049 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL1A1 mRNA]
Dizocilpine Maleate results in increased expression of COL1A1 mRNA		 CTD PMID:28987794 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of COL3A1 mRNA] CTD PMID:28987794 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
decreases phosphorylation		 EXP
ISO		 Dizocilpine Maleate results in increased phosphorylation of CREB1 protein
Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CREB1 mRNA]
Dizocilpine Maleate inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Dopamine results in increased phosphorylation of CREB1 protein]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]]
Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of CREB1 mRNA]
Dizocilpine Maleate results in decreased phosphorylation of CREB1 protein		 CTD PMID:14622123 PMID:15877933 PMID:17434604 PMID:17973980 PMID:31981724 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions		 ISO Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA
Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]		 CTD PMID:31563592 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased activity of CXCL2 protein] CTD PMID:15914698 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]]; Dizocilpine Maleate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CREB1 protein binds to CYP1A1 promoter]] CTD PMID:17973980 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 mRNA]; Dizocilpine Maleate inhibits the reaction [Sodium Glutamate results in increased expression of CYP46A1 protein] CTD PMID:31981724 NCBI chr 6:127,247,543...127,274,765
Ensembl chr 6:127,243,315...127,274,760 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression EXP Dizocilpine Maleate results in increased expression of DLG1 mRNA CTD PMID:11169168 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 increases expression EXP Dizocilpine Maleate results in increased expression of DLG4 mRNA CTD PMID:11169168 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of DNM1L protein] CTD PMID:25416777 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine; Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD1 mRNA] CTD PMID:7906944 PMID:17434604 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD2 mRNA] CTD PMID:17434604 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]] CTD PMID:19217379 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA] CTD PMID:11701771 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA] CTD PMID:11701771 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Zinc results in increased expression of EGR1 protein] CTD PMID:10428039 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein] CTD PMID:17303341 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid] CTD PMID:19014389 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of ERN1 protein] CTD PMID:17303341 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Faah fatty acid amide hydrolase decreases activity EXP Dizocilpine Maleate results in decreased activity of FAAH protein CTD PMID:17591864 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression EXP Dizocilpine Maleate results in increased expression of FGF2 mRNA CTD PMID:9832142 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression		 ISO
EXP		 [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Haloperidol results in increased expression of FOS protein]
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
Dizocilpine Maleate results in increased expression of FOS mRNA
Dizocilpine Maleate results in decreased expression of FOS mRNA; Dizocilpine Maleate results in decreased expression of FOS protein		 CTD PMID:7984056 PMID:8404677 PMID:11421588 PMID:12401322 PMID:12807422 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases response to substance EXP FOSB protein modified form results in increased susceptibility to Dizocilpine Maleate CTD PMID:24067299 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Oxygen deficiency results in decreased expression of GAD1 protein] CTD PMID:29107683 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP Dizocilpine Maleate inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of GAL mRNA] CTD PMID:8730651 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Kainic Acid results in increased expression of GAP43 mRNA] CTD PMID:8774942 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Dizocilpine Maleate results in increased expression of GAPDH protein CTD PMID:21297352 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of GFAP protein] CTD PMID:21863293 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIA1 protein] CTD PMID:11801363 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases activity
multiple interactions
increases expression
affects binding		 ISO
EXP		 Dizocilpine Maleate results in decreased activity of GRIN1 protein
Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN1 protein]; Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN1 protein]; Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]
[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; [GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]
Dizocilpine Maleate results in increased expression of GRIN1 mRNA
Dizocilpine Maleate binds to GRIN1 protein		 CTD PMID:11249956 PMID:11801363 PMID:19224577 PMID:19788891 PMID:20406136 More... NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A multiple interactions
increases phosphorylation		 ISO
EXP		 Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of GRIN2A mRNA]
Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in increased expression of GRIN2A protein]
[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Dizocilpine Maleate; Dizocilpine Maleate inhibits the reaction [[GRIN1 protein co-treated with GRIN2A protein] results in increased susceptibility to Excitatory Amino Acid Agonists]
Dizocilpine Maleate results in increased phosphorylation of GRIN2A protein		 CTD PMID:11249956 PMID:17434604 PMID:19224577 PMID:20406136 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
decreases expression		 EXP
ISO		 Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of GRIN2B protein]; Dizocilpine Maleate inhibits the reaction [Dextromethorphan results in increased expression of GRIN2B protein]
[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to Dizocilpine Maleate
Dizocilpine Maleate results in decreased expression of GRIN2B mRNA		 CTD PMID:11169168 PMID:11801363 PMID:19224577 PMID:28916251 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C decreases expression EXP Dizocilpine Maleate results in decreased expression of GRIN2C mRNA CTD PMID:11169168 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
increases expression		 ISO
EXP		 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein; Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]; Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]
Dizocilpine Maleate results in increased phosphorylation of GSK3B protein		 CTD PMID:15877933 PMID:31563592 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO Dizocilpine Maleate inhibits the reaction [[Kainic Acid co-treated with dihydroxyethyldithiocarbamate] results in increased expression of HSPA1A protein] CTD PMID:16686654 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of HSPA5 protein] CTD PMID:17303341 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL1B protein] CTD PMID:36925032 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of IL6 protein] CTD PMID:36925032 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhba inhibin subunit beta A multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Ibotenic Acid results in increased expression of INHBA protein] CTD PMID:36925032 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUN mRNA] CTD PMID:7984056 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dizocilpine Maleate inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of JUNB mRNA]; Dizocilpine Maleate inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7984056 PMID:9890435 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Maoa monoamine oxidase A multiple interactions EXP Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased activity of MAOA protein] CTD PMID:12885441 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO
EXP		 [Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
Dizocilpine Maleate results in decreased phosphorylation of MAPK1 protein
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO
EXP		 Dizocilpine Maleate results in decreased phosphorylation of MAPK3 protein
[Dizocilpine Maleate co-treated with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline] inhibits the reaction [Dieldrin results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Dronabinol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in increased phosphorylation of MAPK3 protein]
Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11553284 PMID:11923223 PMID:12657697 PMID:15086530 PMID:15385614 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO
EXP		 Dizocilpine Maleate inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPT protein]
Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased cleavage of MAPT protein]		 CTD PMID:21976409 PMID:30822420 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of MFN2 protein] CTD PMID:25416777 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein] CTD PMID:20406136 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Folic Acid deficiency results in decreased expression of MMP9 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein] CTD PMID:20406136 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nefl neurofilament light chain multiple interactions EXP Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFL protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA] CTD PMID:21863293 PMID:31969611 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain multiple interactions EXP Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of NEFM protein] CTD PMID:21863293 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased degradation of NFKBIA protein] CTD PMID:11923223 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression EXP Dizocilpine Maleate results in increased expression of NME1 protein CTD PMID:21297352 NCBI chr10:78,907,036...78,929,659
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of NOS1 protein] CTD PMID:29151189 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Ammonium Chloride results in increased expression of NOS2 protein] CTD PMID:11923223 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nps neuropeptide S decreases activity
multiple interactions		 EXP NPS protein results in decreased activity of Dizocilpine Maleate
3-oxo-1,1-diphenyltetrahydrooxazolo(3,4-a)pyrazine-7-carboxylic acid 4-fluorobenzylamide inhibits the reaction [NPS protein results in decreased activity of Dizocilpine Maleate]		 CTD PMID:21466221 NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase increases expression EXP Dizocilpine Maleate results in increased expression of NSF protein CTD PMID:21297352 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386 		JBrowse link
G Ocln occludin multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of OCLN protein] CTD PMID:26655082 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]] CTD PMID:18652891 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [ammonium acetate results in increased expression of PARP1 protein] CTD PMID:15147502 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pde2a phosphodiesterase 2A multiple interactions ISO Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE2A mRNA] CTD PMID:29151189 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions ISO Dizocilpine Maleate inhibits the reaction [decabromobiphenyl ether results in increased expression of PDE5A mRNA] CTD PMID:29151189 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Penk proenkephalin multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Amphetamine results in increased expression of PENK mRNA] CTD PMID:12850537 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Capsaicin results in increased secretion of POMC protein] CTD PMID:8925284 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]] CTD PMID:18652891 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcg protein kinase C, gamma increases expression
multiple interactions		 EXP
ISO		 Dizocilpine Maleate results in increased expression of PRKCG mRNA
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]		 CTD PMID:11169168 PMID:18652891 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prl prolactin decreases expression EXP Dizocilpine Maleate results in decreased expression of PRL protein CTD PMID:8404677 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prodh proline dehydrogenase affects response to substance ISO PRODH protein affects the susceptibility to Dizocilpine Maleate CTD PMID:16234811 NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:15987631 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptn pleiotrophin multiple interactions EXP Dizocilpine Maleate promotes the reaction [Amphetamine results in increased expression of PTN mRNA] CTD PMID:15862925 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [bisphenol A results in increased expression of RAC1 protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in increased expression of RAC1 protein] CTD PMID:24231043 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions EXP Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]] CTD PMID:15773917 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP Dizocilpine Maleate inhibits the reaction [bisphenol A results in decreased expression of RHOA protein]; Dizocilpine Maleate inhibits the reaction [Estradiol results in decreased expression of RHOA protein] CTD PMID:24231043 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA] CTD PMID:31945382 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [ammonium acetate results in decreased activity of SOD2 protein] CTD PMID:12885441 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases activity
increases expression		 EXP Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]; Dizocilpine Maleate results in increased phosphorylation of and results in increased activity of SRC protein
Dizocilpine Maleate results in increased activity of SRC protein
Dizocilpine Maleate results in increased expression of SRC mRNA; Dizocilpine Maleate results in increased expression of SRC protein		 CTD PMID:11249956 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Sst somatostatin decreases expression
multiple interactions		 EXP Dizocilpine Maleate results in decreased expression of SST mRNA; Dizocilpine Maleate results in decreased expression of SST protein
Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA]; Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein]		 CTD PMID:16567023 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of TAC1 protein modified form] CTD PMID:11074153 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFA] CTD PMID:15987631 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 protein] CTD PMID:20406136 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein] CTD PMID:35257817 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Dizocilpine Maleate results in increased expression of TPI1 protein CTD PMID:21297352 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Vim vimentin multiple interactions EXP Dizocilpine Maleate inhibits the reaction [diphenylditelluride results in decreased phosphorylation of VIM protein] CTD PMID:21863293 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Dizocilpine Maleate inhibits the reaction [ammonium acetate affects the activity of XDH protein] CTD PMID:12885441 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
mirtazapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases export ISO ABCB1 protein results in increased export of mirtazapine CTD PMID:14550684 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] CTD PMID:28623179 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 EXP Mirtazapine results in decreased phosphorylation of AKT1 protein
Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]		 CTD PMID:35066094 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 EXP
ISO		 Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of ATG7 mRNA] CTD PMID:35066094 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO
EXP		 Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of BECN1 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of BECN1 protein]		 CTD PMID:35066094 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Cat catalase multiple interactions EXP mirtazapine inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:19034656 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 ISO
EXP		 Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]		 CTD PMID:35066094 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP mirtazapine results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein] CTD PMID:12523492 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions EXP mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein] CTD PMID:12523492 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression		 ISO Ethanol promotes the reaction [Mirtazapine results in increased expression of GPT protein] CTD PMID:35066094 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions
increases expression		 EXP Ethanol promotes the reaction [Mirtazapine results in increased expression of HMGB1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased expression of LAMP1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of ATG7 mRNA]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of BECN1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of NPPB mRNA]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of PIK3C3 protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of TGFB1 mRNA] CTD PMID:35066094 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO mirtazapine results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
increases expression		 ISO 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein]; mirtazapine binds to and affects the activity of HTR2C protein CTD PMID:18083778 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Mirtazapine inhibits the reaction [Cadmium results in increased expression of IL1B protein] CTD PMID:37403423 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Mirtazapine inhibits the reaction [Cadmium results in increased expression of IL6 protein] CTD PMID:37403423 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO mirtazapine affects the activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions
decreases expression		 EXP Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased expression of LAMP1 protein] CTD PMID:35066094 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP mirtazapine inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:19034656 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 EXP Mirtazapine results in decreased phosphorylation of MTOR protein
Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]]; HMGB1 protein affects the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]		 CTD PMID:35066094 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP Mirtazapine results in increased expression of NFE2L2 protein CTD PMID:37403423 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of NOX1 protein] CTD PMID:28623179 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nppb natriuretic peptide B increases expression
multiple interactions		 ISO
EXP		 Mirtazapine results in increased expression of NPPB mRNA
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of NPPB mRNA]; Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of NPPB mRNA]		 CTD PMID:35066094 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 increases expression
multiple interactions		 EXP Mirtazapine results in increased expression of PIK3C3 protein
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of PIK3C3 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of PIK3C3 protein]		 CTD PMID:35066094 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048 		JBrowse link
G Prl prolactin increases expression ISO mirtazapine results in increased expression of PRL protein CTD PMID:15105766 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression EXP Mirtazapine results in decreased expression of RELA protein CTD PMID:37403423 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO mirtazapine results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO mirtazapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO mirtazapine results in increased expression of SLC2A4 mRNA CTD PMID:16002093 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc2a5 solute carrier family 2 member 5 increases expression ISO mirtazapine results in increased expression of SLC2A5 mRNA CTD PMID:16002093 NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 EXP
ISO		 Mirtazapine results in increased expression of SQSTM1 protein
3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of SQSTM1 protein]		 CTD PMID:35066094 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO mirtazapine results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 ISO
EXP		 Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; Mirtazapine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 protein]
Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]]; HMGB1 protein affects the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]		 CTD PMID:28623179 PMID:35066094 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression EXP Mirtazapine results in decreased expression of TLR4 protein CTD PMID:37403423 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Mirtazapine inhibits the reaction [Cadmium results in increased expression of TNF protein] CTD PMID:37403423 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        pharmaceutical 19579
          drug 19579
            central nervous system drug 16785
              psychotropic drug 15559
                antidepressant 3760
                  tetracyclic antidepressant 132
                    N-demethylmirtazapine 0
                    dizocilpine 3
                    dizocilpine maleate 102
                    mirtazapine 38
                    setiptiline 0
                    setiptiline maleate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic heterocyclic compound 18905
                                  organic heteropolycyclic compound 18317
                                    organic heterotetracyclic compound 9218
                                      tetracyclic antidepressant 132
                                        N-demethylmirtazapine 0
                                        dizocilpine 3
                                        dizocilpine maleate 102
                                        mirtazapine 38
                                        setiptiline 0
                                        setiptiline maleate 0
paths to the root