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Gene: Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Description: Predicted to have cholesterol 24-hydroxylase activity; heme binding activity; and steroid hydroxylase activity. Predicted to be involved in several processes, including cholesterol catabolic process; progesterone metabolic process; and regulation of long-term synaptic potentiation. Predicted to localize to several cellular components, including the dendrite; endoplasmic reticulum membrane; and presynapse. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH 1,3-dinitrobenzene; bisphenol A; furan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cholesterol 24-hydroxylase; LOC362782
Orthologs:
Homo sapiens (human) : CYP46A1 (cytochrome P450 family 46 subfamily A member 1)  HGNC  Alliance
Mus musculus (house mouse) : Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102030124 (cholesterol 24-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100978372 (cholesterol 24-hydroxylase)
Canis lupus familiaris (dog) : CYP46A1 (cytochrome P450 family 46 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101961079 (cholesterol 24-hydroxylase)
Sus scrofa (pig) : LOC100512793 (cholesterol 24-hydroxylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06132,242,328 - 132,273,788 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06141,412,601 - 141,443,684 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46132,700,554 - 132,731,982 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16132,711,108 - 132,737,620 (+)NCBI
Celera6124,801,923 - 124,833,398 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Cyp46a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306605
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.