Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp46a1 (cytochrome P450, family 46, subfamily a, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
RGD ID: 1306605
Description: Predicted to enable cholesterol 24-hydroxylase activity; heme binding activity; and steroid hydroxylase activity. Predicted to be involved in several processes, including cholesterol catabolic process; progesterone metabolic process; and regulation of long-term synaptic potentiation. Predicted to act upstream of with a negative effect on protein localization to membrane raft. Predicted to be located in several cellular components, including dendrite; endoplasmic reticulum membrane; and postsynapse. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholesterol 24-hydroxylase; LOC362782
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26127,247,543 - 127,274,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,243,315 - 127,274,760 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,372,445 - 127,399,673 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,667,502 - 127,694,730 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,025,379 - 127,052,595 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,242,328 - 132,273,788 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,242,328 - 132,273,787 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,412,601 - 141,443,684 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46132,700,554 - 132,731,982 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16132,711,108 - 132,737,620 (+)NCBI
Celera6124,801,923 - 124,833,398 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(24S)-24-hydroxycholesterol  (ISO)
(5alpha)-cholestan-3beta-ol  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
7alpha-hydroxycholesterol  (ISO)
aflatoxin B1  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
cadmium dichloride  (EXP,ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
cholesterol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dextromethorphan  (ISO)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethyl phthalate  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
fipronil  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
glyphosate  (EXP)
ketamine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
methidathion  (ISO)
monosodium L-glutamate  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
O-methyleugenol  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
PCB138  (ISO)
phenacetin  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
tebuconazole  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease. Kolsch H, etal., Mol Psychiatry 2002;7(8):899-902.
4. Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. Lund EG, etal., J Biol Chem 2003 Jun 20;278(25):22980-8. Epub 2003 Apr 9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10377398   PMID:12477932   PMID:14640697   PMID:16505352   PMID:17453958   PMID:18241055   PMID:18621681   PMID:18729719   PMID:20193040   PMID:20559650   PMID:20667828   PMID:23288837  
PMID:25017465  


Genomics

Comparative Map Data
Cyp46a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26127,247,543 - 127,274,765 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6127,243,315 - 127,274,760 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6127,372,445 - 127,399,673 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06127,667,502 - 127,694,730 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06127,025,379 - 127,052,595 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06132,242,328 - 132,273,788 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6132,242,328 - 132,273,787 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06141,412,601 - 141,443,684 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46132,700,554 - 132,731,982 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16132,711,108 - 132,737,620 (+)NCBI
Celera6124,801,923 - 124,833,398 (+)NCBICelera
Cytogenetic Map6q32NCBI
CYP46A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381499,684,298 - 99,727,301 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1499,684,298 - 99,727,301 (+)EnsemblGRCh38hg38GRCh38
GRCh3714100,150,635 - 100,193,638 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361499,220,508 - 99,263,391 (+)NCBINCBI36Build 36hg18NCBI36
Build 341499,220,507 - 99,263,390NCBI
Celera1480,205,602 - 80,248,517 (+)NCBICelera
Cytogenetic Map14q32.2NCBI
HuRef1480,333,998 - 80,376,909 (+)NCBIHuRef
CHM1_114100,088,519 - 100,131,398 (+)NCBICHM1_1
T2T-CHM13v2.01493,915,741 - 93,958,738 (+)NCBIT2T-CHM13v2.0
Cyp46a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912108,300,568 - 108,328,497 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12108,300,640 - 108,328,493 (+)EnsemblGRCm39 Ensembl
GRCm3812108,334,268 - 108,362,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12108,334,381 - 108,362,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712109,572,591 - 109,600,444 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612108,782,188 - 108,810,041 (+)NCBIMGSCv36mm8
Celera12109,576,067 - 109,604,342 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1259.41NCBI
LOC102030124
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543820,961,365 - 20,985,749 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543820,961,621 - 20,986,260 (+)NCBIChiLan1.0ChiLan1.0
CYP46A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan114100,056,722 - 100,099,224 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01480,309,698 - 80,352,181 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11499,628,511 - 99,671,218 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1499,628,511 - 99,671,218 (+)Ensemblpanpan1.1panPan2
CYP46A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1868,064,898 - 68,095,537 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl868,041,344 - 68,095,212 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha867,588,798 - 67,617,580 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0868,352,536 - 68,381,116 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl868,352,532 - 68,381,111 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1868,013,336 - 68,042,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0868,079,753 - 68,108,514 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0868,477,349 - 68,506,246 (+)NCBIUU_Cfam_GSD_1.0
LOC101961079
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086406,591,776 - 6,630,640 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366043,451,842 - 3,491,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366043,451,853 - 3,490,688 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP46A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7120,661,111 - 120,695,016 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17120,658,781 - 120,695,031 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27128,276,297 - 128,302,580 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP46A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12477,641,068 - 77,684,722 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2477,641,034 - 77,684,741 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605364,780,651 - 64,824,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101708822
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247344,242,511 - 4,266,975 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247344,242,070 - 4,267,027 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp46a1
67 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:365
Count of miRNA genes:184
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000009896
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat

Markers in Region
RH142799  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,242,367 - 127,242,532 (+)MAPPERmRatBN7.2
Rnor_6.06132,241,381 - 132,241,545NCBIRnor6.0
Rnor_5.06141,411,654 - 141,411,818UniSTSRnor5.0
RGSC_v3.46132,699,607 - 132,699,771UniSTSRGSC3.4
Celera6124,800,976 - 124,801,140UniSTS
RH 3.4 Map6791.5UniSTS
Cytogenetic Map6q32UniSTS
RH134732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,274,566 - 127,274,754 (+)MAPPERmRatBN7.2
Rnor_6.06132,273,594 - 132,273,781NCBIRnor6.0
Rnor_5.06141,443,486 - 141,443,673UniSTSRnor5.0
RGSC_v3.46132,731,789 - 132,731,976UniSTSRGSC3.4
Celera6124,833,205 - 124,833,392UniSTS
RH 3.4 Map6789.9UniSTS
Cytogenetic Map6q32UniSTS
RH141974  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26127,249,092 - 127,249,273 (+)MAPPERmRatBN7.2
Rnor_6.06132,248,104 - 132,248,284NCBIRnor6.0
Rnor_5.06141,418,377 - 141,418,557UniSTSRnor5.0
RGSC_v3.46132,706,330 - 132,706,510UniSTSRGSC3.4
Celera6124,807,732 - 124,807,912UniSTS
RH 3.4 Map6791.3UniSTS
Cytogenetic Map6q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 3
Low 3 32 10 1 10 1 1 1 31 32 38 11 1
Below cutoff 11 47 40 9 40 7 10 3 7

Sequence


RefSeq Acc Id: ENSRNOT00000009896   ⟹   ENSRNOP00000009896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,247,591 - 127,274,760 (+)Ensembl
Rnor_6.0 Ensembl6132,246,602 - 132,273,787 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081088   ⟹   ENSRNOP00000069874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6127,243,315 - 127,274,760 (+)Ensembl
Rnor_6.0 Ensembl6132,242,328 - 132,273,787 (+)Ensembl
RefSeq Acc Id: NM_001399701   ⟹   NP_001386630
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26127,247,583 - 127,274,761 (+)NCBI
RefSeq Acc Id: XR_593078
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26127,247,543 - 127,274,765 (+)NCBI
Rnor_6.06132,246,564 - 132,273,788 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001386630 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI62019 (Get FASTA)   NCBI Sequence Viewer  
  EDL97571 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009896
  ENSRNOP00000009896.7
  ENSRNOP00000069874.1
RefSeq Acc Id: ENSRNOP00000009896   ⟸   ENSRNOT00000009896
RefSeq Acc Id: ENSRNOP00000069874   ⟸   ENSRNOT00000081088
RefSeq Acc Id: NP_001386630   ⟸   NM_001399701
- Peptide Label: precursor
- UniProtKB: A0A8J8Y4X4 (UniProtKB/TrEMBL),   B1WC64 (UniProtKB/TrEMBL),   F7EN52 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7EN52-F1-model_v2 AlphaFold F7EN52 1-500 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306605 AgrOrtholog
BioCyc Gene G2FUF-36301 BioCyc
Ensembl Genes ENSRNOG00000007147 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009896 ENTREZGENE
  ENSRNOT00000009896.7 UniProtKB/TrEMBL
  ENSRNOT00000081088.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9098323 IMAGE-MGC_LOAD
InterPro CYP46A1 UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report rno:362782 UniProtKB/TrEMBL
MGC_CLONE MGC:187896 IMAGE-MGC_LOAD
NCBI Gene 362782 ENTREZGENE
PANTHER CHOLESTEROL 24-HYDROXYLASE UniProtKB/TrEMBL
  PTHR24293 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp46a1 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007147 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A0A0G2JWG7_RAT UniProtKB/TrEMBL
  A0A8J8Y4X4 ENTREZGENE, UniProtKB/TrEMBL
  B1WC64 ENTREZGENE
  F7EN52 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B1WC64 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cyp46a1  cytochrome P450, family 46, subfamily a, polypeptide 1   Cyp46a1_predicted  cytochrome P450, family 46, subfamily a, polypeptide 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cyp46a1_predicted  cytochrome P450, family 46, subfamily a, polypeptide 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED