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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dizocilpine
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Accession:CHEBI:34725 term browser browse the term
Definition:An organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory.
Synonyms:exact_synonym: (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene
 related_synonym: Formula=C16H15N;   InChI=1S/C16H15N/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16/h2-9,15,17H,10H2,1H3/t15-,16+/m1/s1;   InChIKey=LBOJYSIDWZQNJS-CVEARBPZSA-N;   MK 801;   MK801;   SMILES=[H][C@]12CC3=C(C=CC=C3)[C@](C)(N1)C1=C2C=CC=C1;   dizocilpina;   dizocilpinum
 xref: CAS:77086-21-6;   Chemspider:156718;   KEGG:C13737;   LINCS:LSM-5688;   PDBeChem:BMK;   PMID:28232581;   PMID:29489358;   PMID:29670280;   PMID:30772438;   PMID:31177060;   PMID:32105720;   PMID:32219769;   PMID:32289529;   PMID:32324160;   PMID:32641944;   PMID:32760846;   PMID:32808583;   PMID:32892308;   PMID:32956214;   PMID:32973585;   PMID:33187817;   PMID:33249825;   PMID:33324181;   PMID:33404734;   PMID:33442771;   PMID:33639267;   PMID:33656787;   PMID:33723767;   PMID:33809889;   PMID:33882624;   PMID:33891976;   PMID:33945878;   PMID:33974921;   PMID:34054433;   PMID:34098454;   PMID:34119597;   PMID:34177484;   Wikipedia:Dizocilpine
 cyclic_relationship: is_conjugate_base_of CHEBI:176787


show annotations for term's descendants           Sort by:
dizocilpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 affects binding EXP Dizocilpine binds to Drd2 protein RGD PMID:15852061 RGD:1581406 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Dizocilpine inhibits the reaction [Cocaine increases expression of Gria1 protein in the nucleus accumbens] RGD PMID:11801363 RGD:405650201 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Sirt1 sirtuin 1 increases expression EXP dizocilpine cotreated with cocaine increases expression of Sirt1 protein in nucleus accumbens RGD PMID:27664298 RGD:401900166 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            anaesthetic 11833
              dizocilpine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        secondary amino compound 6953
                                          dizocilpine 3
paths to the root