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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:furochromene
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Accession:CHEBI:39432 term browser browse the term
Synonyms:related_synonym: furochromenes


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5-methoxypsoralen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
increases expression
multiple interactions		 ISO 5-methoxypsoralen results in decreased activity of ABCB1 protein
5-methoxypsoralen results in increased expression of ABCB1 mRNA
[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Verapamil inhibits the reaction [5-Methoxypsoralen results in decreased activity of ABCB1 protein]; Verapamil inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]		 CTD PMID:29079042 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO 5-methoxypsoralen results in increased expression of ABCC1 mRNA CTD PMID:29079042 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases activity
decreases expression		 ISO [5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCC2 protein]; Indomethacin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]
5-methoxypsoralen results in decreased expression of ABCC2 mRNA		 CTD PMID:29079042 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity
multiple interactions
increases expression		 ISO 5-methoxypsoralen results in decreased activity of ABCG2 protein
[5-methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; Novobiocin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCG2 protein]; Novobiocin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]
5-methoxypsoralen results in increased expression of ABCG2 mRNA		 CTD PMID:29079042 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO
EXP		 5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein
5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased phosphorylation of AKT1 protein]
pifithrin inhibits the reaction [5-Methoxypsoralen results in decreased phosphorylation of AKT1 protein]		 CTD PMID:30576070 PMID:35815753 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:34428446 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 5-Methoxypsoralen results in increased expression of BAX protein CTD PMID:30576070 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression		 ISO pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of BBC3 protein] CTD PMID:30576070 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of BDNF protein] CTD PMID:34428446 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of BECN1 protein modified form] CTD PMID:34428446 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]; SB 203580 inhibits the reaction [5-Methoxypsoralen results in increased expression of BMP2 mRNA]
5-methoxypsoralen results in increased expression of BMP2 mRNA		 CTD PMID:17980360 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions		 ISO 5-Methoxypsoralen results in increased cleavage of CASP3 protein
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP3 protein]		 CTD PMID:30576070 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO 5-Methoxypsoralen results in increased cleavage of CASP9 protein
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased cleavage of CASP9 protein]		 CTD PMID:30576070 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased activity of CAT protein] CTD PMID:35815753 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of CCND1 mRNA] CTD PMID:34428446 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO 5-Methoxypsoralen results in decreased expression of CCNE1 protein CTD PMID:30576070 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO 5-Methoxypsoralen results in decreased expression of CDK2 protein CTD PMID:30576070 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO 5-Methoxypsoralen results in increased expression of CDKN1A protein
pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of CDKN1A protein]		 CTD PMID:30576070 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased phosphorylation of CTNNB1 protein] CTD PMID:34428446 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein] CTD PMID:34428446 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of IL1B protein] CTD PMID:35815753 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of IL23A protein] CTD PMID:34428446 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il27 interleukin 27 multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of IL27 protein] CTD PMID:34428446 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of IL6 protein] CTD PMID:35815753 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of MAPK1 protein CTD PMID:17980360 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of MAPK3 protein CTD PMID:17980360 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of MAPT protein modified form] CTD PMID:34428446 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of MTOR protein modified form] CTD PMID:34428446 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in decreased phosphorylation of NOS3 protein] CTD PMID:35815753 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of PPP2CA protein modified form] CTD PMID:34428446 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of PRKG1 protein] CTD PMID:34428446 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases expression		 ISO pifithrin inhibits the reaction [5-Methoxypsoralen results in increased expression of PTEN protein] CTD PMID:30576070 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of RELA protein modified form] CTD PMID:34428446 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Smad1 SMAD family member 1 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of SMAD1 protein CTD PMID:17980360 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad5 SMAD family member 5 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of SMAD5 protein CTD PMID:17980360 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634 		JBrowse link
G Smad9 SMAD family member 9 increases phosphorylation ISO 5-methoxypsoralen results in increased phosphorylation of SMAD9 protein CTD PMID:17980360 NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNF protein] CTD PMID:35815753 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:35815753 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP 5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein] CTD PMID:35815753 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects activity		 ISO 5-Methoxypsoralen results in increased expression of and results in increased phosphorylation of TP53 protein
5-Methoxypsoralen metabolite affects the activity of TP53 protein		 CTD PMID:30576070 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP
ISO		 5-methoxypsoralen promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] CTD PMID:17599282 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO 5-Methoxypsoralen inhibits the reaction [Streptozocin results in decreased expression of WNT3A protein] CTD PMID:34428446 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
6',7'-Dihydroxybergamottin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO
EXP		 6',7'-dihydroxybergamottin results in decreased activity of CYP1A1 protein CTD PMID:27444380 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions		 ISO 6',7'-dihydroxybergamottin results in decreased activity of CYP3A4 protein
6',7'-dihydroxybergamottin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]		 CTD PMID:15860655 PMID:23146034 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Por cytochrome p450 oxidoreductase decreases activity ISO 6',7'-dihydroxybergamottin results in decreased activity of POR protein CTD PMID:23146034 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
Aflatoxicol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [CYP19A1 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxicol; [finrozole inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]] which results in decreased chemical synthesis of aflatoxicol; [Tamoxifen inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]] which results in decreased chemical synthesis of aflatoxicol CTD PMID:21296134 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
angelicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP angelicin results in decreased expression of ABCB11 mRNA; angelicin results in decreased expression of ABCB11 protein CTD PMID:30597224 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP angelicin results in decreased expression of ABCC2 mRNA; angelicin results in decreased expression of ABCC2 protein CTD PMID:30597224 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP angelicin results in increased expression of ABCC3 mRNA; angelicin results in increased expression of ABCC3 protein CTD PMID:30597224 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression ISO angelicin affects the expression of ABCC4 mRNA CTD PMID:22173200 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity EXP angelicin results in increased activity of AHR protein CTD PMID:15670584 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
increases phosphorylation		 ISO angelicin results in increased expression of AKT1 mRNA
angelicin results in increased phosphorylation of AKT1 protein		 CTD PMID:37069639 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO
EXP		 angelicin results in increased expression of CYP1A1 protein
angelicin results in increased expression of CYP1A1 mRNA
angelicin results in increased expression of and results in decreased activity of CYP1A1 protein		 CTD PMID:15670584 PMID:18692084 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO angelicin results in increased expression of CYP1A2 protein CTD PMID:18692084 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO angelicin results in decreased expression of CYP2E1 protein CTD PMID:22173200 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP angelicin results in decreased expression of CYP7A1 mRNA; angelicin results in decreased expression of CYP7A1 protein CTD PMID:30597224 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP angelicin results in increased expression of GPT protein CTD PMID:30597224 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases expression
increases phosphorylation		 ISO angelicin results in increased expression of MTOR mRNA
angelicin results in increased phosphorylation of MTOR protein		 CTD PMID:37069639 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP angelicin results in increased expression of NR1H4 mRNA; angelicin results in increased expression of NR1H4 protein CTD PMID:30597224 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO angelicin results in increased expression of PIK3R1 mRNA CTD PMID:37069639 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases expression
increases expression		 ISO angelicin results in decreased expression of SLC22A1 mRNA
angelicin results in increased expression of SLC22A1 protein		 CTD PMID:22173200 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression ISO angelicin results in increased expression of SLC22A2 mRNA; angelicin results in increased expression of SLC22A2 protein CTD PMID:22173200 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 decreases expression ISO angelicin results in decreased expression of SLC22A4 mRNA CTD PMID:22173200 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO angelicin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases expression ISO angelicin results in increased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression
decreases expression		 ISO angelicin results in increased expression of SLC22A8 protein
angelicin results in decreased expression of SLC22A8 mRNA		 CTD PMID:22173200 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 increases expression ISO angelicin results in increased expression of SLC2A9 mRNA CTD PMID:22173200 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP angelicin results in decreased expression of SULT2A1 mRNA; angelicin results in decreased expression of SULT2A1 protein CTD PMID:30597224 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
bergaptol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO bergaptol results in increased expression of HMOX1 CTD PMID:19642688 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
bergomottin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO bergamottin results in increased expression of ABCB1 mRNA; bergamottin results in increased expression of ABCB1 protein CTD PMID:19148864 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO
EXP		 bergamottin results in increased activity of AHR protein CTD PMID:15670584 PMID:21924250 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO bergamottin results in decreased expression of CD74 mRNA CTD PMID:18818744 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO
EXP		 bergamottin results in increased expression of CYP1A1 protein
bergamottin results in increased expression of CYP1A1 mRNA
bergamottin results in increased expression of and results in decreased activity of CYP1A1 protein		 CTD PMID:15670584 PMID:18692084 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO bergamottin results in increased expression of CYP1A2 protein CTD PMID:18692084 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity		 ISO bergamottin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]
bergamottin results in decreased activity of CYP1B1 protein; bergamottin results in decreased activity of CYP1B1 protein polymorphism		 CTD PMID:15861043 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
increases expression		 ISO bergamottin results in decreased activity of CYP2B6 protein
bergamottin results in increased expression of CYP2B10 protein		 CTD PMID:15769884 PMID:18692084 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression		 ISO bergamottin results in decreased activity of CYP3A4 protein
bergamottin results in increased expression of CYP3A4 mRNA		 CTD PMID:11451028 PMID:15860655 PMID:19148864 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO bergamottin results in increased activity of NR1I2 protein CTD PMID:21924250 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO bergamottin results in increased activity of NR1I3 protein CTD PMID:21924250 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of bergamottin analog CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of bergamottin analog CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Chalepensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO 3-(alpha,alpha-dimethylallyl)psoralen results in increased expression of CYP2B10 mRNA CTD PMID:22790670 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
imperatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP imperatorin analog inhibits the reaction [AGT protein results in decreased expression of ACTA2 protein] CTD PMID:25727310 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions EXP imperatorin analog inhibits the reaction [AGT protein results in decreased expression of ACTA2 protein]; imperatorin analog inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:25727310 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression
multiple interactions		 ISO imperatorin results in increased expression of BMP2 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]; SB 203580 inhibits the reaction [imperatorin results in increased expression of BMP2 mRNA]		 CTD PMID:17980360 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO imperatorin results in increased expression of CYP1A1 protein CTD PMID:18692084 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO imperatorin results in increased expression of CYP1A2 protein CTD PMID:18692084 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity		 ISO imperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]
imperatorin results in decreased activity of CYP1B1 protein; imperatorin results in decreased activity of CYP1B1 protein polymorphism		 CTD PMID:15861043 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO imperatorin results in increased expression of CYP2B10 protein CTD PMID:18692084 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO imperatorin results in increased phosphorylation of MAPK1 protein CTD PMID:17980360 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO imperatorin results in increased phosphorylation of MAPK3 protein CTD PMID:17980360 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to imperatorin CTD PMID:19150646 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO imperatorin binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO imperatorin results in increased expression of SLC22A1 mRNA; imperatorin results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases expression
increases expression		 ISO imperatorin results in decreased expression of SLC22A12 mRNA
imperatorin results in increased expression of SLC22A12 protein		 CTD PMID:22173200 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression
decreases expression		 ISO imperatorin results in increased expression of SLC22A2 protein
imperatorin results in decreased expression of SLC22A2 mRNA		 CTD PMID:22173200 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 decreases expression ISO imperatorin results in decreased expression of SLC22A4 mRNA CTD PMID:22173200 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO imperatorin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression ISO imperatorin results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression ISO imperatorin results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 decreases expression
increases expression		 ISO imperatorin results in decreased expression of SLC2A9 protein
imperatorin results in increased expression of SLC2A9 mRNA		 CTD PMID:22173200 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
G Smad1 SMAD family member 1 increases phosphorylation ISO imperatorin results in increased phosphorylation of SMAD1 protein CTD PMID:17980360 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651 		JBrowse link
G Smad5 SMAD family member 5 increases phosphorylation ISO imperatorin results in increased phosphorylation of SMAD5 protein CTD PMID:17980360 NCBI chr17:7,862,332...7,891,678
Ensembl chr17:7,864,720...7,891,634 		JBrowse link
G Smad9 SMAD family member 9 increases phosphorylation ISO imperatorin results in increased phosphorylation of SMAD9 protein CTD PMID:17980360 NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP imperatorin analog inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:25727310 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP
ISO		 imperatorin promotes the reaction [UGT1A1 protein results in increased glucuronidation of Bilirubin] CTD PMID:17599282 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
isoimperatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO isoimperatorin results in increased expression of ABCC4 mRNA CTD PMID:22173200 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP isoimperatorin promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein] CTD PMID:16829687 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases oxidation ISO CYP1A2 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity		 ISO isoimperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]
isoimperatorin results in decreased activity of CYP1B1 protein; isoimperatorin results in decreased activity of CYP1B1 protein polymorphism		 CTD PMID:15861043 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
multiple interactions		 ISO CYP2B6 protein results in increased oxidation of isoimperatorin
[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein; Mephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]		 CTD PMID:25500267 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases oxidation ISO CYP2D6 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO isoimperatorin results in increased expression of GSTA2 mRNA CTD PMID:16829687 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoimperatorin results in increased expression of HMOX1 CTD PMID:19642688 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization EXP isoimperatorin affects the localization of NFE2L2 protein CTD PMID:16829687 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO isoimperatorin results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases expression
increases expression		 ISO isoimperatorin results in decreased expression of SLC22A12 mRNA
isoimperatorin results in increased expression of SLC22A12 protein		 CTD PMID:22173200 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression
decreases expression		 ISO isoimperatorin results in increased expression of SLC22A2 protein
isoimperatorin results in decreased expression of SLC22A2 mRNA		 CTD PMID:22173200 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO isoimperatorin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression ISO isoimperatorin results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression ISO isoimperatorin results in increased expression of SLC22A8 mRNA; isoimperatorin results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 increases expression
decreases expression		 ISO isoimperatorin results in increased expression of SLC2A9 mRNA
isoimperatorin results in decreased expression of SLC2A9 protein		 CTD PMID:22173200 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
isopimpinellin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity EXP isopimpinellin results in increased activity of AHR protein CTD PMID:15670584 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO
EXP		 isopimpinellin results in increased expression of CYP1A1 protein
isopimpinellin results in increased expression of CYP1A1 mRNA
isopimpinellin results in increased expression of and results in decreased activity of CYP1A1 protein		 CTD PMID:15670584 PMID:18692084 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO isopimpinellin results in increased expression of CYP1A2 protein CTD PMID:18692084 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity		 ISO isopimpinellin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]
isopimpinellin results in decreased activity of CYP1B1 protein; isopimpinellin results in decreased activity of CYP1B1 protein polymorphism		 CTD PMID:15861043 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression		 ISO NR1I3 protein affects the reaction [isopimpinellin results in increased expression of CYP2B10 mRNA]
isopimpinellin results in increased expression of CYP2B10 mRNA; isopimpinellin results in increased expression of CYP2B10 protein		 CTD PMID:18692084 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO isopimpinellin results in increased expression of GSTP1 mRNA CTD PMID:18692084 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO isopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]; isopimpinellin promotes the reaction [NR1I3 protein binds to NCOA1 protein] CTD PMID:18692084 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO isopimpinellin results in increased expression of NQO1 protein CTD PMID:19150646 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO isopimpinellin results in increased activity of NR1I2 protein CTD PMID:18692084 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity		 ISO isopimpinellin inhibits the reaction [Androstenedione inhibits the reaction [NR1I3 protein binds to NCOA1 protein]]; isopimpinellin inhibits the reaction [Androstenedione results in decreased activity of NR1I3 protein]; isopimpinellin promotes the reaction [NR1I3 protein binds to NCOA1 protein]; NR1I3 protein affects the reaction [isopimpinellin results in increased expression of CYP2B10 mRNA]
isopimpinellin results in increased activity of NR1I3 protein		 CTD PMID:18692084 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
methoxsalen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Methoxsalen results in decreased expression of ABCB11 mRNA; Methoxsalen results in decreased expression of ABCB11 protein CTD PMID:28552422 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
increases expression		 ISO Methoxsalen results in decreased activity of ABCB1 protein
[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Verapamil inhibits the reaction [[Methoxsalen results in decreased activity of ABCB1 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Verapamil inhibits the reaction [Methoxsalen results in decreased activity of ABCB1 protein]
Methoxsalen results in increased expression of ABCB1 mRNA		 CTD PMID:29079042 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO
EXP		 Methoxsalen results in decreased expression of ABCB4 mRNA
Methoxsalen results in decreased expression of ABCB4 mRNA; Methoxsalen results in decreased expression of ABCB4 protein		 CTD PMID:28552422 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Methoxsalen results in increased expression of ABCC1 mRNA CTD PMID:29079042 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression
decreases activity
multiple interactions		 ISO Methoxsalen results in decreased expression of ABCC2 mRNA
Methoxsalen results in decreased activity of ABCC2 protein
[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin; Indomethacin inhibits the reaction [[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Indomethacin inhibits the reaction [Methoxsalen results in decreased activity of ABCC2 protein]		 CTD PMID:29079042 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP
ISO		 Methoxsalen results in increased expression of ABCC3 mRNA
Methoxsalen results in increased expression of ABCC3 protein		 CTD PMID:28552422 PMID:30419252 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects expression
increases expression		 ISO Methoxsalen affects the expression of ABCC4 protein
Methoxsalen results in increased expression of ABCC4 mRNA		 CTD PMID:22173200 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases expression
decreases activity		 ISO [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [Methoxsalen results in decreased activity of ABCG2 protein]
Methoxsalen results in increased expression of ABCG2 mRNA		 CTD PMID:29079042 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ahr aryl hydrocarbon receptor increases activity
multiple interactions		 EXP
ISO		 Methoxsalen results in increased activity of AHR protein
Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]		 CTD PMID:7702611 PMID:15670584 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATM protein modified form] CTD PMID:23907605 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of ATR protein modified form] CTD PMID:23907605 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Methoxsalen results in increased expression of BAX protein CTD PMID:22796345 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Methoxsalen inhibits the reaction [Aflatoxin B1 results in decreased expression of BCL2 protein]
Methoxsalen results in decreased expression of BCL2 protein		 CTD PMID:22743290 PMID:22796345 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions
decreases expression
decreases response to substance		 ISO BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein]; BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein]
Methoxsalen results in decreased expression of BHLHE40 mRNA; Methoxsalen results in decreased expression of BHLHE40 protein
BHLHE40 protein results in decreased susceptibility to Methoxsalen		 CTD PMID:22796345 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression		 ISO BHLHE40 protein inhibits the reaction [Methoxsalen results in decreased expression of BIRC5 protein] CTD PMID:22796345 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of BRCA1 protein modified form] CTD PMID:23907605 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO BHLHE40 protein inhibits the reaction [Methoxsalen results in increased activity of and results in decreased expression of CASP3 protein]; Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased cleavage of CASP3 protein]; Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CASP3 protein modified form]; Methoxsalen results in decreased expression of and results in increased activity of CASP3 protein CTD PMID:22743290 PMID:22796345 PMID:23907605 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 decreases expression ISO Methoxsalen results in decreased expression of CASP8 protein CTD PMID:22796345 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 decreases expression ISO Methoxsalen results in decreased expression of CASP9 protein CTD PMID:22796345 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein] CTD PMID:15157999 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases expression		 ISO Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA]
Methoxsalen results in increased expression of CES2 mRNA; Methoxsalen results in increased expression of CES2 protein		 CTD PMID:17003103 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of CHEK2 protein modified form] CTD PMID:23907605 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression		 ISO
EXP		 Methoxsalen inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]
Methoxsalen results in decreased activity of CYP1A1 protein
Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Methoxsalen results in increased expression of CYP1A1 mRNA
Methoxsalen results in increased expression of and results in decreased activity of CYP1A1 protein		 CTD PMID:7702611 PMID:9169082 PMID:15670584 PMID:18420780 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP
ISO		 Methoxsalen results in decreased activity of CYP1A2 protein CTD PMID:8819299 PMID:12814958 PMID:15879494 PMID:18420780 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Methoxsalen results in decreased activity of CYP1B1 protein CTD PMID:18420780 PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP Methoxsalen results in decreased expression of CYP27A1 mRNA CTD PMID:28552422 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 decreases activity
multiple interactions		 EXP
ISO		 Methoxsalen results in decreased activity of CYP2A1 protein
[Methoxsalen results in decreased activity of CYP2A13 protein] which results in decreased susceptibility to Skatole; Methoxsalen inhibits the reaction [CYP2A13 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Methoxsalen inhibits the reaction [CYP2A13 protein results in increased metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]; Methoxsalen inhibits the reaction [CYP2A13 protein results in increased susceptibility to Aflatoxin B1]		 CTD PMID:12814958 PMID:17671098 PMID:18669584 PMID:20795680 PMID:22743290 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 decreases activity EXP
ISO		 Methoxsalen results in decreased activity of CYP2A3 protein
Methoxsalen results in decreased activity of CYP2A4 protein		 CTD PMID:15879494 PMID:18420780 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP Methoxsalen results in decreased activity of CYP2B1 protein CTD PMID:15879494 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Methoxsalen results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP Methoxsalen results in decreased activity of CYP2C11 protein CTD PMID:12814958 PMID:15879494 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity EXP
ISO		 Methoxsalen results in decreased activity of CYP2C6 protein
Methoxsalen results in decreased activity of CYP2C29 protein		 CTD PMID:12814958 PMID:15879494 PMID:18420780 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Methoxsalen results in decreased activity of CYP2D6 protein CTD PMID:18420780 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP
ISO		 Methoxsalen results in decreased activity of CYP2E1 protein CTD PMID:15879494 PMID:18420780 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression
multiple interactions		 EXP
ISO		 Methoxsalen results in decreased activity of CYP3A2 protein
Methoxsalen results in increased expression of CYP3A4 mRNA; Methoxsalen results in increased expression of CYP3A4 protein
Methoxsalen results in decreased activity of CYP3A4 protein
Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]		 CTD PMID:15879494 PMID:17003103 PMID:18420780 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases activity EXP Methoxsalen results in decreased activity of CYP3A23-3A1 protein CTD PMID:15879494 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Methoxsalen results in decreased expression of CYP7A1 mRNA
Methoxsalen results in decreased expression of CYP7A1 protein
Methoxsalen affects the reaction [VDR protein affects the expression of CYP7A1 protein]
Methoxsalen results in increased expression of CYP7A1 protein		 CTD PMID:28552422 PMID:30419252 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP Methoxsalen results in decreased expression of CYP8B1 mRNA CTD PMID:28552422 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Methoxsalen results in increased expression of GPT protein CTD PMID:28552422 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hal histidine ammonia lyase decreases activity ISO Methoxsalen results in decreased activity of HAL protein CTD PMID:20880231 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Methoxsalen results in decreased expression of NR0B2 mRNA
VDR protein affects the reaction [Methoxsalen results in increased expression of NR0B2 protein]		 CTD PMID:28552422 PMID:30419252 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP Methoxsalen results in decreased expression of NR1H4 mRNA; Methoxsalen results in decreased expression of NR1H4 protein CTD PMID:28552422 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO
EXP		 NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CES2 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]
Methoxsalen results in increased activity of NR1I2 protein		 CTD PMID:17003103 PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Methoxsalen inhibits the reaction [Aflatoxin B1 results in increased expression of PARP1 protein modified form] CTD PMID:22743290 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Methoxsalen results in decreased expression of PPARA mRNA; Methoxsalen results in decreased expression of PPARA protein CTD PMID:28552422 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Methoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein] CTD PMID:15157999 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Methoxsalen results in decreased expression of SLC10A1 mRNA; Methoxsalen results in decreased expression of SLC10A1 protein CTD PMID:28552422 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO Methoxsalen results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases expression
increases expression		 ISO Methoxsalen results in decreased expression of SLC22A2 mRNA
Methoxsalen results in increased expression of SLC22A2 protein		 CTD PMID:22173200 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO Methoxsalen results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression ISO Methoxsalen results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression ISO Methoxsalen results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 decreases expression
increases expression		 ISO Methoxsalen results in decreased expression of SLC2A9 protein
Methoxsalen results in increased expression of SLC2A9 mRNA		 CTD PMID:22173200 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Methoxsalen analog results in decreased expression of TNF protein CTD PMID:15052360 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Methoxsalen results in increased expression of TP53 protein
Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]		 CTD PMID:22796345 PMID:23907605 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vdr vitamin D receptor multiple interactions
increases expression		 ISO Methoxsalen affects the reaction [VDR protein affects the expression of CYP7A1 protein]; VDR protein affects the reaction [Methoxsalen results in increased expression of NR0B2 protein]
Methoxsalen results in increased expression of VDR protein		 CTD PMID:30419252 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Nodakenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Urod uroporphyrinogen decarboxylase multiple interactions ISO nodakenin binds to and affects the activity of UROD protein CTD PMID:23209648 NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
Notopterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing		 ISO [CYP1A2 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] CTD PMID:32198085 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing
decreases activity
multiple interactions		 ISO CYP2B6 protein results in increased metabolism of notopterol
notopterol results in decreased activity of CYP2B6 protein
[CYP2B6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; notopterol inhibits the reaction [[CYP2B6 protein results in increased metabolism of Bupropion] which results in increased chemical synthesis of hydroxybupropion]; notopterol inhibits the reaction [CYP2B6 protein results in increased metabolism of Bupropion]		 CTD PMID:32198085 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
increases metabolic processing		 ISO [CYP2C19 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] CTD PMID:32198085 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
increases metabolic processing
multiple interactions		 ISO notopterol results in decreased activity of CYP2D6 protein
CYP2D6 protein results in increased metabolism of notopterol
[CYP2D6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Antioxidants inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]; Glutathione inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]; NADP deficiency inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]; notopterol inhibits the reaction [[CYP2D6 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan]; notopterol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Quinidine inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]		 CTD PMID:32198085 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
decreases activity
multiple interactions		 ISO CYP2E1 protein results in increased metabolism of notopterol
notopterol results in decreased activity of CYP2E1 protein
[CYP2E1 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; notopterol inhibits the reaction [[CYP2E1 protein results in increased metabolism of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; notopterol inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]		 CTD PMID:32198085 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases metabolic processing
multiple interactions		 ISO notopterol results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased metabolism of notopterol
[CYP3A4 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; notopterol inhibits the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone]; notopterol inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone]		 CTD PMID:32198085 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
Phellopterin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO phellopterin results in decreased phosphorylation of AKT1 protein CTD PMID:37708916 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases phosphorylation ISO phellopterin results in decreased phosphorylation of AKT2 protein CTD PMID:37708916 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases phosphorylation ISO phellopterin results in decreased phosphorylation of AKT3 protein CTD PMID:37708916 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO phellopterin results in decreased expression of BCL2 protein CTD PMID:37708916 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO phellopterin results in decreased expression of CDK2 protein CTD PMID:37708916 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Clec5a C-type lectin domain containing 5A decreases expression ISO phellopterin results in decreased expression of CLEC5A protein
phellopterin results in decreased expression of CLEC5A mRNA; phellopterin results in decreased expression of CLEC5A protein		 CTD PMID:37708916 NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO phellopterin promotes the reaction [[Carboplatin results in increased phosphorylation of H2AX protein] which results in increased susceptibility to Carboplatin]; phellopterin promotes the reaction [Carboplatin results in increased phosphorylation of H2AX protein] CTD PMID:37708916 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO phellopterin results in decreased expression of MKI67 protein CTD PMID:37708916 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation ISO phellopterin results in decreased phosphorylation of PIK3R1 protein CTD PMID:37708916 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 decreases phosphorylation ISO phellopterin results in decreased phosphorylation of PIK3R3 protein CTD PMID:37708916 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
psoralen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Ficusin results in decreased expression of ABCB11 mRNA; Ficusin results in decreased expression of ABCB11 protein CTD PMID:30597224 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP Ficusin results in decreased expression of ABCC2 mRNA; Ficusin results in decreased expression of ABCC2 protein CTD PMID:30597224 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Ficusin results in increased expression of ABCC3 mRNA; Ficusin results in increased expression of ABCC3 protein CTD PMID:30597224 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO Ficusin results in increased expression of ABCC4 mRNA; Ficusin results in increased expression of ABCC4 protein CTD PMID:22173200 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase affects binding ISO Ficusin binds to ABL1 protein CTD PMID:35597499 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF4 mRNA] CTD PMID:31364909 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions		 ISO Ficusin results in increased expression of ATF6 mRNA; Ficusin results in increased expression of ATF6 protein
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF6 mRNA]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of ATF6 protein]		 CTD PMID:31364909 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of BAX protein] CTD PMID:31364909 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO Ficusin results in increased activity of CASP3 protein
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP3 protein]		 CTD PMID:31364909 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity		 ISO 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased activity of CASP8 protein] CTD PMID:31364909 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cat catalase multiple interactions EXP Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein] CTD PMID:27350165 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO Ficusin results in decreased expression of CYP2E1 protein CTD PMID:22173200 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Ficusin results in decreased expression of CYP7A1 mRNA; Ficusin results in decreased expression of CYP7A1 protein CTD PMID:30597224 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions		 ISO Ficusin results in increased expression of DDIT3 mRNA; Ficusin results in increased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of DDIT3 mRNA]		 CTD PMID:31364909 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression
multiple interactions		 ISO Ficusin results in increased expression of EIF2A mRNA
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of EIF2A mRNA]		 CTD PMID:31364909 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased phosphorylation of EIF2AK3 protein] CTD PMID:31364909 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression		 EXP Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of GPT protein]
Ficusin results in increased expression of GPT protein		 CTD PMID:27350165 PMID:30597224 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 ISO Ficusin results in increased expression of HSPA5 mRNA; Ficusin results in increased expression of HSPA5 protein
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of HSPA5 mRNA]; 4-phenylbutyric acid inhibits the reaction [Ficusin results in increased expression of HSPA5 protein]		 CTD PMID:31364909 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein] CTD PMID:27350165 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Ficusin results in increased phosphorylation of MAPK8 protein
4-phenylbutyric acid inhibits the reaction [Ficusin results in increased phosphorylation of MAPK8 protein]		 CTD PMID:31364909 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression
multiple interactions		 ISO Ficusin results in decreased expression of MTOR protein
5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-2,4-imidazolidinedione inhibits the reaction [Ficusin results in decreased expression of MTOR protein]; [Imatinib Mesylate co-treated with Ficusin] results in decreased expression of MTOR protein		 CTD PMID:35597499 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions		 ISO Ficusin results in decreased expression of NFE2L2 protein
5-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-2,4-imidazolidinedione inhibits the reaction [Ficusin results in decreased expression of NFE2L2 protein]; [Imatinib Mesylate co-treated with Ficusin] results in decreased expression of NFE2L2 protein		 CTD PMID:35597499 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression EXP Ficusin results in increased expression of NR1H4 mRNA; Ficusin results in increased expression of NR1H4 protein CTD PMID:30597224 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PPARG mRNA] CTD PMID:27350165 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression
decreases expression		 ISO Ficusin results in increased expression of SLC22A1 protein
Ficusin results in decreased expression of SLC22A1 mRNA		 CTD PMID:22173200 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases expression ISO Ficusin results in decreased expression of SLC22A12 protein CTD PMID:22173200 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression ISO Ficusin results in increased expression of SLC22A2 mRNA; Ficusin results in increased expression of SLC22A2 protein CTD PMID:22173200 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a4 solute carrier family 22 member 4 decreases expression ISO Ficusin results in decreased expression of SLC22A4 mRNA CTD PMID:22173200 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO Ficusin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression
increases expression		 ISO Ficusin results in decreased expression of SLC22A8 mRNA
Ficusin results in increased expression of SLC22A8 protein		 CTD PMID:22173200 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SLC2A4 mRNA] CTD PMID:27350165 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 increases expression ISO Ficusin results in increased expression of SLC2A9 mRNA CTD PMID:22173200 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Ficusin results in decreased expression of SULT2A1 mRNA; Ficusin results in decreased expression of SULT2A1 protein CTD PMID:30597224 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
Rutamarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO rutamarin promotes the reaction [Dietary Fats results in increased expression of ADIPOQ mRNA] CTD PMID:22384078 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO rutamarin promotes the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:22384078 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO rutamarin promotes the reaction [INS1 protein results in increased uptake of Glucose] CTD PMID:22384078 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO rutamarin promotes the reaction [INS protein results in increased phosphorylation of AKT1 protein]; rutamarin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:22384078 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor multiple interactions ISO rutamarin promotes the reaction [INS protein results in increased phosphorylation of INSR protein] CTD PMID:22384078 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO rutamarin promotes the reaction [Dietary Fats results in increased expression of PCK1 mRNA] CTD PMID:22384078 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
increases expression
affects localization		 ISO rutamarin promotes the reaction [Dietary Fats results in increased expression of SLC2A4 mRNA]
rutamarin results in increased expression of SLC2A4 mRNA; rutamarin results in increased expression of SLC2A4 protein
rutamarin affects the localization of SLC2A4 protein		 CTD PMID:22384078 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
trioxsalen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO Trioxsalen analog inhibits the reaction [IFNG protein results in increased expression of NOS2 protein] CTD PMID:16259964 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases activity		 ISO Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased activity of JUN protein] CTD PMID:16259964 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased expression of NOS2 mRNA]; Trioxsalen analog inhibits the reaction [IFNG protein results in increased expression of NOS2 protein] CTD PMID:16259964 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          oxygen atom 19488
            oxygen molecular entity 19488
              organooxygen compound 19141
                oxacycle 17866
                  furochromene 132
                    aflatoxin B1 dialdehyde 0
                    furanocoumarin + 132
                    nigrasin H 0
                    velloquercetin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteropolycyclic compound 18278
                                    organic heterotricyclic compound 15623
                                      furochromene 132
                                        aflatoxin B1 dialdehyde 0
                                        furanocoumarin + 132
                                        nigrasin H 0
                                        velloquercetin 0
paths to the root