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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoimperatorin
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Accession:CHEBI:66071 term browser browse the term
Definition:A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
Synonyms:exact_synonym: 4-[(3-methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
 related_synonym: 7,4-[(3-methyl-2-butenyl)oxy]-7H-furo[3,2-g]-1-benzopyran-7-one;   Formula=C16H14O4;   InChI=1S/C16H14O4/c1-10(2)5-7-19-16-11-3-4-15(17)20-14(11)9-13-12(16)6-8-18-13/h3-6,8-9H,7H2,1-2H3;   InChIKey=IGWDEVSBEKYORK-UHFFFAOYSA-N;   SMILES=CC(C)=CCOc1c2ccoc2cc2oc(=O)ccc12
 xref: CAS:482-45-1;   KEGG:C16976
 xref_mesh: MESH:C055542
 xref: PMID:12510838;   PMID:17396918;   PMID:20964319;   PMID:21627108;   Patent:CN102188464;   Reaxys:1291723


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isoimperatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO isoimperatorin results in increased expression of ABCC4 mRNA CTD PMID:22173200 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP isoimperatorin promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein] CTD PMID:16829687 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases oxidation ISO CYP1A2 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
ISO isoimperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]
isoimperatorin results in decreased activity of CYP1B1 protein; isoimperatorin results in decreased activity of CYP1B1 protein polymorphism
CTD PMID:15861043 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases oxidation
multiple interactions
ISO CYP2B6 protein results in increased oxidation of isoimperatorin
[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein; Mephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]
CTD PMID:25500267 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases oxidation ISO CYP2D6 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO isoimperatorin results in increased expression of GSTA2 mRNA CTD PMID:16829687 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO isoimperatorin results in increased expression of HMOX1 CTD PMID:19642688 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization EXP isoimperatorin affects the localization of NFE2L2 protein CTD PMID:16829687 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases expression ISO isoimperatorin results in increased expression of SLC22A1 protein CTD PMID:22173200 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases expression
increases expression
ISO isoimperatorin results in decreased expression of SLC22A12 mRNA
isoimperatorin results in increased expression of SLC22A12 protein
CTD PMID:22173200 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases expression
decreases expression
ISO isoimperatorin results in increased expression of SLC22A2 protein
isoimperatorin results in decreased expression of SLC22A2 mRNA
CTD PMID:22173200 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression ISO isoimperatorin results in increased expression of SLC22A5 protein CTD PMID:22173200 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression ISO isoimperatorin results in decreased expression of SLC22A6 protein CTD PMID:22173200 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases expression ISO isoimperatorin results in increased expression of SLC22A8 mRNA; isoimperatorin results in increased expression of SLC22A8 protein CTD PMID:22173200 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc2a9 solute carrier family 2 member 9 increases expression
decreases expression
ISO isoimperatorin results in increased expression of SLC2A9 mRNA
isoimperatorin results in decreased expression of SLC2A9 protein
CTD PMID:22173200 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            isoimperatorin 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterotricyclic compound 14583
                                      furochromene 100
                                        furanocoumarin 100
                                          psoralens 91
                                            isoimperatorin 16
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