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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:66071
Term: isoimperatorin
Definition: A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
Chemical ID: MESH:C055542
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1decreases activityISORGD:7367656480464CTDisoimperatorin results in decreased activity of CYP1B1 protein isoimperatorin results in decreased activity of CYP1B1 protein polymorphism

PMID:15861043
Cyp1b1multiple interactionsISORGD:7367656480464CTDisoimperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzoapyrene 7 8-dihydrodiol]

PMID:15861043
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