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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:66071
Term: isoimperatorin
Definition: A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
Chemical ID: MESH:C055542
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3increases oxidationISORGD:13467516480464CTDCYP2B6 protein results in increased oxidation of isoimperatorin

PMID:25500267
Cyp2b3multiple interactionsISORGD:13467516480464CTD[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein, Mephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]

PMID:25500267
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.