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Gene: Smad5 (SMAD family member 5) Rattus norvegicus
Symbol: Smad5
Name: SMAD family member 5
RGD ID: 620158
Description: Predicted to have several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and enzyme binding activity. Involved in Mullerian duct regression and ossification. Predicted to localize to cytosol; heteromeric SMAD protein complex; and nucleoplasm. Orthologous to human SMAD5 (SMAD family member 5); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
Also known as: MAD homolog 5; MAD homolog 5 (Drosophila); Madh5; mothers against decapentaplegic homolog 5; mothers against DPP homolog 5; SMAD 5; SMAD, mothers against DPP homolog 5; SMAD, mothers against DPP homolog 5 (Drosophila)
Homo sapiens (human) : SMAD5 (SMAD family member 5)  HGNC  Alliance
Mus musculus (house mouse) : Smad5 (SMAD family member 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad5 (SMAD family member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD5 (SMAD family member 5)
Canis lupus familiaris (dog) : SMAD5 (SMAD family member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad5 (SMAD family member 5)
Sus scrofa (pig) : SMAD5 (SMAD family member 5)
Chlorocebus sabaeus (African green monkey) : SMAD5 (SMAD family member 5)
Heterocephalus glaber (naked mole-rat) : Smad5 (SMAD family member 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0178,307,448 - 8,336,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,311,796 - 8,331,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,484,309 - 10,513,839 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,814,164 - 13,824,358 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11713,814,163 - 13,824,358 (-)NCBI
Celera177,961,603 - 7,971,797 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Smad5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620158
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.