Smad5 (SMAD family member 5) - Rat Genome Database

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Gene: Smad5 (SMAD family member 5) Rattus norvegicus
Analyze
Symbol: Smad5
Name: SMAD family member 5
RGD ID: 620158
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; I-SMAD binding activity; and enzyme binding activity. Involved in Mullerian duct regression and ossification. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of heteromeric SMAD protein complex. Orthologous to human SMAD5 (SMAD family member 5); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAD homolog 5; MAD homolog 5 (Drosophila); Madh5; mothers against decapentaplegic homolog 5; mothers against DPP homolog 5; SMAD 5; SMAD, mothers against DPP homolog 5; SMAD, mothers against DPP homolog 5 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,862,332 - 7,891,678 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl177,864,720 - 7,891,634 (-)Ensembl
Rnor_6.0178,307,448 - 8,336,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,311,796 - 8,331,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,484,309 - 10,513,839 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,814,164 - 13,824,358 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11713,814,163 - 13,824,358 (-)NCBI
Celera177,961,603 - 7,971,797 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxypsoralen  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
aucubin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dimethylselenide  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glycerol 2-phosphate  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
imperatorin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
Salidroside  (ISO)
simvastatin  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:11278251   PMID:11376112   PMID:11404080   PMID:11729207   PMID:12151307   PMID:12477932   PMID:14656760   PMID:15150273   PMID:15557274   PMID:15591122   PMID:17347486   PMID:17456754  
PMID:18548003   PMID:18590716   PMID:18692037   PMID:18776146   PMID:19103752   PMID:19224984   PMID:19252488   PMID:19793887   PMID:20079400   PMID:20522807   PMID:20843790   PMID:21515935  
PMID:22500633   PMID:22964636   PMID:23610558   PMID:25725805   PMID:26687945   PMID:27035233   PMID:28202235   PMID:28369590   PMID:35170385  


Genomics

Comparative Map Data
Smad5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,862,332 - 7,891,678 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl177,864,720 - 7,891,634 (-)Ensembl
Rnor_6.0178,307,448 - 8,336,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,311,796 - 8,331,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,484,309 - 10,513,839 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,814,164 - 13,824,358 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11713,814,163 - 13,824,358 (-)NCBI
Celera177,961,603 - 7,971,797 (-)NCBICelera
Cytogenetic Map17p14NCBI
SMAD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385136,132,845 - 136,182,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5136,132,845 - 136,188,747 (+)EnsemblGRCh38hg38GRCh38
GRCh375135,468,534 - 135,518,421 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,496,435 - 135,546,321 (+)NCBINCBI36hg18NCBI36
Build 345135,496,434 - 135,546,321NCBI
Celera5131,593,276 - 131,643,157 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5130,657,006 - 130,706,874 (+)NCBIHuRef
CHM1_15134,901,165 - 134,951,034 (+)NCBICHM1_1
T2T-CHM13v2.05136,655,377 - 136,705,263 (+)NCBI
Smad5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,850,804 - 56,890,191 (+)NCBIGRCm39mm39
GRCm39 Ensembl1356,850,823 - 56,890,190 (+)Ensembl
GRCm381356,703,010 - 56,742,378 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,703,010 - 56,742,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371356,804,371 - 56,843,739 (+)NCBIGRCm37mm9NCBIm37
MGSCv361356,733,051 - 56,751,999 (+)NCBImm8
Celera1357,765,382 - 57,797,308 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.12NCBI
Smad5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540831,183,659 - 31,229,384 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540831,183,727 - 31,228,355 (+)NCBIChiLan1.0ChiLan1.0
SMAD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15137,663,558 - 137,713,130 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,664,067 - 137,712,635 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05131,524,229 - 131,574,119 (+)NCBIMhudiblu_PPA_v0panPan3
SMAD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11124,027,603 - 24,082,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1124,028,126 - 24,078,169 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,774,580 - 22,829,238 (+)NCBI
ROS_Cfam_1.01124,843,618 - 24,898,398 (+)NCBI
ROS_Cfam_1.0 Ensembl1124,843,660 - 24,898,392 (+)Ensembl
UMICH_Zoey_3.11123,530,270 - 23,584,907 (+)NCBI
UNSW_CanFamBas_1.01123,397,527 - 23,452,566 (+)NCBI
UU_Cfam_GSD_1.01124,046,574 - 24,101,311 (+)NCBI
Smad5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,200,433 - 124,242,080 (+)NCBI
SpeTri2.0NW_0049365973,225,374 - 3,264,604 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2138,287,443 - 138,344,769 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12138,287,635 - 138,344,092 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SMAD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,877,294 - 38,926,208 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2338,877,315 - 38,921,202 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603438,986,583 - 39,035,567 (-)NCBIVero_WHO_p1.0
Smad5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473310,931,061 - 10,983,669 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473310,927,264 - 10,983,049 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH94764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,867,086 - 7,867,256 (+)MAPPERmRatBN7.2
Rnor_6.0178,312,205 - 8,312,374NCBIRnor6.0
Rnor_5.01710,489,061 - 10,489,230UniSTSRnor5.0
RGSC_v3.41713,814,143 - 13,814,312UniSTSRGSC3.4
Celera177,961,582 - 7,961,751UniSTS
Cytogenetic Map17p14UniSTS
RH136684  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,866,784 - 7,866,967 (+)MAPPERmRatBN7.2
Rnor_6.0178,311,903 - 8,312,085NCBIRnor6.0
Rnor_5.01710,488,759 - 10,488,941UniSTSRnor5.0
RGSC_v3.41713,813,841 - 13,814,023UniSTSRGSC3.4
Celera177,961,280 - 7,961,462UniSTS
RH 3.4 Map1773.9UniSTS
Cytogenetic Map17p14UniSTS
Smad5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,873,943 - 7,874,094 (+)MAPPERmRatBN7.2
Rnor_6.0178,319,062 - 8,319,212NCBIRnor6.0
Rnor_5.01710,495,918 - 10,496,068UniSTSRnor5.0
RGSC_v3.41713,821,000 - 13,821,150UniSTSRGSC3.4
Celera177,968,439 - 7,968,589UniSTS
Cytogenetic Map17p14UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:347
Count of miRNA genes:208
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000016704
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 40 24 19 24 8 8 74 35 39 11 8
Low 3 17 17 17 3 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000016704   ⟹   ENSRNOP00000016704
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,866,696 - 7,890,987 (-)Ensembl
Rnor_6.0 Ensembl178,311,796 - 8,331,032 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099544   ⟹   ENSRNOP00000091448
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,864,720 - 7,890,987 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102907   ⟹   ENSRNOP00000077054
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,866,696 - 7,891,634 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105138   ⟹   ENSRNOP00000093149
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,866,678 - 7,878,169 (-)Ensembl
RefSeq Acc Id: NM_021692   ⟹   NP_067724
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,867,108 - 7,877,302 (-)NCBI
Rnor_6.0178,312,226 - 8,322,420 (-)NCBI
Rnor_5.01710,484,309 - 10,513,839 (-)NCBI
RGSC_v3.41713,814,164 - 13,824,358 (-)RGD
Celera177,961,603 - 7,971,797 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253586   ⟹   XP_006253648
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,862,332 - 7,891,660 (-)NCBI
Rnor_6.0178,307,448 - 8,336,996 (-)NCBI
Rnor_5.01710,484,309 - 10,513,839 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253587   ⟹   XP_006253649
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,862,332 - 7,891,678 (-)NCBI
Rnor_6.0178,307,448 - 8,336,996 (-)NCBI
Rnor_5.01710,484,309 - 10,513,839 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253588   ⟹   XP_006253650
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,862,333 - 7,891,288 (-)NCBI
Rnor_6.0178,307,448 - 8,336,851 (-)NCBI
Rnor_5.01710,484,309 - 10,513,839 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600658   ⟹   XP_017456147
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,862,333 - 7,891,286 (-)NCBI
Rnor_6.0178,307,448 - 8,336,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096035   ⟹   XP_038951963
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,862,333 - 7,891,284 (-)NCBI
RefSeq Acc Id: XM_039096036   ⟹   XP_038951964
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,862,332 - 7,891,658 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_067724   ⟸   NM_021692
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253649   ⟸   XM_006253587
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253648   ⟸   XM_006253586
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253650   ⟸   XM_006253588
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456147   ⟸   XM_017600658
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016704   ⟸   ENSRNOT00000016704
RefSeq Acc Id: XP_038951964   ⟸   XM_039096036
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038951963   ⟸   XM_039096035
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000077054   ⟸   ENSRNOT00000102907
RefSeq Acc Id: ENSRNOP00000091448   ⟸   ENSRNOT00000099544
RefSeq Acc Id: ENSRNOP00000093149   ⟸   ENSRNOT00000105138
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1V3-F1-model_v2 AlphaFold Q9R1V3 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620158 AgrOrtholog
BioCyc Gene G2FUF-10278 BioCyc
Ensembl Genes ENSRNOG00000022870 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000016704 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000077054 ENTREZGENE
  ENSRNOP00000093149 ENTREZGENE
Ensembl Transcript ENSRNOT00000016704 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000102907 ENTREZGENE
  ENSRNOT00000105138 ENTREZGENE
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103141 IMAGE-MGC_LOAD
  IMAGE:9099068 IMAGE-MGC_LOAD
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59328 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187371 IMAGE-MGC_LOAD
  MGC:91705 IMAGE-MGC_LOAD
NCBI Gene 59328 ENTREZGENE
PANTHER PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad5 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B1WBR0 ENTREZGENE, UniProtKB/TrEMBL
  Q6IRI8_RAT UniProtKB/TrEMBL
  Q9R1V3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Smad5  SMAD family member 5  Smad5  MAD homolog 5 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Smad5  MAD homolog 5 (Drosophila)    SMAD, mothers against DPP homolog 5 (Drosophila)  Name updated 1299863 APPROVED
2005-01-20 Smad5  SMAD, mothers against DPP homolog 5 (Drosophila)  Madh5  Smad5  Symbol and Name updated 1299863 APPROVED
2002-08-07 Madh5  Smad5      Symbol and Name status set to provisional 70820 PROVISIONAL