Smad5 Rat (1->4)-beta-D-glucan multiple interactions ISO Smad5 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SMAD5 mRNA CTD PMID:36331819 Smad5 Rat 1,2-dimethylhydrazine decreases expression ISO Smad5 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of SMAD5 mRNA CTD PMID:22206623 Smad5 Rat 17beta-estradiol increases expression ISO Smad5 (Mus musculus) 6480464 Estradiol results in increased expression of SMAD5 mRNA CTD PMID:25210133 Smad5 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Smad5 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SMAD5 mRNA CTD PMID:21570461 and PMID:24058054 Smad5 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Smad5 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of SMAD5 mRNA CTD PMID:19770486 Smad5 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SMAD5 mRNA CTD PMID:19490992 and PMID:33387578 Smad5 Rat 4-hydroxyphenyl retinamide increases expression ISO Smad5 (Mus musculus) 6480464 Fenretinide results in increased expression of SMAD5 mRNA CTD PMID:28973697 Smad5 Rat 5-aza-2'-deoxycytidine decreases expression ISO Smad5 (Mus musculus) 6480464 Decitabine results in decreased expression of SMAD5 mRNA CTD PMID:27915011 Smad5 Rat 5-methoxypsoralen increases phosphorylation ISO Smad5 (Mus musculus) 6480464 5-methoxypsoralen results in increased phosphorylation of SMAD5 protein CTD PMID:17980360 Smad5 Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of SMAD5 mRNA CTD PMID:24780913 Smad5 Rat aflatoxin B1 increases expression ISO SMAD5 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of SMAD5 mRNA CTD PMID:22100608 Smad5 Rat aflatoxin B1 increases methylation ISO SMAD5 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of SMAD5 intron CTD PMID:30157460 Smad5 Rat aflatoxin B1 decreases methylation ISO SMAD5 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of SMAD5 gene CTD PMID:27153756 Smad5 Rat Aflatoxin B2 alpha increases methylation ISO SMAD5 (Homo sapiens) 6480464 aflatoxin B2 results in increased methylation of SMAD5 intron CTD PMID:30157460 Smad5 Rat all-trans-retinoic acid decreases expression ISO SMAD5 (Homo sapiens) 6480464 Tretinoin results in decreased expression of SMAD5 mRNA CTD PMID:33167477 Smad5 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SMAD5 mRNA CTD PMID:16483693 Smad5 Rat amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of SMAD5 mRNA CTD PMID:30779732 Smad5 Rat antirheumatic drug increases expression ISO SMAD5 (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of SMAD5 mRNA CTD PMID:24449571 Smad5 Rat aristolochic acid A decreases expression ISO SMAD5 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of SMAD5 protein modified form CTD PMID:22525892 Smad5 Rat aristolochic acid A multiple interactions ISO SMAD5 (Homo sapiens) 6480464 GREM1 mutant form inhibits the reaction [aristolochic acid I results in decreased expression of SMAD5 protein modified form] CTD PMID:22525892 Smad5 Rat arsane affects expression ISO SMAD5 (Homo sapiens) 6480464 Arsenic affects the expression of SMAD5 protein CTD PMID:24675094 Smad5 Rat arsane increases phosphorylation EXP 6480464 Arsenic results in increased phosphorylation of SMAD5 protein CTD PMID:28903487 Smad5 Rat arsenic atom affects expression ISO SMAD5 (Homo sapiens) 6480464 Arsenic affects the expression of SMAD5 protein CTD PMID:24675094 Smad5 Rat arsenic atom increases phosphorylation EXP 6480464 Arsenic results in increased phosphorylation of SMAD5 protein CTD PMID:28903487 Smad5 Rat aucubin increases expression ISO SMAD5 (Homo sapiens) 6480464 aucubin results in increased expression of SMAD5 protein CTD PMID:29408431 Smad5 Rat benzo[a]pyrene increases methylation ISO SMAD5 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of SMAD5 promoter CTD PMID:27901495 Smad5 Rat benzo[a]pyrene affects methylation ISO SMAD5 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of SMAD5 intron CTD PMID:30157460 Smad5 Rat benzo[a]pyrene decreases methylation ISO SMAD5 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of SMAD5 5' UTR CTD PMID:27901495 Smad5 Rat benzo[a]pyrene diol epoxide I decreases expression ISO SMAD5 (Homo sapiens) 6480464 7 more ... CTD PMID:20018196 Smad5 Rat benzo[a]pyrene diol epoxide I increases expression ISO SMAD5 (Homo sapiens) 6480464 7 more ... CTD PMID:26238291 Smad5 Rat beta-lapachone decreases expression ISO SMAD5 (Homo sapiens) 6480464 beta-lapachone results in decreased expression of SMAD5 mRNA CTD PMID:38218311 Smad5 Rat bexarotene increases expression ISO SMAD5 (Homo sapiens) 6480464 bexarotene results in increased expression of SMAD5 mRNA CTD PMID:17178900 Smad5 Rat bisphenol A decreases expression ISO SMAD5 (Homo sapiens) 6480464 bisphenol A results in decreased expression of SMAD5 mRNA CTD PMID:22576693 Smad5 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SMAD5 mRNA CTD PMID:30816183 more ... Smad5 Rat bisphenol A affects methylation ISO Smad5 (Mus musculus) 6480464 bisphenol A affects the methylation of SMAD5 promoter CTD PMID:27334623 Smad5 Rat bisphenol A increases expression ISO Smad5 (Mus musculus) 6480464 bisphenol A results in increased expression of SMAD5 mRNA CTD PMID:26063408 and PMID:33221593 Smad5 Rat cadmium atom multiple interactions ISO SMAD5 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SMAD5 mRNA CTD PMID:35301059 Smad5 Rat cadmium dichloride decreases expression ISO SMAD5 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of SMAD5 mRNA CTD PMID:38568856 Smad5 Rat cadmium dichloride multiple interactions ISO SMAD5 (Homo sapiens) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SMAD5 mRNA CTD PMID:35301059 Smad5 Rat caffeine increases phosphorylation ISO SMAD5 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of SMAD5 protein CTD PMID:35688186 Smad5 Rat carbon nanotube increases expression ISO SMAD5 (Homo sapiens) 6480464 Nanotubes and Carbon results in increased expression of SMAD5 mRNA CTD PMID:23634900 Smad5 Rat carbon nanotube increases expression ISO Smad5 (Mus musculus) 6480464 Nanotubes and Carbon results in increased expression of SMAD5 mRNA CTD PMID:25554681 Smad5 Rat CGP 52608 multiple interactions ISO SMAD5 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to SMAD5 gene] CTD PMID:28238834 Smad5 Rat chlorpyrifos decreases expression ISO Smad5 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of SMAD5 mRNA CTD PMID:32715474 and PMID:37019170 Smad5 Rat cocaine multiple interactions EXP 6480464 [Cocaine co-treated with Cocaine deficiency] inhibits the reaction [SMURF1 protein binds to SMAD5 protein modified form] and [Cocaine co-treated with Cocaine deficiency] results in increased expression of and results in increased phosphorylation of SMAD5 protein CTD PMID:30158054 Smad5 Rat copper atom multiple interactions ISO SMAD5 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of SMAD5 mRNA CTD PMID:20971185 Smad5 Rat copper(0) multiple interactions ISO SMAD5 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of SMAD5 mRNA CTD PMID:20971185 Smad5 Rat copper(II) sulfate increases expression ISO SMAD5 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of SMAD5 mRNA CTD PMID:19549813 Smad5 Rat coumarin decreases phosphorylation ISO SMAD5 (Homo sapiens) 6480464 coumarin results in decreased phosphorylation of SMAD5 protein CTD PMID:35688186 Smad5 Rat crocidolite asbestos decreases phosphorylation ISO Smad5 (Mus musculus) 6480464 Asbestos and Crocidolite results in decreased phosphorylation of SMAD5 protein CTD PMID:17975199 Smad5 Rat cyclosporin A decreases expression ISO SMAD5 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of SMAD5 mRNA CTD PMID:27989131 Smad5 Rat deguelin increases expression ISO SMAD5 (Homo sapiens) 6480464 deguelin results in increased expression of SMAD5 mRNA CTD PMID:33512557 Smad5 Rat dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of SMAD5 CTD PMID:20079400 Smad5 Rat dexamethasone multiple interactions ISO Smad5 (Mus musculus) 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SMAD5 mRNA more ... CTD PMID:26492236 Smad5 Rat dexamethasone multiple interactions EXP 6480464 Dexamethasone inhibits the reaction [SMAD5 protein binds to AKT2 gene] CTD PMID:20079400 Smad5 Rat dimethylselenide multiple interactions ISO SMAD5 (Homo sapiens) 6480464 [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of SMAD5-AS1 mRNA] which results in increased expression of SMAD5 mRNA and [[Ozone results in increased oxidation of dimethylselenide] which results in increased expression of SMAD5-AS1 mRNA] which results in increased expression of SMAD5 mRNA CTD PMID:33656867 Smad5 Rat dorsomorphin multiple interactions ISO SMAD5 (Homo sapiens) 6480464 dorsomorphin inhibits the reaction [GDF2 protein results in increased phosphorylation of SMAD5 protein] CTD PMID:23936038 Smad5 Rat ethanol increases expression ISO Smad5 (Mus musculus) 6480464 Ethanol results in increased expression of SMAD5 mRNA CTD PMID:30319688 Smad5 Rat ethyl methanesulfonate increases expression ISO SMAD5 (Homo sapiens) 6480464 Ethyl Methanesulfonate results in increased expression of SMAD5 mRNA CTD PMID:23649840 Smad5 Rat flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of SMAD5 mRNA and Flutamide results in decreased expression of SMAD5 protein CTD PMID:16166221 Smad5 Rat formaldehyde increases expression ISO SMAD5 (Homo sapiens) 6480464 Formaldehyde results in increased expression of SMAD5 mRNA CTD PMID:23649840 Smad5 Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of SMAD5 mRNA CTD PMID:33387578 Smad5 Rat glycerol 2-phosphate multiple interactions ISO Smad5 (Mus musculus) 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SMAD5 mRNA more ... CTD PMID:26492236 Smad5 Rat hydrogen peroxide multiple interactions ISO SMAD5 (Homo sapiens) 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD5 protein CTD PMID:18951874 Smad5 Rat hydroxyl multiple interactions ISO SMAD5 (Homo sapiens) 6480464 [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of SMAD5-AS1 mRNA] which results in increased expression of SMAD5 mRNA CTD PMID:33656867 Smad5 Rat imperatorin increases phosphorylation ISO Smad5 (Mus musculus) 6480464 imperatorin results in increased phosphorylation of SMAD5 protein CTD PMID:17980360 Smad5 Rat ivermectin decreases expression ISO SMAD5 (Homo sapiens) 6480464 Ivermectin results in decreased expression of SMAD5 protein CTD PMID:32959892 Smad5 Rat L-ascorbic acid multiple interactions ISO Smad5 (Mus musculus) 6480464 [Ascorbic Acid co-treated with Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of SMAD5 mRNA more ... CTD PMID:26492236 Smad5 Rat lead diacetate multiple interactions ISO Smad5 (Mus musculus) 6480464 lead acetate inhibits the reaction [BMP2 protein results in increased phosphorylation of SMAD5 protein] CTD PMID:17805416 Smad5 Rat lead diacetate increases methylation EXP 6480464 lead acetate results in increased methylation of SMAD5 gene CTD PMID:29571894 Smad5 Rat leflunomide increases expression ISO SMAD5 (Homo sapiens) 6480464 leflunomide results in increased expression of SMAD5 mRNA CTD PMID:28988120 Smad5 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of SMAD5 gene CTD PMID:35440735 Smad5 Rat methyl methanesulfonate increases expression ISO SMAD5 (Homo sapiens) 6480464 Methyl Methanesulfonate results in increased expression of SMAD5 mRNA CTD PMID:23649840 Smad5 Rat ozone multiple interactions ISO Smad5 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of Ozone] which results in increased expression of SMAD5 mRNA CTD PMID:27106289 Smad5 Rat ozone multiple interactions ISO SMAD5 (Homo sapiens) 6480464 [[Ozone results in increased oxidation of dimethylselenide] which results in increased expression of SMAD5-AS1 mRNA] which results in increased expression of SMAD5 mRNA CTD PMID:33656867 Smad5 Rat paracetamol multiple interactions ISO Smad5 (Mus musculus) 6480464 Acetaminophen results in decreased phosphorylation of [SMAD1 protein binds to SMAD5 protein binds to SMAD9 protein] CTD PMID:22610607 Smad5 Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of SMAD5 mRNA CTD PMID:33387578 Smad5 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Smad5 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SMAD5 mRNA CTD PMID:36331819 Smad5 Rat phencyclidine decreases expression ISO Smad5 (Mus musculus) 6480464 Phencyclidine results in decreased expression of SMAD5 mRNA CTD PMID:12105081 Smad5 Rat phenobarbital affects expression ISO Smad5 (Mus musculus) 6480464 Phenobarbital affects the expression of SMAD5 mRNA CTD PMID:23091169 Smad5 Rat picoxystrobin increases expression ISO SMAD5 (Homo sapiens) 6480464 picoxystrobin results in increased expression of SMAD5 mRNA CTD PMID:33512557 Smad5 Rat pirinixic acid decreases expression ISO Smad5 (Mus musculus) 6480464 pirinixic acid results in decreased expression of SMAD5 mRNA CTD PMID:20813756 Smad5 Rat quercetin decreases expression ISO SMAD5 (Homo sapiens) 6480464 Quercetin results in decreased expression of SMAD5 mRNA CTD PMID:15309432 Smad5 Rat resveratrol increases phosphorylation ISO SMAD5 (Homo sapiens) 6480464 resveratrol results in increased phosphorylation of SMAD5 protein CTD PMID:21745208 Smad5 Rat resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of SMAD5 mRNA CTD PMID:25905778 Smad5 Rat rotenone increases expression ISO SMAD5 (Homo sapiens) 6480464 Rotenone results in increased expression of SMAD5 mRNA CTD PMID:33512557 Smad5 Rat Salidroside multiple interactions ISO Smad5 (Mus musculus) 6480464 rhodioloside results in increased phosphorylation of and results in increased expression of SMAD5 protein CTD PMID:24929042 Smad5 Rat Salidroside increases expression ISO Smad5 (Mus musculus) 6480464 rhodioloside results in increased expression of SMAD5 mRNA CTD PMID:24929042 Smad5 Rat simvastatin multiple interactions ISO Smad5 (Mus musculus) 6480464 Simvastatin inhibits the reaction [TNF inhibits the reaction [BMP2 results in increased phosphorylation of SMAD5 protein]] CTD PMID:18310456 Smad5 Rat sirtinol decreases phosphorylation ISO SMAD5 (Homo sapiens) 6480464 sirtinol results in decreased phosphorylation of SMAD5 protein CTD PMID:21745208 Smad5 Rat sodium arsenite multiple interactions ISO SMAD5 (Homo sapiens) 6480464 EGF protein promotes the reaction [sodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD5 protein]] and sodium arsenite inhibits the reaction [BMP6 protein results in increased phosphorylation of SMAD5 protein] CTD PMID:23566955 Smad5 Rat sodium arsenite decreases expression ISO SMAD5 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of SMAD5 mRNA CTD PMID:38568856 Smad5 Rat sodium arsenite decreases expression ISO Smad5 (Mus musculus) 6480464 sodium arsenite results in decreased expression of SMAD5 mRNA CTD PMID:16014739 Smad5 Rat tert-butyl hydroperoxide decreases methylation ISO SMAD5 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in decreased methylation of SMAD5 gene CTD PMID:27509014 Smad5 Rat tert-butyl hydroperoxide increases expression ISO SMAD5 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of SMAD5 mRNA CTD PMID:27509014 Smad5 Rat testosterone enanthate affects expression ISO SMAD5 (Homo sapiens) 6480464 testosterone enanthate affects the expression of SMAD5 mRNA CTD PMID:17440010 Smad5 Rat theophylline multiple interactions ISO SMAD5 (Homo sapiens) 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of SMAD5 protein CTD PMID:18951874 Smad5 Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of SMAD5 mRNA CTD PMID:34492290 Smad5 Rat titanium dioxide decreases methylation ISO Smad5 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of SMAD5 gene CTD PMID:35295148 Smad5 Rat titanium dioxide increases methylation ISO Smad5 (Mus musculus) 6480464 titanium dioxide results in increased methylation of SMAD5 promoter CTD PMID:35295148 Smad5 Rat trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of SMAD5 gene CTD PMID:27618143 Smad5 Rat triphenyl phosphate affects expression ISO SMAD5 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of SMAD5 mRNA CTD PMID:37042841 Smad5 Rat triptonide increases expression ISO Smad5 (Mus musculus) 6480464 triptonide results in increased expression of SMAD5 mRNA CTD PMID:33045310 Smad5 Rat valproic acid decreases methylation ISO SMAD5 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of SMAD5 gene CTD PMID:29154799 Smad5 Rat valproic acid affects expression ISO Smad5 (Mus musculus) 6480464 Valproic Acid affects the expression of SMAD5 mRNA CTD PMID:17963808 Smad5 Rat valproic acid decreases expression ISO SMAD5 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of SMAD5 mRNA CTD PMID:23179753 more ... Smad5 Rat vitamin E decreases expression ISO SMAD5 (Homo sapiens) 6480464 Vitamin E results in decreased expression of SMAD5 mRNA CTD PMID:19244175