Smad5 (SMAD family member 5) - Rat Genome Database

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Gene: Smad5 (SMAD family member 5) Rattus norvegicus
Analyze
Symbol: Smad5
Name: SMAD family member 5
RGD ID: 620158
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; I-SMAD binding activity; and enzyme binding activity. Involved in Mullerian duct regression and ossification. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of heteromeric SMAD protein complex. Orthologous to human SMAD5 (SMAD family member 5); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAD homolog 5; MAD homolog 5 (Drosophila); Madh5; mothers against decapentaplegic homolog 5; mothers against DPP homolog 5; SMAD 5; SMAD, mothers against DPP homolog 5; SMAD, mothers against DPP homolog 5 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,867,640 - 7,896,983 (-)NCBIGRCr8
mRatBN7.2177,862,332 - 7,891,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,864,720 - 7,891,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx177,885,190 - 7,895,389 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,416,674 - 9,426,832 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0177,881,573 - 7,891,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,307,448 - 8,336,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,311,796 - 8,331,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,484,309 - 10,513,839 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,814,164 - 13,824,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11713,814,163 - 13,824,358 (-)NCBI
Celera177,961,603 - 7,971,797 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxypsoralen  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
aucubin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dimethylselenide  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
gentamycin  (EXP)
glycerol 2-phosphate  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
imperatorin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phencyclidine  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
Salidroside  (ISO)
simvastatin  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. Fukada T, etal., PLoS One. 2008;3(11):e3642. doi: 10.1371/journal.pone.0003642. Epub 2008 Nov 5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Pangas SA, etal., Mol Cell Biol. 2008 Jan;28(1):248-57. Epub 2007 Oct 29.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Takahashi H, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Mar;290(3):L450-8. Epub 2005 Dec 16.
12. TGF-beta, BMPS, and their signal transducing mediators, Smads, in rat fracture healing. Yu Y, etal., J Biomed Mater Res 2002 Jun 5;60(3):392-7.
13. Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60. Zavadil J, etal., Leukemia. 1997 Aug;11(8):1187-92.
14. Mullerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Mullerian duct regression. Zhan Y, etal., Development. 2006 Jun;133(12):2359-69. Epub 2006 May 10.
Additional References at PubMed
PMID:11278251   PMID:11376112   PMID:11404080   PMID:11729207   PMID:12151307   PMID:12477932   PMID:14656760   PMID:15150273   PMID:15557274   PMID:15591122   PMID:17347486   PMID:17456754  
PMID:18548003   PMID:18590716   PMID:18692037   PMID:18776146   PMID:19103752   PMID:19224984   PMID:19252488   PMID:19793887   PMID:20079400   PMID:20522807   PMID:20843790   PMID:21515935  
PMID:22500633   PMID:22964636   PMID:23610558   PMID:25725805   PMID:26687945   PMID:27035233   PMID:28202235   PMID:28369590   PMID:35170385  


Genomics

Comparative Map Data
Smad5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,867,640 - 7,896,983 (-)NCBIGRCr8
mRatBN7.2177,862,332 - 7,891,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,864,720 - 7,891,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx177,885,190 - 7,895,389 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,416,674 - 9,426,832 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0177,881,573 - 7,891,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,307,448 - 8,336,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,311,796 - 8,331,032 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,484,309 - 10,513,839 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41713,814,164 - 13,824,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11713,814,163 - 13,824,358 (-)NCBI
Celera177,961,603 - 7,971,797 (-)NCBICelera
Cytogenetic Map17p14NCBI
SMAD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385136,132,845 - 136,182,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5136,132,845 - 136,188,747 (+)EnsemblGRCh38hg38GRCh38
GRCh375135,468,534 - 135,518,421 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,496,435 - 135,546,321 (+)NCBINCBI36Build 36hg18NCBI36
Build 345135,496,434 - 135,546,321NCBI
Celera5131,593,276 - 131,643,157 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,657,006 - 130,706,874 (+)NCBIHuRef
CHM1_15134,901,165 - 134,951,034 (+)NCBICHM1_1
T2T-CHM13v2.05136,655,373 - 136,705,263 (+)NCBIT2T-CHM13v2.0
Smad5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,850,804 - 56,890,191 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,850,823 - 56,890,190 (+)EnsemblGRCm39 Ensembl
GRCm381356,703,010 - 56,742,378 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,703,010 - 56,742,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371356,804,371 - 56,843,739 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,733,051 - 56,751,999 (+)NCBIMGSCv36mm8
Celera1357,765,382 - 57,797,308 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.12NCBI
Smad5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540831,183,659 - 31,229,384 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540831,183,727 - 31,228,355 (+)NCBIChiLan1.0ChiLan1.0
SMAD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24131,419,826 - 131,469,837 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,559,444 - 129,609,397 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,524,229 - 131,574,119 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,663,558 - 137,713,130 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,664,067 - 137,712,635 (+)Ensemblpanpan1.1panPan2
SMAD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11124,027,603 - 24,082,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1124,028,126 - 24,078,169 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,774,580 - 22,829,238 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,843,618 - 24,898,398 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,843,660 - 24,898,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,530,270 - 23,584,907 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,397,527 - 23,452,566 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01124,046,574 - 24,101,311 (+)NCBIUU_Cfam_GSD_1.0
Smad5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,200,433 - 124,242,080 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365973,225,374 - 3,264,604 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365973,225,374 - 3,264,604 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2138,287,710 - 138,344,762 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12138,287,635 - 138,344,092 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SMAD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,877,294 - 38,926,208 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2338,877,315 - 38,921,202 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603438,986,583 - 39,035,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473310,931,061 - 10,983,669 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473310,927,264 - 10,983,049 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smad5
99 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:347
Count of miRNA genes:208
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000016704
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat

Markers in Region
RH94764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,867,086 - 7,867,256 (+)MAPPERmRatBN7.2
Rnor_6.0178,312,205 - 8,312,374NCBIRnor6.0
Rnor_5.01710,489,061 - 10,489,230UniSTSRnor5.0
RGSC_v3.41713,814,143 - 13,814,312UniSTSRGSC3.4
Celera177,961,582 - 7,961,751UniSTS
Cytogenetic Map17p14UniSTS
RH136684  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,866,784 - 7,866,967 (+)MAPPERmRatBN7.2
Rnor_6.0178,311,903 - 8,312,085NCBIRnor6.0
Rnor_5.01710,488,759 - 10,488,941UniSTSRnor5.0
RGSC_v3.41713,813,841 - 13,814,023UniSTSRGSC3.4
Celera177,961,280 - 7,961,462UniSTS
RH 3.4 Map1773.9UniSTS
Cytogenetic Map17p14UniSTS
Smad5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,873,943 - 7,874,094 (+)MAPPERmRatBN7.2
Rnor_6.0178,319,062 - 8,319,212NCBIRnor6.0
Rnor_5.01710,495,918 - 10,496,068UniSTSRnor5.0
RGSC_v3.41713,821,000 - 13,821,150UniSTSRGSC3.4
Celera177,968,439 - 7,968,589UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000016704   ⟹   ENSRNOP00000016704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,866,696 - 7,890,987 (-)Ensembl
Rnor_6.0 Ensembl178,311,796 - 8,331,032 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099544   ⟹   ENSRNOP00000091448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,864,720 - 7,890,987 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102907   ⟹   ENSRNOP00000077054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,866,696 - 7,891,634 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105138   ⟹   ENSRNOP00000093149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,866,678 - 7,878,169 (-)Ensembl
RefSeq Acc Id: NM_021692   ⟹   NP_067724
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,872,414 - 7,882,608 (-)NCBI
mRatBN7.2177,867,108 - 7,877,302 (-)NCBI
Rnor_6.0178,312,226 - 8,322,420 (-)NCBI
Rnor_5.01710,484,309 - 10,513,839 (-)NCBI
RGSC_v3.41713,814,164 - 13,824,358 (-)RGD
Celera177,961,603 - 7,971,797 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253586   ⟹   XP_006253648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,867,640 - 7,896,954 (-)NCBI
mRatBN7.2177,862,332 - 7,891,660 (-)NCBI
Rnor_6.0178,307,448 - 8,336,996 (-)NCBI
Rnor_5.01710,484,309 - 10,513,839 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253587   ⟹   XP_006253649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,867,640 - 7,896,983 (-)NCBI
mRatBN7.2177,862,332 - 7,891,678 (-)NCBI
Rnor_6.0178,307,448 - 8,336,996 (-)NCBI
Rnor_5.01710,484,309 - 10,513,839 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253588   ⟹   XP_006253650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,867,640 - 7,896,812 (-)NCBI
mRatBN7.2177,862,333 - 7,891,288 (-)NCBI
Rnor_6.0178,307,448 - 8,336,851 (-)NCBI
Rnor_5.01710,484,309 - 10,513,839 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600658   ⟹   XP_017456147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,867,640 - 7,896,812 (-)NCBI
mRatBN7.2177,862,333 - 7,891,286 (-)NCBI
Rnor_6.0178,307,448 - 8,336,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096035   ⟹   XP_038951963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,867,640 - 7,896,811 (-)NCBI
mRatBN7.2177,862,333 - 7,891,284 (-)NCBI
RefSeq Acc Id: XM_039096036   ⟹   XP_038951964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,867,640 - 7,896,950 (-)NCBI
mRatBN7.2177,862,332 - 7,891,658 (-)NCBI
RefSeq Acc Id: XM_063276717   ⟹   XP_063132787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,867,640 - 7,896,947 (-)NCBI
RefSeq Acc Id: NP_067724   ⟸   NM_021692
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL),   A0A8I5Y0N4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253649   ⟸   XM_006253587
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL),   A0A8I5Y0N4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253648   ⟸   XM_006253586
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL),   A0A8I5Y0N4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253650   ⟸   XM_006253588
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL),   A0A8I5Y0N4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456147   ⟸   XM_017600658
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL),   A0A8I5Y0N4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016704   ⟸   ENSRNOT00000016704
RefSeq Acc Id: XP_038951964   ⟸   XM_039096036
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL),   A0A8I5Y0N4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951963   ⟸   XM_039096035
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL),   A0A8I5Y0N4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077054   ⟸   ENSRNOT00000102907
Ensembl Acc Id: ENSRNOP00000091448   ⟸   ENSRNOT00000099544
Ensembl Acc Id: ENSRNOP00000093149   ⟸   ENSRNOT00000105138
RefSeq Acc Id: XP_063132787   ⟸   XM_063276717
- Peptide Label: isoform X1
- UniProtKB: Q9R1V3 (UniProtKB/Swiss-Prot),   B1WBR0 (UniProtKB/TrEMBL)
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1V3-F1-model_v2 AlphaFold Q9R1V3 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620158 AgrOrtholog
BioCyc Gene G2FUF-10278 BioCyc
Ensembl Genes ENSRNOG00000022870 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024650 UniProtKB/Swiss-Prot
  ENSRNOG00060019755 UniProtKB/Swiss-Prot
  ENSRNOG00065024555 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016704.5 UniProtKB/Swiss-Prot
  ENSRNOT00000099544.1 UniProtKB/TrEMBL
  ENSRNOT00000102907.1 UniProtKB/TrEMBL
  ENSRNOT00000105138.1 UniProtKB/TrEMBL
  ENSRNOT00055042516 UniProtKB/Swiss-Prot
  ENSRNOT00060034308 UniProtKB/Swiss-Prot
  ENSRNOT00065042234 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103141 IMAGE-MGC_LOAD
  IMAGE:9099068 IMAGE-MGC_LOAD
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59328 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187371 IMAGE-MGC_LOAD
  MGC:91705 IMAGE-MGC_LOAD
NCBI Gene 59328 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN MOTHERS AGAINST DPP UniProtKB/TrEMBL
  PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad5 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022870 RatGTEx
  ENSRNOG00055024650 RatGTEx
  ENSRNOG00060019755 RatGTEx
  ENSRNOG00065024555 RatGTEx
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0N4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEH5_RAT UniProtKB/TrEMBL
  A0A8I6AJ12_RAT UniProtKB/TrEMBL
  A6KAM2_RAT UniProtKB/TrEMBL
  B1WBR0 ENTREZGENE, UniProtKB/TrEMBL
  Q6IRI8_RAT UniProtKB/TrEMBL
  Q9R1V3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Smad5  SMAD family member 5  Smad5  MAD homolog 5 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Smad5  MAD homolog 5 (Drosophila)    SMAD, mothers against DPP homolog 5 (Drosophila)  Name updated 1299863 APPROVED
2005-01-20 Smad5  SMAD, mothers against DPP homolog 5 (Drosophila)  Madh5  Smad5  Symbol and Name updated 1299863 APPROVED
2002-08-07 Madh5  Smad5      Symbol and Name status set to provisional 70820 PROVISIONAL