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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620158
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad5
Name: SMAD family member 5
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad5multiple interactionsISOSMAD5 (Homo sapiens)6480464CTD[[Ozone results in increased oxidation of dimethylselenide] which results in increased expression of SMAD5-AS1 mRNA] which results in increased expression of SMAD5 mRNAPMID:33656867
Smad5multiple interactionsISOSmad5 (Mus musculus)6480464CTD[Air Pollutants results in increased abundance of Ozone] which results in increased expression of SMAD5 mRNAPMID:27106289
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