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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621628
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a12
Name: solute carrier family 22 member 12
Acc ID: CHEBI:66071
Term: isoimperatorin
Definition: A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
Chemical ID: MESH:C055542
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a12decreases expressionISORGD:13235446480464CTDisoimperatorin results in decreased expression of SLC22A12 mRNA

PMID:22173200
Slc22a12increases expressionISORGD:13235446480464CTDisoimperatorin results in increased expression of SLC22A12 protein

PMID:22173200
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.