dimethylarsinous acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	dimethylarsinous acid	go back to main search page
Accession:	CHEBI:23808	browse the term
Definition:	A methylarsinous acid that has formula C2H7AsO.
Synonyms:	related_synonym:	Formula=C2H7AsO; InChI=1S/C2H7AsO/c1-3(2)4/h4H,1-2H3; InChIKey=VDEGQTCMQUFPFH-UHFFFAOYSA-N; Me2AsOH; SMILES=C[As](C)O; [As(CH3)2(OH)]
	xref:	Beilstein:1730818
	xref_mesh:	MESH:C472511
	xref:	UM-BBD_compID:c0773

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Genes (282)

dimethylarsinous acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 0610030E20 gene

decreases expression

dimethylarsinous acid results in decreased expression of C2ORF68 mRNA

NCBI chr 6:72,324,017...72,330,145
Ensembl chr 6:72,324,300...72,330,131

G

ATP-binding cassette, sub-family C member 1

decreases response to substance

ABCC1 protein results in decreased susceptibility to dimethylarsinous acid

NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601

G

abhydrolase domain containing 2

increases expression

dimethylarsinous acid results in increased expression of ABHD2 mRNA

NCBI chr 7:78,923,002...79,015,257
Ensembl chr 7:78,922,947...79,015,256

G

acyl-CoA synthetase short-chain family member 2

decreases expression

dimethylarsinous acid results in decreased expression of ACSS2 mRNA

NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644

G

ADAM metallopeptidase domain 12

increases expression

dimethylarsinous acid results in increased expression of ADAM12 mRNA

NCBI chr 7:133,484,928...133,826,859
Ensembl chr 7:133,484,928...133,833,875

G

ADAM metallopeptidase with thrombospondin type 1 motif 6

increases expression

dimethylarsinous acid results in increased expression of ADAMTS6 mRNA

NCBI chr13:104,423,026...104,633,203
Ensembl chr13:104,424,343...104,633,203

G

AF4/FMR2 family, member 4

increases expression

dimethylarsinous acid results in increased expression of AFF4 mRNA

NCBI chr11:53,240,807...53,312,657
Ensembl chr11:53,241,660...53,312,657

G

AHNAK nucleoprotein 2

decreases expression

dimethylarsinous acid results in decreased expression of AHNAK2 mRNA

NCBI chr12:112,738,631...112,766,278
Ensembl chr12:112,738,628...112,766,277

G

aldo-keto reductase family 1, member C20

increases expression

dimethylarsinous acid results in increased expression of AKR1C1 mRNA

NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344

G

thymoma viral proto-oncogene 3

decreases expression

dimethylarsinous acid results in decreased expression of AKT3 mRNA

NCBI chr 1:176,847,642...177,091,688
Ensembl chr 1:176,847,639...177,085,769

G

aldehyde dehydrogenase family 1, subfamily A3

increases expression

dimethylarsinous acid results in increased expression of ALDH1A3 mRNA

NCBI chr 7:66,040,640...66,077,225
Ensembl chr 7:66,040,638...66,077,265

G

aldehyde dehydrogenase 2, mitochondrial

increases expression

dimethylarsinous acid results in increased expression of ALDH2 mRNA

NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887

G

arachidonate 5-lipoxygenase activating protein

decreases expression

dimethylarsinous acid results in decreased expression of ALOX5AP mRNA

NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963

G

ankyrin repeat domain 1

increases expression

dimethylarsinous acid results in increased expression of ANKRD1 mRNA

NCBI chr19:36,089,365...36,097,244
Ensembl chr19:36,089,361...36,097,499

G

annexin A1

increases expression

dimethylarsinous acid results in increased expression of ANXA1 mRNA

NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308

G

annexin A10

increases expression

dimethylarsinous acid results in increased expression of ANXA10 mRNA

NCBI chr 8:62,510,076...62,576,227
Ensembl chr 8:62,510,076...62,576,184

G

apolipoprotein E

affects response to substance

APOE protein affects the susceptibility to dimethylarsinous acid

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

ADP-ribosylation factor-like 15

decreases expression

dimethylarsinous acid results in decreased expression of ARL15 mRNA

NCBI chr13:113,929,963...114,293,998
Ensembl chr13:113,931,041...114,293,997

G

ADP-ribosylation factor-like 4C

decreases expression

dimethylarsinous acid results in decreased expression of ARL4C mRNA

NCBI chr 1:88,625,947...88,629,913
Ensembl chr 1:88,600,847...88,629,943

G

arsenite methyltransferase

increases chemical synthesis
multiple interactions
affects response to substance

AS3MT protein results in increased chemical synthesis of dimethylarsinous acid
[AS3MT gene SNP affects the susceptibility to Arsenic] which affects the abundance of dimethylarsinous acid; [AS3MT protein binds to and results in increased methylation of arsenite] which results in increased chemical synthesis of dimethylarsinous acid; [AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid; [AS3MT protein polymorphism results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of dimethylarsinous acid; [AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid; [AS3MT protein results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of dimethylarsinous acid; [AS3MT protein results in increased methylation of arsenite] which results in increased chemical synthesis of dimethylarsinous acid; [AS3MT protein results in increased methylation of monomethylarsonous acid] which results in increased chemical synthesis of dimethylarsinous acid; Cysteine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; Unithiol inhibits the reaction [[AS3MT protein results in increased methylation of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]; Unithiol inhibits the reaction [[AS3MT protein results in increased methylation of monomethylarsonous acid] which results in increased chemical synthesis of dimethylarsinous acid]
AS3MT affects the susceptibility to dimethylarsinous acid

PMID:22868225 PMID:22955273 PMID:23376817 PMID:25194983 PMID:25349987 More...

NCBI chr19:46,695,124...46,729,538
Ensembl chr19:46,695,897...46,729,538

G

asparagine synthetase

increases expression

dimethylarsinous acid results in increased expression of ASNS mRNA

PMID:23487506 PMID:23876855

NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254

G

aspartate-beta-hydroxylase

increases expression

dimethylarsinous acid results in increased expression of ASPH mRNA

NCBI chr 4:9,449,085...9,669,344
Ensembl chr 4:9,448,069...9,669,344

G

activating transcription factor 4

increases expression

dimethylarsinous acid results in increased expression of ATF4 mRNA

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

aurora kinase B

affects localization

dimethylarsinous acid affects the localization of AURKB protein

NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490

G

BCL2-associated X protein

multiple interactions

dimethylarsinous acid affects the expression of and affects the cleavage of BAX protein

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

increases expression

dimethylarsinous acid results in increased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

basic helix-loop-helix family, member e41

decreases expression

dimethylarsinous acid results in decreased expression of BHLHE41 mRNA

NCBI chr 6:145,803,969...145,811,146
Ensembl chr 6:145,803,969...145,811,284

G

caldesmon 1

decreases expression

dimethylarsinous acid results in decreased expression of CALD1 mRNA

NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

decreases expression

dimethylarsinous acid results in decreased expression of CAMK2N1 mRNA

NCBI chr 4:138,182,459...138,187,437
Ensembl chr 4:138,181,625...138,187,434

G

calcium/calmodulin-dependent protein kinase IV

decreases expression

dimethylarsinous acid results in decreased expression of CAMK4 mRNA

NCBI chr18:33,067,995...33,328,820
Ensembl chr18:33,067,984...33,324,281

G

carbonic anhydrase 9

decreases expression

dimethylarsinous acid results in decreased expression of CA9 mRNA

NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729

G

caspase 1

affects expression

dimethylarsinous acid affects the expression of CASP1 mRNA

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 14

decreases expression

dimethylarsinous acid results in decreased expression of CASP14 mRNA

NCBI chr10:78,547,829...78,554,181
Ensembl chr10:78,547,825...78,554,128

G

caspase 3

multiple interactions

[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased activity of and results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of CASP3 protein]

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 9

increases activity

dimethylarsinous acid results in increased activity of CASP9 protein

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

decreases oxidation
affects activity
multiple interactions

CAT protein results in decreased oxidation of dimethylarsinous acid
dimethylarsinous acid affects the activity of CAT protein
[CAT protein results in decreased oxidation of dimethylarsinous acid] which results in decreased chemical synthesis of Cacodylic Acid

PMID:18619986 PMID:23353816

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

caveolin 2

decreases expression

dimethylarsinous acid results in decreased expression of CAV2 mRNA

NCBI chr 6:17,281,184...17,289,129
Ensembl chr 6:17,281,184...17,289,114

G

coiled-coil domain containing 9B

decreases expression

dimethylarsinous acid results in decreased expression of CCDC9B mRNA

NCBI chr 2:118,584,626...118,593,421
Ensembl chr 2:118,584,639...118,593,142

G

C-C motif chemokine ligand 2

decreases expression

dimethylarsinous acid results in decreased expression of CCL2 mRNA

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cyclin A1

decreases expression

dimethylarsinous acid results in decreased expression of CCNA1 mRNA

NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922

G

cyclin D1

increases expression
decreases expression

dimethylarsinous acid results in increased expression of CCND1 mRNA
dimethylarsinous acid results in decreased expression of CCND1 mRNA

PMID:19945496 PMID:23487506

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

CD109 antigen

decreases expression

dimethylarsinous acid results in decreased expression of CD109 mRNA

NCBI chr 9:78,522,828...78,623,542
Ensembl chr 9:78,522,828...78,623,535

G

CD44 antigen

increases expression

dimethylarsinous acid results in increased expression of CD44 mRNA

NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010

G

cadherin 6

decreases expression

dimethylarsinous acid results in decreased expression of CDH6 mRNA

NCBI chr15:13,028,785...13,176,493
Ensembl chr15:13,028,787...13,173,761

G

cyclin dependent kinase 16

increases expression

dimethylarsinous acid results in increased expression of CDK16 mRNA

NCBI chr X:20,554,210...20,566,119
Ensembl chr X:20,554,193...20,566,119

G

cyclin dependent kinase 4

decreases expression

dimethylarsinous acid results in decreased expression of CDK4 mRNA

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

cyclin dependent kinase inhibitor 1A

increases expression

dimethylarsinous acid results in increased expression of CDKN1A mRNA

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 2B

decreases expression

dimethylarsinous acid results in decreased expression of CDKN2B mRNA

NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276

G

CCAAT/enhancer binding protein beta

decreases expression
increases expression

dimethylarsinous acid results in decreased expression of CEBPB mRNA
dimethylarsinous acid results in increased expression of CEBPB mRNA

PMID:16507463 PMID:23487506

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

centrosomal protein 78

decreases expression

dimethylarsinous acid results in decreased expression of CEP78 mRNA

NCBI chr19:15,933,134...15,962,396
Ensembl chr19:15,933,137...15,962,353

G

claudin 14

increases expression

dimethylarsinous acid results in increased expression of CLDN14 mRNA

NCBI chr16:93,715,919...93,809,733
Ensembl chr16:93,715,919...93,809,696

G

clusterin

increases expression

dimethylarsinous acid results in increased expression of CLU mRNA

PMID:20886546 PMID:23876855

NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996

G

collagen, type XIII, alpha 1

decreases expression

dimethylarsinous acid results in decreased expression of COL13A1 mRNA

NCBI chr10:61,674,013...61,814,985
Ensembl chr10:61,674,015...61,814,887

G

collagen, type I, alpha 1

decreases expression
increases expression

dimethylarsinous acid results in decreased expression of COL1A1 mRNA
dimethylarsinous acid results in increased expression of COL1A1 mRNA

PMID:16507463 PMID:23876855

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type IV, alpha 1

decreases expression

dimethylarsinous acid results in decreased expression of COL4A1 mRNA

NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826

G

collagen, type IV, alpha 2

decreases expression

dimethylarsinous acid results in decreased expression of COL4A2 mRNA

NCBI chr 8:11,362,878...11,499,287
Ensembl chr 8:11,362,805...11,499,287

G

cAMP responsive element binding protein 1

decreases expression

dimethylarsinous acid results in decreased expression of CREB1 mRNA

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

crystallin, alpha B

increases expression

dimethylarsinous acid results in increased expression of CRYAB mRNA

PMID:20886546 PMID:23876855

NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936

G

cystathionine gamma lyase

increases expression

dimethylarsinous acid results in increased expression of CTH mRNA

NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714

G

catenin beta interacting protein 1

decreases expression

dimethylarsinous acid results in decreased expression of CTNNBIP1 mRNA

NCBI chr 4:149,602,698...149,650,894
Ensembl chr 4:149,602,693...149,650,894

G

C-X-C motif chemokine ligand 14

increases expression

dimethylarsinous acid results in increased expression of CXCL14 mRNA

NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364

G

C-X-C motif chemokine ligand 15

increases expression
increases secretion
multiple interactions

dimethylarsinous acid results in increased expression of CXCL8 mRNA
dimethylarsinous acid results in increased secretion of CXCL8 protein
Lipopolysaccharides promotes the reaction [dimethylarsinous acid results in increased secretion of CXCL8 protein]

PMID:23487506 PMID:23876855 PMID:24140498

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine ligand 2

increases expression

dimethylarsinous acid results in increased expression of CXCL2 mRNA

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

cytoglobin

decreases expression

dimethylarsinous acid results in decreased expression of CYGB mRNA

NCBI chr11:116,536,421...116,544,887
Ensembl chr11:116,536,421...116,545,139

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

dimethylarsinous acid results in increased expression of CYP1A1 mRNA

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

death associated protein kinase 1

affects expression

dimethylarsinous acid affects the expression of DAPK mRNA

NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005

G

DNA-damage inducible transcript 3

decreases expression
increases expression

dimethylarsinous acid results in decreased expression of DDIT3 mRNA
dimethylarsinous acid results in increased expression of DDIT3 mRNA

PMID:16507463 PMID:22425709 PMID:23487506

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DEAD box helicase 17

decreases expression

dimethylarsinous acid results in decreased expression of DDX17 mRNA

NCBI chr15:79,411,897...79,430,976
Ensembl chr15:79,411,937...79,430,942

G

DEAD box helicase 3, X-linked

increases expression

dimethylarsinous acid results in increased expression of DDX3X mRNA

NCBI chr X:13,147,261...13,160,222
Ensembl chr X:13,147,209...13,160,291

G

DEP domain containing 1a

increases expression

dimethylarsinous acid results in increased expression of DEPDC1 mRNA

NCBI chr 3:159,201,042...159,235,690
Ensembl chr 3:159,201,070...159,235,592

G

dehydrogenase/reductase member 2

increases expression

dimethylarsinous acid results in increased expression of DHRS2 mRNA

NCBI chr14:55,459,464...55,478,897
Ensembl chr14:55,459,464...55,478,892

G

DnaJ heat shock protein family (Hsp40) member A4

increases expression

dimethylarsinous acid results in increased expression of DNAJA4 mRNA

NCBI chr 9:54,606,132...54,623,601
Ensembl chr 9:54,606,157...54,623,599

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

dimethylarsinous acid results in increased expression of DNAJB9 mRNA

NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109

G

dolichyl-phosphate mannosyltransferase polypeptide 3

decreases expression

dimethylarsinous acid results in decreased expression of DPM3 mRNA

NCBI chr 3:89,166,567...89,174,386
Ensembl chr 3:89,166,665...89,174,386

G

dual specificity phosphatase 1

increases expression

dimethylarsinous acid results in increased expression of DUSP1 mRNA

NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102

G

dual specificity phosphatase 5

increases expression

dimethylarsinous acid results in increased expression of DUSP5 mRNA

NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862

G

endothelin 1

increases expression

dimethylarsinous acid results in increased expression of EDN1 mRNA

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

early growth response 1

decreases expression

dimethylarsinous acid results in decreased expression of EGR1 mRNA

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases phosphorylation

Cycloheximide inhibits the reaction [dimethylarsinous acid results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229

G

leucine rich repeat and fibronectin type III, extracellular 2

decreases expression

dimethylarsinous acid results in decreased expression of ELFN2 mRNA

NCBI chr15:78,551,531...78,603,056
Ensembl chr15:78,551,531...78,602,971

G

ELOVL fatty acid elongase 6

decreases expression

dimethylarsinous acid results in decreased expression of ELOVL6 mRNA

NCBI chr 3:129,326,035...129,432,144
Ensembl chr 3:129,326,004...129,432,144

G

endoplasmic reticulum to nucleus signalling 1

increases expression

dimethylarsinous acid results in increased expression of ERN1 mRNA

NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678

G

endoplasmic reticulum oxidoreductase 1 beta

increases expression

dimethylarsinous acid results in increased expression of ERO1B mRNA

NCBI chr13:12,580,701...12,624,422
Ensembl chr13:12,580,755...12,626,285

G

ets variant 1

decreases expression

dimethylarsinous acid results in decreased expression of ETV1 mRNA

NCBI chr12:38,829,655...38,920,484
Ensembl chr12:38,829,379...38,920,483

G

fatty acid 2-hydroxylase

increases expression

dimethylarsinous acid results in increased expression of FA2H mRNA

NCBI chr 8:112,071,770...112,120,453
Ensembl chr 8:112,071,767...112,120,456

G

family with sequence similarity 210, member B

decreases expression

dimethylarsinous acid results in decreased expression of FAM210B mRNA

NCBI chr 2:172,187,444...172,197,669
Ensembl chr 2:172,187,485...172,197,669

G

flap structure specific endonuclease 1

decreases expression

dimethylarsinous acid results in decreased expression of FEN1 mRNA

NCBI chr19:10,176,496...10,181,757
Ensembl chr19:10,176,496...10,181,533

G

FER tyrosine kinase

decreases expression

dimethylarsinous acid results in decreased expression of FER mRNA

NCBI chr17:64,136,945...64,453,515
Ensembl chr17:64,170,057...64,446,491

G

FYVE, RhoGEF and PH domain containing 6

increases expression

dimethylarsinous acid results in increased expression of FGD6 mRNA

NCBI chr10:93,871,862...93,981,201
Ensembl chr10:93,871,863...93,981,201

G

fibroblast growth factor binding protein 1

decreases expression

dimethylarsinous acid results in decreased expression of FGFBP1 mRNA

PMID:23487506 PMID:23876855

NCBI chr 5:44,136,200...44,139,173
Ensembl chr 5:44,136,200...44,139,121

G

fibroblast growth factor receptor 1

decreases expression

dimethylarsinous acid results in decreased expression of FGFR1 mRNA

NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734

G

formin homology 2 domain containing 3

decreases expression

dimethylarsinous acid results in decreased expression of FHOD3 mRNA

NCBI chr18:24,841,445...25,266,564
Ensembl chr18:24,841,680...25,266,558

G

FK506 binding protein 4

increases expression

dimethylarsinous acid results in increased expression of FKBP4 mRNA

NCBI chr 6:128,407,066...128,415,619
Ensembl chr 6:128,406,698...128,415,640

G

fibronectin 1

increases expression
decreases expression

dimethylarsinous acid results in increased expression of FN1 mRNA
dimethylarsinous acid results in decreased expression of FN1 mRNA

PMID:20886546 PMID:23487506

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

FBJ osteosarcoma oncogene

decreases expression

dimethylarsinous acid results in decreased expression of FOS mRNA

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

FBJ osteosarcoma oncogene B

increases expression

dimethylarsinous acid results in increased expression of FOSB mRNA

NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976

G

fos-like antigen 2

increases expression

dimethylarsinous acid results in increased expression of FOSL2 mRNA

NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186

G

ferritin light polypeptide 1

increases expression

dimethylarsinous acid results in increased expression of FTL mRNA

NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308

G

GATA binding protein 6

decreases expression

dimethylarsinous acid results in decreased expression of GATA6 mRNA

NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635

G

glutamine amidotransferase like class 1 domain containing 1

decreases expression

dimethylarsinous acid results in decreased expression of GATD1 mRNA

NCBI chr 7:140,988,097...140,994,038
Ensembl chr 7:140,987,707...140,994,049

G

growth differentiation factor 15

increases expression

dimethylarsinous acid results in increased expression of GDF15 mRNA

NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106

G

gap junction protein, alpha 1

decreases expression

dimethylarsinous acid results in decreased expression of GJA1 mRNA

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

predicted gene, 29695

decreases expression

dimethylarsinous acid results in decreased expression of BLACAT1 mRNA

NCBI chr 1:132,115,960...132,137,285
Ensembl chr 1:132,119,195...132,137,284

G

predicted gene, 40318

increases expression

dimethylarsinous acid results in increased expression of S100P mRNA

NCBI chr 5:36,919,848...36,924,763
Ensembl chr 5:36,919,961...36,924,039

G

glycerol-3-phosphate acyltransferase 3

increases expression

dimethylarsinous acid results in increased expression of GPAT3 mRNA

NCBI chr 5:100,994,095...101,046,968
Ensembl chr 5:100,993,579...101,046,968

G

glutathione S-transferase, mu 5

increases expression

dimethylarsinous acid results in increased expression of GSTM3 mRNA

NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002

G

G two S phase expressed protein 1

increases expression

dimethylarsinous acid results in increased expression of GTSE1 mRNA

NCBI chr15:85,743,928...85,760,774
Ensembl chr15:85,743,946...85,760,774

G

H1.5 linker histone, cluster member

increases expression

dimethylarsinous acid results in increased expression of H1-5 mRNA

NCBI chr13:21,964,002...21,964,795
Ensembl chr13:21,964,053...21,964,795

G

H2A clustered histone 13

increases expression

dimethylarsinous acid results in increased expression of H2AC8 mRNA

NCBI chr13:21,900,582...21,901,029
Ensembl chr13:21,900,592...21,900,984

G

H2B clustered histone 3

increases expression

dimethylarsinous acid results in increased expression of H2BC3 mRNA

NCBI chr13:23,930,717...23,931,206
Ensembl chr13:23,930,717...23,931,224

G

H2B clustered histone 7

increases expression

dimethylarsinous acid results in increased expression of H2BC13 mRNA

NCBI chr13:23,757,934...23,758,381
Ensembl chr13:23,757,910...23,758,370

G

H3 clustered histone 1

increases expression

dimethylarsinous acid results in increased expression of H3C1 mRNA

NCBI chr13:23,945,868...23,946,369
Ensembl chr13:23,945,836...23,946,369

G

heparin-binding EGF-like growth factor

decreases expression
increases expression

dimethylarsinous acid results in decreased expression of HBEGF mRNA
dimethylarsinous acid results in increased expression of HBEGF mRNA

PMID:16507463 PMID:23487506

NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858

G

homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

increases expression

dimethylarsinous acid results in increased expression of HERPUD1 mRNA

NCBI chr 8:95,113,057...95,121,999
Ensembl chr 8:95,113,066...95,122,005

G

hypoxia inducible factor 1, alpha subunit

decreases expression

dimethylarsinous acid results in decreased expression of HIF1A mRNA

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

high mobility group box 1

decreases expression

dimethylarsinous acid results in decreased expression of HMGB1 mRNA

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

hyaluronan mediated motility receptor (RHAMM)

increases expression

dimethylarsinous acid results in increased expression of HMMR mRNA

NCBI chr11:40,592,215...40,624,290
Ensembl chr11:40,592,222...40,624,249

G

heme oxygenase 1

increases expression

dimethylarsinous acid results in increased expression of HMOX1 mRNA

PMID:19945496 PMID:23876855

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

hook microtubule tethering protein 3

decreases expression

dimethylarsinous acid results in decreased expression of HOOK3 mRNA

NCBI chr 8:26,511,449...26,609,646
Ensembl chr 8:26,511,449...26,609,252

G

heat shock protein 70 family, member 13

increases expression

dimethylarsinous acid results in increased expression of HSPA13 mRNA

NCBI chr16:75,552,078...75,564,575
Ensembl chr16:75,542,319...75,563,992

G

heat shock protein 1

increases expression

dimethylarsinous acid results in increased expression of HSPB1 mRNA

NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417

G

HtrA serine peptidase 1

decreases expression

dimethylarsinous acid results in decreased expression of HTRA1 mRNA

NCBI chr 7:130,537,933...130,587,388
Ensembl chr 7:130,537,841...130,587,390

G

hypoxia up-regulated 1

increases expression

dimethylarsinous acid results in increased expression of HYOU1 mRNA

NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666

G

immediate early response 5-like

decreases expression

dimethylarsinous acid results in decreased expression of IER5L mRNA

NCBI chr 2:30,362,643...30,364,211
Ensembl chr 2:30,361,549...30,364,231

G

interferon-induced protein 44

decreases expression

dimethylarsinous acid results in decreased expression of IFI44 mRNA

NCBI chr 3:151,436,559...151,455,580
Ensembl chr 3:151,436,559...151,455,597

G

interferon-induced protein 44 like

decreases expression

dimethylarsinous acid results in decreased expression of IFI44L mRNA

NCBI chr 3:151,464,374...151,468,528
Ensembl chr 3:151,464,374...151,468,529

G

interferon-induced protein with tetratricopeptide repeats 2

decreases expression

dimethylarsinous acid results in decreased expression of IFIT2 mRNA

NCBI chr19:34,527,961...34,553,934
Ensembl chr19:34,528,094...34,553,819

G

interferon-induced protein with tetratricopeptide repeats 3

increases expression

dimethylarsinous acid results in increased expression of IFIT3 mRNA

NCBI chr19:34,560,519...34,566,382
Ensembl chr19:34,560,931...34,566,131

G

insulin-like growth factor binding protein 5

decreases expression

dimethylarsinous acid results in decreased expression of IGFBP5 mRNA

NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043

G

IKAROS family zinc finger 5

increases expression

dimethylarsinous acid results in increased expression of IKZF5 mRNA

NCBI chr 7:130,990,378...131,012,243
Ensembl chr 7:130,990,381...131,012,250

G

interleukin 1 alpha

decreases expression
increases expression

dimethylarsinous acid results in decreased expression of IL1A mRNA
dimethylarsinous acid results in increased expression of IL1A mRNA

PMID:19945496 PMID:23487506

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 receptor, type II

increases expression

dimethylarsinous acid results in increased expression of IL1R2 mRNA

NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391

G

interleukin 24

increases expression

dimethylarsinous acid results in increased expression of IL24 mRNA

NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191

G

interleukin 6

multiple interactions
increases expression

[dimethylarsinous acid co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein
dimethylarsinous acid results in increased expression of IL6 mRNA

PMID:23487506 PMID:23876855 PMID:24140498

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

inflammation and lipid regulator with UBA-like and NBR1-like domains

increases expression

dimethylarsinous acid results in increased expression of ILRUN mRNA

NCBI chr17:27,970,206...28,039,516
Ensembl chr17:27,970,209...28,039,622

G

insulin I

multiple interactions

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [dimethylarsinous acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; dimethylarsinous acid inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester promotes the reaction [Glucose results in increased secretion of INS1 protein]]; dimethylarsinous acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]; dimethylarsinous acid inhibits the reaction [Potassium Chloride results in increased secretion of INS1 protein]; Tolbutamide inhibits the reaction [dimethylarsinous acid inhibits the reaction [Glucose results in increased secretion of INS1 protein]]

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

IQ motif containing GTPase activating protein 1

decreases expression

dimethylarsinous acid results in decreased expression of IQGAP1 mRNA

NCBI chr 7:80,361,331...80,453,288
Ensembl chr 7:80,361,331...80,475,722

G

integrin beta 3

decreases expression
increases expression

dimethylarsinous acid results in decreased expression of ITGB3 mRNA
dimethylarsinous acid results in increased expression of ITGB3 mRNA

PMID:16507463 PMID:23876855

NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302

G

junction-mediating and regulatory protein

increases expression

dimethylarsinous acid results in increased expression of JMY mRNA

NCBI chr13:93,566,605...93,636,316
Ensembl chr13:93,566,609...93,636,316

G

kirre like nephrin family adhesion molecule 1

decreases expression

dimethylarsinous acid results in decreased expression of KIRREL1 mRNA

NCBI chr 3:86,985,900...87,082,084
Ensembl chr 3:86,985,900...87,082,054

G

karyopherin subunit alpha 4

increases expression

dimethylarsinous acid results in increased expression of KPNA4 mRNA

NCBI chr 3:68,979,554...69,034,425
Ensembl chr 3:68,974,482...69,034,446

G

keratin 15

decreases expression

dimethylarsinous acid results in decreased expression of KRT15 mRNA

PMID:23487506 PMID:23876855

NCBI chr11:100,022,585...100,026,775
Ensembl chr11:100,022,584...100,026,754

G

keratin 19

decreases expression

dimethylarsinous acid results in decreased expression of KRT19 mRNA

NCBI chr11:100,031,636...100,036,752
Ensembl chr11:100,031,636...100,039,491

G

keratin 34

increases expression

dimethylarsinous acid results in increased expression of KRT34 mRNA

NCBI chr11:99,928,173...99,932,380
Ensembl chr11:99,928,173...99,932,380

G

keratin 75

increases expression

dimethylarsinous acid results in increased expression of KRT75 mRNA

NCBI chr15:101,471,778...101,482,339
Ensembl chr15:101,471,780...101,482,339

G

lymphocyte cytosolic protein 1

increases expression

dimethylarsinous acid results in increased expression of LCP1 mRNA

NCBI chr14:75,368,570...75,468,282
Ensembl chr14:75,368,541...75,468,282

G

LIM and calponin homology domains 1

decreases expression

dimethylarsinous acid results in decreased expression of LIMCH1 mRNA

NCBI chr 5:66,903,232...67,214,502
Ensembl chr 5:66,903,170...67,214,501

G

latent transforming growth factor beta binding protein 2

decreases expression

dimethylarsinous acid results in decreased expression of LTBP2 mRNA

NCBI chr12:84,829,986...84,923,581
Ensembl chr12:84,829,986...84,923,306

G

mannosidase 2, alpha 2

decreases expression

dimethylarsinous acid results in decreased expression of MAN2A2 mRNA

NCBI chr 7:79,998,843...80,021,222
Ensembl chr 7:79,998,845...80,021,123

G

melanophilin

decreases expression

dimethylarsinous acid results in decreased expression of MLPH mRNA

NCBI chr 1:90,842,750...90,878,864
Ensembl chr 1:90,842,807...90,878,864

G

matrix metallopeptidase 10

increases expression

dimethylarsinous acid results in increased expression of MMP10 mRNA

NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241

G

matrix metallopeptidase 1b (interstitial collagenase)

increases expression

dimethylarsinous acid results in increased expression of MMP1 mRNA

PMID:23487506 PMID:23876855

NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047

G

matrix metallopeptidase 2

decreases expression

dimethylarsinous acid results in decreased expression of MMP2 mRNA

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 9

increases expression

dimethylarsinous acid results in increased expression of MMP9 mRNA

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

msh homeobox 1

decreases expression

dimethylarsinous acid results in decreased expression of MSX1 protein

NCBI chr 5:37,977,835...37,981,929
Ensembl chr 5:37,977,829...37,981,927

G

MX dynamin-like GTPase 1

decreases expression

dimethylarsinous acid results in decreased expression of MX1 mRNA

NCBI chr16:97,248,235...97,264,106
Ensembl chr16:97,248,235...97,264,107

G

myosin, light polypeptide kinase

decreases expression

dimethylarsinous acid results in decreased expression of MYLK mRNA

NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790

G

myosin IB

increases expression

dimethylarsinous acid results in increased expression of MYO1B mRNA

NCBI chr 1:51,788,915...51,955,143
Ensembl chr 1:51,788,924...51,955,230

G

myogenic differentiation 1

affects localization
decreases expression

dimethylarsinous acid affects the localization of MYOD1 protein
dimethylarsinous acid results in decreased expression of MYOD1 protein

NCBI chr 7:46,025,898...46,028,516
Ensembl chr 7:46,025,898...46,028,523

G

myogenin

decreases expression

dimethylarsinous acid results in decreased expression of MYOG protein

NCBI chr 1:134,217,742...134,220,286
Ensembl chr 1:134,217,727...134,220,286

G

myocardial zonula adherens protein

increases expression

dimethylarsinous acid results in increased expression of MYZAP mRNA

NCBI chr 9:71,411,629...71,499,642
Ensembl chr 9:71,411,629...71,499,642

G

N-6 adenine-specific DNA methyltransferase 1 (putative)

multiple interactions

[N6AMT1 protein results in increased metabolism of monomethylarsonous acid] which results in increased chemical synthesis of dimethylarsinous acid

NCBI chr16:87,151,073...87,165,537
Ensembl chr16:87,151,073...87,165,630

G

nicotinamide phosphoribosyltransferase

increases expression

dimethylarsinous acid results in increased expression of NAMPT mRNA

NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348

G

N-ethylmaleimide sensitive fusion protein attachment protein alpha

increases expression

dimethylarsinous acid results in increased expression of NAPA mRNA

NCBI chr 7:15,832,127...15,851,907
Ensembl chr 7:15,832,383...15,851,900

G

neuron navigator 2

increases expression

dimethylarsinous acid results in increased expression of NAV2 mRNA

NCBI chr 7:48,608,796...49,259,838
Ensembl chr 7:48,558,464...49,259,838

G

neurogenic differentiation 1

affects localization
decreases expression

dimethylarsinous acid affects the localization of NEUROD1 protein
dimethylarsinous acid results in decreased expression of NEUROD1 protein

NCBI chr 2:79,282,981...79,286,980
Ensembl chr 2:79,282,865...79,287,095

G

nucleolar and coiled-body phosphoprotein 1

increases expression

dimethylarsinous acid results in increased expression of NOLC1 mRNA

NCBI chr19:46,064,286...46,073,982
Ensembl chr19:46,064,302...46,073,969

G

NAD(P)H dehydrogenase, quinone 1

increases expression

dimethylarsinous acid results in increased expression of NQO1 mRNA

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 1, group I, member 2

increases expression

dimethylarsinous acid results in increased expression of NR1I2 mRNA

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

neuregulin 1

decreases expression

dimethylarsinous acid results in decreased expression of NRG1 mRNA

NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825

G

N-ethylmaleimide sensitive fusion protein

decreases expression

dimethylarsinous acid results in decreased expression of NSF mRNA

NCBI chr11:103,712,608...103,844,882
Ensembl chr11:103,712,608...103,844,882

G

nucleoporin 88

decreases expression

dimethylarsinous acid results in decreased expression of NUP88 mRNA

NCBI chr11:70,833,884...70,860,799
Ensembl chr11:70,833,884...70,860,799

G

nuclear RNA export factor 1

increases expression

dimethylarsinous acid results in increased expression of NXF1 mRNA

NCBI chr19:8,734,467...8,748,274
Ensembl chr19:8,734,437...8,748,286

G

2'-5' oligoadenylate synthetase 1G

increases expression

dimethylarsinous acid results in increased expression of OAS1 mRNA

NCBI chr 5:121,014,205...121,025,676
Ensembl chr 5:121,014,205...121,025,676

G

ornithine decarboxylase, structural 1

decreases expression

dimethylarsinous acid results in decreased expression of ODC1 mRNA

NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506

G

oxysterol binding protein

increases expression

dimethylarsinous acid results in increased expression of OSBP mRNA

NCBI chr19:11,943,208...11,971,478
Ensembl chr19:11,943,305...11,971,476

G

poly (ADP-ribose) polymerase family, member 1

decreases activity
multiple interactions

dimethylarsinous acid results in decreased activity of PARP1 protein
[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; dimethylarsinous acid inhibits the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein]

PMID:17011244 PMID:29774349

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

polycomb group ring finger 2

decreases expression

dimethylarsinous acid results in decreased expression of PCGF2 mRNA

NCBI chr11:97,579,647...97,593,260
Ensembl chr11:97,579,649...97,591,323

G

programmed cell death 1 ligand 2

increases expression

dimethylarsinous acid results in increased expression of PDCD1LG2 mRNA

NCBI chr19:29,388,319...29,450,327
Ensembl chr19:29,388,319...29,448,561

G

pyruvate dehydrogenase kinase, isoenzyme 3

decreases expression

dimethylarsinous acid results in decreased expression of PDK3 mRNA

NCBI chr X:92,798,923...92,875,756
Ensembl chr X:92,808,213...92,875,807

G

pleckstrin homology like domain, family A, member 1

increases expression

dimethylarsinous acid results in increased expression of PHLDA1 mRNA

NCBI chr10:111,342,147...111,344,510
Ensembl chr10:111,342,147...111,344,506

G

plasminogen activator, urokinase receptor

increases expression

dimethylarsinous acid results in increased expression of PLAUR mRNA

NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393

G

pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

decreases expression

dimethylarsinous acid results in decreased expression of PLEKHH2 mRNA

NCBI chr17:84,819,303...84,929,571
Ensembl chr17:84,819,323...84,929,566

G

phospholipid phosphatase 4

decreases expression

dimethylarsinous acid results in decreased expression of PLPP4 mRNA

NCBI chr 7:128,858,114...128,993,138
Ensembl chr 7:128,858,755...128,993,136

G

prostate transmembrane protein, androgen induced 1

decreases expression

dimethylarsinous acid results in decreased expression of PMEPA1 mRNA

NCBI chr 2:173,066,251...173,118,329
Ensembl chr 2:173,066,251...173,118,326

G

promyelocytic leukemia

multiple interactions

[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased degradation of PML protein

NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069

G

PNN interacting serine/arginine-rich

decreases expression

dimethylarsinous acid results in decreased expression of PNISR mRNA

NCBI chr 4:21,846,621...21,876,475
Ensembl chr 4:21,847,583...21,876,475

G

polymerase (DNA directed), epsilon 2 (p59 subunit)

decreases expression

dimethylarsinous acid results in decreased expression of POLE2 mRNA

NCBI chr12:69,248,547...69,274,979
Ensembl chr12:69,248,547...69,274,969

G

periplakin

decreases expression

dimethylarsinous acid results in decreased expression of PPL mRNA

NCBI chr16:4,904,155...4,950,345
Ensembl chr16:4,904,155...4,950,285

G

protein phosphatase 2, regulatory subunit B', epsilon

decreases expression

dimethylarsinous acid results in decreased expression of PPP2R5E mRNA

NCBI chr12:75,496,237...75,643,064
Ensembl chr12:75,497,655...75,643,019

G

PML-RAR alpha-regulated adaptor molecule 1

multiple interactions

[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased expression of PRAM1 protein

NCBI chr17:33,857,030...33,864,680
Ensembl chr17:33,857,030...33,864,680

G

protein kinase C, alpha

decreases expression

dimethylarsinous acid results in decreased expression of PRKCA mRNA

NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754

G

serine protease 12 neurotrypsin (motopsin)

decreases expression

dimethylarsinous acid results in decreased expression of PRSS12 mRNA

NCBI chr 3:123,240,562...123,300,251
Ensembl chr 3:123,240,562...123,300,246

G

serine protease 23

decreases expression

dimethylarsinous acid results in decreased expression of PRSS23 mRNA

NCBI chr 7:89,156,988...89,176,399
Ensembl chr 7:89,156,991...89,176,395

G

proteasome subunit alpha 3

decreases expression

dimethylarsinous acid results in decreased expression of PSMA3 mRNA

NCBI chr12:71,016,082...71,042,651
Ensembl chr12:71,021,395...71,043,121

G

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

decreases expression

dimethylarsinous acid results in decreased expression of PSMD11 mRNA

NCBI chr11:80,319,441...80,364,074
Ensembl chr11:80,319,441...80,364,074

G

prostaglandin-endoperoxide synthase 1

increases expression

dimethylarsinous acid results in increased expression of PTGS1 mRNA

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

increases expression

dimethylarsinous acid results in increased expression of PTGS2 mRNA

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

protein tyrosine phosphatase, non-receptor type 1

affects binding
decreases activity

dimethylarsinous acid binds to PTPN1 protein
dimethylarsinous acid results in decreased activity of PTPN1 protein

NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305

G

protein tyrosine phosphatase receptor type C

decreases activity

dimethylarsinous acid results in decreased activity of PTPRC protein

NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446

G

protein tyrosine phosphatase receptor type Z, polypeptide 1

decreases expression

dimethylarsinous acid results in decreased expression of PTPRZ1 mRNA

NCBI chr 6:22,875,302...23,052,915
Ensembl chr 6:22,875,501...23,052,915

G

quinolinate phosphoribosyltransferase

decreases expression

dimethylarsinous acid results in decreased expression of QPRT mRNA

NCBI chr 7:126,706,942...126,721,201
Ensembl chr 7:126,706,286...126,721,398

G

RAS, dexamethasone-induced 1

increases expression

dimethylarsinous acid results in increased expression of RASD1 mRNA

NCBI chr11:59,854,007...59,855,770
Ensembl chr11:59,854,007...59,855,770

G

regulator of calcineurin 1

increases expression

dimethylarsinous acid results in increased expression of RCAN1 mRNA

NCBI chr16:92,188,839...92,263,057
Ensembl chr16:92,188,841...92,267,755

G

reelin

increases expression

dimethylarsinous acid results in increased expression of RELN mRNA

NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700

G

rhomboid domain containing 2

increases expression

dimethylarsinous acid results in increased expression of RHBDD2 mRNA

NCBI chr 5:135,661,508...135,675,230
Ensembl chr 5:135,661,472...135,675,302

G

ras homolog family member D

increases expression

dimethylarsinous acid results in increased expression of RHOD mRNA

NCBI chr19:4,473,500...4,489,562
Ensembl chr19:4,475,487...4,489,460

G

RIO kinase 3

increases expression

dimethylarsinous acid results in increased expression of RIOK3 mRNA

NCBI chr18:12,259,114...12,290,424
Ensembl chr18:12,261,798...12,290,444

G

Rho family GTPase 3

increases expression

dimethylarsinous acid results in increased expression of RND3 mRNA

NCBI chr 2:51,020,451...51,039,123
Ensembl chr 2:51,020,450...51,039,123

G

RNA pseudouridylate synthase domain containing 4

decreases expression

dimethylarsinous acid results in decreased expression of RPUSD4 mRNA

NCBI chr 9:35,179,177...35,187,253
Ensembl chr 9:35,179,161...35,189,027

G

ribonucleotide reductase M2 B (TP53 inducible)

increases expression

dimethylarsinous acid results in increased expression of RRM2B mRNA

NCBI chr15:37,924,196...37,961,562
Ensembl chr15:37,924,196...37,961,562

G

retinoid X receptor alpha

increases expression

dimethylarsinous acid results in increased expression of RXRA mRNA

NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969

G

S100 calcium binding protein A2

decreases expression

dimethylarsinous acid results in decreased expression of S100A2 mRNA

NCBI chr 3:90,497,554...90,498,815
Ensembl chr 3:90,467,670...90,498,838

G

S100 calcium binding protein A8 (calgranulin A)

decreases expression

dimethylarsinous acid results in decreased expression of S100A8 mRNA

NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342

G

sterile alpha motif domain containing 8

increases expression

dimethylarsinous acid results in increased expression of SAMD8 mRNA

NCBI chr14:21,800,599...21,848,794
Ensembl chr14:21,800,599...21,848,794

G

secretion associated Ras related GTPase 1A

increases expression

dimethylarsinous acid results in increased expression of SAR1A mRNA

NCBI chr10:61,516,096...61,529,076
Ensembl chr10:61,516,078...61,529,076

G

stearoyl-Coenzyme A desaturase 2

decreases expression

dimethylarsinous acid results in decreased expression of SCD mRNA

NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303

G

sodium channel, nonvoltage-gated 1 alpha

decreases expression

dimethylarsinous acid results in decreased expression of SCNN1A mRNA

NCBI chr 6:125,286,657...125,321,906
Ensembl chr 6:125,297,622...125,321,906

G

SDE2 telomere maintenance homolog (S. pombe)

increases expression

dimethylarsinous acid results in increased expression of SDE2 mRNA

NCBI chr 1:180,678,716...180,695,678
Ensembl chr 1:180,678,692...180,695,678

G

SEC14-like lipid binding 1

decreases expression

dimethylarsinous acid results in decreased expression of SEC14L1 mRNA

NCBI chr11:117,005,994...117,050,094
Ensembl chr11:117,005,994...117,050,094

G

serine (or cysteine) peptidase inhibitor, clade B, member 2

increases expression

dimethylarsinous acid results in increased expression of SERPINB2 mRNA

PMID:23487506 PMID:23876855

NCBI chr 1:107,439,153...107,453,330
Ensembl chr 1:107,439,153...107,463,208

G

serine (or cysteine) peptidase inhibitor, clade B, member 7

increases expression

dimethylarsinous acid results in increased expression of SERPINB7 mRNA

NCBI chr 1:107,350,418...107,380,419
Ensembl chr 1:107,327,385...107,380,419

G

sestrin 2

increases expression

dimethylarsinous acid results in increased expression of SESN2 mRNA

NCBI chr 4:132,220,115...132,237,767
Ensembl chr 4:132,219,343...132,237,812

G

S-phase kinase-associated protein 1

increases expression

dimethylarsinous acid results in increased expression of SKP1 mRNA

NCBI chr11:52,121,349...52,137,685
Ensembl chr11:52,122,822...52,137,685

G

S-phase kinase-associated protein 2

increases expression

dimethylarsinous acid results in increased expression of SKP2 mRNA

NCBI chr15:9,112,070...9,155,512
Ensembl chr15:9,112,073...9,155,512

G

solute carrier family 12, member 6

increases expression

dimethylarsinous acid results in increased expression of SLC12A6 mRNA

NCBI chr 2:112,096,659...112,193,508
Ensembl chr 2:112,096,170...112,193,508

G

solute carrier family 26 (sulfate transporter), member 2

decreases expression

dimethylarsinous acid results in decreased expression of SLC26A2 mRNA

NCBI chr18:61,329,926...61,344,668
Ensembl chr18:61,325,991...61,344,684

G

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

increases expression

dimethylarsinous acid results in increased expression of SLC3A2 mRNA

NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733

G

solute carrier family 41, member 2

increases expression

dimethylarsinous acid results in increased expression of SLC41A2 mRNA

NCBI chr10:83,066,712...83,174,657
Ensembl chr10:83,066,712...83,173,746

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

increases expression

dimethylarsinous acid results in increased expression of SLC7A11 mRNA

NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063

G

schlafen 5

increases expression

dimethylarsinous acid results in increased expression of SLFN5 mRNA

NCBI chr11:82,842,175...82,855,681
Ensembl chr11:82,842,175...82,855,666

G

slit guidance ligand 2

increases expression

dimethylarsinous acid results in increased expression of SLIT2 mRNA

NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075

G

SLIT and NTRK-like family, member 6

decreases expression

dimethylarsinous acid results in decreased expression of SLITRK6 mRNA

NCBI chr14:110,984,770...110,992,640
Ensembl chr14:110,986,012...110,992,581

G

SMAD family member 7

decreases expression

dimethylarsinous acid results in decreased expression of SMAD7 mRNA

NCBI chr18:75,500,436...75,529,006
Ensembl chr18:75,500,600...75,529,006

G

superoxide dismutase 1, soluble

increases expression
increases response to substance

dimethylarsinous acid results in increased expression of SOD1 mRNA
SOD1 protein results in increased susceptibility to dimethylarsinous acid

PMID:20740636 PMID:20886546

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

increases expression

dimethylarsinous acid results in increased expression of SOD2 mRNA

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

SRY (sex determining region Y)-box 10

decreases expression

dimethylarsinous acid results in decreased expression of SOX10 protein

NCBI chr15:79,039,113...79,048,690
Ensembl chr15:79,039,108...79,049,440

G

SRY (sex determining region Y)-box 9

decreases expression

dimethylarsinous acid results in decreased expression of SOX9 mRNA

NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586

G

spermatogenesis associated 2

increases expression

dimethylarsinous acid results in increased expression of SPATA2 mRNA

NCBI chr 2:167,323,053...167,334,804
Ensembl chr 2:167,323,053...167,334,807

G

splA/ryanodine receptor domain and SOCS box containing 1

increases expression

dimethylarsinous acid results in increased expression of SPSB1 mRNA

NCBI chr 4:149,980,740...150,039,494
Ensembl chr 4:149,980,740...150,039,500

G

serine palmitoyltransferase, small subunit A

decreases expression

dimethylarsinous acid results in decreased expression of SPTSSA mRNA

NCBI chr12:54,692,159...54,703,357
Ensembl chr12:54,692,177...54,703,358

G

serine and arginine-rich splicing factor 11

decreases expression

dimethylarsinous acid results in decreased expression of SRSF11 mRNA

NCBI chr 3:157,716,552...157,742,304
Ensembl chr 3:157,716,110...157,742,276

G

signal transducer and activator of transcription 1

increases expression

dimethylarsinous acid results in increased expression of STAT1 mRNA

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

stanniocalcin 1

increases expression

dimethylarsinous acid results in increased expression of STC1 mRNA

NCBI chr14:69,266,738...69,278,850
Ensembl chr14:69,266,687...69,279,253

G

stanniocalcin 2

increases expression

dimethylarsinous acid results in increased expression of STC2 mRNA

NCBI chr11:31,309,441...31,320,061
Ensembl chr11:31,307,307...31,320,074

G

striatin, calmodulin binding protein 3

affects expression

dimethylarsinous acid affects the expression of STRN3 mRNA

NCBI chr12:51,655,324...51,743,942
Ensembl chr12:51,656,415...51,738,680

G

sulfotransferase family 1B, member 1

decreases expression

dimethylarsinous acid results in decreased expression of SULT1B1 mRNA

NCBI chr 5:87,661,186...87,686,054
Ensembl chr 5:87,661,198...87,686,054

G

small ubiquitin-like modifier 1

multiple interactions

[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased localization of SUMO1 protein

NCBI chr 1:59,678,593...59,709,993
Ensembl chr 1:59,625,717...59,709,993

G

tumor-associated calcium signal transducer 2

decreases expression

dimethylarsinous acid results in decreased expression of TACSTD2 mRNA

NCBI chr 6:67,511,043...67,512,806
Ensembl chr 6:67,511,046...67,512,780

G

transgelin

increases expression

dimethylarsinous acid results in increased expression of TAGLN mRNA

NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356

G

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

increases expression

dimethylarsinous acid results in increased expression of TAP1 mRNA

NCBI chr17:34,406,530...34,416,199
Ensembl chr17:34,406,527...34,416,199

G

transcription factor 12

decreases expression

dimethylarsinous acid results in decreased expression of TCF12 mRNA

NCBI chr 9:71,751,534...72,019,611
Ensembl chr 9:71,749,970...72,019,153

G

transcription factor CP2-like 1

decreases expression

dimethylarsinous acid results in decreased expression of TFCP2L1 mRNA

NCBI chr 1:118,555,646...118,612,898
Ensembl chr 1:118,555,675...118,612,898

G

transforming growth factor, beta 2

increases expression

dimethylarsinous acid results in increased expression of TGFB2 mRNA

PMID:19945496 PMID:20886546

NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186

G

thrombomodulin

increases expression

dimethylarsinous acid results in increased expression of THBD mRNA

NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108

G

thrombospondin 1

decreases expression

dimethylarsinous acid results in decreased expression of THBS1 mRNA

NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614

G

thrombospondin 2

decreases expression

dimethylarsinous acid results in decreased expression of THBS2 mRNA

NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497

G

Trp53 induced glycolysis regulatory phosphatase

increases expression

dimethylarsinous acid results in increased expression of TIGAR mRNA

NCBI chr 6:127,062,079...127,086,564
Ensembl chr 6:127,062,079...127,086,520

G

toll-like receptor 4

increases expression

dimethylarsinous acid results in increased expression of TLR4 mRNA

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

transmembrane p24 trafficking protein 2

increases expression

dimethylarsinous acid results in increased expression of TMED2 mRNA

NCBI chr 5:124,678,835...124,688,566
Ensembl chr 5:124,678,758...124,688,569

G

transmembrane protein 158

increases expression

dimethylarsinous acid results in increased expression of TMEM158 mRNA

NCBI chr 9:123,088,122...123,089,854
Ensembl chr 9:123,088,118...123,089,829

G

transmembrane protein 44

decreases expression

dimethylarsinous acid results in decreased expression of TMEM44 mRNA

NCBI chr16:30,330,673...30,369,643
Ensembl chr16:30,330,673...30,369,660

G

transmembrane protein 50B

decreases expression

dimethylarsinous acid results in decreased expression of TMEM50B mRNA

NCBI chr16:91,371,390...91,394,573
Ensembl chr16:91,371,391...91,394,688

G

transmembrane protein 80

decreases expression

dimethylarsinous acid results in decreased expression of TMEM80 mRNA

NCBI chr 7:140,908,046...140,917,069
Ensembl chr 7:140,907,652...140,917,069

G

tumor necrosis factor

increases expression
multiple interactions
increases secretion

dimethylarsinous acid results in increased expression of TNF mRNA
Lipopolysaccharides inhibits the reaction [dimethylarsinous acid results in increased expression of TNF mRNA]; Lipopolysaccharides inhibits the reaction [dimethylarsinous acid results in increased secretion of TNF protein]

PMID:23487506 PMID:24140498

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tripartite motif-containing 30A

decreases expression

dimethylarsinous acid results in decreased expression of TRIM22 mRNA

NCBI chr 7:104,058,232...104,114,400
Ensembl chr 7:104,058,232...104,114,400

G

triple functional domain (PTPRF interacting)

increases expression

dimethylarsinous acid results in increased expression of TRIO mRNA

NCBI chr15:27,730,735...28,025,954
Ensembl chr15:27,730,737...28,025,934

G

transformation related protein 53 inducible nuclear protein 1

increases expression

dimethylarsinous acid results in increased expression of TP53INP1 mRNA

NCBI chr 4:11,156,441...11,174,379
Ensembl chr 4:11,156,431...11,174,379

G

tubulin, gamma complex component 3

increases expression

dimethylarsinous acid results in increased expression of TUBGCP3 mRNA

NCBI chr 8:12,664,277...12,722,141
Ensembl chr 8:12,664,277...12,722,248

G

thioredoxin domain containing 17

decreases expression

dimethylarsinous acid results in decreased expression of TXNDC17 mRNA

NCBI chr11:72,098,380...72,101,313
Ensembl chr11:72,098,373...72,100,841

G

uveal autoantigen with coiled-coil domains and ankyrin repeats

decreases expression

dimethylarsinous acid results in decreased expression of UACA mRNA

NCBI chr 9:60,700,488...60,787,713
Ensembl chr 9:60,701,824...60,787,652

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

increases expression

dimethylarsinous acid results in increased expression of UGT1A6 mRNA

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

ubiquitin specific peptidase 36

increases expression

dimethylarsinous acid results in increased expression of USP36 mRNA

NCBI chr11:118,150,477...118,181,086
Ensembl chr11:118,150,477...118,181,070

G

versican

decreases expression

dimethylarsinous acid results in decreased expression of VCAN mRNA

NCBI chr13:89,803,429...89,891,146
Ensembl chr13:89,803,431...89,890,628

G

vestigial like family member 3

increases expression

dimethylarsinous acid results in increased expression of VGLL3 mRNA

NCBI chr16:65,612,075...65,663,254
Ensembl chr16:65,612,143...65,663,254

G

very low density lipoprotein receptor

increases expression

dimethylarsinous acid results in increased expression of VLDLR mRNA

NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631

G

WASP like actin nucleation promoting factor

decreases expression

dimethylarsinous acid results in decreased expression of WASL mRNA

NCBI chr 6:24,613,809...24,665,185
Ensembl chr 6:24,613,804...24,665,008

G

WD repeat domain 72

decreases expression

dimethylarsinous acid results in decreased expression of WDR72 mRNA

NCBI chr 9:74,017,608...74,190,485
Ensembl chr 9:74,017,638...74,190,590

G

WAP four-disulfide core domain 17

increases expression

dimethylarsinous acid results in increased expression of ANOS1 mRNA

NCBI chr11:83,594,882...83,597,095
Ensembl chr11:83,594,817...83,597,094

G

XIAP associated factor 1

affects expression

dimethylarsinous acid affects the expression of XAF1 mRNA

NCBI chr11:72,192,229...72,204,560
Ensembl chr11:72,192,455...72,204,559

G

zinc finger, CCHC domain containing 2

increases expression

dimethylarsinous acid results in increased expression of ZCCHC2 mRNA

NCBI chr 1:105,916,929...105,961,807
Ensembl chr 1:105,918,136...105,961,804

G

zinc finger protein 827

increases expression

dimethylarsinous acid results in increased expression of ZNF827 mRNA

NCBI chr 8:79,753,754...79,920,397
Ensembl chr 8:79,755,066...79,920,395

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22182
chemical entity	22181
atom	22174
metalloid atom	15121
arsenic atom	13907
arsenic molecular entity	13907
organoarsenic compound	1397
methylarsinous acid	282
dimethylarsinous acid	282
Path 2
Term	Annotations
CHEBI ontology	22182
subatomic particle	22174
composite particle	22174
hadron	22174
baryon	22174
nucleon	22174
atomic nucleus	22174
atom	22174
main group element atom	22108
main group molecular entity	22108
p-block molecular entity	22108
carbon group molecular entity	21909
organic molecular entity	21835
organometalloidal compound	1397
organoarsenic compound	1397
methylarsinous acid	282
dimethylarsinous acid	282

paths to the root