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Gene: Ptpn1 (protein tyrosine phosphatase, non-receptor type 1) Mus musculus
Symbol: Ptpn1
Name: protein tyrosine phosphatase, non-receptor type 1
Description: Predicted to have several functions, including protein phosphatase 2A binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; regulation of signal transduction; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to the early endosome and sorting endosome. Predicted to colocalize with the plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in central nervous system; midbrain; and superior colliculus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: protein-protein-tyrosine phosphatase HA2; protein-tyrosine phosphatase 1B; protein-tyrosine phosphatase HA2; PTP-1B; PTP-HA2; PTP1B; tyrosine-protein phosphatase non-receptor type 1
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382167,930,750 - 167,979,385 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372167,757,827 - 167,804,885 (+)NCBIGRCm37mm9NCBIm37
MGSCv362167,623,579 - 167,668,124 (+)NCBImm8
Celera2173,874,374 - 173,921,508 (+)NCBICelera
Cytogenetic Map2 H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ptpn1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62258
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.