Ptpn1 (protein tyrosine phosphatase, non-receptor type 1) - Rat Genome Database

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Gene: Ptpn1 (protein tyrosine phosphatase, non-receptor type 1) Mus musculus
Analyze
Symbol: Ptpn1
Name: protein tyrosine phosphatase, non-receptor type 1
RGD ID: 62258
MGI Page MGI
Description: Predicted to enable several functions, including protein phosphatase 2A binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; negative regulation of signal transduction; and peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Acts upstream of or within insulin receptor signaling pathway and protein dephosphorylation. Located in early endosome and sorting endosome. Is expressed in central nervous system; midbrain; and superior colliculus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: protein-protein-tyrosine phosphatase HA2; protein-tyrosine phosphatase 1B; protein-tyrosine phosphatase HA2; PTP; PTP-; PTP-1B; PTP-HA2; PTP1B; tyrosine-protein phosphatase non-receptor type 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,772,670 - 167,821,305 (+)NCBIGRCm39mm39
GRCm39 Ensembl2167,773,977 - 167,821,305 (+)Ensembl
GRCm382167,930,750 - 167,979,385 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,932,057 - 167,979,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,757,827 - 167,804,885 (+)NCBIGRCm37mm9NCBIm37
MGSCv362167,623,579 - 167,668,124 (+)NCBImm8
Celera2173,874,374 - 173,921,508 (+)NCBICelera
Cytogenetic Map2H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (EXP)
1,2-naphthoquinone  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrophenyl phosphate  (ISO)
9,10-phenanthroquinone  (ISO)
acetamide  (ISO)
acrolein  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (ISO)
anthranilic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
Bardoxolone methyl  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
bisphenol A  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chloropicrin  (ISO)
chromium atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
Cryptotanshinone  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
Didymin  (ISO)
dimethylarsinous acid  (ISO)
disodium selenite  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (EXP)
flavonoids  (ISO)
folic acid  (EXP)
fucosterol  (ISO)
genistein  (ISO)
glycidol  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (ISO)
isoliquiritigenin  (EXP)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
lipopolysaccharide  (EXP)
LY294002  (ISO)
metformin  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
morin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nitrofen  (ISO)
paracetamol  (EXP)
phenethyl caffeate  (ISO)
pirinixic acid  (EXP)
pyrithione  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
selenic acid  (EXP,ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
streptozocin  (EXP)
tamoxifen  (EXP)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (EXP)
thiazolidines  (ISO)
triptonide  (EXP)
tris(picolinato)chromium  (ISO)
tunicamycin  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal body composition  (IAGP)
abnormal eating behavior  (IAGP)
abnormal energy expenditure  (IAGP)
abnormal fat cell morphology  (IAGP)
abnormal fat pad morphology  (IAGP)
abnormal food intake  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal homeostasis  (IAGP)
abnormal hormone level  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal respiratory quotient  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased epididymal fat pad weight  (IAGP)
decreased food intake  (IAGP)
decreased inguinal fat pad weight  (IAGP)
decreased interscapular fat pad weight  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased percent water in carcass  (IAGP)
decreased respiratory quotient  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased triglyceride level  (IAGP)
decreased white adipose tissue amount  (IAGP)
hyperglycemia  (IAGP)
impaired glucose tolerance  (IAGP)
improved glucose tolerance  (IAGP)
increased basal metabolism  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating leptin level  (IAGP)
increased core body temperature  (IAGP)
increased energy expenditure  (IAGP)
increased insulin sensitivity  (IAGP)
increased oxygen consumption  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
pancreatic islet hyperplasia  (IAGP)
premature death  (IAGP)
References

Additional References at PubMed
PMID:1378268   PMID:1932742   PMID:7804149   PMID:7832766   PMID:8267598   PMID:8875997   PMID:8955893   PMID:10066179   PMID:10349636   PMID:10891488   PMID:11042159   PMID:11076861  
PMID:11106648   PMID:11137300   PMID:11217851   PMID:11788587   PMID:11832424   PMID:11884589   PMID:11907034   PMID:11970898   PMID:11970899   PMID:12145151   PMID:12169659   PMID:12424235  
PMID:12477932   PMID:12520002   PMID:12748279   PMID:12782412   PMID:14527337   PMID:14610273   PMID:14693698   PMID:14766979   PMID:14966296   PMID:14976221   PMID:15031294   PMID:15369800  
PMID:15465829   PMID:15489334   PMID:15561934   PMID:15632081   PMID:15699041   PMID:15737620   PMID:15782199   PMID:16115959   PMID:16141072   PMID:16141073   PMID:16198645   PMID:16234234  
PMID:16267035   PMID:16477024   PMID:16522684   PMID:16626396   PMID:16845389   PMID:17068137   PMID:17128263   PMID:17159996   PMID:17238862   PMID:17259984   PMID:17323378   PMID:17339486  
PMID:17347513   PMID:17448901   PMID:17545163   PMID:17576811   PMID:17664276   PMID:17724080   PMID:17908559   PMID:17967808   PMID:18281274   PMID:18449947   PMID:18451337   PMID:18467448  
PMID:18535291   PMID:18571728   PMID:18716132   PMID:18719666   PMID:18819921   PMID:19017730   PMID:19029027   PMID:19074988   PMID:19474293   PMID:19528236   PMID:19687357   PMID:19712109  
PMID:19727691   PMID:19782770   PMID:19797171   PMID:19797268   PMID:19930043   PMID:20026400   PMID:20028942   PMID:20059965   PMID:20061388   PMID:20160350   PMID:20177806   PMID:20230796  
PMID:20417620   PMID:20482862   PMID:20506299   PMID:20876718   PMID:21135139   PMID:21216966   PMID:21305007   PMID:21311858   PMID:21406170   PMID:21406615   PMID:21605081   PMID:21677750  
PMID:21791607   PMID:21849469   PMID:21979919   PMID:22000581   PMID:22000926   PMID:22031842   PMID:22156494   PMID:22160220   PMID:22221695   PMID:22252315   PMID:22266903   PMID:22389718  
PMID:22427664   PMID:22446161   PMID:22509299   PMID:22580159   PMID:22761160   PMID:22789536   PMID:22802463   PMID:22844492   PMID:23045458   PMID:23065825   PMID:23085227   PMID:23089336  
PMID:23129613   PMID:23135963   PMID:23139353   PMID:23154416   PMID:23178931   PMID:23218930   PMID:23229720   PMID:23246914   PMID:23263557   PMID:23275627   PMID:23321074   PMID:23349485  
PMID:23439647   PMID:23512805   PMID:23588220   PMID:23590304   PMID:23639442   PMID:23685806   PMID:23702782   PMID:23711960   PMID:23832083   PMID:23901112   PMID:23937695   PMID:23951017  
PMID:24003221   PMID:24030252   PMID:24120971   PMID:24139759   PMID:24186864   PMID:24203758   PMID:24204775   PMID:24519936   PMID:24578383   PMID:24587334   PMID:24590766   PMID:24625984  
PMID:24749060   PMID:24760754   PMID:24803538   PMID:24937445   PMID:24948418   PMID:24951831   PMID:24956127   PMID:24982127   PMID:25018087   PMID:25056348   PMID:25083988   PMID:25083990  
PMID:25288805   PMID:25395617   PMID:25520316   PMID:25586181   PMID:25594176   PMID:25796170   PMID:25974252   PMID:26063615   PMID:26064877   PMID:26214522   PMID:26362633   PMID:26523876  
PMID:26813343   PMID:26935109   PMID:26953321   PMID:26989693   PMID:27020859   PMID:27095436   PMID:27105736   PMID:27151949   PMID:27207947   PMID:27288485   PMID:27311921   PMID:27323329  
PMID:27391439   PMID:27461362   PMID:27521458   PMID:27826746   PMID:27872190   PMID:28094236   PMID:28111468   PMID:28246125   PMID:28272165   PMID:28378742   PMID:28479249   PMID:28651353  
PMID:28744004   PMID:28752048   PMID:28899902   PMID:28919207   PMID:28941626   PMID:28987240   PMID:29122767   PMID:29126873   PMID:29217773   PMID:29301787   PMID:29351427   PMID:29390191  
PMID:29569957   PMID:29705509   PMID:29708510   PMID:31217339   PMID:31299613   PMID:31309546   PMID:31410531   PMID:31474996   PMID:31509751   PMID:31532798   PMID:31711802   PMID:31915254  
PMID:32094367   PMID:32244182   PMID:32265274   PMID:32610340   PMID:32958258   PMID:33054766   PMID:33058302   PMID:33293360   PMID:33627831   PMID:33921658   PMID:34044147   PMID:34203825  


Genomics

Comparative Map Data
Ptpn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,772,670 - 167,821,305 (+)NCBIGRCm39mm39
GRCm39 Ensembl2167,773,977 - 167,821,305 (+)Ensembl
GRCm382167,930,750 - 167,979,385 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,932,057 - 167,979,385 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,757,827 - 167,804,885 (+)NCBIGRCm37mm9NCBIm37
MGSCv362167,623,579 - 167,668,124 (+)NCBImm8
Celera2173,874,374 - 173,921,508 (+)NCBICelera
Cytogenetic Map2H3NCBI
PTPN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2050,510,321 - 50,585,241 (+)EnsemblGRCh38hg38GRCh38
GRCh382050,510,383 - 50,585,241 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372049,126,920 - 49,201,778 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,560,298 - 48,634,495 (+)NCBINCBI36hg18NCBI36
Build 342048,560,297 - 48,634,491NCBI
Celera2045,831,156 - 45,905,376 (+)NCBI
Cytogenetic Map20q13.13NCBI
HuRef2045,875,585 - 45,950,061 (+)NCBIHuRef
CHM1_12049,031,996 - 49,106,433 (+)NCBICHM1_1
Ptpn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23156,638,811 - 156,687,503 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl3156,638,769 - 156,687,504 (+)Ensembl
Rnor_6.03164,665,462 - 164,711,936 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,665,532 - 164,711,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,816,897 - 170,866,071 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,070,473 - 159,116,792 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13158,976,466 - 159,025,198 (+)NCBI
Celera3155,215,176 - 155,261,496 (+)NCBICelera
Cytogenetic Map3q42NCBI
Ptpn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,754,319 - 7,819,275 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554457,754,313 - 7,819,229 (-)NCBIChiLan1.0ChiLan1.0
PTPN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12047,983,098 - 48,057,421 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2047,983,098 - 48,057,421 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02046,854,918 - 46,929,509 (+)NCBIMhudiblu_PPA_v0panPan3
PTPN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,936,469 - 37,010,929 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,936,298 - 37,003,720 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2436,179,442 - 36,246,435 (+)NCBI
ROS_Cfam_1.02437,642,503 - 37,713,189 (+)NCBI
UMICH_Zoey_3.12436,882,533 - 36,949,558 (+)NCBI
UNSW_CanFamBas_1.02437,016,127 - 37,083,208 (+)NCBI
UU_Cfam_GSD_1.02437,560,457 - 37,627,492 (+)NCBI
Ptpn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640188,603,904 - 188,630,208 (-)NCBI
SpeTri2.0NW_0049365144,065,455 - 4,083,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,017,104 - 52,086,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11752,017,100 - 52,086,747 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,450,256 - 58,474,772 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,385,681 - 13,459,180 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl213,387,727 - 13,459,105 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605061,816,170 - 61,890,307 (-)NCBIVero_WHO_p1.0
Ptpn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247905,070,537 - 5,135,243 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
AI256593  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,933,013 - 167,933,145UniSTSGRCm38
MGSCv372167,758,513 - 167,758,645UniSTSGRCm37
Celera2173,875,060 - 173,875,192UniSTS
Cytogenetic Map2H3UniSTS
Whitehead/MRC_RH21904.71UniSTS
UniSTS:234610  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,978,128 - 167,978,412UniSTSGRCm38
MGSCv372167,803,628 - 167,803,912UniSTSGRCm37
Celera2173,920,251 - 173,920,535UniSTS
Cytogenetic Map2H3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163844614182113224Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145676855179677006Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162791700182113224Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152857301169276004Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145355029179355165Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142751556178800659Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145386799179386921Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162895006178800659Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135857301169857441Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162895006178800659Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2139124680173124809Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144673941181254801Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155982127182113224Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156354671182113224Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164873361182113224Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158236417178800659Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2150146982182113224Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151936377182113224Mouse
1301378Hpdty_mhindlimb polydactyly (mouse)Not determined2165822973168781758Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163844614182113224Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150370301182113224Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149394987182113224Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143931525169276004Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148822973182113224Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135857301169857441Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135857301169857441Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135857301169857441Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150370301182113224Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142586427176586530Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150370301182113224Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148396284182113224Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151867353174547331Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152487900182113224Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
12801461Intim1_mintima modifier 1 (mouse)2142586427176586530Mouse
11353826Bdln10_mbody length 10 (mouse)2140599562174599562Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135590624173607823Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160769245169952882Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160769245169952882Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir210mmu-miR-210-3pOncomiRDBexternal_infoNANA22962263

Predicted Target Of
Summary Value
Count of predictions:1923
Count of miRNA genes:791
Interacting mature miRNAs:1016
Transcripts:ENSMUST00000029053, ENSMUST00000124039, ENSMUST00000126839, ENSMUST00000142717, ENSMUST00000144249, ENSMUST00000147210, ENSMUST00000151705
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006498981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK085713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL928998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI639356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M97590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z23057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000029053   ⟹   ENSMUSP00000029053
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,774,247 - 167,821,305 (+)Ensembl
GRCm38.p6 Ensembl2167,932,327 - 167,979,385 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124039
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,774,315 - 167,809,653 (+)Ensembl
GRCm38.p6 Ensembl2167,932,395 - 167,967,733 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126839
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,774,292 - 167,821,305 (+)Ensembl
GRCm38.p6 Ensembl2167,932,372 - 167,979,385 (+)Ensembl
RefSeq Acc Id: ENSMUST00000142717
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,792,968 - 167,806,987 (+)Ensembl
GRCm38.p6 Ensembl2167,951,048 - 167,965,067 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144249
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,774,315 - 167,805,607 (+)Ensembl
GRCm38.p6 Ensembl2167,932,395 - 167,963,687 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147210
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,773,977 - 167,816,657 (+)Ensembl
GRCm38.p6 Ensembl2167,932,057 - 167,974,737 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151705
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,774,292 - 167,809,705 (+)Ensembl
GRCm38.p6 Ensembl2167,932,372 - 167,967,785 (+)Ensembl
RefSeq Acc Id: NM_011201   ⟹   NP_035331
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,774,247 - 167,821,305 (+)NCBI
GRCm382167,932,327 - 167,979,385 (+)NCBI
MGSCv372167,757,827 - 167,804,885 (+)RGD
Celera2173,874,374 - 173,921,508 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006498981   ⟹   XP_006499044
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,774,234 - 167,821,305 (+)NCBI
GRCm382167,930,750 - 167,979,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159686   ⟹   XP_036015579
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,772,670 - 167,821,305 (+)NCBI
RefSeq Acc Id: XM_036159687   ⟹   XP_036015580
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,772,670 - 167,821,305 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_035331   ⟸   NM_011201
- UniProtKB: P35821 (UniProtKB/Swiss-Prot),   Q3TZW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006499044   ⟸   XM_006498981
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000029053   ⟸   ENSMUST00000029053
RefSeq Acc Id: XP_036015580   ⟸   XM_036159687
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036015579   ⟸   XM_036159686
- Peptide Label: isoform X2
Promoters
RGD ID:6832224
Promoter ID:MM_KWN:33131
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_011201,   OTTMUST00000038317,   OTTMUST00000038318,   OTTMUST00000038320,   OTTMUST00000038321,   UC008OAK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,756,971 - 167,757,972 (+)MPROMDB
RGD ID:6832223
Promoter ID:MM_KWN:33132
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Kidney
Transcripts:OTTMUST00000038319
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,776,491 - 167,776,991 (+)MPROMDB
RGD ID:6847684
Promoter ID:MM_ACW:30609
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:PTPN1.FSEP07-UNSPLICED,   PTPN1.GSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,800,681 - 167,801,181 (+)MPROMDB
RGD ID:6879820
Promoter ID:EPDNEW_M3361
Type:initiation region
Name:Ptpn1_1
Description:Mus musculus protein tyrosine phosphatase, non-receptor type1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3362  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382167,932,372 - 167,932,432EPDNEW
RGD ID:6879826
Promoter ID:EPDNEW_M3362
Type:multiple initiation site
Name:Ptpn1_2
Description:Mus musculus protein tyrosine phosphatase, non-receptor type1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3361  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382167,944,551 - 167,944,611EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97805 AgrOrtholog
Ensembl Genes ENSMUSG00000027540 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000029053 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029053 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000126839 ENTREZGENE
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ptpn1/Ptpn2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19246 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97805 ENTREZGENE
NCBI Gene 19246 ENTREZGENE
Pfam Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptpn1 PhenoGen
PIRSF Tyr-Ptase_nr1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P35821 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3T9Y9_MOUSE UniProtKB/TrEMBL
  Q3TB93_MOUSE UniProtKB/TrEMBL
  Q3TZW9 ENTREZGENE, UniProtKB/TrEMBL
  Q3UCZ5_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q60840 UniProtKB/Swiss-Prot
  Q62131 UniProtKB/Swiss-Prot
  Q64498 UniProtKB/Swiss-Prot
  Q99JS1 UniProtKB/Swiss-Prot