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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:23808
Term: dimethylarsinous acid
Definition: A methylarsinous acid that has formula C2H7AsO.
Chemical ID: MESH:C472511
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDdimethylarsinous acid results in increased expression of TNF mRNAPMID:23487506 PMID:24140498
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDdimethylarsinous acid results in increased secretion of TNF proteinPMID:24140498
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDLipopolysaccharides inhibits the reaction [dimethylarsinous acid results in increased expression of TNF mRNA]; Lipopolysaccharides inhibits the reaction [dimethylarsinous acid results in increased secretion of TNF protein]PMID:24140498
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