Rrm2b (ribonucleotide reductase M2 B (TP53 inducible)) - Rat Genome Database

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Gene: Rrm2b (ribonucleotide reductase M2 B (TP53 inducible)) Mus musculus
Analyze
Symbol: Rrm2b
Name: ribonucleotide reductase M2 B (TP53 inducible)
RGD ID: 1557502
MGI Page MGI
Description: Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in mitochondrial DNA replication and positive regulation of G0 to G1 transition. Acts upstream of or within several processes, including DNA repair; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of ribonucleoside-diphosphate reductase complex. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: p53; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm8616  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391537,924,196 - 37,961,562 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1537,924,196 - 37,961,562 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381537,923,952 - 37,961,119 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1537,923,952 - 37,961,318 (-)Ensemblmm10GRCm38
MGSCv371537,853,707 - 37,890,810 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361537,868,541 - 37,905,644 (-)NCBIMGSCv36mm8
Celera1538,542,769 - 38,579,866 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
antimycin A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
chloramphenicol  (ISO)
chlordecone  (EXP)
chloroacetaldehyde  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dicrotophos  (ISO)
diethanolamine  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
hydroxyurea  (ISO)
ifosfamide  (ISO)
inulin  (EXP)
isobutyraldehyde  (ISO)
isoniazide  (ISO)
lead(0)  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP)
potassium bromate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
triapine  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zebularine  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood homeostasis  (IAGP)
abnormal compact bone morphology  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal glomerular capillary endothelium morphology  (IAGP)
abnormal glomerular capillary morphology  (IAGP)
abnormal glomerular capsule parietal layer morphology  (IAGP)
abnormal glomerular endothelium fenestra morphology  (IAGP)
abnormal glomerular mesangium morphology  (IAGP)
abnormal kidney physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal mesenteric lymph node morphology  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal renal glomerular capsule morphology  (IAGP)
abnormal renal glomerulus basement membrane morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal sciatic nerve morphology  (IAGP)
abnormal submandibular gland morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
cardiac fibrosis  (IAGP)
cortical renal glomerulopathies  (IAGP)
decreased circulating alkaline phosphatase level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased glomerular capillary number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased lean body mass  (IAGP)
decreased spleen white pulp amount  (IAGP)
decreased total body fat amount  (IAGP)
dilated renal tubule  (IAGP)
enlarged kidney  (IAGP)
glomerulosclerosis  (IAGP)
hyperlipidemia  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating phosphate level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased glomerular capsule space  (IAGP)
increased kidney apoptosis  (IAGP)
increased kidney cell proliferation  (IAGP)
increased renal glomerulus basement membrane thickness  (IAGP)
increased renal tubule apoptosis  (IAGP)
increased urine protein level  (IAGP)
kidney failure  (IAGP)
muscular atrophy  (IAGP)
pale kidney  (IAGP)
podocyte foot process effacement  (IAGP)
podocyte hypertrophy  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
proximal convoluted tubule brush border loss  (IAGP)
renal glomerulus fibrosis  (IAGP)
renal tubular necrosis  (IAGP)
renal tubule atrophy  (IAGP)
skeletal muscle atrophy  (IAGP)
slow postnatal weight gain  (IAGP)
spleen atrophy  (IAGP)
thrombocytosis  (IAGP)
thymus atrophy  (IAGP)
thymus cortex hypoplasia  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10716435   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11517226   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12858174   PMID:14610273  
PMID:14681479   PMID:15322079   PMID:15489334   PMID:15723268   PMID:16141072   PMID:16141073   PMID:17486094   PMID:21146511   PMID:21873635   PMID:23139867   PMID:23643536   PMID:30662615  
PMID:31519977   PMID:32325033   PMID:32750454   PMID:32876667   PMID:34599703   PMID:35906243  


Genomics

Comparative Map Data
Rrm2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391537,924,196 - 37,961,562 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1537,924,196 - 37,961,562 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381537,923,952 - 37,961,119 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1537,923,952 - 37,961,318 (-)Ensemblmm10GRCm38
MGSCv371537,853,707 - 37,890,810 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361537,868,541 - 37,905,644 (-)NCBIMGSCv36mm8
Celera1538,542,769 - 38,579,866 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1515.1NCBI
RRM2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,204,501 - 102,238,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8102,204,502 - 102,238,961 (-)Ensemblhg38GRCh38
GRCh378103,216,729 - 103,251,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,285,907 - 103,320,522 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348103,285,907 - 103,320,522NCBI
Celera899,401,627 - 99,436,245 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef898,415,432 - 98,450,050 (-)NCBIHuRef
CHM1_18103,257,019 - 103,291,637 (-)NCBICHM1_1
T2T-CHM13v2.08103,330,401 - 103,364,861 (-)NCBIT2T-CHM13v2.0
Rrm2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8770,962,008 - 70,993,726 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl770,965,590 - 70,993,670 (-)EnsemblGRCr8
mRatBN7.2769,077,024 - 69,108,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,078,291 - 69,108,633 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx770,964,402 - 70,992,039 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0773,166,927 - 73,194,570 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0773,034,966 - 73,062,605 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0776,750,045 - 76,780,817 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl776,750,050 - 76,780,817 (-)Ensemblrn6Rnor6.0
Rnor_5.0776,865,854 - 76,898,097 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4773,432,161 - 73,459,541 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera766,144,175 - 66,172,166 (-)NCBICelera
RGSC_v3.1773,452,888 - 73,480,282 (-)NCBI
Cytogenetic Map7q22NCBI
Rrm2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541726,949,686 - 26,976,726 (-)Ensembl
ChiLan1.0NW_00495541726,949,686 - 26,976,976 (-)NCBIChiLan1.0ChiLan1.0
RRM2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27119,564,086 - 119,603,582 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1895,100,314 - 95,136,516 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0898,854,101 - 98,890,365 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18101,016,069 - 101,052,235 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,019,699 - 101,052,056 (-)EnsemblpanPan2panpan1.1
RRM2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1133,774,725 - 3,838,576 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl133,799,025 - 3,837,934 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha133,776,853 - 3,840,752 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0133,934,984 - 3,998,893 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl133,956,962 - 3,998,249 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1133,777,888 - 3,841,775 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0133,890,675 - 3,954,582 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0133,907,686 - 3,971,792 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rrm2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,928,024 - 33,975,215 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647041,354,287 - 41,401,317 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647041,354,387 - 41,401,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRM2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,823,758 - 34,859,778 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1434,823,869 - 34,859,777 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,679,202 - 37,715,064 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RRM2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,055,111 - 97,091,980 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603943,559,489 - 43,596,372 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rrm2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,362,663 - 19,391,443 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476319,362,793 - 19,391,401 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rrm2b
945 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1531
Count of miRNA genes:722
Interacting mature miRNAs:907
Transcripts:ENSMUST00000022901, ENSMUST00000127362, ENSMUST00000137636, ENSMUST00000144498, ENSMUST00000145155, ENSMUST00000145175, ENSMUST00000146821, ENSMUST00000153481
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11252136Modvl4_mmodifier of vacuolated lens (mouse)15562049439620614Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
1302165Yv_myellow value (mouse)Not determined151384700647847148Mouse
12904003Opfaq12_mopen field activity QTL 12 (mouse)153435891138447901Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15692948175871849Mouse
1301406Egrd2_mearly growth rate (mouse)Not determined152631178060311880Mouse
1301020Pheo_mpheomelanin (mouse)Not determined151384700647847148Mouse
10412172Habiir5_mhyperoxic acute lung injury imprinted region 5 (mouse)Not determined15927302243311880Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15762948155263396Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15722948155263396Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15762948159271849Mouse
26884409Bzwq16_mbi-zygomatic width QTL 16, 16 week (mouse)15612948138000244Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15612948171471849Mouse
1301557Bbaa22_mB.burgdorferi-associated arthritis 22 (mouse)Not determined152446257258462805Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
1301951Eila3_methanol induced locomotor activity 3 (mouse)Not determined151492758748927756Mouse
27226800Scvln20_msacral vertebrae length 2, 16 week (mouse)152660008666371849Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930014676084200Mouse
4141192Ssrq2_mstress response QTL 2 (mouse)Not determined927302256186850Mouse
1300772Bglq16_mbody growth late QTL 16 (mouse)Not determined152631178060311880Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15612948168271849Mouse
26884384Skwq12_mskull length QTL 12, 16 week (mouse)15612948150763396Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15612948175871849Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15612948178684200Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884439Sklq11_mskull length QTL 11, 10 week (mouse)15812948447663396Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
4141423Nstr2_mnerve sheath tumor resistance QTL 2 (mouse)Not determined1492758748927756Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
26884429Zlq6_mzygomatic length QTL 6, 10 week (mouse)15682948144963396Mouse
1301450Bpq6_mblood pressure QTL 6 (mouse)Not determined152828264662282739Mouse
14928313Manh78_mmandible shape 78 (mouse)152148464155484641Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15612948172471849Mouse
12859288Criq1_mCitrobacter rodentium infection QTL 1 (mouse)151603395450033954Mouse
1357512Bsbob5_mBSB obesity 5 (mouse)Not determined152828264662282739Mouse
26884423Zlq10_mzygomatic length QTL 10, 16 week (mouse)152060008650763396Mouse
12859289Criq3_mCitrobacter rodentium infection QTL 3 (mouse)152259376556593765Mouse
4141409Radsvq1_mradiation sensitivity QTL 1 (mouse)Not determined2548497859484978Mouse
1357514Mbis3_mMycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)Not determined162631178060311880Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
1301324Cdif_mcolor difference (mouse)Not determined153597590669976019Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15612948176384200Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1302007Bbaa14_mB.burgdorferi-associated arthritis 14 (mouse)Not determined151492758748927756Mouse
1301499Bdln2_mbody length 2 (mouse)Not determined151564534349645470Mouse
27095922Pglq11_mpelvic girdle length QTL 11, 10 week (mouse)15812948438763395Mouse
4142160Femwf10_mfemur work to failure 10 (mouse)Not determined2289301456893160Mouse
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15347438971197538Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
1300578Cd8ts3_mCD8 T cell subset 3 (mouse)Not determined153400469468004804Mouse
1301345Bgeq14_mbody growth early QTL 14 (mouse)Not determined152631178060311880Mouse
1300967Bdt6_mbone density traits 6 (mouse)Not determined152529580659295928Mouse
4140994Shali3_msurvival time to hyperoxic acute lung injury 3 (mouse)Not determined927302243311880Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15692948175871849Mouse
26884452Sklq17_mskull length QTL 17, 16 week (mouse)153020014657963396Mouse

Markers in Region
UniSTS:236967  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38133,353,772 - 3,353,983UniSTSGRCm38
MGSCv37133,353,018 - 3,353,229UniSTSGRCm37
Celera133,342,462 - 3,342,673UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map13A1UniSTS
UniSTS:236969  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381537,926,708 - 37,927,003UniSTSGRCm38
GRCm38133,354,232 - 3,354,527UniSTSGRCm38
MGSCv37133,353,478 - 3,353,773UniSTSGRCm37
MGSCv371537,856,463 - 37,856,758UniSTSGRCm37
Celera1538,545,525 - 38,545,820UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map13A1UniSTS
UniSTS:236970  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381537,924,138 - 37,924,492UniSTSGRCm38
GRCm38133,356,847 - 3,357,203UniSTSGRCm38
MGSCv37133,356,093 - 3,356,449UniSTSGRCm37
MGSCv371537,853,893 - 37,854,247UniSTSGRCm37
Celera1538,542,955 - 38,543,309UniSTS
Celera133,345,527 - 3,345,883UniSTS
Cytogenetic Map15B3.1UniSTS
D11Bhm20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map5E2UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map12D1UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map7B4UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map4E1UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map3BUniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map10A3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map6A3.3UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map13D2UniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map18B3UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map16C4UniSTS
Cytogenetic Map3G1UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map7B1-B2UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map15B3.1UniSTS
Cytogenetic Map8D3UniSTS
Cytogenetic Map10D2UniSTS
Cytogenetic Map15E3UniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map7E3UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map11A3.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map16B4UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map19BUniSTS
cM Map1144.15UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001416552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_199476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_184224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000022901   ⟹   ENSMUSP00000022901
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,924,196 - 37,961,347 (-)Ensembl
GRCm38.p6 Ensembl1537,923,952 - 37,961,103 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127362
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,945,292 - 37,955,382 (-)Ensembl
GRCm38.p6 Ensembl1537,945,048 - 37,955,138 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137636   ⟹   ENSMUSP00000119400
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,927,489 - 37,961,135 (-)Ensembl
GRCm38.p6 Ensembl1537,927,245 - 37,960,891 (-)Ensembl
Ensembl Acc Id: ENSMUST00000144498   ⟹   ENSMUSP00000121069
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,931,881 - 37,961,173 (-)Ensembl
GRCm38.p6 Ensembl1537,931,637 - 37,960,929 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145155   ⟹   ENSMUSP00000120215
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,946,996 - 37,961,562 (-)Ensembl
GRCm38.p6 Ensembl1537,946,752 - 37,961,318 (-)Ensembl
Ensembl Acc Id: ENSMUST00000145175   ⟹   ENSMUSP00000114343
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,945,397 - 37,961,093 (-)Ensembl
GRCm38.p6 Ensembl1537,945,153 - 37,960,849 (-)Ensembl
Ensembl Acc Id: ENSMUST00000146821   ⟹   ENSMUSP00000123691
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,927,489 - 37,961,135 (-)Ensembl
GRCm38.p6 Ensembl1537,927,245 - 37,960,891 (-)Ensembl
Ensembl Acc Id: ENSMUST00000153481   ⟹   ENSMUSP00000121188
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,927,489 - 37,961,135 (-)Ensembl
GRCm38.p6 Ensembl1537,927,245 - 37,960,891 (-)Ensembl
Ensembl Acc Id: ENSMUST00000227688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1537,945,873 - 37,948,686 (-)Ensembl
GRCm38.p6 Ensembl1537,945,629 - 37,948,442 (-)Ensembl
RefSeq Acc Id: NM_001357022   ⟹   NP_001343951
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,924,196 - 37,961,173 (-)NCBI
GRCm381537,923,952 - 37,960,856 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001357023   ⟹   NP_001343952
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,924,196 - 37,961,173 (-)NCBI
GRCm381537,923,952 - 37,960,856 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001416546   ⟹   NP_001403475
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,924,196 - 37,961,329 (-)NCBI
RefSeq Acc Id: NM_001416547   ⟹   NP_001403476
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,924,196 - 37,961,562 (-)NCBI
RefSeq Acc Id: NM_001416548   ⟹   NP_001403477
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,942,910 - 37,961,329 (-)NCBI
RefSeq Acc Id: NM_001416549   ⟹   NP_001403478
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,942,910 - 37,961,329 (-)NCBI
RefSeq Acc Id: NM_001416550   ⟹   NP_001403479
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,938,291 - 37,961,329 (-)NCBI
RefSeq Acc Id: NM_001416551   ⟹   NP_001403480
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,924,196 - 37,961,329 (-)NCBI
RefSeq Acc Id: NM_001416552   ⟹   NP_001403481
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,942,910 - 37,961,329 (-)NCBI
RefSeq Acc Id: NM_199476   ⟹   NP_955770
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,924,196 - 37,961,329 (-)NCBI
GRCm381537,923,952 - 37,961,055 (-)NCBI
MGSCv371537,853,707 - 37,890,810 (-)RGD
Celera1538,542,769 - 38,579,866 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_184224
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391537,924,196 - 37,961,329 (-)NCBI
RefSeq Acc Id: NP_955770   ⟸   NM_199476
- Peptide Label: isoform 1
- UniProtKB: Q6PEE3 (UniProtKB/Swiss-Prot),   D3Z2A4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001343952   ⟸   NM_001357023
- Peptide Label: isoform 3
- UniProtKB: D3Z2A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001343951   ⟸   NM_001357022
- Peptide Label: isoform 2
- UniProtKB: D3Z2A4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000120215   ⟸   ENSMUST00000145155
Ensembl Acc Id: ENSMUSP00000114343   ⟸   ENSMUST00000145175
Ensembl Acc Id: ENSMUSP00000121069   ⟸   ENSMUST00000144498
Ensembl Acc Id: ENSMUSP00000123691   ⟸   ENSMUST00000146821
Ensembl Acc Id: ENSMUSP00000022901   ⟸   ENSMUST00000022901
Ensembl Acc Id: ENSMUSP00000121188   ⟸   ENSMUST00000153481
Ensembl Acc Id: ENSMUSP00000119400   ⟸   ENSMUST00000137636
RefSeq Acc Id: NP_001403476   ⟸   NM_001416547
- Peptide Label: isoform 3
- UniProtKB: D3Z2A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001403480   ⟸   NM_001416551
- Peptide Label: isoform 8
RefSeq Acc Id: NP_001403475   ⟸   NM_001416546
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001403479   ⟸   NM_001416550
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001403478   ⟸   NM_001416549
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001403481   ⟸   NM_001416552
- Peptide Label: isoform 9
RefSeq Acc Id: NP_001403477   ⟸   NM_001416548
- Peptide Label: isoform 5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PEE3-F1-model_v2 AlphaFold Q6PEE3 1-351 view protein structure

Promoters
RGD ID:6826436
Promoter ID:MM_KWN:18302
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000081651,   OTTMUST00000081653,   OTTMUST00000081654,   OTTMUST00000081655,   OTTMUST00000081656,   OTTMUST00000081657,   OTTMUST00000081658
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361537,890,536 - 37,891,702 (-)MPROMDB
RGD ID:8683620
Promoter ID:EPDNEW_M19841
Type:initiation region
Name:Rrm2b_1
Description:Mus musculus ribonucleotide reductase M2 B , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381537,961,048 - 37,961,108EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2155865 AgrOrtholog
Ensembl Genes ENSMUSG00000022292 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022901 ENTREZGENE
  ENSMUST00000022901.16 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.620.20 UniProtKB/Swiss-Prot
InterPro Ferritin-like_SF UniProtKB/Swiss-Prot
  RNR-like UniProtKB/Swiss-Prot
  RNR_small UniProtKB/Swiss-Prot
  RNR_small_AS UniProtKB/Swiss-Prot
  RNR_small_fam UniProtKB/Swiss-Prot
KEGG Report mmu:382985 UniProtKB/Swiss-Prot
MGD MGI:2155865 ENTREZGENE
NCBI Gene Rrm2b ENTREZGENE
PANTHER PTHR23409 UniProtKB/Swiss-Prot
  RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 B UniProtKB/Swiss-Prot
Pfam Ribonuc_red_sm UniProtKB/Swiss-Prot
PhenoGen Rrm2b PhenoGen
PIRSF NrdB UniProtKB/Swiss-Prot
PROSITE RIBORED_SMALL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47240 UniProtKB/Swiss-Prot
UniProt D3YVM0_MOUSE UniProtKB/TrEMBL
  D3YXX2_MOUSE UniProtKB/TrEMBL
  D3Z0X2_MOUSE UniProtKB/TrEMBL
  D3Z2A4 ENTREZGENE, UniProtKB/TrEMBL
  D6RFN4_MOUSE UniProtKB/TrEMBL
  D6RFP5_MOUSE UniProtKB/TrEMBL
  Q6PEE3 ENTREZGENE, UniProtKB/Swiss-Prot