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Gene: Il1r2 (interleukin 1 receptor, type II) Mus musculus
Symbol: Il1r2
Name: interleukin 1 receptor, type II
Description: Exhibits interleukin-1 binding activity and interleukin-1 receptor activity. Involved in negative regulation of cytokine production; negative regulation of interleukin-1-mediated signaling pathway; and negative regulation of protein processing. Localizes to the cytoplasm. Human ortholog(s) of this gene implicated in aggressive periodontitis. Is expressed in several structures, including dorsal aorta; gut; pituitary gland; reproductive system; and thymus. Orthologous to human IL1R2 (interleukin 1 receptor type 2); PARTICIPATES IN interleukin-1 signaling pathway; Entamoebiasis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD121 antigen-like family member B; CD121b; IL-1 receptor beta chain; IL-1 type II receptor; IL-1R-2; IL-1R-beta; IL-1RT-2; IL-1RT2; Il1r-2; interleukin-1 receptor beta; interleukin-1 receptor type 2; interleukin-1 receptor type II
Homo sapiens (human) : IL1R2 (interleukin 1 receptor type 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il1r2 (interleukin 1 receptor type 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il1r2 (interleukin 1 receptor type 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IL1R2 (interleukin 1 receptor type 2)
Canis lupus familiaris (dog) : IL1R2 (interleukin 1 receptor type 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il1r2 (interleukin 1 receptor type 2)
Sus scrofa (pig) : IL1R2 (interleukin 1 receptor type 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl140,074,079 - 40,125,231 (+)Ensembl
GRCm38140,084,692 - 40,125,230 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37140,141,613 - 40,182,070 (+)NCBIGRCm37mm9NCBIm37
MGSCv36140,029,314 - 40,069,771 (+)NCBImm8
Celera139,891,137 - 39,931,702 (+)NCBICelera
Cytogenetic Map1 BNCBI
cM Map118.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il1r2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731689
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.