Ifi44l (interferon-induced protein 44 like) - Rat Genome Database

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Gene: Ifi44l (interferon-induced protein 44 like) Mus musculus
Analyze
Symbol: Ifi44l
Name: interferon-induced protein 44 like
RGD ID: 1618423
MGI Page MGI
Description: Acts upstream of or within immune response. Predicted to be located in cytoplasm. Is expressed in nervous system; salivary gland primordium; sensory organ; tail mesenchyme; and urethra. Orthologous to human IFI44L (interferon induced protein 44 like).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H-28; H28; H28-1; H28c minor histocompatibility antigen 1; histocompatibility 28; interferon-induced protein 44-like; NS11; NS1178
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393151,464,374 - 151,468,528 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3151,464,374 - 151,468,529 (-)EnsemblGRCm39 Ensembl
GRCm383151,758,737 - 151,762,891 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3151,758,737 - 151,762,892 (-)EnsemblGRCm38mm10GRCm38
MGSCv373151,421,701 - 151,425,855 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363151,696,123 - 151,700,277 (-)NCBIMGSCv36mm8
Celera3158,225,587 - 158,234,632 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map376.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-phenylprop-2-enal  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (EXP)
6alpha-methylprednisolone  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diallyl trisulfide  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
gadodiamide hydrate  (ISO)
gentamycin  (ISO)
hydroquinone  (ISO)
lead diacetate  (EXP)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
methcathinone  (ISO)
methotrexate  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
oxaliplatin  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
picoxystrobin  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
succimer  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
toluene 2,4-diisocyanate  (EXP)
topotecan  (ISO)
trovafloxacin  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vincristine  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:447069   PMID:2451911   PMID:6203959   PMID:11021531   PMID:11125038   PMID:12477932   PMID:21267068   PMID:21525387   PMID:21677750   PMID:21873635   PMID:32611756  


Genomics

Comparative Map Data
Ifi44l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393151,464,374 - 151,468,528 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3151,464,374 - 151,468,529 (-)EnsemblGRCm39 Ensembl
GRCm383151,758,737 - 151,762,891 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3151,758,737 - 151,762,892 (-)EnsemblGRCm38mm10GRCm38
MGSCv373151,421,701 - 151,425,855 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363151,696,123 - 151,700,277 (-)NCBIMGSCv36mm8
Celera3158,225,587 - 158,234,632 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map376.94NCBI
IFI44L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,620,448 - 78,646,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,619,902 - 78,646,145 (+)EnsemblGRCh38hg38GRCh38
GRCh37179,086,133 - 79,111,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,858,741 - 78,880,657 (+)NCBINCBI36Build 36hg18NCBI36
Build 34178,798,169 - 78,820,090NCBI
Celera177,325,610 - 77,351,345 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef177,217,681 - 77,243,415 (+)NCBIHuRef
CHM1_1179,202,478 - 79,228,218 (+)NCBICHM1_1
T2T-CHM13v2.0178,459,314 - 78,485,000 (+)NCBIT2T-CHM13v2.0
Ifi44l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,328,629 - 243,366,404 (+)NCBIGRCr8
mRatBN7.22240,668,742 - 240,706,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2240,668,713 - 240,706,359 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02256,948,722 - 256,979,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2256,964,860 - 256,978,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02275,622,784 - 275,657,880 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2232,607,742 - 232,643,820 (+)NCBICelera
Cytogenetic Map2q45NCBI
IFI44L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21148,249,515 - 148,275,320 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11147,405,954 - 147,431,788 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,833,514 - 77,855,664 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,914,137 - 79,936,095 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,914,051 - 79,936,084 (+)Ensemblpanpan1.1panPan2
IFI44L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1668,382,157 - 68,400,880 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl668,382,317 - 68,398,053 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha671,038,802 - 71,059,253 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0668,965,744 - 68,986,198 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1668,472,590 - 68,493,039 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0668,418,216 - 68,438,467 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0668,902,410 - 68,922,858 (-)NCBIUU_Cfam_GSD_1.0
Ifi44l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505889,846,825 - 89,865,805 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365715,357,203 - 5,376,157 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFI44L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6134,659,639 - 134,679,331 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16134,660,230 - 134,679,212 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26124,816,723 - 124,836,006 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IFI44L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12054,563,728 - 54,586,018 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2054,561,775 - 54,586,030 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603362,941,726 - 62,963,152 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ifi44l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474218,625,764 - 18,640,009 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ifi44l
133 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:102
Interacting mature miRNAs:103
Transcripts:ENSMUST00000046739
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126270248159745316Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126352986159745316Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126460514159745316Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3130736935159745316Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3130849375159745316Mouse
1301528Loco1_mlocomotor activity 1 (mouse)Not determined3133461893159745316Mouse
1301222Scc7_mcolon tumor susceptibility 7 (mouse)Not determined3143352986156364108Mouse
10045615Hrtfm8_mheart failure modifier 8 (mouse)Not determined3148451045152592311Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000046739   ⟹   ENSMUSP00000044765
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3151,464,374 - 151,468,529 (-)Ensembl
GRCm38.p6 Ensembl3151,758,737 - 151,762,892 (-)Ensembl
RefSeq Acc Id: NM_031367   ⟹   NP_112735
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393151,464,374 - 151,468,528 (-)NCBI
GRCm383151,758,737 - 151,762,891 (-)ENTREZGENE
MGSCv373151,421,701 - 151,425,855 (-)RGD
Celera3158,225,587 - 158,234,632 (-)RGD
cM Map3 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_112735 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH24930 (Get FASTA)   NCBI Sequence Viewer  
  AAK07660 (Get FASTA)   NCBI Sequence Viewer  
  EDL11942 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000044765
  ENSMUSP00000044765.6
GenBank Protein Q9BDB7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112735   ⟸   NM_031367
- UniProtKB: Q8SP46 (UniProtKB/Swiss-Prot),   Q9BDB7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000044765   ⟸   ENSMUST00000046739
Protein Domains
TLDc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BDB7-F1-model_v2 AlphaFold Q9BDB7 1-447 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95975 AgrOrtholog
Ensembl Genes ENSMUSG00000039146 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000046739 ENTREZGENE
  ENSMUST00000046739.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  TLDc_dom UniProtKB/Swiss-Prot
KEGG Report mmu:15061 UniProtKB/Swiss-Prot
MGD MGI:95975 ENTREZGENE
NCBI Gene 15061 ENTREZGENE
PANTHER INTERFERON-INDUCED PROTEIN 44 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERFERON-INDUCED PROTEIN 44-LIKE UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
PhenoGen Ifi44l PhenoGen
PROSITE TLDC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt F6ZI78_MOUSE UniProtKB/TrEMBL
  IF44L_MOUSE UniProtKB/Swiss-Prot
  Q8SP46 ENTREZGENE
  Q9BDB7 ENTREZGENE
UniProt Secondary Q8SP46 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-27 Ifi44l  interferon-induced protein 44 like  H28  histocompatibility 28  Symbol and/or name change 5135510 APPROVED