N6amt1 (N-6 adenine-specific DNA methyltransferase 1 (putative)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: N6amt1 (N-6 adenine-specific DNA methyltransferase 1 (putative)) Mus musculus
Analyze
Symbol: N6amt1
Name: N-6 adenine-specific DNA methyltransferase 1 (putative)
RGD ID: 1323513
MGI Page MGI
Description: Enables protein-glutamine N-methyltransferase activity. Involved in peptidyl-glutamine methylation. Located in nucleus. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human N6AMT1 (N-6 adenine-specific DNA methyltransferase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5830445C04Rik; HemK methyltransferase family member 2; Hemk2; lysine N-methyltransferase 9; M-N6DNA MTase A; methylarsonite methyltransferase N6AMT1; methyltransferase N6AMT1; MGC106447; N(6)-adenine-specific DNA methyltransferase 1; N6-DNA methyltransferase A; Pred; Pred28
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391687,151,073 - 87,165,537 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1687,151,073 - 87,165,630 (+)EnsemblGRCm39 Ensembl
GRCm381687,354,185 - 87,368,649 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1687,354,185 - 87,368,742 (+)EnsemblGRCm38mm10GRCm38
MGSCv371687,354,430 - 87,368,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361687,243,381 - 87,257,845 (+)NCBIMGSCv36mm8
Celera1687,539,465 - 87,553,925 (+)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1649.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, etal., Nature 2002 Dec 5;420(6915):586-90.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Human chromosome 21 gene expression atlas in the mouse. Reymond A, etal., Nature 2002 Dec 5;420(6915):582-6.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16684535   PMID:18389380   PMID:18539146   PMID:19116772   PMID:20606008  
PMID:21677750   PMID:21873635   PMID:26797129   PMID:32968282   PMID:37624905  


Genomics

Comparative Map Data
N6amt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391687,151,073 - 87,165,537 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1687,151,073 - 87,165,630 (+)EnsemblGRCm39 Ensembl
GRCm381687,354,185 - 87,368,649 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1687,354,185 - 87,368,742 (+)EnsemblGRCm38mm10GRCm38
MGSCv371687,354,430 - 87,368,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361687,243,381 - 87,257,845 (+)NCBIMGSCv36mm8
Celera1687,539,465 - 87,553,925 (+)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1649.52NCBI
N6AMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382128,575,598 - 28,885,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2128,872,191 - 28,885,371 (-)EnsemblGRCh38hg38GRCh38
GRCh372130,244,513 - 30,257,689 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362129,166,384 - 29,179,564 (-)NCBINCBI36Build 36hg18NCBI36
Celera2115,427,774 - 15,440,965 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2115,649,537 - 15,662,924 (-)NCBIHuRef
CHM1_12129,806,890 - 29,820,072 (-)NCBICHM1_1
T2T-CHM13v2.02127,235,374 - 27,248,586 (-)NCBIT2T-CHM13v2.0
N6amt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81140,071,017 - 40,083,463 (+)NCBIGRCr8
mRatBN7.21126,584,750 - 26,597,790 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1126,584,724 - 26,608,248 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1135,282,689 - 35,295,029 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01127,982,937 - 27,995,276 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,171,867 - 27,184,209 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01127,004,335 - 27,016,690 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,004,320 - 27,016,941 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01130,629,574 - 30,641,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41127,107,106 - 27,119,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11127,107,109 - 27,119,546 (+)NCBI
Celera1126,337,923 - 26,356,638 (+)NCBICelera
Cytogenetic Map11q11NCBI
Hemk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540728,256,649 - 28,276,460 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540728,256,654 - 28,277,514 (+)NCBIChiLan1.0ChiLan1.0
HEMK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22224,764,439 - 25,067,011 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12119,621,921 - 19,925,542 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02115,303,430 - 15,316,596 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12128,691,847 - 28,704,745 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2128,694,294 - 28,704,745 (-)Ensemblpanpan1.1panPan2
N6AMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13123,895,558 - 23,934,183 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3123,895,584 - 23,909,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3123,888,155 - 23,926,785 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03124,008,039 - 24,046,658 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3124,008,051 - 24,024,515 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13123,959,405 - 23,997,823 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03123,961,154 - 23,999,634 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03124,432,448 - 24,471,137 (+)NCBIUU_Cfam_GSD_1.0
Hemk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497124,368,003 - 24,381,211 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650013,084,595 - 13,099,844 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650013,086,873 - 13,099,814 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
N6AMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13192,249,246 - 192,265,629 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113192,248,511 - 192,265,923 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213202,558,051 - 202,782,210 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HEMK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1263,348,897 - 63,363,709 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl263,348,745 - 63,363,090 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660715,935,090 - 5,950,770 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hemk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474516,908,686 - 16,920,351 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474516,908,683 - 16,922,941 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in N6amt1
483 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2318
Count of miRNA genes:767
Interacting mature miRNAs:1026
Transcripts:ENSMUST00000054442, ENSMUST00000118115, ENSMUST00000118310, ENSMUST00000120284
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301394Eae11_msusceptibility to experimental allergic encephalomyelitis 11 (mouse)Not determined165356189187562035Mouse
1302194Pgia10_mproteoglycan induced arthritis 10 (mouse)Not determined166860072298008968Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
1558740Bpq9_mblood pressure QTL 9 (mouse)Not determined166332733697327472Mouse
4141113Tgq28_mtriglyceride QTL 28 (mouse)Not determined6298664696986646Mouse
1301364Lith14_mlithogenic gene 14 (mouse)Not determined165566184689661961Mouse
4142262Lmr18_mleishmaniasis resistance 18 (mouse)Not determined166912761198008968Mouse
11049573Lmr18b_mleishmaniasis resistance 18b (mouse)166912761198008968Mouse
1301598Renf2_mrenal failure 2 (mouse)Not determined167038025298008968Mouse
11049574Lmr18a_mleishmaniasis resistance 18a (mouse)166912761198008968Mouse
11522753Cocia19_mcocaine-induced activity, QTL 19 (mouse)166925448298008968Mouse
1300928Etia_methanol induced activation (mouse)Not determined166331390797314016Mouse
1301125Sluc27_msusceptibility to lung cancer 27 (mouse)Not determined166160864495608764Mouse
1301032Tauph_mtau phosphorylation (mouse)Not determined166907613298008968Mouse

Markers in Region
N6amt1-pending  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C3.3UniSTS
cM Map16 UniSTS
N6amt1-pending  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C3.3UniSTS
cM Map16 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000054442   ⟹   ENSMUSP00000061835
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1687,151,073 - 87,165,630 (+)Ensembl
GRCm38.p6 Ensembl1687,354,185 - 87,368,742 (+)Ensembl
Ensembl Acc Id: ENSMUST00000118115   ⟹   ENSMUSP00000113217
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1687,151,133 - 87,164,573 (+)Ensembl
GRCm38.p6 Ensembl1687,354,245 - 87,367,685 (+)Ensembl
Ensembl Acc Id: ENSMUST00000118310   ⟹   ENSMUSP00000113229
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1687,151,115 - 87,165,630 (+)Ensembl
GRCm38.p6 Ensembl1687,354,227 - 87,368,742 (+)Ensembl
Ensembl Acc Id: ENSMUST00000120284   ⟹   ENSMUSP00000112510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1687,151,131 - 87,162,558 (+)Ensembl
GRCm38.p6 Ensembl1687,354,243 - 87,365,670 (+)Ensembl
RefSeq Acc Id: NM_001159331   ⟹   NP_001152803
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391687,151,073 - 87,165,537 (+)NCBI
GRCm381687,354,185 - 87,368,649 (+)ENTREZGENE
MGSCv371687,354,430 - 87,368,894 (+)RGD
Celera1687,539,465 - 87,553,925 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_026366   ⟹   NP_080642
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391687,151,073 - 87,165,537 (+)NCBI
GRCm381687,354,185 - 87,368,649 (+)ENTREZGENE
MGSCv371687,354,430 - 87,368,894 (+)RGD
Celera1687,539,465 - 87,553,925 (+)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_080642   ⟸   NM_026366
- Peptide Label: isoform 1
- UniProtKB: Q4KMV5 (UniProtKB/Swiss-Prot),   E9PXT7 (UniProtKB/Swiss-Prot),   D3Z6J0 (UniProtKB/Swiss-Prot),   Q6PRU9 (UniProtKB/Swiss-Prot),   Q6SKR2 (UniProtKB/TrEMBL),   A0A4W7N3B2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001152803   ⟸   NM_001159331
- Peptide Label: isoform 2
- UniProtKB: Q6PRU9 (UniProtKB/TrEMBL),   Q6SKR2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000113217   ⟸   ENSMUST00000118115
Ensembl Acc Id: ENSMUSP00000113229   ⟸   ENSMUST00000118310
Ensembl Acc Id: ENSMUSP00000061835   ⟸   ENSMUST00000054442
Ensembl Acc Id: ENSMUSP00000112510   ⟸   ENSMUST00000120284
Protein Domains
Methyltransferase small

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6SKR2-F1-model_v2 AlphaFold Q6SKR2 1-214 view protein structure

Promoters
RGD ID:13674298
Promoter ID:EPDNEW_M21298
Type:multiple initiation site
Name:N6amt1_1
Description:Mus musculus N-6 adenine-specific DNA methyltransferase 1 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381687,354,224 - 87,354,284EPDNEW
RGD ID:6827327
Promoter ID:MM_KWN:21544
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000118310,   OTTMUST00000065657,   UC007ZUB.1,   UC007ZUC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361687,354,321 - 87,354,872 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915018 AgrOrtholog
Ensembl Genes ENSMUSG00000044442 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000054442 ENTREZGENE
  ENSMUST00000054442.11 UniProtKB/Swiss-Prot
  ENSMUST00000118115.2 UniProtKB/TrEMBL
  ENSMUST00000118310 ENTREZGENE
  ENSMUST00000118310.8 UniProtKB/Swiss-Prot
  ENSMUST00000120284.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA_methylase_N6_adenine_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Euk-Arch_PrmC-MTase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PrmC-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_mtfrase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67768 UniProtKB/Swiss-Prot
MGD MGI:1915018 ENTREZGENE
NCBI Gene 67768 ENTREZGENE
PANTHER METHYLTRANSFERASE N6AMT1 UniProtKB/Swiss-Prot
  METHYLTRANSFERASE N6AMT1 UniProtKB/Swiss-Prot
  METHYLTRANSFERASE N6AMT1 UniProtKB/TrEMBL
  METHYLTRANSFERASE N6AMT1 UniProtKB/TrEMBL
Pfam MTS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen N6amt1 PhenoGen
PROSITE N6_MTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4W7N3B2 ENTREZGENE, UniProtKB/TrEMBL
  D3Z6J0 ENTREZGENE
  E9PXT7 ENTREZGENE
  N6MT1_MOUSE UniProtKB/Swiss-Prot
  Q4KMV5 ENTREZGENE
  Q6PRU9 ENTREZGENE
  Q6SKR2 ENTREZGENE
  Q9CUX0_MOUSE UniProtKB/TrEMBL
UniProt Secondary D3Z6J0 UniProtKB/Swiss-Prot
  E9PXT7 UniProtKB/Swiss-Prot
  Q4KMV5 UniProtKB/Swiss-Prot
  Q6PRU9 UniProtKB/Swiss-Prot