Tmem158 (transmembrane protein 158) - Rat Genome Database
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Gene: Tmem158 (transmembrane protein 158) Mus musculus
Analyze
Symbol: Tmem158
Name: transmembrane protein 158
RGD ID: 733050
MGI Page MGI
Description: Predicted to have peptide binding activity. Predicted to localize to integral component of membrane. Is expressed in several structures, including central nervous system; genitourinary system; immune system; intestine; and liver. Orthologous to human TMEM158 (transmembrane protein 158); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310037P21Rik; 40 kDa BINP-binding protein; BINP binding protein p40BBP; brain injury-derived neurotrophic peptide (BINP) binding protein; p40BBP; R; Ras-induced senescence 1; ras-induced senescence protein 1; Ris1
RGD Orthologs
Human
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,088,122 - 123,089,854 (-)NCBIGRCm39mm39
GRCm389123,259,057 - 123,260,789 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,259,053 - 123,260,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv379123,168,175 - 123,169,907 (-)NCBIGRCm37mm9NCBIm37
MGSCv369123,108,383 - 123,109,243 (-)NCBImm8
Celera9123,709,260 - 123,710,992 (-)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carmustine  (ISO)
chromium(6+)  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
lead diacetate  (ISO)
medroxyprogesterone acetate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
propanal  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15102471   PMID:16141072   PMID:16141073   PMID:16964279  
PMID:21677750   PMID:21873635  


Genomics

Comparative Map Data
Tmem158
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,088,122 - 123,089,854 (-)NCBIGRCm39mm39
GRCm389123,259,057 - 123,260,789 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,259,053 - 123,260,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv379123,168,175 - 123,169,907 (-)NCBIGRCm37mm9NCBIm37
MGSCv369123,108,383 - 123,109,243 (-)NCBImm8
Celera9123,709,260 - 123,710,992 (-)NCBICelera
Cytogenetic Map9F4NCBI
TMEM158
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl345,224,466 - 45,226,287 (-)EnsemblGRCh38hg38GRCh38
GRCh38345,224,466 - 45,226,287 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37345,265,956 - 45,267,814 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36345,240,960 - 45,242,818 (-)NCBINCBI36hg18NCBI36
Build 34345,240,961 - 45,242,758NCBI
Celera345,204,342 - 45,206,200 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef345,309,816 - 45,311,719 (-)NCBIHuRef
CHM1_1345,215,889 - 45,217,747 (-)NCBICHM1_1
Tmem158
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08132,344,710 - 132,345,708 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,344,710 - 132,345,708 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08131,497,629 - 131,498,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,037,014 - 128,038,012 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,056,750 - 128,057,749 (-)NCBI
Celera8122,025,073 - 122,026,071 (-)NCBICelera
Cytogenetic Map8q32NCBI
TMEM158
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0345,126,759 - 45,128,582 (-)NCBIMhudiblu_PPA_v0panPan3
Tmem158
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936695601,732 - 602,112 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM158
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1328,405,187 - 28,406,074 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11328,404,542 - 28,406,369 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21331,445,301 - 31,447,087 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM158
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl226,698,545 - 6,699,423 (-)Ensembl
ChlSab1.1226,697,883 - 6,699,713 (-)NCBI
Tmem158
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473075,434,178 - 75,435,686 (+)NCBI

Position Markers
Tmem158  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389123,260,403 - 123,260,715UniSTSGRCm38
MGSCv379123,169,521 - 123,169,833UniSTSGRCm37
Celera9123,710,606 - 123,710,918UniSTS
Cytogenetic Map9F4UniSTS
cM Map9 UniSTS
UniSTS:493273  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389123,259,444 - 123,260,712UniSTSGRCm38
MGSCv379123,168,562 - 123,169,830UniSTSGRCm37
Celera9123,709,647 - 123,710,915UniSTS
Cytogenetic Map9F4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:182
Interacting mature miRNAs:205
Transcripts:ENSMUST00000068140
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000068140   ⟹   ENSMUSP00000069161
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9123,259,053 - 123,260,764 (-)Ensembl
RefSeq Acc Id: NM_001002267   ⟹   NP_001002267
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399123,088,122 - 123,089,854 (-)NCBI
GRCm389123,259,057 - 123,260,789 (-)ENTREZGENE
MGSCv379123,168,175 - 123,169,907 (-)RGD
Celera9123,709,260 - 123,710,992 (-)RGD
cM Map9 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001002267 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI39428 (Get FASTA)   NCBI Sequence Viewer  
  AAI39429 (Get FASTA)   NCBI Sequence Viewer  
  BAD27475 (Get FASTA)   NCBI Sequence Viewer  
  EDL09068 (Get FASTA)   NCBI Sequence Viewer  
  Q6F5E0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001002267   ⟸   NM_001002267
- Peptide Label: precursor
- UniProtKB: B2RTM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000069161   ⟸   ENSMUST00000068140

Promoters
RGD ID:6845254
Promoter ID:MM_KWN:59268
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:NM_001002267
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369123,168,846 - 123,169,917 (-)MPROMDB
RGD ID:8671336
Promoter ID:EPDNEW_M13698
Type:initiation region
Name:Tmem158_1
Description:Mus musculus transmembrane protein 158 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389123,260,764 - 123,260,824EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919559 AgrOrtholog
Ensembl Genes ENSMUSG00000054871 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000069161 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000068140 ENTREZGENE, UniProtKB/TrEMBL
InterPro TMEM158 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72309 UniProtKB/TrEMBL
MGD MGI:1919559 ENTREZGENE
NCBI Gene 72309 ENTREZGENE
PANTHER PTHR38324 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem158 PhenoGen
UniGene Mm.8569 ENTREZGENE
UniProt B2RTM1 ENTREZGENE, UniProtKB/TrEMBL
  Q6F5E0 ENTREZGENE, UniProtKB/Swiss-Prot