Pdk3 (pyruvate dehydrogenase kinase, isoenzyme 3) - Rat Genome Database

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Gene: Pdk3 (pyruvate dehydrogenase kinase, isoenzyme 3) Mus musculus
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Symbol: Pdk3
Name: pyruvate dehydrogenase kinase, isoenzyme 3
RGD ID: 1557432
MGI Page MGI
Description: Predicted to enable ATP binding activity; protein serine/threonine kinase activity; and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Predicted to be involved in several processes, including hypoxia-inducible factor-1alpha signaling pathway; peroxisome proliferator activated receptor signaling pathway; and regulation of acetyl-CoA biosynthetic process from pyruvate. Predicted to act upstream of or within glucose metabolic process and phosphorylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 6. Orthologous to human PDK3 (pyruvate dehydrogenase kinase 3); PARTICIPATES IN pyruvate metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610001M10Rik; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; AI035637; MGC6383; pyruvate dehydrogenase kinase 3; pyruvate dehydrogenase kinase, isozyme 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X92,798,923 - 92,875,756 (-)NCBIGRCm39mm39
GRCm39 EnsemblX92,808,213 - 92,875,807 (-)Ensembl
GRCm38X93,764,616 - 93,832,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX93,764,607 - 93,832,201 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X91,009,955 - 91,077,434 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X90,017,335 - 90,084,814 (-)NCBImm8
CeleraX80,688,439 - 80,755,738 (-)NCBICelera
Cytogenetic MapXC3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14651853   PMID:14681479   PMID:15226823   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:18614015   PMID:21267068   PMID:21677750   PMID:21873635   PMID:25991547   PMID:27113764   PMID:27215380   PMID:27388934   PMID:27597886   PMID:27760309   PMID:28378742   PMID:30482839  
PMID:30550785   PMID:32325033   PMID:32581705   PMID:33773101  


Genomics

Comparative Map Data
Pdk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X92,798,923 - 92,875,756 (-)NCBIGRCm39mm39
GRCm39 EnsemblX92,808,213 - 92,875,807 (-)Ensembl
GRCm38X93,764,616 - 93,832,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX93,764,607 - 93,832,201 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X91,009,955 - 91,077,434 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X90,017,335 - 90,084,814 (-)NCBImm8
CeleraX80,688,439 - 80,755,738 (-)NCBICelera
Cytogenetic MapXC3NCBI
PDK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX24,465,270 - 24,550,466 (+)EnsemblGRCh38hg38GRCh38
GRCh38X24,465,286 - 24,550,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X24,483,403 - 24,568,583 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X24,393,475 - 24,462,463 (+)NCBINCBI36hg18NCBI36
Build 34X24,243,210 - 24,312,199NCBI
CeleraX28,606,234 - 28,691,468 (+)NCBI
Cytogenetic MapXp22.11NCBI
HuRefX22,225,142 - 22,310,559 (+)NCBIHuRef
CHM1_1X24,514,817 - 24,600,156 (+)NCBICHM1_1
Pdk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X58,477,471 - 58,553,932 (-)NCBI
Rnor_6.0 EnsemblX62,836,131 - 62,903,554 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X62,836,131 - 62,904,114 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X63,428,816 - 63,497,161 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X81,104,667 - 81,171,536 (-)NCBIRGSC3.4rn4RGSC3.4
CeleraX58,924,116 - 58,991,740 (-)NCBICelera
Cytogenetic MapXq22NCBI
Pdk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555094,809,399 - 4,878,976 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555094,809,422 - 4,888,802 (+)NCBIChiLan1.0ChiLan1.0
PDK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X24,430,028 - 24,514,873 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX24,430,028 - 24,504,730 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X17,062,278 - 17,147,489 (+)NCBIMhudiblu_PPA_v0panPan3
PDK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X19,994,383 - 20,058,979 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX19,994,393 - 20,058,485 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X19,949,236 - 20,023,756 (+)NCBI
UMICH_Zoey_3.1X19,987,464 - 20,061,958 (+)NCBI
UNSW_CanFamBas_1.0X20,020,576 - 20,095,075 (+)NCBI
UU_Cfam_GSD_1.0X20,078,072 - 20,152,369 (+)NCBI
Pdk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X12,944,337 - 13,025,336 (+)NCBI
SpeTri2.0NW_004936624141,745 - 213,495 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX20,436,815 - 20,602,716 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X20,486,205 - 20,598,492 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X21,996,492 - 22,076,913 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X22,948,162 - 23,030,542 (+)NCBI
ChlSab1.1 EnsemblX22,948,203 - 23,029,868 (+)Ensembl
Vero_WHO_p1.0NW_02366605624,819,882 - 24,896,265 (+)NCBI
Pdk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624897759,367 - 833,947 (+)NCBI

Position Markers
AI035637  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X93,764,979 - 93,765,184UniSTSGRCm38
MGSCv37X91,010,318 - 91,010,523UniSTSGRCm37
CeleraX80,688,802 - 80,689,007UniSTS
Cytogenetic MapXC3UniSTS
Whitehead/MRC_RHX1042.44UniSTS
Pdk3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXC3UniSTS
cM MapX UniSTS
UniSTS:238047  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X93,765,115 - 93,765,221UniSTSGRCm38
MGSCv37X91,010,454 - 91,010,560UniSTSGRCm37
CeleraX80,688,938 - 80,689,044UniSTS
Cytogenetic MapXC3UniSTS
px-13b4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X93,777,487 - 93,777,763UniSTSGRCm38
MGSCv37X91,022,826 - 91,023,102UniSTSGRCm37
CeleraX80,701,169 - 80,701,445UniSTS
Cytogenetic MapXC3UniSTS
px-44a9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X93,819,732 - 93,819,944UniSTSGRCm38
MGSCv37X91,065,071 - 91,065,283UniSTSGRCm37
CeleraX80,743,378 - 80,743,590UniSTS
Cytogenetic MapXC3UniSTS
px-6g10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X93,815,555 - 93,815,654UniSTSGRCm38
MGSCv37X91,060,894 - 91,060,993UniSTSGRCm37
CeleraX80,739,201 - 80,739,300UniSTS
Cytogenetic MapXC3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7360056151324042Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined48090244130864007Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X55000000150000000Mouse
25314318Sccor2_msynaptonemal complex length to mean MLH1 count ratio 2 (mouse)X7150000097500000Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined72410246140302463Mouse
12879918Shm4_msperm head morphology 4 (mouse)X73028444103019114Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX76263065110263152Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX77080730103019114Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X81146308115146453Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined86019000120019114Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:279
Interacting mature miRNAs:311
Transcripts:ENSMUST00000045748, ENSMUST00000134502, ENSMUST00000154717
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000045748   ⟹   ENSMUSP00000036604
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX93,764,607 - 93,832,201 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134502
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX93,782,150 - 93,789,325 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154717
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX93,765,096 - 93,769,120 (-)Ensembl
RefSeq Acc Id: NM_145630   ⟹   NP_663605
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X92,808,222 - 92,875,756 (-)NCBI
GRCm38X93,764,616 - 93,832,150 (-)NCBI
MGSCv37X91,009,955 - 91,077,434 (-)RGD
CeleraX80,688,439 - 80,755,738 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036161924   ⟹   XP_036017817
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X92,798,923 - 92,870,482 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_663605   ⟸   NM_145630
- UniProtKB: Q922H2 (UniProtKB/Swiss-Prot),   Q4FJR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000036604   ⟸   ENSMUST00000045748
RefSeq Acc Id: XP_036017817   ⟸   XM_036161924
- Peptide Label: isoform X1
Protein Domains
BCDHK_Adom3   HATPase_c   Histidine kinase

Promoters
RGD ID:6846072
Promoter ID:MM_KWN:61148
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000043402
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X91,035,291 - 91,035,791 (-)MPROMDB
RGD ID:6846070
Promoter ID:MM_KWN:61149
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000043401
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X91,077,181 - 91,077,787 (-)MPROMDB
RGD ID:13680934
Promoter ID:EPDNEW_M24616
Type:initiation region
Name:Pdk3_1
Description:Mus musculus pyruvate dehydrogenase kinase, isoenzyme 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X93,832,118 - 93,832,178EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384308 AgrOrtholog
Ensembl Genes ENSMUSG00000035232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000036604 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000045748 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.140.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AK/P_DHK_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCDHK/PDK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BCKD/PDK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:236900 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2384308 ENTREZGENE
NCBI Gene 236900 ENTREZGENE
PANTHER PTHR11947 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BCDHK_Adom3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdk3 PhenoGen
PROSITE HIS_KIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HATPase_c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69012 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PDK3_MOUSE UniProtKB/Swiss-Prot
  Q3V250_MOUSE UniProtKB/TrEMBL
  Q4FJR4 ENTREZGENE, UniProtKB/TrEMBL
  Q922H2 ENTREZGENE
UniProt Secondary Q8BTX1 UniProtKB/Swiss-Prot